3WRX


Conserved Protein Domain Family
Viral_helicase1

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pfam01443: Viral_helicase1 
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Viral (Superfamily 1) RNA helicase
Helicase activity for this family has been demonstrated and NTPase activity. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis.
Statistics
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PSSM-Id: 307550
View PSSM: pfam01443
Aligned: 73 rows
Threshold Bit Score: 103.609
Threshold Setting Gi: 81920794
Created: 15-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3WRX_C       165 LVDGVPGCGKTKEILSRVnFeedl--ilvpGRQaAEMIRRRAnasgiIVATKDNVRTVDSFLMNYGKGarcQFKRLFIDE 242
gi 548840    912 AIHGAGGAGKSRALQELLrSspeladsiniVVPtINLANDWK-----AKLPQMDPRRVMTFQKACERE---CKSVTIFDD 983
gi 81919757  745 VIHGAGGAGKSRALQEILrSnsidtnqvniIVPtINLAVDWK-----KKLPKIDPRRVMTFEKACERE---GKSVVIMDD 816
gi 139143    602 VIHGAGGSGKSQRLQDWMrSlkknsrectvILPtAELRTDWV-----NKVPKQSLDTFKTWEKGLVQP---PNRVVILDD 673
gi 81920793  660 VIHGAGGCGKSYAIQKWLrScsdpc-aatvVCPtLELRNDWL-----NKIGSYEQTNIKTFEKALIQP---VNNVVIFDD 730
gi 139141    732 VIHGAGGSGKSHAIQKALrEigkgs-ditvVLPtNELRLDWS-----KKVPNTEPYMFKTYEKALIGG---TGSIVIFDD 802
gi 139133    600 VLHGAGGSGKSYALQEFMrNnsdt--pitvILPtNELRADWK-----KKLPAHDKDTFMTYENALLCP---RGDIFIMDD 669
gi 81935454  634 VIHGAGGSGKSRALQEYMrNnked--pivtILPtNELRADWK-----AKLPAHDPDMFMTFENALLIP---KGNVVIMDD 703
gi 81935932  732 VIHGAGGSGKSAALQDLLrDhpel--piqvILPtNELRMDWL-----SKLPRNRPENFRTFEKAYLQT---NAPSIIMDD 801
gi 1173174   662 VIHGAGGSGKSQALQTLLrQdhsl--pievVLPtNELRLDWL-----KKLPHNPPEQFRTFERAFVSS---HSPVVIFDD 731
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3WRX_C       243 GLMLHtgcvNFlv-emSLCDIAYVYGDTQQIPYInrvtgfPYPAHFAKLevDEVETRRTTLRCPADVTHFLNQRYEGhVM 321
gi 548840    984 YGKLPagfvDAylaikVNVELAILTGDQRQSTHHqer-esQISSLQSNI--AQFSKYADYYLNATHRQPRRLANPIK-VH 1059
gi 81919757  817 YGKLPagyiDAylaikFNVEIVILTGDQRQSVFHndrkdsQIALLTSNT--AHFKRYCDYYLNATHRQPRRLANPIR-VH 893
gi 139143    674 YGKLPagypEAlcanyPNIELLILTGDSRQSVHNehnkqaATASLESNI--EFWTQYCRFYVNATHRNVKRLANALG-VY 750
gi 81920793  731 YTKLPpgyiETmvyhhHNLDLIILTGDPMQSAYHetnrdaYISLIPDAS--AIFSEYCEFNINATHRNVAELACLLG-VY 807
gi 139141    803 YSKLPpgyiEAlvsfsTKIKLIILTGDSRQSVYHetsddaSIRHLGPAT--EVFAKYCRYYLNATHRNKKDLANMLG-VY 879
gi 139133    670 YTKLPrgyiEAfvqnaPALSLLILTGDPNQAEHFettednEINSLAPAS--VVFGKFSRYHINATHRNPRNLANALG-VY 746
gi 81935454  704 YTKLPrgyiEAyvqnsPMLDLLILTGDPRQSEHFesaegnTINDLSPSP--VVFSAYARYYINATHRNNQDLANALG-VY 780
gi 81935932  802 YGKLPqgyvEAfavthPNVELIVLTGDNKQSVHHetneqaMIAQLEPST--QIFSQFSRYYINATHRNAKKLANMLG-VY 878
gi 1173174   732 YGKLPqgylEAfalthANLELVILTGDPRQSTHHesneeaLISKLPPAT--TIYSAFSRYYINATLRNSKFLANKLG-VY 808
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3WRX_C       322 CTSSEKksvsqemVsgAASINPVsk--plKGKILTFTQSDKEaLLSRgyadVHTVHEVQGETYADVSLVRLtpTPvsiia 399
gi 548840   1060 AERQLG-------GavLKANIVPdl--amVLVPAFRSQSLLTdLGRH----AMTYAGCQGLTLNHLTIILDkdTPl---- 1122
gi 81919757  894 AEREVG-------GaiKHSTLIPth--amTLVPAFRSQSLLTdLGRQ----AMTYAGCQGLTLPHLTIVLDkdTPl---- 956
gi 139143    751 GERDEP-------LkvTCSSHVYdg--wpVLAPGLLKAGNLAeCGRR----AFTYAGCQGLTAPRVQILLDndTPl---- 813
gi 81920793  808 SERQGK-------LtvSFSTAPLskgkvpILVPSRMKQEAFAdVGNR----CMTYAGCQGLTAPKIQILIDnhTTf---- 872
gi 139141    880 SERTGT-------TeiSMSSEFLeg--vpTLVPSDEKRRLYMgTGRNd---TFTYAGCQGLTKPKVQIVLDhnTQv---- 943
gi 139133    747 SETPGE-------VkvLYTRNIKtg--yhNLVPSQMKMRNYAsLGQR----ASTYAGCQGITAPRVQIILDsdTPr---- 809
gi 81935454  781 SEKQGK-------TriSVSNHIEdg--rhTLVPSQIKQRNYVsMGRK----TSTYAGCQGITASRVQVIIDndTAk---- 843
gi 81935932  879 SDNNKE-------LkiTHGFQPIkd--ihLLVPSLIKKAAFSeAGHK----TSTYAGCQGITARKLQILLDsnTPm---- 941
gi 1173174   809 SANSCP-------LnvTYGFQPLpg--lhLLVPSLMKKAAFTdAGHK----VSSYAGCQGITAPKVQILLDndTTm---- 871
                        250       260
                 ....*....|....*....|.
3WRX_C       400 rDSPHVLVSLSRHTKSLKYYT 420
gi 548840   1123 cSDEVLYTAFSRASESITFVN 1143
gi 81919757  957 cSDEVLYTALSRASETITFVN 977
gi 139143    814 cSQRVMYTALSRAVNEIHFVN 834
gi 81920793  873 cSEQTLYTCLSRAVDQIHFIN 893
gi 139141    944 cSANVMYSALSRATDRIHFIN 964
gi 139133    810 cTRQVMYTALSRATTEVVLCN 830
gi 81935454  844 cSHQVLYTAFSRAADEIHFCN 864
gi 81935932  942 cSQEVLYTALSRAVDSIHFIN 962
gi 1173174   872 cTKEVLYTALSRAVDSIHFVN 892
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