2YRF,1T5O,5B04,3ECS


Conserved Protein Domain Family
IF-2B

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pfam01008: IF-2B 
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Initiation factor 2 subunit family
This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Statistics
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PSSM-Id: 334341
View PSSM: pfam01008
Aligned: 22 rows
Threshold Bit Score: 165.537
Threshold Setting Gi: 74552666
Created: 16-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YRF_A        70 KVRGAPAIGITAAFGLALAAKDIEtdnvt---------efrrRLEDIKQYLNSSRPTAINLSWALERLSHsvenai---- 136
gi 74552666  195 RTHGSAWLSLRALEVLRDEAALADagrsddletaerdgddweALAALAAEIREARPSMVVIANRLDRAMAavt------- 267
gi 121065     15 EEDTEMTMPIAAIEALVTLLRIKTpetaa---------eminTIKSSTEELIKSIPNSVSLRAGCDIFMRfvlrnlhl-- 83
gi 2494303    15 KEDPDMASAVAAIRTLLEFLKRDKgetiq---------glraNLTSAIETLCGVD-SSVAVSSGGELFLRfislasle-- 82
gi 466059     15 ENDPSKSTSLATVETLLEVLDRSRattva---------efqnELNQVVAALEKTDYSSTSIRSAADLFTRftslapaall 85
gi 341940487 219 LISGSNARCIALLHALQQVIQDYTtppseel-----srdlvnKLKPYISFLTQCRPMSASMCNAIKFLTKevtgmss--- 290
gi 121058    285 KIVGSIPRCIAMLEVFQIVIKDYQtpkgttl-----srnltsYLSHQIDLLKKARPLSVTMGNAIRWLKQeislidp--- 356
gi 1352329   156 KIFGSNQRCIDLLKTFKIVIQDYQtpygttl-----srhlttHINSQIAYLVSTRPLSISMGNAIRFLKLeisvldi--- 227
gi 417036     33 QVQGSYAIALETLQLLMRFISAARwnhvn---------dlieQIRDLGNSLEKAHPTAFSCGNVIRRILAvlrdeveedt 103
5B04_G       156 KIFGSNQRCIDLLKTFKIVIQDYQtpygttl-----srhlttHINSQIAYLVSTRPLSISMGNAIRFLKLeisvldi--- 227
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YRF_A       137 ---svneaKTN---------------------------------------LVHEAIQIQ-VE-DEETCRLIGQNALQLFK 172
gi 74552666  268 -----desPAA---------------------------------------VERAATEAL-NH-AVTADRVAAAVAAEHV- 300
gi 121065     84 -ygdwencKQH---------------------------------------LIENGQLFV-SR-AKKSRNKIAEIGVDFIA 121
gi 2494303    83 -ysdyskcKKI---------------------------------------MIERGELFL-RR-ISLSRNKIADLCHTFIK 120
gi 466059     86 dqedfsqvLDL---------------------------------------YRQRARSFI-KN-VRGSRAKISKCARLFFT 124
gi 341940487 291 -skreeeaKSE---------------------------------------LREALDRYV-QEkIVLAAQAISRFASTKIS 329
gi 121058    357 -stpdkaaKKD---------------------------------------LCEKIGQFA-KEkIELADQLIIDNASTQIE 395
gi 1352329   228 -dltddegKEL---------------------------------------LLEKIDSYI-RDrIIIAGQVIVQAATEKIQ 266
gi 417036    104 msttvtstSVAeplissmfnllqkpeqphqnrknssgsssmktktdyrqvAIQGIKDLI-DE-IKNIDEGIQQIAIDLIH 181
5B04_G       228 -dltddegKEL---------------------------------------LLEKIDSYIrDR-IIIAGQVIVQAATEKIQ 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YRF_A       173 KGDRIMTIC-NAGsiatsrygTALAPFYL-AKQKDLGLHIYACETRP-VLQGsRLTAWELMQGGIDVTLITDSMAAHTMK 249
gi 74552666  301 -GDRIATLS-RSG--------TVRAVAAA-AAPEA----VLVAESRP-GGEG--VGVAETLAESTAVTLTTDAAFGHELD 362
gi 121065    122 DDDIILVHG-YSR--------AVFSLLNH-AANKFIRFRCVVTESRP-SKQG-NQLYTLLEQKGIPVTLIVDSAVGAVID 189
gi 2494303   121 DGATILTHA-YSR--------VVLRVLEA-AVAAKKRFSVYVTESQP-DLSG-KKMAKALCHLNVPVTVVLDAAVGYIME 188
gi 466059    125 HHMNILTHS-YSK--------VVLETILD-AHKSGYHLHVWVTESQP-DASG-KLVFEELKKNGVPTTLVLDSCVGYVME 192
gi 341940487 330 DGDVILVYG-CSS--------LVSRILQE-ARVEGRRFRVVVVDSRP-RLEG-RHMLHSLVRAGVPTSYLLIPAASYVLP 397
