5UE9,1JQV,4ORI,6I4B


Conserved Protein Domain Family
DHO_dh

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pfam01180: DHO_dh 
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Dihydroorotate dehydrogenase
Statistics
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Aligned: 15 rows
Threshold Bit Score: 364.364
Threshold Setting Gi: 730436
Created: 14-Mar-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UE9_A   2 RLSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNkLGSIMVKATTLHPRFGNPTPRVAETASG--MLNAIGLQNPGLEV 79  Lactococcus lactis su...
Q63707  77 MLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLG-FGFVEVGSVTPQPQEGNPRPRVFRLPEDqaVINRYGFNSHGLSV 155 Norway rat
P28272   4 SLTTKFLNNTYENPFMNASGVHCMTTQELDELANSkAGAFITKSATTLEREGNPEPRYISVPLG--SINSMGLPNEGIDY 81  Saccharomyces cerevis...
Q9CFC9   1 MLKTTFANAEFANPFMNASGVHCMTTEDLEELKASqAGAYITKSSTLEKREGNPLPRYVDLELG--SINSMGLPNLGFDY 78  Lactococcus lactis su...
Q58070   5 MLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGgAGAVTTKSIGLNPNPGHKNPTIVEVYGG--FLNAMGLPNPGVDE 82  Methanocaldococcus ja...
P25996   1 MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLScLGAIMIKATTKEPRFGNPTPRVAETGAG--MLNAIGLQNPGLDS 78  Bacillus subtilis sub...
P0DH74   5 pLAVSIPGLTLKNPIIPASGCFGFGEEYANYYDLDqLGSIMIKATTPQARYGNPTPRVAETPSG--MLNAIGLQNPGLEV 82  Enterococcus faecalis...
Q9CFW8   6 rLSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNkLGSIMVKATTLHPRFGNPTPRVAETASG--MLNAIGLQNPGLEV 83  Lactococcus lactis su...
P32747 104 SLAVEVWGKKFCNPIGLAAGFDKQADAISGLLNFG-FSYLEIGSVTPKPQPGNPKPRYFRLKPDlsVINRYGFNSIGHDA 182 Schizosaccharomyces p...
4ORI_A  46 MLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLG-FGFVEVGSVTPQPQEGNPRPRVFRLPEDqaVINRYGFNSHGLSV 124 Norway rat
5UE9_A  80 IMAEKLPWLNENF---------------------------------P-----DLPIIANVAGS-E--ED---DYVAVCAK 115 Lactococcus lactis su...
Q63707 156 VEHRLRARQQKqaqlt--------------------------adglP------LGINLGKNKTsEdaAA---DYAEGVRT 200 Norway rat
P28272  82 YLSYVLNRQKNYPd--------------------------------------APAIFFSVAGMs---ID---ENLNLLRK 117 Saccharomyces cerevis...
Q9CFC9  79 YLDYVLKNQKEKAq--------------------------------------EAPIFFSIAGMs---AA---ENIAMLKK 114 Lactococcus lactis su...
Q58070  83 YLEEIEKVRDELNr--------------------------------M-----DVRIIGSIYGKd---EE---EFAEVAKK 119 Methanocaldococcus ja...
P25996  79 VLHHELPWL-EQF---------------------------------------DTPIIANVAGSq---VD---DYVEVAEH 112 Bacillus subtilis sub...
P0DH74  83 VMQEKLPKLEKYP---------------------------------------NLPIIANVAGAc---EE---DYVAVCAK 117 Enterococcus faecalis...
Q9CFW8  84 IMAEKLPWLNENFp--------------------------------------DLPIIANVAGSe---ED---DYVAVCAK 119 Lactococcus lactis su...
P32747 183 ILAKIQKRVRKYIaktspqllkqfdanpasctdpavlgvprslipnK-----FLGINLGKNKN-GneIE---DYVEGVRT 253 Schizosaccharomyces p...
4ORI_A 125 VEHRLRARQQKQAq--------------------------------LtadglPLGINLGKNKT-S--EDaaaDYAEGVRT 169 Norway rat
5UE9_A 116 IGdaPNVKVIELNISCPNVKhGGQAFGTDPDVAAALVKACKAVS------KVPLYVKLSPNVTDIVPIAKAVEAAgADGL 189 Lactococcus lactis su...
Q63707 201 LG--PLADYLVVNVSSPNTA-GLRSLQGKTELRHLLSKVLQERDalkgtrKPAVLVKIAPDLTAQDKEDIASVAR-ELGI 276 Norway rat
P28272 118 IQdsEFNGITELNLSCPNVP-GKPQVAYDFDLTKETLEKVFAFF------KKPLGVKLPP-YFDFAHFDIMAKILnEFPL 189 Saccharomyces cerevis...
Q9CFC9 115 IQesNFSGITELNLSCPNVP-GKPQLAYDFEATEKLLKEVFTFF------TKPLGVKLPP-YFDLVHFDIMAEILnQFPL 186 Lactococcus lactis su...
