2ZZF,3WQY


Conserved Protein Domain Family
tRNA-synt_2c

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pfam01411: tRNA-synt_2c 
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tRNA synthetases class II (A)
Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Statistics
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PSSM-Id: 279719
View PSSM: pfam01411
Aligned: 24 rows
Threshold Bit Score: 603.5
Threshold Setting Gi: 3334348
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZZF_A  61 EMREKFLRFFEKHEiypHGRVKRYPVLPR-WRDDVLLVGASIMDFQPWVISGE---ADPPANPLVISQPSIRFT----DI 132 Pyrococcus horikoshii
Q8U425  61 EMREKFLSFFEKHEvypHGRVKRYPVLPR-WRDDVLLVGASIMDFQPWVISGE---ADPPANPLTISQPSIRFT----DI 132 Pyrococcus furiosus D...
O27718  58 EIQDKFMEFFAERG---HEPIRRYPVLAKrWRDDVFLVGASIYNFQPWVTSGL---VKPPANPLVVAQPSIRLN----DV 127 Methanothermobacter t...
Q57984  61 EMVKEFINFFKEHG---HEPIKRAPVTARrWRDDILLTIASIAVFQPWITKGI---VKPKANPLVIAQPCIRLN----DI 130 Methanocaldococcus ja...
O67323   7 EIRELFLSFFEKKG---HTRVKSAPLVPE-NDPTLLFVNAGMVPFKNVFLGLE----KRPYKRATSCQKCLRVSgkhnDL 78  Aquifex aeolicus VF5
P75368   7 KVRQTWLDYFTAKG---HLALPSKSLIPV-NDPSLLWINSGVATLKDYFSAKK----TPPSKRLANAQICLRVN----DI 74  Mycoplasma pneumoniae...
O34526   8 EVRQMFLDFFKEKG---HAVEPSASLVPH-EDPSLLWINSGVATLKKYFDGRV----VPENPRIVNAQKAIRTN----DI 75  Bacillus subtilis sub...
P9WFW7   5 EIRKRFLDHFVKAG---HTEVPSASVIL--DDPNLLFVNAGMVQFVPFFLGQR----TPPYPTATSIQKCIRTP----DI 71  Mycobacterium tubercu...
P74423  12 EIRQQFLNFFADRQ---HQILPSASLVP--EDPTVLLTIAGMLPFKPIFLGQK----SAEFPRATTSQKCIRTN----DI 78  Synechocystis sp. PCC...
P74941   5 EIREKFLSFFEGKG---HLRLPSFSLIPE-DDPSLLFTSAGMAPLKPYFLGAKpifGGREWRRVTTCQECLRVG----DI 76  Thermus thermophilus HB8
2ZZF_A 133 DNVGITGRHFTIFEMMAHHAFNypgkpIYWMDETVELAFEFFTk--E-----LKMKPEDITFKENPWAggG--NAGPAFE 203 Pyrococcus horikoshii
Q8U425 133 DNVGITGRHFTIFEMMAHHAFNypgkhIYWIDETVELAFEFFTk--E-----LKMKPEDITFKENPWA--GggNAGPAFE 203 Pyrococcus furiosus D...
O27718 128 DNVGRTGRHLTCFTMGGHHAFNsedntVYWEEETIKYCHDFLT---H-----IGIDPSEITFIESWWQ--GggNEGPCYE 197 Methanothermobacter t...
Q57984 131 DNVGRTGRHLTCFTMGGHHAFNreddfKYWQDETVELCFNFFK---K-----LGIDEKSITFIESWWE--GggNAGPCYE 200 Methanocaldococcus ja...
O67323  79 EQVGYTSRHHTFFEMLGNFSFG-----DYFKKEAIEYAWEFVTe--V-----LKLPKEKLYVSVYKDD--E--EAYRIWN 142 Aquifex aeolicus VF5
P75368  75 ENVGFTSRHQTLFEMLGNFSIG-----DYFKEEAIGFANDLLVn--H-----YHLDPKRFYITVYQDD--E--LTFNTWL 138 Mycoplasma pneumoniae...
O34526  76 ENVGKTARHHTFFEMLGNFSIG-----DYFKEEAITWAWEFLTsdkW-----IGFDKELLSVTVHPED--E--EAYEFWA 141 Bacillus subtilis sub...
P9WFW7  72 DEVGITTRHNTFFQMAGNFSFG-----DYFKRGAIELAWALLTn--SlaaggYGLDPERIWTTVYFDD--D--EAVRLWQ 140 Mycobacterium tubercu...
