4AID,2NN6,3U1K,3U1K,3KRN,4OO1,5C0W


Conserved Protein Domain Family
RNase_PH

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pfam01138: RNase_PH 
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3' exoribonuclease family, domain 1
This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.
Statistics
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PSSM-Id: 334400
View PSSM: pfam01138
Aligned: 166 rows
Threshold Bit Score: 31.4
Threshold Setting Gi: 156847039
Created: 18-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AID_A       342 PILGEVGILPRTHGSALFTRGETQAIVVATLGTGDdeQFIDalegtyKES--FLLHYNFPPYSVGETgrmGSPGRREIGH 419 Caulobacter cre...
Q6CTP4        35 DVKIEIG---EAYGDVTVTMGNTKVHCRISCEIAQpyEDRPfe-------glFHISTETTPMAGAQFengNNTGEEEVLI 104 Kluyveromyces l...
Q5B019        35 PLTLSFG---EEYGHVKVQLGKTSLVVRISAEVAKphDDRPfd-------giFNIAMELTAMGSPAWe-nGRQGDLETYV 103 Aspergillus nid...
Q55BJ2        33 AIKIEFG---KSYGVVEVQLGKTRVFTAITCDIVEpkPERPne-------gfYIFNTDISPMSSVSVn-vNQPNPMESEL 101 Dictyostelium d...
A0BEI4        26 MIQCHFG--PQSTGAVELSLGETRVFATTSASITTpnPIRPse-------gfLKFHLDLQVLRDTGYm--hNPIKLGMEI 94  Paramecium tetr...
Q5XJQ5        34 NIKISFG---TDYGCCVVELGKTRVLSQVSCELVPpkDSRPte-------giVFFNLELSPMASPAFe-pNRQSELLVTL 102 zebrafish
Q7QBX4        34 KLRISFG---SEWGLVHVILGETRALARITCEVVEpkAT-R------PNEgmLFLNVELGPMAAPHFd-gGRQSDECVQL 102 Anopheles gambi...
XP_002641920  34 GVKLVVG---SEIGTAICTIGNTKVIAAVSAQIAEpsSMRPhk-------gvIIIDVDLSPMANVSNe-hDRLGSKGMEL 102 Caenorhabditis ...
XP_001609180  43 PRKIHVEQL-ANPGNVIVSLGDTIVFVAVSSEIVPpnVEHPte-------giVTFSVELSPMCSLNYe-pGKASDVEQEI 113 Babesia bovis T2Bo
XP_015622945  37 RLKILFG---REDGSAEVQLGDTRVMGYATAQLVQpyKDR-------PNEgtLAIFTEFSPMADPAFe-pGRPGESAIEL 105 Japanese rice
4AID_A       420 GKLAWRALRPMLPT--------KEDfpYTIRLVSEITESNGSSSMATVCGSSLAMMDAGVP 472 Caulobacter crescentus CB15
Q6CTP4       105 SRMIEKAVRRSGALdveglciiAGSkcWSLRADVHFLDCDGGLIDASCIAVMAGLLHFKKP 165 Kluyveromyces lactis
Q5B019       104 TNVLDRVIRHSNALdteslcilKGVscWTIRADVHITDYDGNLIDASCIGVMAGLQHFRRP 164 Aspergillus nidulans
Q55BJ2       102 GRIIEKGLKDSRAIdtealciiSGSkvWSIKIAIHVLDDCGNLLDCASISVMTALIHFRKP 162 Dictyostelium discoideum AX4
A0BEI4        95 EKYIEKVIKGSKALdteslcilSGKnvWSIDVNVALINNDGNLLDAMYLCCIFSLQHFRRP 155 Paramecium tetraurelia
Q5XJQ5       103 NRQLERCLRNSKCIdteslcvvSGEkvWQIRVDVHVLNHDGNLMDAASIAAISALSHFRRP 163 zebrafish
Q7QBX4       103 NRILERALKDSNCVdleslclvSEEkvWKLRVDVTVLNHEGNAIDCCSIAALTALAHFKRP 163 Anopheles gambiae str. PEST
XP_002641920 103 IRLLELIIRDSRCIdveslcirAGKeiWKVRVDVRILDEDGSLLDCACLAAITALQHFKRP 163 Caenorhabditis briggsae
XP_001609180 114 SYAIEKIYKDSGIIdveslcivSRKhvWCLRVNIHILQNDGNLLDATNIAVFKALMSYRKP 174 Babesia bovis T2Bo
XP_015622945 106 GRVVDRGLRESRAVdmeslcvvAGKhvWSVRVDLHILDNGGNLIDAANIAALAALSTFRRP 166 Japanese rice
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