3PCO,4P71,1EIY,2DU3,2DU7


Conserved Protein Domain Family
tRNA-synt_2d

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pfam01409: tRNA-synt_2d 
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tRNA synthetases class II core domain (F)
Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.
Statistics
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PSSM-Id: 307526
View PSSM: pfam01409
Aligned: 44 rows
Threshold Bit Score: 236.696
Threshold Setting Gi: 145579180
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PCO_C  91 TIDVSLP---GRRIENGGLHPVTRTIDRIESFFGELGFTVAT-GPEIEDDYHNFDALNIPGHHPARADHDTFWFd----- 161 Escherichia coli
2DU3_B 103 P-NVGISaekIRQIEAITKREVDS--KPLQEIFHRYKKGEIDgDDLS---YLIAEVLDVDDITAVKILDEVFPEfkel-- 174 Archaeoglobus fulgidus
2DU7_C 113 P-DVGLGnekVEIIKNLGIDIDEEKKERLREVLHLYKKGAID-GDDL--VFEIAKALNVSNEMGLKVLETAFPEfkdl-- 186 Methanocaldococcus ja...
O83938 280 RYNVHIP---PARIIPGRSNAYADFLEHIKDRLVALGFQEFD-GPLVETDFWNADALFMPQFHPARDIHDVYYLkhptha 355 Treponema pallidum su...
Q8U261 222 pFNIKAP---VKKIYPGKKQPYRVFLDKIRRKLIEMGFIEITvDSLIETQFWNFDALFQPQNHPAREWTDTYQLkypekg 298 Pyrococcus furiosus D...
Q9Y9I6 218 PYNVKAE---PPRVLPARRHFLAEFIERLRDILRELGFREVR-GPLVELELFNFDVLFQAQDHPAREIHDSLWIksprrg 293 Aeropyrum pernix K1
P95961 200 KYNVEAF---PPYYTISKKHYFREFLEKVKDIMISLGFKEIN-TGYIEMEFYNFDLLFQPQDHPAREIHDSFSVegsgki 275 Sulfolobus solfataric...
Q57911 212 PYDVKVP---TKPIYPAKVHPLTRIIREVKEILLAMGFKEVK-SPIVETEFWNFDMLFEPQDHPAREMQDTFFLkypneg 287 Methanocaldococcus ja...
O28324 200 KYDITIP---AKEIYGGKIHPYERIIEECRKVFLEMGFTEIK-GHYVQPAFWNFDALFQPQDHPARDMQDTFYLdryidl 275 Archaeoglobus fulgidu...
O26837 232 GYNIDAE---YPLVYPGKMHPLRRIIDEIRSIFLKLGFTESR-GPIVESAFWNFDCLFQPQDHAAREMQDTFYVknpavt 307 Methanothermobacter t...
3PCO_C 162 ----------------------------------T-TRLLRTQTSGVQIRTM-----KAQQPPIRIIAPGRVYRNDY--D 199 Escherichia coli
2DU3_B 175 -------------------------------kpiSsTLTLRSHMTTGWFITLsh-iaDKLPLPIKLFSIDRCFRREQgeD 222 Archaeoglobus fulgidus
2DU7_C 187 -------------------------------kpeStTLTLRSHMTSGWFITLss-liKKRKLPLKLFSIDRCFRREQreD 234 Methanocaldococcus ja...
O83938 356 ptipepflsrvaathergadsgslgwrysfdrdfTrRLLLRSQGTALSARHL-----PTAHIPGKYFGIARCFRHDQv-D 429 Treponema pallidum su...
Q8U261 299 ylpnrelvervkea-herglagsrgwgyvwsperAmFLMPRAHATALSARQLa----KGIEIPGKYFTIQRVFRPDVl-D 372 Pyrococcus furiosus D...
Q9Y9I6 294 dlsgysdlver------vasvhergwkyrwspevAsRYILRSQTTAVSARILa----TRPNPPARFFTVGKVFRSDAv-G 362 Aeropyrum pernix K1
P95961 276 edkdllnnvk---------eihekfwkyewkqdiTlRLMLRSQTTATTARVLa----SRPKAPQKVFTLGKVFRPDAi-D 341 Sulfolobus solfataric...
Q57911 288 dipedllskv--------kevhercwkykfdenvSrRLILRTHTTASSIRYLaslsdEEKNKPHKVFCIDRVFRNEAi-D 358 Methanocaldococcus ja...
O28324 276 egeivervkathe---ngwitgstgwggewslekArQLVLRTHTTAITIHYLa----ENPEPPQKAFCIDRVYRRETi-D 347 Archaeoglobus fulgidu...
