1G76,5ESC,1RFE,1XXO,2FHQ,1VL7,3DB0,2HQ7,5JAB,2ARZ,2E83,2IG6,3GAS,3DNH


Conserved Protein Domain Family
Putative_PNPOx

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pfam01243: Putative_PNPOx 
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Pyridoxamine 5'-phosphate oxidase
Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.
Statistics
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PSSM-Id: 334450
View PSSM: pfam01243
Aligned: 138 rows
Threshold Bit Score: 31.0609
Threshold Setting Gi: 81624628
Created: 16-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1G76_A        39 LSQACEAKLADPTAMVVAT----VD-EHGQPYQRIVLLKH-YDEk-------gMVFYTNLGSRKAHQIENNPRVSLLFPW 105
gi 81739735   29 VTPLYRVFIEKAPFAALAT----IG-PEG-IDCSPRGDLPgFVRihdpktlmlPDRRGNNRVDSLRNILRDPRMSLMFLV 102
gi 81546379   50 LTDDDRDILARSPFCLLAT----SD-AGGNCDVSPRGDVPgFTHvldsrtlalPDRAGNRRGDSFHNVLDNPHAGLLYLI 124
gi 81549998   37 LTPAMREFIARQNMVFLST----AD-SRGACDASFRAGPPgFCVslddrsltyPEYRGNGVLASAGNMTENPQLGMLFMD 111
gi 81771279  164 LSDTNQLWITQADTFFIAS----YH-PESGADASHRGGFPgFIQvvnsnqlvfPDYSGNNMFQTFGNLNVNPKAGLLFID 238
gi 81540547  167 LDPRWLSLVSCSDTLFIASq--hADpLRGGVDVSHRGGPPgFLRlgadgrlwlPDYAGNRLFNTLGNLLQDPRCGLLFID 244
gi 81813895  185 LDAAARALVAQADTFFVATya-dLA-GGRQLDVSHRGGPAgFVRaggdgwltiPDFVGNRFFNTLGNIAVNPRAGLTFPD 262
gi 81441910  171 LDTSTVSMIQAADTFFVASyvehAY-GQRSVDVSHRGGRPgFIKvegn-rltiPDYAGNLHFNTLGNLVVNPRAGLLFID 248
gi 81779486   42 VTPDLAAFIAMQTSVFLST----AN-GDGQPYIQHRGGPAgFLKvldektigfADFSGNRQFITQGNLADNPRAFLFLID 116
gi 493357893  29 LTAEYRQMIEASPFLALAT----VG-PEG-MDCSPRGDKGgVVRvaddrtvllPDWRGNNRVDSLLNIVRDPRVALMFLI 102
                         90
                 ....*....|....*...
1G76_A       106 HT-LERQVMVIGKAERLS 122
gi 81739735  103 PG-SGNAVRANGRAHLSI 119
gi 81546379  125 PG-GKEVLRVNGRARILT 141
gi 81549998  112 FThDHIGLHVNGTVRLYT 129
gi 81771279  239 FE-KGHTLQITGKAQVIW 255
gi 81540547  245 FD-NGDLLHLHAEAELFW 261
gi 81813895  263 FS-TGGLLQMSGEAELLS 279
gi 81441910  249 FK-NGNVLQLYGRAEVLL 265
gi 81779486  117 YM-LRQRIKIWGTARVVE 133
gi 493357893 103 PG-SNTTMRINGRAVVSV 119
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