1BC9,3LTL,1RE0,6FNE,1XSZ,4D7R


Conserved Protein Domain Family
Sec7

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pfam01369: Sec7 
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Sec7 domain
The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.
Statistics
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PSSM-Id: 366596
View PSSM: pfam01369
Aligned: 441 rows
Threshold Bit Score: 36.2725
Threshold Setting Gi: 159103089
Created: 3-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BC9_A                      6 RNKQVAMGRKKFNM--DPKKGIQFL--IENDLL------KNT-CEDIAQFLYKG--EGLNKTAIGDYLGERDEFNIqVLH 72   h...
EAY04607                  363 LLEKLTSFSKKFQE--DP----KFL--QDSQIS----------PPEAAFCLAVA--PGIQKQAIGELFSKNTPFSNdTMT 422  T...
WGS:AAFB:cds.EHI_024590A  438 KKKIISDGLLLFEK--SPKKGVEFF--IEKELC------TSS-AQSIVHFLHHL--NGLNRKAFGEYLGGAGELNKeCLT 504  E...
ELQ75694                  360 SKDVVKQKFAHFSA--N-GDALDF---ENKHLI-------------LRSFP-------LNKRSIGKFLSNNPs----VLK 409  T...
EPR78510                  261 IKHKIINASESFNN----KKDIKPLekVFKEIFkdk-eyNNT-NNLLILFLRYS--EYICRKTLGEFLASTK--NKiHLK 330  S...
WGS:AFBI:EDEG_00003       560 HTKVIKSFKDKINNtiQSQKIEETF--AELEKY------VKN-PFLILRHNFLTnfSKL-----GNFISKEK--NIkHLE 623  E...
EIJ88275                  320 NKQRVEVELEEFNKtgEVDGLVELM--RVIGYR------ESP-ALSACRLLRSH--TDTNLQMLGKCLGREG--ADaFLD 386  N...
Q22BX7                    349 NKLKWTELFNIFNE--NPKDFLKKI--ASFKQVqdfrnlDDDsIKQITRFLRVY--SDINQKHMIEILGGTEKFHNkCLI 422  T...
XP_007476495              565 HEPHCEMRSTEFLEk-EPSETISNG--TNSNVEa---------ARRLAKRLYHL--DHFKRSDVAKHLGKNNEFSQlVAE 630  g...
XP_023371304              544 LESLSEMGSTELVE----KETSESL--SNGTSS------NVDaAKRLAKRLYQL--DRFKRSDVAKHLGKNNEFSKlVAE 609  s...
1BC9_A                     73 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRY--Cq---------------CNN-------------- 121  h...
EAY04607                  423 EFIKLFDFSSLDFDESIRLFLTSFRILGEGQVVDRNLEYFSKIF--Ye--------------sHKNd------------- 473  T...
WGS:AAFB:cds.EHI_024590A  505 ELLKMIDMKDVEIDEALRLMFDTFVMGGEGQVVERVIGAFSARY--C----------------ECNp------------- 553  E...
ELQ75694                  410 EYLTTFDFTNLDLLGALRAFLRNFYLPTESQAINKILSAFSERYyeCnkegfgsdgneldsivCGNggdvkrvngivgne 489  T...
EPR78510                  331 QYIDTFNFKDIDILSGLRSILNTFILAGESQQIIRILLAFSEKY--Y----------------NDNftndnn-------- 384  S...
WGS:AFBI:EDEG_00003       624 LFLDTFDFSEMNIMTCVRTFLSTFTLPGEYQVIVRVLGVLSKKF--YqdklrkfqkniyidniSSNdiknvkndnistne 701  E...
EIJ88275                  387 VFCSSFDFSEYDLVTALRVFLLSFTLPGEGQKINRIISAFSKKY--S----------------EDQk------------- 435  N...
Q22BX7                    423 EYLKLFNFSQISILEATRVVFSTFLMTGETQQVLRFLEAYSNMY--Fe---------------NNN-------------- 471  T...
XP_007476495              631 EYLKFFDFTGMTLDQSLRYFFKAFSLMGETQERERVLVHFSNRY--F----------------HCNp------------- 679  g...
XP_023371304              610 EYLKFFDFTGMTLDQSLRYFFKAFSLAGETQERERVLIHFSNRY--Fy---------------C-Np------------- 658  s...
1BC9_A                    122 -----------------------------------------------------------------------------GV- 123  h...
EAY04607                  474 -----------------------------------------------------------------------------KN- 475  T...
WGS:AAFB:cds.EHI_024590A  554 -----------------------------------------------------------------------------TG- 555  E...
ELQ75694                  490 nagaesdeiydgedvvrgddrgdngddmtnvrgkrlpnesdtpvqgvceivnqnsidnlmknskehaekdavktgtrNT- 568  T...
