5L5G


Conserved Protein Domain Family
Sema

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pfam01403: Sema 
Sema domain
The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805
Statistics
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PSSM-Id: 460197
Aligned: 191 rows
Threshold Bit Score: 81.5477
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L5G_A        279 LQAAYLAKPGEALaqafnissdedVLFAIFSKGqkqyHHPPD-DSALCAFPIRAINLQIkERLQSCyhgEGNLELNWLL- 356  house mouse
XP_015134695  317 LQAAYVSKPGAALahemglglnddILYGVFAQSkpdsSEPTN-RSAVCAVSVRTINEFF--NKIVD-----KQNMKCLQh 388 
Q75ZY9        318 LQAAYVSKPGAHLakqiganlnddILYGVFAQSkpdsAEPMN-RSAVCAFPIKYVNEFF--NKIVN-----KNNVRCLQh 389  dog
Q07E01        318 LQAAYVSKPGAHLarqigtglnddILYGVFAQSkpdsAEPMN-RSAICAFPIKYINEFF--SKIVN-----KNNVRCLQh 389  platypus
XP_004186282  318 LQAAHAARPGARLardlginhtdtVLFGAFAESrp-eSRVPQeNSAVCAFPLRLLNQAMeEGMEKC---CGTGHQPLLRg 393 
XP_004915612  305 LKAAHVATVGSTLageldisekdpVLFAVFAQSep-kSAQPRyNSAVCAFPLRLIDLSIeDGMNAC-----CSNTNSVRl 378 
XP_009443794  321 LRVAHSAPVGAQLatelsiaegqeVLFGVFVTGkdggPGVGP-NSVVCAFPIDLLDTLIdEGVERC---CESPVHPGLRr 396 
XP_013015359  343 LQAAHSAHVGAQFaselniaegheVLFGAFVTGra-gDSGMGpNSVVCAFPIDQLNTLIgEGVERC-----CGSSVISGp 416 
Q62190        322 LQAAHSAPVDAKLavelsisegqeVLFGVFVTVkd-gGSGMGpNSVVCAFPIYHLNILIeEGVEYC---CHSSNSSSLLs 397  house mouse
XP_005996741  317 LQAAHVSKPGAALakemgiapdedVLFGVFSQSkldsPEPTK-TSAVCAVGIKTINELF-NKRIEE-----CNTKHIYHf 389  coelacanth
5L5G_A        357 -------GKDVQCTKAPVp-------iDDNFC-GLDINQPLGGST--PVEGL-TLYTTSR--DRLTSVASY---VYNG-Y 412  house mouse
XP_015134695  389 fy----gkdSKYCLNRAFs--------RNASY-CRAQDDEYRLEVttPLQRV-DLFMGQFnnILLTSISVF----TKGnL 450 
Q75ZY9        390 f----ygPNHEHCFNRTLl--------RNSSG-CEARNDEYRTEFttALQRV-DLFMGQFnqVLLTSISTF----IKGdL 451  dog
Q07E01        390 fy----gnhHRHCANRTFq-------wNSSGC--EVRDDEYRMEFttPLQRV-DLSMGKFshVLLTSISTF----IKGnL 451  platypus
XP_004186282  394 lsf---fqpVEYCPHNVNl--------SAPVVnTSCWDQPTLXPAa--sHKV-DLFNGQLtgVLLTSLFVTam--gDV-- 455 
XP_004915612  379 trglnffQPEMDCPQKDNqsdtscknvPTLVL-PPLRRVDIFNGQldGVLLT-SVYVSPQ-----EDLTIG--------- 442 
XP_009443794  397 gl--dffQSPSFCPNPPGlea----lsPNTSC----RHFPLLVSSs---fSRvDLFNGLLgpVQVTALYVTrldNV---- 459 
XP_013015359  417 rrgleffQTLSFCPNLPFpe------aPSPNI--SCHYFPLLVSGs---fSRvDLFNGLLgpAQITALYVTrfdNV---- 481 
Q62190        398 rgl-dffQTPSFCPNPPGgea----sgPSSRC----HYFPLMVHAs---fTRvDLFNGLLgsVKVTALHVTrlgNV---- 461  house mouse
XP_005996741  390 dn-----kdSKFCLNKARs--------NDAKY-CGEKSEEYRMEItiPFQRL-DLFMGMFsnVLLTSVAVF----TQGkL 450  coelacanth
5L5G_A        413 SVVFVGTKSGKLKKIrADGPPHg--GVQYEMVSVFKDGSPILRDMAFS 458  house mouse
XP_015134695  451 TIANLGTSEGRFMQI-VVSRSE----PTAPHVSFQLDSHAVSPQVVVE 493 
Q75ZY9        452 TIANLGTSEGRFMQV-VVSRSG----LSTPHVNFRLDSHPVSPEAIVE 494  dog
Q07E01        452 TVANLGTAEGRFMQV-VISRSD----PPSPHVDFLLDNHPVSPEVIVV 494  platypus
XP_004186282  456 TVAHLGTAEGRIFQM-VLQRSSs-yLLTLSNFSLGEPG-PVRGAMGLQ 500 
XP_004915612  443 ---FLGTSAGRLLQV-VLQRNSn--PRTLSNFSISDNY-PVSREVTQI 483 
XP_009443794  460 TVAHMGTMDGRILQV-ELVRSLn-yLLYVSNFSLGDSGQPVQRDVSRL 505 
XP_013015359  482 TVAHMGTADGRILQVeLARSLNy--LLYVSNFSLGSSGQPIRRDVSRL 527 
Q62190        462 TVAHMGTVDGRVLQVeIARSLNy--LLYVSNFSLGSSGQPVHRDVSRL 507  house mouse
XP_005996741  451 TVANLGTSEGRVMQV-VISRTVqkkPHVNFQLHLD----PVSPQVAIG 493  coelacanth
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