1A0I,1X9N,3GDE,2CFM,3L2P


Conserved Protein Domain Family
DNA_ligase_A_M

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pfam01068: DNA_ligase_A_M 
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ATP dependent DNA ligase domain
This domain belongs to a more diverse superfamily, including pfam01331 and pfam01653.
Statistics
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PSSM-Id: 279417
View PSSM: pfam01068
Aligned: 32 rows
Threshold Bit Score: 138.957
Threshold Setting Gi: 118770
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1A0I_A   7 PFKAVSFVesAIKKALDN--------------------AGYLIAEIKYDGVRgnICVD---NTANSYWLSRVSKTIPAle 63   Enterobacteria phage T7
P35970 126 PMLVKYFN--IIPKTFFEe-------------------ETDPIVQRKRNGVRavACQQ---GDGCILLYSRTEKEFLG-- 179  African swine fever ...
P52496 259 PQLSERLTt-SYKTLVKKlqrkhemdppyekkfqelglENKFYIEEKMDGDR--MLLHk--DGDSFKFFSRRLKDYSYly 333  Candida albicans SC5314
Q08387 256 PQLAKKVNl-SYEKICRTl-------------------hDDFLVEEKMDGER--IQVHymnYGESIKFFSRRGIDYTYly 313  Saccharomyces cerevi...
P49917 248 PMLAAIADieHIEKDMKH---------------------QSFYIETKLDGER--MQMHk--DGDVYKYFSRNGYNYTDqf 302  human
Q9VYA5 258 PMLCERFPg-DIQELm---------------------qSDVLYLETKMDGER--FQLHi--DRGRFMYISRNGVDYTRnf 311  fruit fly
Q9XAM3  11 PMLAKSVA--KI--------------------------PPGMHYEAKWDGFR--AIVYr--DGDEVELGSRTGKPLTR-- 56   Streptomyces coelicolor
L0TDE1  11 PMLAKSVT--AI--------------------------PPDASYEPKWDGFR--SICFr--DGDQVELGSRNERPMTR-- 56   Mycobacterium tuberc...
O34398  13 PPI-----------------------------------GAEWRYEVKYDGYRciLRIH----SSGVTLTSRNGVELSS-- 51   Bacillus subtilis su...
O28549  10 PMLAVRSK--Pf-------------------------sSDDHIYEVKWDGTRclAFVDv--EGKRVRLQNRRLLDITY-- 58   Archaeoglobus fulgidus
1A0I_A  64 hlngfdVRWKRLLNDDRCFYKDG----FMLDGELMVkgVDFNTGSGLLRTKWTDTKnQEFHeelfvepirkKdkVPFKlh 139  Enterobacteria phage T7
P35970 180 -------LDNIKKELKQLYLFIDv--rVYLDGELYL--------HRKPLQWIAGQAnAKTD------------------- 223  African swine fever ...
P52496 334 g--esfQFGALTKFLAHAFAGNIq--sVILDGEMVA--YDYERNVILPFGTLKSSAiQESVrqft---tidQ--YEQQ-- 400  Candida albicans SC5314
Q08387 314 g--aslSSGTISQHL--RFTDSVk--eCVLDGEMVT--FDAKRRVILPFGL---V--KGSAkeal--sfnsI--NNVD-- 374  Saccharomyces cerevi...
P49917 303 g--aspTEGSLTPFIHNAFKADIq--iCILDGEMMA--YNPNTQTFMQKGTKFDI--KRMV----------E--DSDL-- 360  human
Q9VYA5 312 g--hsyDHGTLTPKLRGLLPLGLe--sIILDGEMMV--WDTNKLRFREKGENTDV--KSLK----------P--EGSWqp 371  fruit fly
Q9XAM3  57 ------YFPELVVAVRERLPER-----CVVDGEIVI-----ARDGHLDFDALTERIhPADS----------R--VRTLae 108  Streptomyces coelicolor
L0TDE1  57 ------YFPELVAAIRAELPHR-----CVIDGEIII-----ATDHGLDFEALQQRIhPAES----------R--VRMLad 108  Mycobacterium tuberc...
