1A0I,1X9N,3GDE,2CFM,3L2P


Conserved Protein Domain Family
DNA_ligase_A_M

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pfam01068: DNA_ligase_A_M 
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ATP dependent DNA ligase domain
This domain belongs to a more diverse superfamily, including pfam01331 and pfam01653.
Statistics
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PSSM-Id: 279417
View PSSM: pfam01068
Aligned: 32 rows
Threshold Bit Score: 138.957
Threshold Setting Gi: 118770
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A0I_A         7 PFKAVSFVesAIKKALDN--------------------AGYLIAEIKYDGVRgnICVD---NTANSYWLSRVSKTIPAle 63
gi 544183    126 PMLVKYFN--IIPKTFFEe-------------------ETDPIVQRKRNGVRavACQQ---GDGCILLYSRTEKEFLG-- 179
gi 205371792 259 PQLSERLTt-SYKTLVKKlqrkhemdppyekkfqelglENKFYIEEKMDGDR--MLLHk--DGDSFKFFSRRLKDYSYly 333
gi 2494163   256 PQLAKKVNl-SYEKICRTl-------------------hDDFLVEEKMDGER--IQVHymnYGESIKFFSRRGIDYTYly 313
gi 88911290  248 PMLAAIADieHIEKDMKH---------------------QSFYIETKLDGER--MQMHk--DGDVYKYFSRNGYNYTDqf 302
gi 74871650  258 PMLCERFPg-DIQELm---------------------qSDVLYLETKMDGER--FQLHi--DRGRFMYISRNGVDYTRnf 311
gi 81554346   11 PMLAKSVA--KI--------------------------PPGMHYEAKWDGFR--AIVYr--DGDEVELGSRTGKPLTR-- 56
gi 597501005  11 PMLAKSVT--AI--------------------------PPDASYEPKWDGFR--SICFr--DGDQVELGSRNERPMTR-- 56
gi 81342307   13 PPI-----------------------------------GAEWRYEVKYDGYRciLRIH----SSGVTLTSRNGVELSS-- 51
gi 74512146   10 PMLAVRSK--Pf-------------------------sSDDHIYEVKWDGTRclAFVDv--EGKRVRLQNRRLLDITY-- 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A0I_A        64 hlngfdVRWKRLLNDDRCFYKDG----FMLDGELMVkgVDFNTGSGLLRTKWTDTKnQEFHeelfvepirkKdkVPFKlh 139
gi 544183    180 -------LDNIKKELKQLYLFIDv--rVYLDGELYL--------HRKPLQWIAGQAnAKTD------------------- 223
gi 205371792 334 g--esfQFGALTKFLAHAFAGNIq--sVILDGEMVA--YDYERNVILPFGTLKSSAiQESVrqft---tidQ--YEQQ-- 400
gi 2494163   314 g--aslSSGTISQHL--RFTDSVk--eCVLDGEMVT--FDAKRRVILPFGL---V--KGSAkeal--sfnsI--NNVD-- 374
gi 88911290  303 g--aspTEGSLTPFIHNAFKADIq--iCILDGEMMA--YNPNTQTFMQKGTKFDI--KRMV----------E--DSDL-- 360
gi 74871650  312 g--hsyDHGTLTPKLRGLLPLGLe--sIILDGEMMV--WDTNKLRFREKGENTDV--KSLK----------P--EGSWqp 371
gi 81554346   57 ------YFPELVVAVRERLPER-----CVVDGEIVI-----ARDGHLDFDALTERIhPADS----------R--VRTLae 108
gi 597501005  57 ------YFPELVAAIRAELPHR-----CVIDGEIII-----ATDHGLDFEALQQRIhPAES----------R--VRMLad 108
gi 81342307   52 ------TFPEITQFAKTAFQHLEkelpLTLDGEIVC--LVNPCRADFEHLQVRGRLkRPDK-------------IQESan 110
gi 74512146   59 ------RYPEI-----KLLDAVEr--nAILDGEVVV--I-KDGKPSFPLLQKREHV-DSRF----------K--IEILsk 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A0I_A       140 TGHLHIKLYAILPLhivesgedcDVMTlLMQEHVKNMLPLLQEYF-------PEIEWQAAESYEVYDMVELQQLYEQKRA 212
gi 544183    224 SSELHFYVFDCFWS---------DQ----LQMPSNKRQQLLTNIFkq---keDLTFIHQVENFSVKNVDEALRLKAQFIK 287
gi 205371792 401 TAYPFFLVFDILFL---------NGKD-LTNYPLFFRKNILNRILr-----pIPNRFEVLDTRLGSSSEDIERAIREVVS 465
gi 2494163   375 -FHPLYMVFDLLYL---------NGTS-LTPLPLHQRKQYLNSILs-----pLKNIVEIVRSSRCYGVESIKKSLEVAIS 438
gi 88911290  361 --QTCYCVFDVLMV---------NNKK-LGHETLRKRYEILSSIFt-----pIPGRIEIVQKTQAHTKNEVIDALNEAID 423
gi 74871650  372 C----FVVYDLLYF---------NGQS-LLDHTYIQRAYKLQKLIv-----eQSGVLQLMRARKIGSVQEFNELFQQALD 432
gi 81554346  109 RTPASLVAFDLLAL---------DDAS-LLDVGLADRRALLVRAL-------SGVTPPVHVAPATDDIEVARRWFEQYEG 171
gi 597501005 109 RTPASFIAFDLLAL---------GDDD-YTGRPFSERRAALVDAVtg---sgADADLSIHVTPATTDMATAQRWFSEFEG 175
gi 81342307  111 ARPCCFLAFDLLER---------SGED-VTLLSYLDRKKSLRELIsaaklpaSPDPYAKETIQSIPCYDHFDQLWEMVIK 180
gi 74512146  110 TIPAVYIVFDVLYC---------DG-W-VVDLELMERKKILSEVLq------SRGRVVVEEWIEGKG----EEFYRKAVE 168
                        250       260       270
                 ....*....|....*....|....*....|.
1A0I_A       213 EGHEGLIVKDPMCIYKRG--KK--SGWWKMK 239
gi 544183    288 EGYEGAIVRNANGPYEPGynNYhsAHLAKLK 318
gi 205371792 466 SRCEGLVLKNVQSKYEIDg-FRn-PDWIKVK 494
gi 2494163   439 LGSEGVVLKYYNSSYNVA--Sr-nNNWIKVK 466
gi 88911290  424 KREEGIMVKQPLSIYKPD--KRg-EGWLKIK 451
gi 74871650  433 SHAEGIVLKKQGSRYQPG--VRlgGGWYKDK 461
gi 81554346  172 AGLDGVVAKPLDLRYRQD--ER---AMYKIK 197
gi 597501005 176 AGLDGVIAKPPHITYQPD--KR---VMFKIK 201
gi 81342307  181 YDGEGIVAKKTNSKWLEK--KRs-SDWLKYK 208
gi 74512146  169 MGLEGIVAKKKDGRYLIG--KRs-RLWKKIK 196
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