Q58070 120 ME--RYVDIIELNISCPHAKgYGATIGQNPDLSYDVCKAVKKAV------KIPVFAKLTPNVTDIIEIAQAVVDAgVDGL 191 Methanocaldococcus ja...
P25996 113 ISkaPNVHALELNISCPNVKtGGIAFGTNPEMAADLTKAVKEVS------DVPVYVKLSPNVANITEIALAIEEAgADGL 186 Bacillus subtilis sub...
P0DH74 118 IGqaPNVKAIELNISCPNVKhGGIAFGTDPEVAFQLTQAVKKVA------SVPIYVKLSPNVTDIVPIAQAIEAGgADGF 191 Enterococcus faecalis...
Q9CFW8 120 IGdaPNVKVIELNISCPNVKhGGQAFGTDPDVAAALVKACKAVS------KVPLYVKLSPNVTDIVPIAKAVEAAgADGL 193 Lactococcus lactis su...
P32747 254 FG--NFADILVINVSSPNTP-GLRNLQKKSALSTLLTAVVSERNkln-spHPPVLVKIAPDLNEEELTDIADVLK-KCKI 328 Schizosaccharomyces p...
4ORI_A 170 LG--PLADYLVVNVSSPNTA-GLRSLQGKTELRHLLSKVLQERDalkgtrKPAVLVKIAPDLTAQDKEDIASVAR-ELGI 245 Norway rat
5UE9_A 190 TMIN----TLMGVrfDLKTRKPVLan--iTGgLSGPAIKPVALKLIHQVAQVVD--IPIIGMGGVESAQDVLEMYMAGAS 261 Lactococcus lactis su...
Q63707 277 DGLIvtntTVSRPv-GLQG-ALRSe----TGgLSGKPLRDLSTQTIREMYALTQgrIPIIGVGGVSSGQDALEKIQAGAS 350 Norway rat
P28272 190 AYVNsinsIGNGLfiDVEKESVVVkpkngFGgIGGEYVKPTALANVRAFYTRLRpeIKVIGTGGIKSGKDAFEHLLCGAS 269 Saccharomyces cerevis...
Q9CFC9 187 TYVNsvnsIGNGLfiDSEAESVVIkpkdgFGgIGGAYIKPTALANVRAFYTRLKpeIKIIGTGGIETGQDAFEHLLCGAT 266 Lactococcus lactis su...
Q58070 192 VAIN----TVRGMaiDIRAKKPILan--kFGgLSGKAIKSIGIKVVWDLYENFD--VPIIGVGGIMSGEDAIEYMMAGAS 263 Methanocaldococcus ja...
P25996 187 TMIN----TLIGMrlDLKTGKPILan--kTGgLSGPAVKPVAIRMVYEVSQMVN--IPIIGMGGVQTAEDALEFLLAGAS 258 Bacillus subtilis sub...
P0DH74 192 SMIN----TLLGMriDLKTRKPILan--qTGgLSGPAIKPVAIRLIRQVASVSQ--LPIIGMGGVQTVDDVLEMFMAGAS 263 Enterococcus faecalis...
Q9CFW8 194 TMIN----TLMGVrfDLKTRKPVLan--iTGgLSGPAIKPVALKLIHQVAQVVD--IPIIGMGGVESAQDVLEMYMAGAS 265 Lactococcus lactis su...
P32747 329 DGVIvgntTVQRPk-TLKSTSHVEe----TGgLSGPPLKPIALNTLRTLRKHLSsdIPIIGCGGISSGKDAIEYARAGAT 403 Schizosaccharomyces p...
4ORI_A 246 DGLIvtntTVSRP----VGLQGALrs--eTGgLSGKPLRDLSTQTIREMYALTQgrIPIIGVGGVSSGQDALEKIQAGAS 319 Norway rat
5UE9_A 262 AVAVGTAN-FADPFVCPKIIEKLPEVM 287 Lactococcus lactis subsp. lactis
Q63707 351 LVQLYTALiFLGPPVVVRVKRELEALL 377 Norway rat
P28272 270 MLQIGTELqKEGVKIFERIEKELKDIM 296 Saccharomyces cerevisiae S288C
Q9CFC9 267 MLQIGTALhKEGPAIFDRIIKELEEIM 293 Lactococcus lactis subsp. lactis Il1403
Q58070 264 AVQIGSGVyYRGYDIFKKVCDEIISFL 290 Methanocaldococcus jannaschii DSM 2661
P25996 259 AVAVGTAN-FVNPFACPEIIEQLPSVL 284 Bacillus subtilis subsp. subtilis str. 168
P0DH74 264 AVGVGTAN-FTDPYICPKLIDGLPKRM 289 Enterococcus faecalis V583
Q9CFW8 266 AVAVGTAN-FADPFVCPKIIEKLPEVM 291 Lactococcus lactis subsp. lactis Il1403
P32747 404 MVQVYTALgYDGPVIAHKIKQEILAEL 430 Schizosaccharomyces pombe 972h-
4ORI_A 320 LVQLYTALiFLGPPVVVRVKRELEALL 346 Norway rat
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