Conserved Protein Domain Family
tRNA-synt_2d

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pfam01409: tRNA-synt_2d 
tRNA synthetases class II core domain (F)
Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.
Statistics
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PSSM-Id: 366623
View PSSM: pfam01409
Aligned: 44 rows
Threshold Bit Score: 237.467
Threshold Setting Gi: 74514623
Created: 18-Mar-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O42870 208 SYNFAAE---GIPPAGGCLHPLMKVREEFRKFFFELGFEEMPtNNFVESGFWNFDALFVPQQHSARDAQDTFFLkvpast 284 Schizosaccharomyces p...
O30126 103 P-NVGISaekIRQIEAITKREVDS--KPLQEIFHRYKKGEIDgDDLS---YLIAEVLDVDDITAVKILDEVFPEfkel-- 174 Archaeoglobus fulgidu...
Q59054 103 P-DVGLGnekVEIIKNLGIDIDEEKKERLREVLHLYKKGAID-GDDL--VFEIAKALNVSNEMGLKVLETAFPEfkdl-- 176 Methanocaldococcus ja...
O83938 280 RYNVHIP---PARIIPGRSNAYADFLEHIKDRLVALGFQEFD-GPLVETDFWNADALFMPQFHPARDIHDVYYLkhptha 355 Treponema pallidum su...
Q8U261 222 pFNIKAP---VKKIYPGKKQPYRVFLDKIRRKLIEMGFIEITvDSLIETQFWNFDALFQPQNHPAREWTDTYQLkypekg 298 Pyrococcus furiosus D...
Q9Y9I6 218 PYNVKAE---PPRVLPARRHFLAEFIERLRDILRELGFREVR-GPLVELELFNFDVLFQAQDHPAREIHDSLWIksprrg 293 Aeropyrum pernix K1
P95961 200 KYNVEAF---PPYYTISKKHYFREFLEKVKDIMISLGFKEIN-TGYIEMEFYNFDLLFQPQDHPAREIHDSFSVegsgki 275 Saccharolobus solfata...
Q57911 212 PYDVKVP---TKPIYPAKVHPLTRIIREVKEILLAMGFKEVK-SPIVETEFWNFDMLFEPQDHPAREMQDTFFLkypneg 287 Methanocaldococcus ja...
O28324 200 KYDITIP---AKEIYGGKIHPYERIIEECRKVFLEMGFTEIK-GHYVQPAFWNFDALFQPQDHPARDMQDTFYLdryidl 275 Archaeoglobus fulgidu...
O26837 232 GYNIDAE---YPLVYPGKMHPLRRIIDEIRSIFLKLGFTESR-GPIVESAFWNFDCLFQPQDHAAREMQDTFYVknpavt 307 Methanothermobacter t...
O42870 285 dklpdpeyvarvkathenggetkgigyrapfsleeTRKLVLRTHTTAVSANMLyk-laQNGFHPAKYFSIDRVFRNET-V 362 Schizosaccharomyces p...
O30126 175 --------------------------------kpiSSTLTLRSHMTTGWFITLsh-iaDKLPLPIKLFSIDRCFRREQgE 221 Archaeoglobus fulgidu...
Q59054 177 --------------------------------kpeSTTLTLRSHMTSGWFITLss-liKKRKLPLKLFSIDRCFRREQrE 223 Methanocaldococcus ja...
O83938 356 ptipepflsrvaat-hergadsgslgwrysfdrdfTRRLLLRSQGTALSARHL-----PTAHIPGKYFGIARCFRHDQ-V 428 Treponema pallidum su...
Q8U261 299 ylpnrelvervkea--herglagsrgwgyvwsperAMFLMPRAHATALSARQLa----KGIEIPGKYFTIQRVFRPDV-L 371 Pyrococcus furiosus D...
Q9Y9I6 294 dlsgysdlver-------vasvhergwkyrwspevASRYILRSQTTAVSARILa----TRPNPPARFFTVGKVFRSDA-V 361 Aeropyrum pernix K1
P95961 276 edkdllnnvk----------eihekfwkyewkqdiTLRLMLRSQTTATTARVLa----SRPKAPQKVFTLGKVFRPDA-I 340 Saccharolobus solfata...
Q57911 288 dipedllskv---------kevhercwkykfdenvSRRLILRTHTTASSIRYLaslsdEEKNKPHKVFCIDRVFRNEA-I 357 Methanocaldococcus ja...
O28324 276 egeivervkathe----ngwitgstgwggewslekARQLVLRTHTTAITIHYLa----ENPEPPQKAFCIDRVYRRET-I 346 Archaeoglobus fulgidu...