O34398  52 ------TFPEITQFAKTAFQHLEkelpLTLDGEIVC--LVNPCRADFEHLQVRGRLkRPDK-------------IQESan 110  Bacillus subtilis su...
O28549  59 ------RYPEI-----KLLDAVEr--nAILDGEVVV--I-KDGKPSFPLLQKREHV-DSRF----------K--IEILsk 109  Archaeoglobus fulgidus
1A0I_A 140 TGHLHIKLYAILPLhivesgedcDVMTlLMQEHVKNMLPLLQEYF-------PEIEWQAAESYEVYDMVELQQLYEQKRA 212  Enterobacteria phage T7
P35970 224 SSELHFYVFDCFWS---------DQ----LQMPSNKRQQLLTNIFkq---keDLTFIHQVENFSVKNVDEALRLKAQFIK 287  African swine fever ...
P52496 401 TAYPFFLVFDILFL---------NGKD-LTNYPLFFRKNILNRILr-----pIPNRFEVLDTRLGSSSEDIERAIREVVS 465  Candida albicans SC5314
Q08387 375 -FHPLYMVFDLLYL---------NGTS-LTPLPLHQRKQYLNSILs-----pLKNIVEIVRSSRCYGVESIKKSLEVAIS 438  Saccharomyces cerevi...
P49917 361 --QTCYCVFDVLMV---------NNKK-LGHETLRKRYEILSSIFt-----pIPGRIEIVQKTQAHTKNEVIDALNEAID 423  human
Q9VYA5 372 C----FVVYDLLYF---------NGQS-LLDHTYIQRAYKLQKLIv-----eQSGVLQLMRARKIGSVQEFNELFQQALD 432  fruit fly
Q9XAM3 109 RTPASLVAFDLLAL---------DDAS-LLDVGLADRRALLVRAL-------SGVTPPVHVAPATDDIEVARRWFEQYEG 171  Streptomyces coelicolor
L0TDE1 109 RTPASFIAFDLLAL---------GDDD-YTGRPFSERRAALVDAVtg---sgADADLSIHVTPATTDMATAQRWFSEFEG 175  Mycobacterium tuberc...
O34398 111 ARPCCFLAFDLLER---------SGED-VTLLSYLDRKKSLRELIsaaklpaSPDPYAKETIQSIPCYDHFDQLWEMVIK 180  Bacillus subtilis su...
O28549 110 TIPAVYIVFDVLYC---------DG-W-VVDLELMERKKILSEVLq------SRGRVVVEEWIEGKG----EEFYRKAVE 168  Archaeoglobus fulgidus
1A0I_A 213 EGHEGLIVKDPMCIYKRG--KK--SGWWKMK 239  Enterobacteria phage T7
P35970 288 EGYEGAIVRNANGPYEPGynNYhsAHLAKLK 318  African swine fever virus BA71V
P52496 466 SRCEGLVLKNVQSKYEIDg-FRn-PDWIKVK 494  Candida albicans SC5314
Q08387 439 LGSEGVVLKYYNSSYNVA--Sr-nNNWIKVK 466  Saccharomyces cerevisiae S288c
P49917 424 KREEGIMVKQPLSIYKPD--KRg-EGWLKIK 451  human
Q9VYA5 433 SHAEGIVLKKQGSRYQPG--VRlgGGWYKDK 461  fruit fly
Q9XAM3 172 AGLDGVVAKPLDLRYRQD--ER---AMYKIK 197  Streptomyces coelicolor
L0TDE1 176 AGLDGVIAKPPHITYQPD--KR---VMFKIK 201  Mycobacterium tuberculosis H37Rv
O34398 181 YDGEGIVAKKTNSKWLEK--KRs-SDWLKYK 208  Bacillus subtilis subsp. subtilis str. 168
O28549 169 MGLEGIVAKKKDGRYLIG--KRs-RLWKKIK 196  Archaeoglobus fulgidus
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