O26837 308 dlpcedlvravqdahetggstgsegwqyewdrdvArQSVLRTHTTCVSARFL-----SENEPPLKMFSVGRVFRRETi-T 381 Methanothermobacter t...
3PCO_C 200 QTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFfEEDl-QIRFRPSYFPFTEPSAEVDVm-----------GKNGKWL 267 Escherichia coli
2DU3_B 223 ATRLYTYFSASCVLVDEELSVDDGKAVAEALLRQF-GFEnfRFRKDEKRSKYYIPDTQTEVfafhpklvgsstKYSDGWI 301 Archaeoglobus fulgidus
2DU7_C 235 RSHLMSYHSASCVVVGEDVSVDDGKVVAEGLLAQF-GFTkfKFKPDEKKSKYYTPETQTEVya--------yhPKLGEWI 305 Methanocaldococcus ja...
O83938 430 ATHLADFYQTEGIVLGTDVNVCTLLGMLKILATEIaGAQ--EVRYVGGYFPFTEPSIELHAl-----------hPALGWF 496 Treponema pallidum su...
Q8U261 373 RTHLIEFNQIDGFVAAEDLTFRHLLGILKKFAIEIaGAK--KVKFFPDYYPFTEPSVQLSAy-----------hPELGWV 439 Pyrococcus furiosus D...
Q9Y9I6 363 PTRLPEFHQLDGIEGDEGYTFRDLLGRLDEIASML-GLK---LKFKPAYFPFTEPSVEGYVk-----------lPNGRWL 427 Aeropyrum pernix K1
P95961 342 ATHLIEFHQLDGVIIDNNFTFKELLGVLKEIFYRL-GIK--EVKFKPAYFPFTEPSVEAYGy-----------lEKLGWV 407 Sulfolobus solfataric...
Q57911 359 YKHLPEFYQCEGIIMDDNVNFNNLIGVLKEFLNRL-GFE--KVRFRPAYFPFTEPSLEAEVy-----------lEGKGWL 424 Methanocaldococcus ja...
O28324 348 ATHLPEFDQLEGVVLDRDVGFKHLLGLLKEFFTKM-GFE--DVRFRPGYFPYTEPSVEPEVy-----------vEGLGWV 413 Archaeoglobus fulgidu...
O26837 382 YKHLPEFHQVEGIVAGDEVNFRNLLGILREFYRKL-GFE---VRFRPAYFPYTYLSTECEIy----------lPEKKSWI 447 Methanothermobacter t...
3PCO_C 268 EVLGCGMVHPNVLRNVGIdpeVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQF 326 Escherichia coli
2DU3_B 302 EIATFGIYSPTALAEYDI---PYPVMNLGLGVERLAMILYGYDDVRKMVYP--QIHGEI 355 Archaeoglobus fulgidus
2DU7_C 306 EVATFGVYSPIALAKYNI---DVPVMNLGLGVERLAMIIYGYEDVRAMVYP--QFY-EY 358 Methanocaldococcus jannaschii
O83938 497 ELGGAGLLRPEVTDPLGV---HVPVMAWGLGVDRMALLALGISDVRELFSPDIESVRLR 552 Treponema pallidum subsp. pallidum str. Ni...
Q8U261 440 EFGGAGVFREEMTKALGI---DVPVIAWGIGIDRLAMFRLGIDDIRYLFSYDLKWLREa 495 Pyrococcus furiosus DSM 3638
Q9Y9I6 428 ELFGAGMFRPEVLEAVGV---DYPVGAWGFGIERLAMAFYGVSDIRKLYTRNVDEVREM 483 Aeropyrum pernix K1
P95961 408 EMCGAGLLRPEILSSVGI---DSTAGAWGIGIERLAMSFLNISDIRLLYSNNIEYIRDT 463 Sulfolobus solfataricus P2
Q57911 425 EILGAGIFRPEVLEPIGI---EKPVLAWGIGFSRLAMLRYGLTDIRDLHKNDLDWLKRV 480 Methanocaldococcus jannaschii DSM 2661
O28324 414 ELGGAGVFRKEVTEPLGI---RGKVLAWGLGIGRLAMLKIGLKDLRRLYLPDLGWLRSM 469 Archaeoglobus fulgidus DSM 4304
O26837 448 ELGGAGMFRPEVLEPLGV---ETPVAAFGLGIERLAMIRFDIKDIRMLYQSDLGWLRGL 503 Methanothermobacter thermautotrophicus str...
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