EPR78510                  385 ------------------------------------------------------------------------nishpNPn 392  S...
WGS:AFBI:EDEG_00003       702 sselnidrnienknisvdikkindki------------knnnsnidikkiddkiknnnsnididkiddniknnnsnvDIn 769  E...
EIJ88275                      -------------------------------------------------------------------------------- N...
Q22BX7                    472 -----------------------------------------------------------------------------HM- 473  T...
XP_007476495              680 -----------------------------------------------------------------------------NT- 681  g...
XP_023371304              659 -----------------------------------------------------------------------------DT- 660  s...
1BC9_A                        -------------------------------------------------------------------------------- h...
EAY04607                      -------------------------------------------------------------------------------- T...
WGS:AAFB:cds.EHI_024590A      -------------------------------------------------------------------------------- E...
ELQ75694                      -------------------------------------------------------------------------------- T...
EPR78510                  393 nkspik-------------------------------------------------------------------------- 398  S...
WGS:AFBI:EDEG_00003       770 knnnsdvdinkiedkiknnnsnidikkindntdnnntseidinkindnkkttndkninmknkdntsinntvgntdetkki 849  E...
EIJ88275                      -------------------------------------------------------------------------------- N...
Q22BX7                        -------------------------------------------------------------------------------- T...
XP_007476495                  -------------------------------------------------------------------------------- g...
XP_023371304                  -------------------------------------------------------------------------------- s...
1BC9_A                    124 -------------------F--QST-----------------DTCYVLSFAIIMLNTSLHNP-N-V--K-DKP-TVERFI 159  h...
EAY04607                  476 -------------------F--KNV-----------------EAVHILSYGWLMLHTSLYNQ-N-V--T-KKN-TLPEFF 511  T...
WGS:AAFB:cds.EHI_024590A  556 -------------------YggITQ-----------------DELYQLAMSIICLATETHNP-S-A--KiKAFdTFEKFK 595  E...
ELQ75694                  569 -------------------A--FDF-----------------DSVDILTFCILCLNTDLHNA-A-I--R-VKT-LKLSFI 604  T...
EPR78510                  399 ------------esmydstF--NNEe---------------kDSIYILSFSILVLNTNLHN----IsnK-IKM-TKKEFI 443  S...
WGS:AFBI:EDEG_00003       850 ednknlnktesfnaenqnfL--SDTpitdyklfdpdpsnyteKDIYIILYSIIILNTNLHST-I----K-FKT-QKDVFI 920  E...
EIJ88275                  436 ----------------------QDS-----------------ETVISIAMAVIYINTSIHNV-NtV----KKI-SLEEFT 470  N...
Q22BX7                    474 -------------------F--LSS-----------------DSIYVYISAMMMLHSDLHNE-N-N--Q-NKM-QLEQFI 509  T...
XP_007476495              682 -------------------V--FSA-----------------DGVHCLTCAIMLLNTDLHGHvN-I--G-KKM-SCQEFI 718  g...
XP_023371304              661 -------------------I--ASQ-----------------DGVHCLTCAIMLLNTDLHGH-N-I--G-KKM-TCQEFI 696  s...
1BC9_A                    160 AMNRG--IN------DG-G-DLPEELLRNLYESIKNEPF 188  human
EAY04607                  512 TMLKG--QN------DG-D-DFDSQFLTKIYNSVKRHEV 540  Trichomonas vaginalis G3
WGS:AAFB:cds.EHI_024590A  596 DVVT---TE------KGfNiKMDDQPLKGIFERVVATPF 625  Entamoeba histolytica HM-1:IMSS
ELQ75694                  605 ERARK--CN------L--SyFFSDRYLSYVYDSVKKDPL 633  Trachipleistophora hominis
EPR78510                  444 DNNKQckIS------S--S--ISDNYLSMVYDSIKEKEF 472  Spraguea lophii 42_110
WGS:AFBI:EDEG_00003       921 SNVRK--CN------L--NsIFPDDFISFLYDDIKETQI 949  Edhazardia aedis USNM 41457
EIJ88275                  471 RIIMK--TC---------K-DVDVEYIETLYGQIKQRKL 497  Nematocida parisii ERTm3
Q22BX7                    510 NQVRG--CNlqqgqhTG-GvDLPKEFVTECYQNIQKEEI 545  Tetrahymena thermophila SB210
XP_007476495              719 TNLQG--VN------EG-S-DFPRDQLKALYNSIKNEKL 747  gray short-tailed opossum
XP_023371304              697 ANLQG--VN------GG-V-AFSKDLLKALYNSIKNEKL 725  small-eared galago
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