1O1R,1O1R,1DCE,1DCE,1DCE,4YDE


Conserved Protein Domain Family
PPTA

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pfam01239: PPTA 
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Protein prenyltransferase alpha subunit repeat
Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.
Statistics
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PSSM-Id: 334449
View PSSM: pfam01239
Aligned: 828 rows
Threshold Bit Score: 28.4909
Threshold Setting Gi: 675878784
Created: 17-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20
                 ....*....|....*....|....*..
1O1R_A       188 ELEFIADILNQDAKNYHAWQHRQWVIQ 214
gi 19075963  129 EMMITEKLLSADARNFHGWHYRRYVVS 155
gi 367014675 127 ELAMVSKLLQLDARNFHGWHYRRLILD 153
gi 403217469 127 ELDIVSALLEVDARNFHGWHYRRMVVG 153
gi 365984883 127 ELFIVNQMLELDSRNYHGWHYRRIVIQ 153
gi 156844879 127 ELVIASKVLEMDARNYHAWHYRRIIVN 153
gi 573028481 170 ELRLVERMLELDARNFHGWNCRRAIID 196
gi 858044377 181 ELKLVEKMLDLDPRNFHGWNCRRAILQ 207
gi 123976180 117 EIQLCTLLLNADFRNFHAWRHRRWAVK 143
gi 84579437  121 ERELCAKMIGKDSRNFHCWGYYLWVLE 147
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