P74423  79 ENVGRTARHHTFFEMLGNFSFG-----DYFKSQAIAWAWELSTq--V-----FKLPAERLVVSVFEED--D--EAFAIWR 142 Synechocystis sp. PCC...
P74941  77 ENVGRTSRHNTYFEMLGNFSFG-----DYFKKEAILWAWEFLTe--H-----LKLDPGRLWVTVFEDD--D--EAYEIWR 140 Thermus thermophilus HB8
2ZZF_A 204 VLYrGLEVATLVF---MQYK-----KAPEN-------------APqdqvvvikgekyiPMETKVVDTGYgleRLVWMSQG 262 Pyrococcus horikoshii
Q8U425 204 VLYkGLEVATLVF---MQYK-----KAPANadpsqvviikgekYV-------------PMETKVVDTGYgleRLVWMSQG 262 Pyrococcus furiosus D...
O27718 198 VCVrGVELATLVF---IQYR-----TLPDGg------------RE-------------EIPLKIVDTGYgleRFAWISQG 244 Methanothermobacter t...
Q57984 201 VIThGVELATLVF---MQYE-----KVGDN-------------YK-------------EIPLKIVDTGYgieRFVWASTG 246 Methanocaldococcus ja...
O67323 143 EHIgIPSERIWRLgeeDNFW-----QMGDV-------------GP-------------CGPSSEIYVDRgeeYEG----- 186 Aquifex aeolicus VF5
P75368 139 KHG-IPASRIIKCdrdRNFW-----DLGL--------------GP-------------CGPCTEIYYDRgerFDPHKVGE 185 Mycoplasma pneumoniae...
O34526 142 KKIgIPEERIIRLe--GNFW-----DIGE--------------GP-------------SGPNTEIFYDRgeaYGNDPEDP 187 Bacillus subtilis sub...
P9WFW7 141 EVAgLPAERIQRRgmaDNYW-----SMGIP-------------GP-------------CGPSSEIYYDRgpeFGP--AGG 187 Mycobacterium tubercu...
P74423 143 DEIgIPAHRIQRMgadDNFW-----VSGPT-------------GP-------------CGPCSEIYYDFhpeLGD--EKL 189 Synechocystis sp. PCC...
P74941 141 DLVgVPEERIGRFgedENYWpggaiTHGPN-------------GP-------------SGPCSEIFYDRgpaYGTPDETG 194 Thermus thermophilus HB8
2ZZF_A 263 TPT---AYDAVLGYVVEPLKKMAGIE-------KIDEKILMENSRLAGMFDIEDLGDLRYLREQVAKRVGITVEELEKAI 332 Pyrococcus horikoshii
Q8U425 263 TPT---AYDAVLGYVIEPLKRMAGVE-------KIDERILMENSRLAGMFDIEDMGDLRYLREQVAKRVGISVEELERLI 332 Pyrococcus furiosus D...
O27718 245 TPT---AYDACLGPVIEKLVELTGVK--------IDEEILAENAQVAGMMDIETYADLRELRKRVADKLGISVEELERAA 313 Methanothermobacter t...
Q57984 247 EPT---IYDAIFKNIVNKLKEDAGVK-------DIDKEILAKITEVAGLMDVKDVGDLRKLREEVANKVNIPVEELDKLI 316 Methanocaldococcus ja...
O67323 187 -DE-------RYLEIWNLVFMQYNRDe------NGVLTPLPHPNIDTGMGLERIASVLQGKNSNFEIDIIFPLIQFGEEV 252 Aquifex aeolicus VF5
P75368 186 KLFfedIENDRYVEVWNIVFSQFNNDg------NGNYSELAQKNIDTGAGIERLVAILQDAPTNFDTDIFLKLIGIIEQH 259 Mycoplasma pneumoniae...
O34526 188 ELYp-gGENDRYLEVWNLVFSEFNHNp------DGTYTPLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESI 260 Bacillus subtilis sub...
P9WFW7 188 PIV----SEDRYLEVWNLVFMQNERGegttkedYQILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARV 263 Mycobacterium tubercu...
P74423 190 DLE----DDSRFIEFYNLVFMQYNRDn------AGNLTPLEKKNIDTGMGLERMAQILQKVPNNYETDLIFPIIQTAANI 259 Synechocystis sp. PCC...
P74941 195 PNT---GSGDRFVEIWNLVFTQYDRQgpi--pgPGILKPLPQKNIDTGMGLYRVAAILQDVEDFYRTDTFFPIIQEVARM 269 Thermus thermophilus HB8
2ZZF_A 333 RP------------------YELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVP-LSEIVAL 393 Pyrococcus horikoshii
Q8U425 333 RP------------------YELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVP-LAEIVAM 393 Pyrococcus furiosus D...