O26837 308 dlpcedlvravqda-hetggstgsegwqyewdrdvARQSVLRTHTTCVSARFL-----SENEPPLKMFSVGRVFRRET-I 380 Methanothermobacter t...
O42870 363 DATHLAEFHQVEGVICDRNITLGDLIGFLEVFFGKM-NVK--NLRFKPAYNPYTEPSLEVFSYH----------EKLGKW 429 Schizosaccharomyces p...
O30126 222 DATRLYTYFSASCVLVDEELSVDDGKAVAEALLRQF-GFEnfRFRKDEKRSKYYIPDTQTEVFAfhpklvgsstKYSDGW 300 Archaeoglobus fulgidu...
Q59054 224 DRSHLMSYHSASCVVVGEDVSVDDGKVVAEGLLAQF-GFTkfKFKPDEKKSKYYTPETQTEVYAy--------hPKLGEW 294 Methanocaldococcus ja...
O83938 429 DATHLADFYQTEGIVLGTDVNVCTLLGMLKILATEIaGAQ--EVRYVGGYFPFTEPSIELHALH-----------PALGW 495 Treponema pallidum su...
Q8U261 372 DRTHLIEFNQIDGFVAAEDLTFRHLLGILKKFAIEIaGAK--KVKFFPDYYPFTEPSVQLSAYH-----------PELGW 438 Pyrococcus furiosus D...
Q9Y9I6 362 GPTRLPEFHQLDGIEGDEGYTFRDLLGRLDEIASML-GLK---LKFKPAYFPFTEPSVEGYVKL-----------PNGRW 426 Aeropyrum pernix K1
P95961 341 DATHLIEFHQLDGVIIDNNFTFKELLGVLKEIFYRL-GIK--EVKFKPAYFPFTEPSVEAYGYL-----------EKLGW 406 Saccharolobus solfata...
Q57911 358 DYKHLPEFYQCEGIIMDDNVNFNNLIGVLKEFLNRL-GFE--KVRFRPAYFPFTEPSLEAEVYL-----------EGKGW 423 Methanocaldococcus ja...
O28324 347 DATHLPEFDQLEGVVLDRDVGFKHLLGLLKEFFTKM-GFE--DVRFRPGYFPYTEPSVEPEVYV-----------EGLGW 412 Archaeoglobus fulgidu...
O26837 381 TYKHLPEFHQVEGIVAGDEVNFRNLLGILREFYRKL-GFE---VRFRPAYFPYTYLSTECEIYL----------PEKKSW 446 Methanothermobacter t...
O42870 430 VEVGNSGMFRPEMLEPMGLpkDVRCLGFGLSLERPTMIKYGVADIRQLIGPkvNLDLIEAS 490 Schizosaccharomyces pombe 972h-
O30126 301 IEIATFGIYSPTALAEYDI--PYPVMNLGLGVERLAMILYGYDDVRKMVYP----QIHGEI 355 Archaeoglobus fulgidus DSM 4304
Q59054 295 IEVATFGVYSPIALAKYNI--DVPVMNLGLGVERLAMIIYGYEDVRAMVYP----QFY-EY 348 Methanocaldococcus jannaschii DSM 2661
O83938 496 FELGGAGLLRPEVTDPLGV--HVPVMAWGLGVDRMALLALGISDVRELFSP--DIESVRLR 552 Treponema pallidum subsp. pallidum str. ...
Q8U261 439 VEFGGAGVFREEMTKALGI--DVPVIAWGIGIDRLAMFRLGIDDIRYLFSY--DLKWLREa 495 Pyrococcus furiosus DSM 3638
Q9Y9I6 427 LELFGAGMFRPEVLEAVGV--DYPVGAWGFGIERLAMAFYGVSDIRKLYTR--NVDEVREM 483 Aeropyrum pernix K1
P95961 407 VEMCGAGLLRPEILSSVGI--DSTAGAWGIGIERLAMSFLNISDIRLLYSN--NIEYIRDT 463 Saccharolobus solfataricus P2
Q57911 424 LEILGAGIFRPEVLEPIGI--EKPVLAWGIGFSRLAMLRYGLTDIRDLHKN--DLDWLKRV 480 Methanocaldococcus jannaschii DSM 2661
O28324 413 VELGGAGVFRKEVTEPLGI--RGKVLAWGLGIGRLAMLKIGLKDLRRLYLP--DLGWLRSM 469 Archaeoglobus fulgidus DSM 4304
O26837 447 IELGGAGMFRPEVLEPLGV--ETPVAAFGLGIERLAMIRFDIKDIRMLYQS--DLGWLRGL 503 Methanothermobacter thermautotrophicus s...
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