Conserved Protein Domain Family
PseudoU_synth_1

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pfam01416: PseudoU_synth_1 
tRNA pseudouridine synthase
Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.
Statistics
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Aligned: 311 rows
Threshold Bit Score: 46.7468
Threshold Setting Gi: 151425285
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHY53673      387 AAKKLEGLHDFR-NLCKIDPSKqmPSCERRITYADIVewedTGkmfsshpalnqtgasssgldsasnsnglnvaallgkg 465 Exophiala derm...
Q54RR6          7 IIYEYIGKSFTG--FQRLKYPVv-KLPVQQVLEDSLEkihgY-------------------------------------- 45  Dictyostelium ...
CBV42120        1 MAVEYDGSQYCG--W--QRLKH--AASVQASLEQALSrvagA-------------------------------------- 36  Halomonas elon...
jgi:Maqu_1560  21 IIFEYDGQAFHG--W-QLQKSG--VRSVEAELSRAAArvadH-------------------------------------- 57  Marinobacter h...
jgi:Haur_4942   7 LCFEYLGTAFCG----SQWQPG--GRAVQTELETAWQrltsET------------------------------------- 43  Herpetosiphon ...
XP_004343582   82 LAVEYDGTAFSGvAASPDEPPD--RPSVGSVLDRAIAqatrQ-------------------------------------- 121 Capsaspora owc...
CDD22955        6 IIFSYKGTNFYG----SQKQPG--LNTVQNLFEDTLSriydE-------------------------------------- 41  Firmicutes bac...
CDC25280        5 IFFGYDGTNYHG--W--QIQPN--ANSVQQELQKALStllrR-------------------------------------- 40  Prevotella sp....
CCY35799        5 ASISYNGSGLSG--W--QIQDN--APSVQDEIQKAVSavlgE-------------------------------------- 40  Alistipes sp. ...
XP_002526453   58 IAVEYIGTKFAG----SQKQLN--GRTVVGVLEEAFCkfigQ-------------------------------------- 93  castor bean
EHY53673      466 dayssspsptvagvggasgpkvyAFCVHGSAFLWHQVRCMVAIL-FLV------------GQ--GLEQPSIVDDLLDVEK 530 Exophiala derm...
Q54RR6         46 -----------------------KIPIVGSSRTDHGVSAVGQVShFDVktrts---ksgiEM--PLLSPEELTMAINYNV 97  Dictyostelium ...
CBV42120       37 -----------------------PVRVHASGRTDSGVHATRQIV--HFd-----------PP--APRSEKAWVFGANANL 78  Halomonas elon...
jgi:Maqu_1560  58 -----------------------PVDLVCAGRTDAGVHASFQVA-HFD------------TP--SVRNLRSWVMGMNTAL 99  Marinobacter h...
jgi:Haur_4942  44 ------------------------GRWIFAGRTDAGVHALAQVA-HIV------------SD--TPRSLDTIAKAINAIT 84  Herpetosiphon ...
XP_004343582  122 -----------------------DARVTFSSRTDAGVHALWNTC--HVdieprtrrgdlmTQ--QQWTPLALGSAINYFS 174 Capsaspora owc...
CDD22955       42 -----------------------KIKFCLSSRLDRGVHAIFMGGnFKT------------SK--EKMKMDKLKYALNRLF 84  Firmicutes bac...
CDC25280       41 -----------------------DMEVVGAGRTDTGVHARKMAAhFDW------------EG--EELDAPQLTYRLNRIL 83  Prevotella sp....
CCY35799       41 -----------------------KISVVGAGRTDAGVHASDFTAhFDSd----------sLC--LLEDPAHVIYKINAIL 85  Alistipes sp. ...
XP_002526453   94 -----------------------QVSVSLSSRTDAGVHALSNVChVDIeris----krkpGEvlPPHEPAVVRRAVNHFL 146 castor bean
EHY53673      531 tpTR----PMYEMADDAPLVL--WDCIFP 553 Exophiala dermatitidis NIH/UT8656
Q54RR6         98 g-KEy---LKSIRIIKTEIVDdkFHCRFN 122 Dictyostelium discoideum AX4
CBV42120       79 p-RD----IAVRWVMPVGE-D--FHARFK 99  Halomonas elongata DSM 2581
jgi:Maqu_1560 100 p-DD----ISVHWAGNGQG-D--FHARFS 120 Marinobacter hydrocarbonoclasticus VT8
jgi:Haur_4942  85 p-PD----ISVHEAWEMPT-G--FHARFS 105 Herpetosiphon aurantiacus DSM 785
XP_004343582  175 r-GKvpypMSVRAVCAVPE-Q--VHARFN 199 Capsaspora owczarzaki ATCC 30864
CDD22955       85 p-LY----IQVIDIKEVGE-D--FSARYD 105 Firmicutes bacterium CAG:345
CDC25280       84 p-RD----IAVKDIKRVAD-D--MHARFS 104 Prevotella sp. CAG:386
CCY35799       86 p-KN----IVFRSITRVRD-D--AHARFD 106 Alistipes sp. CAG:831
XP_002526453  147 q-KNeg-dIMVTDVRCVPS-D--FHARFK 170 castor bean
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