Conserved Protein Domain Family
ANF_receptor

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pfam01094: ANF_receptor 
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Receptor family ligand binding region
This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
Statistics
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PSSM-Id: 307306
View PSSM: pfam01094
Aligned: 77 rows
Threshold Bit Score: 106.678
Threshold Setting Gi: 81634060
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam01094 is a member of the superfamily cl27603.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MR8_A        23 ACQPAVEMALEDVNSRRDILPDY-ELKLIH--HDSKCDPGQATKYLYELLY-NdP-IKIILM--------PGCS-SVSTL 88
gi 209572626  39 GERLALALAREQINGIIEVPAKA-RVEVDIfeLQRDSQYETTDTMCQILPK-G---VVSVLG--------PSSSpASAST 105
gi 209572625  40 GERLSITLAKNRINRAPERLGKA-KVEVDIfeLLRDSEYETAETMCQILPK-G---VVAVLG--------PSSSpASSSI 106
gi 81634060   46 PGYNGAKVAVKYLNDNGGLLGK--QIEFIN--IDGKSDPVTVGNVAVELIDkG---AEIIVApcdfdfgsPASReAQSAG 118
gi 81591858   55 QLSLGARLYFNAVNAAGGIH-GR-KIDFKV--LDDGFDADTSARNTRMLIN-D-AkAFALFG--------YVGT-QSSMA 119
gi 81592143   54 QMNLGAKLYFKSINAAGGIY-GR-KIELKV--LDDFYEPEAAERNTKTLIN-D-TkVFALFG--------YVGT-PTSLA 118
gi 81772028   74 QMAAAVPLVVETVNACGGVNGQ--PVSLVA--VDDQTDPKAGAAGMTKLAT-VdK-VAGVVG--------SFAS-SVSTA 138
gi 81672127   83 NMPLAVQLAVDTINACGGVNGQ--DVTVVI--EDDQTDPTAGVSAMTKLAE-AdQ-VAGVVG--------SFAS-SVSSA 147
gi 74563613  130 LAAAAATLAEQDVNAYLTKINATfRIRVVT--ADTAADPTKALDQMKALHS-R---GVKFYI--------VRTS-GEVRT 194
gi 74562133   74 LAQCAAELAIDDLNAKYG-SKGY-KFELYV--EDTQLDPNIALQKLQALYA-K-G-VRAVHA--------GLTS-REASG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MR8_A        89 VAEAARMWNLIVLSYGSSSPA-LSNRQRFPTF----FRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTE-VFTSTLDDL 162
gi 209572626 106 VSHICGEKEIPHI------KVgPEETPRLQYLrfasVSLYPSNEDVSLAVSRILKSFNYPSASLICAKA--ECLLRLEEL 177
gi 209572625 107 ISNICGEKEVPHF------KVaPEEFVKFQFQrfttLNLHPSNTDISVAVAGILNFFNCTTACLICAKA--ECLLNLEKL 178
gi 81634060  119 LVGISTCASDPLYSSWS-----LGDKQF--------TLSMWNTTMGATAADFAVKEKGWKTAYVVTDQFiaYTKSLSKYF 185
gi 81591858  120 ALKVANPAGVPFFAPYAGAQS-LREPFARNVFh---VRAGFND--ETAAIIQQIRAVGQKRIAVIYNDDA-YGRAGLDGL 192
gi 81592143  119 ALKVANPAGVPFFAPYSGAMA-LREPFARNVFh---VRASYND--ETAAIVQQIRTTGHKRVAVVYNDDS-YGAAGLAGV 191
gi 81772028  139 AVSIAAQNKVLLISPGSTSPV-FTEKAQKGDFngfwARTVPPDSYQGPALAELANKKGFKRVSTIVINND-YGVGFEKAF 216
gi 81672127  148 AVPIAVRNNIMMISPGSTSPV-FTDQAKKGEFkgfwARTAPPDTYQAQALAALAKKQGFTDAATVVINND-YGVGFEKVF 225
gi 74563613  195 MKPYADENKLIVISVSSTAPA-LAIPGDYV------FRLPPDDTKQVKAISKILQDAGVKAVVVIWRNDD-WGNGLVKGL 266
gi 74562133  138 EKPFADQNKIILFSAWSTSSL-LAIPNDWL------YRIVGTDAKQIRAIGAILKELGVKNVALIYRKDT-YGEGLYLEL 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MR8_A       163 EE----RVKEAg-IEITFRQSFFs----------DPAVPVKnlkRQ--DA--RIIVGLFYE-----TEARKVFCE-VYKE 217
gi 209572626 178 VRgfliSKETLs-VRMLdd--------------sRDPTPLLkeiRDdkVS---TIIIDANA-----SISHLILRK-ASEL 233
gi 209572625 179 LRqfliSKDTLs-VRMLdd--------------tRDPTPLLkeiRDdkTA---TIIIHANA-----SMSHTILLK-AAEL 234
gi 81634060  186 VE----QFKADg-GEILLEDTYTng-------dnNFSAQLArlqALgkKP--DVIFVSSYG-----TDIGVIIRA-LREV 245
gi 81591858  193 RHa--lALPANagLALVGQASVAry-------ttDIKAVLSsvlAQ--KP--EVIAVVCGY-----QTVVALVSE-AQVQ 253
gi 81592143  192 KRa--lALPENkaVALAVEASVPrn-------stTVKAALSkvlPS--KA--DSVVVISTY-----QTTAALVKE-ALAE 252
