Conserved Protein Domain Family
MARVEL

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pfam01284: MARVEL 
Membrane-associating domain
MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.
Statistics
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PSSM-Id: 334471
View PSSM: pfam01284
Aligned: 89 rows
Threshold Bit Score: 34.2041
Threshold Setting Gi: 121776662
Created: 17-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823  38 RWSSPPGIIKIMSiliVVMC--VGIFACVASTLpwdlditgqsmgygmgsgsysggytgygfggsqmglgfayggnyTDP 115
gi 94730398  25 ALTQPLGLLRLLQ---LIST--CVAFSLVASVG--------------------------------------------AWT 55
gi 74732278  91 YMASELGLLKVLE---TFVA--CLIFVFINSPYv-------------------------------------------YHN 122
gi 34922025  29 FLTSHKGILLETE---LALT--LIIFICFTASI----------------------------------------------- 56
gi 61214406  19 FSRTKKGILLFAE---IILC--LVILICFSAST----------------------------------------------- 46
gi 416563    19 FSRTRKGILLFAE---IILC--LVILICFSAST----------------------------------------------- 46
gi 34098353  13 FCLSLKCFVKTLR---LVVTvaSMIFFIVAQAP----------------------------------------------- 42
gi 34921873  82 FWLLGHAEIKIRSlgcLIAA--MILLSSLTVHP----------------------------------------------- 112
gi 74871505  30 FVLSRIGLLKLMQ---LGLA--MLCEGLLIRYGvp----------------------------------------yaDSI 64
gi 19923929  40 YPRTHAALLKVAQ---MVTL--LIAFICVRSSL--------------------------------------------WTN 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 116 RAAKGFILAMAAFCFIIGLVIFVMLVTR-TPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPvaqasgsafytqiv 194
gi 94730398  56 GPMGNWAMFTWCFCFAVTLIILIVELGG-LQAHFPLSWRNFPITFACYAALFCLSSSIIYPTTYVQ-------------- 120
gi 74732278 123 RPALEWCVAVYALCFVLAALTVLLSLGH-CTNMLPIRFPSFLLGLALLSVLLYATALVLWPLYQFNekygvqpw------ 195
gi 34922025  57 ----SAYMAAALLEFFITLAFLFLYATQyYQRFDRINWPCLLQGHGQSGGPHPLDLLSHSAKVQPQpw------------ 120
gi 61214406  47 ---TSAYSSLSVIEMICAAVLLVFYTCDlHSKISFINWPWTDFFRSLIATILYLITSIVVLVEGRG-------------- 109
gi 416563    47 ----PGYSSLSVIEMILAAIFFVVYMCDlHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGN-------------- 108
gi 34098353  43 ----EPYIVITGFEVTIILFLIALYMCSlDKTMRSFFWPLLDVINSVVTTLFMLIVSVSALIPETS-------------- 104
gi 34921873 113 -----ILRLIITMEISFFSFFILLYSFAiHRYIPFILWPISDLFNDLIACAFLVGAVVFAVRSRRS-------------- 173
gi 74871505  65 GQALTSFLATTGHCFTTTGILLLCYAFS-DKSYSLIRQSLFETLFNGLASCMYFSSSSYMGFACVVwl------------ 131
gi 19923929  71 YSAYSYFEVVTICDLIMILAFYLVHLFRfYRVLTCISWPLSELLHYLIGTLLLLIASIVAASKSYN-------------- 136
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 27923823 195 sicnqfyspvqtgvfvNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFF 244
gi 94730398 121 -------------------FLAHGRTRDHAIAATTFSCVACLAYATEVAW 151
gi 74732278 196 ---------qtrdvscSDRNPYLVCIWDRRLAVTNLTAVNLLAYVGDLVY 236
gi 34922025 121 --------------pgLTPPGWHTPAAVPWVPAPAPGFWSWLLW----FI 152
gi 61214406 110 ---------------------------SSRVVAGILGLLATLLFGYDAYI 132
gi 416563   109 ---------------------------HSKIVAGVLGLIATCLFGYDAYV 131
gi 34098353 105 ---------------------------TMIMVGGVFGFLTVICTVADCAL 127
gi 34921873 174 -------------------------MNLHYLLAVILIGAAGVFAFIDVCL 198
gi 74871505 132 --------------hpQFLVRPGFWAYPAMTACYYMGYAAGILHALDAYL 167
gi 19923929 137 --------------------------QSGLVAGAIFGFMATFLCMASIWL 160
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