O27718 314 AP------------------MESVYAIADHTRCLAFMLADGVIPSNVKEGYLARLIIRRTLRLMKDLGMKES-LKDIMNI 374 Methanothermobacter t...
Q57984 317 SP------------------YEDIYAIVDHTRALAFMLGDGIVPSNVKDGYLVRMLIRKTLRHMDRLNLSTP-ITEIVAM 377 Methanocaldococcus ja...
O67323 253 SGkkyge---------kfetDVALRVIADHLRAITFAISDGVIPSNEGRGYVIRRILRRAMRFGYKLGIENPfLYKGVDL 323 Aquifex aeolicus VF5
P75368 260 CKhkydtnlyfkfdqklneaQSAFRIISDHFKAITFTIAEGVLPGPNERSYIVRRLLRRALLACKKLDLDLKfIDPMVDA 339 Mycoplasma pneumoniae...
O34526 261 SGetygk---------dnvkDTAFKVIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPfMFDLVPV 331 Bacillus subtilis sub...
P9WFW7 264 AAraydv--------gnhedDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAiVGDLMAT 335 Mycobacterium tubercu...
P74423 260 AGidyaq--------anektKVSLKVIGDHVRSVVHMIADGISASNLGRGYVLRRLIRRVVRHGRLLGINGEfTTKVAAT 331 Synechocystis sp. PCC...
P74941 270 SGrpye-----------gktSVSHRVIADHVRAVVAALSDGATFSNTGRGYVIRRLLRRALRHGYLLGLSDPfLHRLAPL 338 Thermus thermophilus HB8
2ZZF_A 394 HIKELHktfPEFKEMEDIILEMIELEEKKYAETLRRGSDLVRREIAkl--kKKgiKEIPVEKLVTFYESHGLTPEIVKEI 471 Pyrococcus horikoshii
Q8U425 394 HIKELSptfPEFKEMEDIILEMIELEEKKYAETLRRGSDLVKREIAklkkkGA--NEIPLEKLITFYESHGLTPEIVKEI 471 Pyrococcus furiosus D...
O27718 375 QVEFLEghyPEIRSHHEHILNIIDLEEHRYARTVKRGRRIVEKTIKylkrdGK--AEMPLEILIKLYDSHGIPPETIGEI 452 Methanothermobacter t...
Q57984 378 QLNELKdlyPELLDMEDYIMEILEIETNKYRQTIERGKGIVERLLKs-----K--KEIDLENLIELYDSHGLPPEIVKDV 450 Methanocaldococcus ja...
O67323 324 VVDIMKepyPELELSREFVKGIVKGEEKRFIKTLKAGMEYIQEVIQkaleeGR--KTLSGKEVFTAYDTYGFPVDLIDEI 401 Aquifex aeolicus VF5
P75368 340 IISVYGsyyQQLQGKNQVVQQAIWKEVTAFDKTINLGLMLFEKSIAh--------NALQPQVAFQLYETYGFPIEMIKEL 411 Mycoplasma pneumoniae...
O34526 332 VAEIMAdfyPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKkekdkGS--SVISGADVFKLYDTYGFPVELTEEY 409 Bacillus subtilis sub...
P9WFW7 336 VRNAMGpsyPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASstkksGA--TVLSGSDAFTLHDTYGFPIELTLEM 413 Mycobacterium tubercu...
P74423 332 AVQLAQpvyPNVLERQSLIEQELQREEAAFLKTLERGEKLLADLMAd----GV--TEIAGADAFTLYDTFGFPLELTQEI 405 Synechocystis sp. PCC...
P74941 339 VAELLGdfyPEMRENLPAVEKQIRLEEERFLETLEGGLKRLDALLSgl--kpG--EVLPGKEAFRLYDTYGFPLDLTVEI 414 Thermus thermophilus HB8
2ZZF_A 472 AEKEGVKVNIPDNFYSMVAKEAERtKEEKGEElv---dFELLKDLPDT---Rr-LYYEDpf----------mKEFDAKVL 534 Pyrococcus horikoshii
Q8U425 472 AEKEGVKVHIPDNFYSLVAKEAEKqVEEKEEEvv---dFELVKDLPDT---Rt-LYYEDpf----------mKEFDAKVL 534 Pyrococcus furiosus D...
O27718 453 AEESGFQVKIPDNFYTLVAERNETeTEMPE--------EDVHLDYPAT---El-LFYDEpd----------dLEFQAEVI 510 Methanothermobacter t...
Q57984 451 AKSLGKDVKIPDNFYTIVAERHENkKEVKEKI------KLPEVNVDKT---El-LFYEYpk----------mKEFEAKIL 510 Methanocaldococcus ja...
