5AUN,2KDX


Conserved Protein Domain Family
HypA

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pfam01155: HypA 
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Hydrogenase/urease nickel incorporation, metallochaperone, hypA
HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.
Statistics
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PSSM-Id: 334405
View PSSM: pfam01155
Aligned: 491 rows
Threshold Bit Score: 58.272
Threshold Setting Gi: 521296682
Created: 16-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AUN_A         1 MHEWALADAIVRTVLDYA-QR-EGasRVKAVRVVLGELQDVAEDIVKFAMEQLFAGt-iAEGAE--IEFVEEEAVFKCRN 75  Thermococcus ko...
WP_004603284   1 MHEMSYVLRLVNLAEEAA-RE-QQakRVTRILVSVGETSGVLPEYLHKYYTKAVQGt-lLEGSV--LETVDDPVVAVCSD 75  Eubacterium cel...
WP_013282347   1 ---MSYIAKMVNLAEEIA-RE-NGakEVKKLVVEVGKTSGVMPYYMYKYFPEAAKGs-lLENAE--LECVETDVKALCEE 72  Butyrivibrio pr...
WP_020460950   1 MHEAGLARSAVSAIAEASeGTpVR-------TVVLAAAAGVDIASATAAWQSAAAGtclEN-TH--LSWQHAADRLRCFT 70  Frankia sp. EAN...
WP_012237209   1 MHESSIARQLLSAALDRAaAEgAT--RVVSVRGWVAEAEALSPESLSLHFAAHARGt-pAEGAR--LDLRLHRVEARCLS 75  Sorangium cellu...
ADG89321       1 MHELGICEGLVDLIERRAaGR-----RVTGARVRVGARHAVTEKAFGQAFAIASEGtaaAG-AA--VDVVITPASVDCRA 72  Thermobispora b...
WP_012890484   1 MHEFGIAEAILDAVERRAdGR-----RVERARVHAGAMLRITEPVINQAFAMVADGs-lAEGAR--VDLVIVPVQLICRS 72  Streptosporangi...
WP_012854899   1 MHEMGLCQAIVEATLRRA-AGr----PVRAVRVRVGG-HPVDPQVIAQGFRMAAAGt-yAEGAE--LDLVVEPQTAHCRS 71  Thermomonospora...
WP_011522360   1 MYELSVAQELYTVARARAdEMeVR--ELESVRVAVGELAGVTPDLLRSAWRFVTAEsadEN-SR--LDIDLRSGRQICPQ 75  Candidatus Kori...
WP_012845075   1 MHELSIARELVRLIEAEArRAgAR--RVRSARVVLGARSHVSAEILQFYVTHL-LDpegPA-AGlvLTCERQPMRFRCGP 76  Rhodothermus ma...
5AUN_A        76 CNYEW--K-LK----EvkdkfderikedihfipevvhaFLACPKCGSH-DFEVVK-GR-GVYVAGIKI 133 Thermococcus kodakarensis KOD1
WP_004603284  76 CGLSYhpE-KE----H----------------------CYACPACGSN-RADLSG-GR-GVKLVNIEI 113 Eubacterium cellulosolvens
WP_013282347  73 CGREYfpnk---------------------------enryLCPHCGGR-KAHIIE-GK-GVVLRDLVI 110 Butyrivibrio proteoclasticus
WP_020460950  71 CAHEY--DgARld---------------------------pCPSCSGN-GLVVAA-AD-ELAVVSwtt 106 Frankia sp. EAN1pec
WP_012237209  76 CGATY--A-PDhh-------------------------vvLCPRCGGDqATLL---GRlGLGLDAMEV 112 Sorangium cellulosum
ADG89321      73 CGRWS--EtLDpv--------------------------aACAYCGAT-DVEVSG-GD-ELVLESLRf 109 Thermobispora bispora DSM 4...
WP_012890484  73 CGQTA--TsVDpf--------------------------aTCPECGGS-DIDTEG-GD-DLVLESIQM 109 Streptosporangium roseum
WP_012854899  72 CGADS--P-VTaatvL----------------------VA-CPRCGGL-DMDAPL-TE-QLVVESIAI 110 Thermomonospora curvata
WP_011522360  76 CGalpgpd--------------------------viaypaHCERCKCHmRVES---GD---RVELLEI 111 Candidatus Koribacter versa...
WP_012845075  77 CRIDY--EpSEtd--------------------------wRCPRCGRIgEL--LEtGD-EVFLESLEI 113 Rhodothermus marinus
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