gi 81772028  217 VQ----AFEKLg-GTVVNKNNPVry--------dPKATTFEteaAAafAGkpDAVLGVFYV-----ETGSLLLKS-AYQQ 277
gi 81672127  226 VE----SFTADg-GNVTNKDNPVry--------dPKAATLDteaAQgfANspDAVAAILYA-----DTGSVLVQS-AYRQ 286
gi 74563613  267 EA----VAQSRg-FEVIRAATYDpqkgefstevsVLAQKVReaiAKygAD--KVAVAAFGF-----AELQTIFITaAKYE 334
gi 74562133  210 QK----EAARRg-FKLVSVAAYDpdpkafpqaapEAVRKISsevKDlvGP--DFALVIVSFeddgaVVLK----T-IAQD 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MR8_A       218 RLFGKkYVWFligwyadnwfkiydpsinctvdemteaveghitteivmlnpantrsisnmtsqefVEKLTKRL----KRH 293
gi 209572626 234 GMTSAfYKYIlttmdfpilhldgiv-------------------------edssnilgfsmfntsHPFYPEFVrslnMSW 288
gi 209572625 235 GMVSAyYTYIftnlefslqrmdslv-------------------------ddrvnilgfsifnqsHAFFQEFAqslnQSW 289
gi 81634060  246 GYDApvlggdayddpamhealgek---------------------fgndvyfvthtwmgpeahpdMPKFIELY------- 297
gi 81591858  254 GYAGQfYNLSlvgskmqtkelgt-----------------------------tgsgvvisqvmpyPRSVSTPIvreyQKL 304
gi 81592143  253 GFTGQfYNVSfvgtkeladalgs-----------------------------agggvvvsqvmpfPHSMSSALtrdyEKL 303
gi 81772028  278 GVAQgvqimltdgmksdefpaqvg---------------------ktadgkfiasgiigtvpgsdGKGLEALT----KLW 332
gi 81672127  287 GLMDgvtllltdgvyspdfvekvg---------------------kdangvsllsgalgtvpgadGKSLEAFT----AQW 341
gi 74563613  335 ELKQ--VKWYgadgstglsellvpdaaq--------------------favqvggfvspkfaparSPYYDRVR----DYI 388
gi 74562133  278 PVLSK-ARLIgtegmayspillqeggd---------------------vmakgkiigtanwaiptTPEYQEFY----KKF 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MR8_A       294 PEETGGFQ---EApl---aYDAIWALALALNKTSGGGgrsgvrledfnynNQTI----------------TDQIYRAMNS 351
gi 209572626 289 RENCEASTylgPAlsaalmFDAVHVVVSAVRELNRSQe------------IGVKplacts----aniwphGTSLMNYLRM 352
gi 209572625 290 QENCDHVPftgPAlssallFDAVYAVVTAVQELNRSQe------------IGVKplscgs----aqiwqhGTSLMNYLRM 353
gi 81634060  298 KEMFGKAP---DTsfvstgWDTIMLLAEAVKAAGtt---------------------------------eGAALAKALED 341
gi 81591858  305 LKANGITD---FDycslegYIAARALVDGLRGAGrd--------------------------------ltRDKFIRALEA 349
gi 81592143  304 LKADGVTS---FDygsmegYIAARIFVEGLKRAGrd--------------------------------ltREKLITALET 348
gi 81772028  333 QSKKGSAP----GefapqaWDATALLVLAAQAAKENTgv---------giAGKIrdvssapgvevtdvceGLKLLQEGKD 399
gi 81672127  342 KDATGGKD---VTafvphtYDATVLMMLAAEAAKSNTga---------giQSKIrdvsngpgeevtdaceAIAMVREGKD 409
gi 74563613  389 LKNYNREP---DSyay-naYDAVWLIAYSILQAGta---------------------------------dSQKIHDTLPT 431
gi 74562133  332 KAKCGAEP---ITpap-qsYDIIKMLGEIMATIGTDDp-----------dKVRA------------------TLEQWGKQ 378
                        410       420       430
                 ....*....|....*....|....*....|....*..
4MR8_A       352 SSFE--GVSGH-VVF--DASGSRM-AWTLIEQLQGGS 382
gi 209572626 353 VEYD--GLTGR-VEF--NSKGQRTnYTLRILEKSRQG 384
gi 209572625 354 VELE--GLTGH-IEF--NSKGQRSnYALKILQFTRNG 385
gi 81634060  342 GQFK--LLTGD-LDYgtNEEGHVPnKAAAVIELKGGK 375
gi 81591858  350 LGNH--DMGGFvLNF--SPSNHLGsSFVEMTIVSARG 382
gi 81592143  349 MGST--DLGGFaVSF--SPTNHVAsKFVEMTVINSHG 381
gi 81772028  400 INYQ--GASGN-VDI--DANGDVI-GVYDVWTVGDDG 430
gi 81672127  410 INYQ--GASGN-VDI--DENGDVV-GTYDVWTVKGDG 440
gi 74563613  432 VAAKyfGASGY-TKL--NEAGDREsADYEIWAIVKS- 464
gi 74562133  379 GTYK--GATGV-VLL--DENGDRAnPSFILWSVAIKD 410
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