O67323 402 AREKGLGIDLEGFQCELEEQRERArKHFKVEAkkvkpvYSHLKELGKT---SafVGYEHmewesqvvglvkgEGLVSELK 478 Aquifex aeolicus VF5
P75368 412 VDKRQLQVDWKAVEQLMEQHRLISkQNSNTLSfe--kqNEHLVNFKTA---SefLYEANeitakv-iglfdeQYQPVQKL 485 Mycoplasma pneumoniae...
O34526 410 AEDENMTVDHEGFEEEMNQQRERArNARQDVGsmq-vqGGALRDVTVE---StfVGYSQtkadaniivllqdGQLIEEAH 485 Bacillus subtilis sub...
P9WFW7 414 AAETGLQVDEIGFRELMAEQRRRAkADAAARKhah-adLSAYRELVDAg-aTefTGFDElrsqarilgifvdGKRVPVVA 491 Mycobacterium tubercu...
P74423 406 AEEQGITVDVEGFEKAMQEQQERSkAAHETIDltvqesLDKLANHIHP---TefLGYTDlqssaivkavlvgGELVDQAV 482 Synechocystis sp. PCC...
P74941 415 AAERGYGVDTEGFQKAMEEQQSRSrAAMAFEReifkkgAQVLEELYAErgaTefLGYNAleaeaevlallagDQSLLEAG 494 Thermus thermophilus HB8
2ZZF_A 535 RVIKDW--------VILDATAFYPEGGGQPYDTG-VLIVNG----REVKVTNVQKVG-KVIIHKVEDp-GAFKEGMIVHG 599 Pyrococcus horikoshii
Q8U425 535 KVIEDW--------VVLDQTAFYPEGGGQPYDTG-ILVVDG----EEVKVTNVQKVG-KVILHKVERp-ELFKEGTIVHG 599 Pyrococcus furiosus D...
O27718 511 GIHENG--------LILDRTLFYPEGGGQPSDTG-YITAEG----CRLRIKHAEKIG-AVVVHRTDDe-ICIEPGTTIRG 575 Methanothermobacter t...
Q57984 511 RIVDDY--------VILDRTAFYPEGGGQKADTG-YIIKGD----KKFRVVDVQKEN-NIVYHKIENlnDELKEGDIVKG 576 Methanocaldococcus ja...
O67323 479 EGEEGE--------VVLKETPFYPEGGGQIGDAG-IIESDK----ALFKVEDTQKPTeGIIVHIGKVlkGTLKVGDTVHA 545 Aquifex aeolicus VF5
P75368 486 HNQSGY--------VVFDQTVLYATSGGQRYDEGyCINHSQ----NDQRVSFQGVFKgPNKQHFHFFltGSFQLGDKVIL 553 Mycoplasma pneumoniae...
O34526 486 EGESVQ--------IILDETPFYAESGGQIGDKG-YLRSEQ----AVVRIKDVQKAPnGQHVHEGVVesGTVQKGLHVTA 552 Bacillus subtilis sub...
P9WFW7 492 HGVAGGagegqrveLVLDRTPLYAESGGQIADEG-TISGTGsseaARAAVTDVQKIAkTLWVHRVNVesGEFVEGDTVIA 570 Mycobacterium tubercu...
P74423 483 AGQTVQ--------IVLDQTPFYGESGGQIGDKG-FLNGDN----LLIRIEDVKRES-GIFIHFGRVerGTVQIGTTITA 548 Synechocystis sp. PCC...
P74941 495 PGTEVQ--------VVLDKTPFYAEGGGQIGDFG-LLEWPG----GRARVETTRKTErGIFLHKARVeeGVLRVGERVRA 561 Thermus thermophilus HB8
2ZZF_A 600 KIDWKR 605 Pyrococcus horikoshii
Q8U425 600 RIDWER 605 Pyrococcus furiosus DSM 3638
O27718 576 FIDSDR 581 Methanothermobacter thermautotrophicus str. Delta H
Q57984 577 VIDWKR 582 Methanocaldococcus jannaschii DSM 2661
O67323 546 RVDKER 551 Aquifex aeolicus VF5
P75368 554 VHDGKW 559 Mycoplasma pneumoniae M129
O34526 553 EVEDHM 558 Bacillus subtilis subsp. subtilis str. 168
P9WFW7 571 AVDPgw 576 Mycobacterium tuberculosis H37Rv
P74423 549 TIDRAC 554 Synechocystis sp. PCC 6803 substr. Kazusa
P74941 562 VVD-PR 566 Thermus thermophilus HB8
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