3J8B,4O8X,4D10,3J8B,4KIT,3RZU


Conserved Protein Domain Family
JAB

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pfam01398: JAB 
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JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain and PAD-1-like domain, JABP1 domain or JAMM domain. These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signalling and protein turnover pathways in eukaryotes. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are shown to have a similar role, and the archael protein from Haloferax volcanii is found to cleave ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates.
Statistics
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PSSM-Id: 279706
View PSSM: pfam01398
Aligned: 26 rows
Threshold Bit Score: 93.9478
Threshold Setting Gi: 510102277
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3J8B_H        34 SAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVED-------------------------RLEITNCFPFPQHT 88
gi 30913004   30 EFFRSVKISAVALLKMLRHVSQGMPL--EVMGYVQGKVEGA-------------------------SLIILDSFALPVEG 82
gi 55976536   54 NYFKRVHISALALLKMVVHARSGGTI--EIMGLMQGKTEGD-------------------------TIIVMDAFALPVEG 106
gi 55976287   51 HYFKQIKISAIALLKMTMHAKRGGNL--EIMGLLQGRIDANs------------------------FI-ILDVFALPVEG 103
gi 239938615  66 PSYTHVLISKLSCEKITHYAVRGGNI--EIMGILMGFTLKD-------------------------NIVVMDCFNLPVVG 118
gi 3334476    25 DNSECVYISSLALLKMLRHGRHGTPM--EVMGLMLGEFVDDf------------------------TVRVVDVFAMPQSG 78
gi 20532383    7 QAVQAVHLESDAFLVCLNHALSTEKE--EVMGLCIGELNDDt-----------------------rSDSKFAYTGTEMRT 61
gi 1168720     7 QAVQAVHLESDAFLVCLNHALSTEKE--EVMGLCIGELNDDirsdskftytgtemrtvqekmdtirIVHIHSVIILRRSD 84
4KIT_C        42 ETGYTYILPKNVLKKFICISDLRAQI----AGYLYGVSPPDnp----------------------qVKEIRCIVMVPQWG 95
gi 74854377  532 SKLRKIIVHGEVFQEFMRLAENNTKRSIETCGILSGTLSND-------------------------VFRITTIIIPKQEG 586
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3J8B_H        89 EDDADFDEVQYQMEMMRSLRHVNID----------------------------------HLHVGWYQSTYYG-SFVTRAL 133
gi 30913004   83 TETRVNAHEEAQEYSVQYHTLCKSVyr-------------------------------hENVIGWYHSHPNYgCWLSGVD 131
gi 55976536  107 TETRVNAQSDAYEYMVEYSQTSKLAgr-------------------------------lENVVGWYHSHPGYgCWLSGID 155
gi 55976287  104 TETRVNAQAQAYEYMTVYSEMCDTEgr-------------------------------kEKVVGWYHSHPGYgCWLSGID 152
gi 239938615 119 TETRVNAQLESYEYMVQYIDEMYNHndggdgr---------------------dykgakLNVVGWFHSHPGYdCWLSNID 177
gi 3334476    79 TGVSVEAVDPVFQ--KNMMDMLKQTgr-------------------------------pEMVVGWYHSHPGFgCWLSSVD 125
gi 20532383   62 VAEKVDAVRIVHI------HSVIILrrsdkrkdrveispeqlsaasteaerlaeltgrpMRVVGWYHSHPHItVWPSHVD 135
gi 1168720    85 KRKDRVEISPEQL--SAASTEAERLaelt---------------------------grpMRVVGWYHSHPHItVWPSHVD 135
4KIT_C        96 THQTVHLPGQLPQ-----HEYLKE-----------------------------------MEPLGWIHTQPNEsPQLSPQD 135
gi 74854377  587 TTDTCNTIEEHEI-------FEYQLen-------------------------------dLLTLGWIHTHPTQdCFLSAVD 628
                        170
                 ....*....|...
3J8B_H       134 LDSQFSYQHAIEE 146
gi 30913004  132 VETQRQNQKYQDP 144
gi 55976536  156 VSTQMLNQQYQEP 168
gi 55976287  153 VSTQTLNQKFQEP 165
gi 239938615 178 IQTQDLNQRFQDP 190
gi 3334476   126 INTQQSFEQLTPR 138
gi 20532383  136 VRTQAMYQMMDQG 148
gi 1168720   136 VRTQAMYQMMDQG 148
4KIT_C       136 VTTHAKIMADNPS 148
gi 74854377  629 VHTHCSYQYLLQE 641
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