gi 121058    396 ESTTIVTYG-SSK--------VLTELLLHnAISLKKNIKVIVVDSRP-LFEG-RKMAETLRNAGVNVMYALITSLDTIFN 464
gi 1352329   267 DGDVILTYL-HSS--------TVNDVLIH-AKNVGKKFRVVVVDSRP-EFEG-RVCLKLLTEHGIECTYVMISALSYIMQ 334
gi 417036    182 DHEILLTPTpDSK--------TVLKFLITaRERSNRTFTVLVTEGFPnNTKNaHEFAKKLAQHNIETLVVPDSAVFALMS 253
5B04_G       267 DGDVILTYL-HSS--------TVNDVLIH-AKNVGKKFRVVVVDSRP-EFEG-RVCLKLLTEHGIECTYVMISALSYIMQ 334
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YRF_A       250 EkqISAVIVGADRIAKNGd-TANKIGTYGLAILANAFDIPFFVAAPLSTFDTKvKCGADIPIEERDPEEVRQISGVRTAP 328
gi 74552666  363 AwsADTLVVGADRILPDGc-VVNKVGTRSAALSAAAADVDCYAVCATDKIAPRaAWDR----EERDAQEVYAGAA----- 432
gi 121065    190 K--VDKVFVGAEGVAESGg-IINLVGTYSVGVLAHNARKPFYVVTESHKFVRMfPLSSDDLPMAGPPLDFTRRTDDL--- 263
gi 2494303   189 K--ADLVIVGAEGVVENGg-IINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLfPLNQQDV-----PDKFKYKADTLKVA 260
gi 466059    193 R--IQAVLVGAEGVMETGg-IINKIGTVNVCIIAKSRHVPVYVCAETIKFVREfPLNQADI-----PQEFKYRTSVIERN 264
gi 341940487 398 E--VSKVLLGAHALLANGs-VMSRVGTAQLALVARAHNVPVLVCCETYKFCERvQTDAFVSNELDDPDDLQCKRGDQVAL 474
gi 121058    465 Md-VDYVFLGAHSILSNGf-LYSRAGTAMLAMSAKRRNIPVLVCCESLKFSQRvQLDSVTFNELADPNDLVNIDYENPVE 542
gi 1352329   335 E--VTKIFLGGHAMLSNGa-LYSRAGTSLISLLGHESNVPVIACCESYKFTERiQLDSLVYNELAPGDQLVNMGVDDFEE 411
gi 417036    254 R--VGKVIIGTKAVFVNGgtISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLyPFDVEKFVEFGGSQRILPRMDPRK-- 329
5B04_G       335 E--VTKIFLGGHAMLSNGa-LYSRAGTSLISLLGHESNVPVIACCESYKFTERiQLDSLVYNELAPGDQLVNMGVDDFEE 411
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YRF_A       329 -----------S-----------------------------------------------------------------NVP 332
gi 74552666  433 -----------------------------------------------------------------------------DIA 435
gi 121065    264 -----------------------------------------------------------------------------EDA 266
gi 2494303   261 -----------Qtg--------------------------------------------------------------qDLK 267
gi 466059    265 -----------------------------------------------------------------------------NLE 267
gi 341940487 475 -----------Anwq-----------------------------------------------------------shpSLR 484
gi 121058    543 -----------RrgnkgallnqfikerkfekkklamenkpkgnkiggkkgsegeskdasneedsnsknildgwqelpSLN 611
gi 1352329   412 -----------Kpgvlan------------------------------------------------------wksvkNLK 426
gi 417036    330 -----------------------------------------------------------------------------RLD 332
5B04_G       412 kpgvlanwksvK-----------------------------------------------------------------NLK 426
                        410       420
                 ....*....|....*....|....*
2YRF_A       333 VFNPAFDITPHDLISGIITEKGIMT 357
gi 74552666  436 VSNPTFDITPASAVT-VVTERGVLE 459
gi 121065    267 LRGPTIDYTAQEYITALITDLGVLT 291
gi 2494303   268 EEHPWVDYTAPSLITLLFTDLGVLT 292
gi 466059    268 LEHPDVDYTAPEFLTLIITDVGAMK 292
gi 341940487 485 LLNLVYDVTPPELVDLVITELGMIP 509
gi 121058    612 IVNILYDLTPPEYIKKVITEFGALP 636
gi 1352329   427 LLSLKYDVTPPRLITVCVCEMGLLP 451
gi 417036    333 TVNQITDYVPPENIDIYITNVGGFN 357
5B04_G       427 LLSLKYDVTPPRLITVCVCEMGLLP 451
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