4EVZ,1H5Y,5AHE,4GJ1,2X30,4AXK,1QO2


Conserved Protein Domain Family
His_biosynth

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pfam00977: His_biosynth 
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Histidine biosynthesis protein
Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalyzed by eight enzymes. The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold. In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel. This family belong to the common phosphate binding site TIM barrel family.
Statistics
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Aligned: 142 rows
Threshold Bit Score: 116.814
Threshold Setting Gi: 74560794
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4EVZ_A          5 RIIPCLDVKDGRVV---KGVNFENLRDAGDPVELAARYDEEGADELVFLDITASHEGRETMLEVVERTAEQVF---IPLT 78  synthetic cons...
Q8G4S5          4 TLLPAVDVRDGKAVrlrQGES-GSETDYGSPFEAARTWVEAGAEWIHLVDLDAAF-GTGNNRDQLREIVHELGd-rVNIE 80  Bifidobacteriu...
P16250          5 ELLPAVDVRDGQAVrlvHGESGTETSYGS-PLEAALAWQRSGAEWLHLVDLDAAF-GTGDNRALIAEVAQAMD---IKVE 79  Streptomyces c...
O29276          3 RVIPAIDLKDGKVVrlrQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLRHEEIIAEIAKM-----AEVQ 77  Archaeoglobus ...
O26931          2 LIIPAVDIKDGKCVqlvQGKPGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGAL-GLEKNTGILKEITERVS---VPLQ 77  Methanothermob...
Q8TU55          4 EVIPAVDMRGGKCVqlvQGVPGSEIVSLNDPLAVALDWIGKGAKTLHLVDLDGAIEGERKNAPIIEKIVQACRekgVSIQ 83  Methanosarcina...
jgi:Mvol_1636   2 dIIPAVDMKEGKCVqliQGDPTKRHVEYDNPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESK---VPVQ 78  Methanococcus ...
Q58927          2 IIIPAVDLKDKKCVqliQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTGNNRDVIKNIIKEVN---VPVE 77  Methanocaldoco...
Q8TYD6          4 VVIPSVDVVEGKCVqlvEGDPERRTFESDDPVETAHQW-SEFFPWIHVVDVDAA-RGEGDNSDIIGRICEEVD---AKVQ 78  Methanopyrus k...
2X30_A          5 ELLPAVDVRDGQAVrlvHGESGTETSY-GSPLEAALAWQRSGAEWLHLVDLDAAF-GTGDNRALIAEVAQAMD---IKVE 79  Streptomyces c...
4EVZ_A         79 VGGGIRSVEDASRLLRAGADKVSINTAAV-KNPEL--ITEAAEEFGSQAVVVAIDAKR---VggGwEVFTHGGRKPTGLD 152 synthetic cons...
Q8G4S5         81 LSGGVRDDASLDAALEAGAARVNIGTAAL-ENPDW--TASVIKKYGD-RVAVGLDVR-------GhTLAARGWTRE-GGD 148 Bifidobacteriu...
P16250         80 LSGGIRDDDTLAAALATGCTRVNLGTAAL-ETPEW--VAKVIAEHGD-KIAVGLDVRGttlR--G-----RGWTRD-GGD 147 Streptomyces c...
O29276         78 VGGGIRDFRVAERLFELGVDRVIFGTIAV-ERVEE--LREFAKKWKG-RVMVAIDSKK------G-RVAVKGWKEVVELT 146 Archaeoglobus ...
O26931         78 IGGGIRSREYAGKLLDMGFERVILGTMAI-ENPAI--VEELAGEYGSERIMVSLDSRD---S----RVVIRGWTEKVPFT 147 Methanothermob...
Q8TU55         84 VGGGIRSFEDAASLLELGVSRIILGTAAL-QNPEL--VKQLSDAFGSSCVNVALDAKN------G-KISIKGWTEECAQT 153 Methanosarcina...
jgi:Mvol_1636  79 MGGGIRTIEDVEELVNLGINRVIIGTVAV-QNPDF--VEKLAKKVGSEKIMVALDAKD------G-KVVIKGWKEKTEYT 148 Methanococcus ...
Q58927         78 VGGGIRNLEIAKELISLGVDRVIVGTKAI-LEPKF--IDDLNKEIGKDKIVLAVECKE------G-KVVIKGWKEKVDKT 147 Methanocaldoco...
Q8TYD6         79 VGGGIRSAERAEELIELGADRLIVGTVAFtDKDDFskIVDVCHDHGI-EVFVALDv----nE--NhEVLVSGWKEDAGVT 151 Methanopyrus k...
2X30_A         80 LSGGIRDDDTLAAALATGCTRVNLGTAAL-ETPEW--VAKVIAEHG-DKIAVGLDVR-------GtTLRGNGWTRDGG-D 147 Streptomyces c...
4EVZ_A        153 AVEWARKVVELGAGEILLTSMDRDGTKAGYDLELTRAVSEAVSVPVIASGGAGELEHFAE---VF---ElEGADAALAAS 226 synthetic cons...
Q8G4S5        149 LFETMKFLDSVGCSRYVVTDVAKDGMMSGPNIQLLSEVAERTDAKVTASGGISKLDDLRA---IKelaE-IGVDSAILGK 224 Bifidobacteriu...
P16250        148 LYETLDRLNKEGCARYVVTDIAKDGTLQGPNLELLKNVCAATDRPVVASGGVSSLDDLRA---IAglvP-AGVEGAIVGK 223 Streptomyces c...
O29276        147 PVQLA-ELYDDLDVSFLYTNIDVEGLVSGIERERIEEVVKSLRNPVYVAGGISSIEDIRF---AK---R-VGAAGVVIGS 218 Archaeoglobus ...
O26931        148 AEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEIPVIYSGGVSSLNDLRM---LQ---G-TGVMGVVIGS 220 Methanothermob...
Q8TU55        154 PVEMGREFEELGAGSLLFTNIDTEGLMQGVNPGPTRELVESVSIPVIASGGVSSLEDLKV---LK---Q-TGASGVVVGS 226 Methanosarcina...
jgi:Mvol_1636 149 PVQMGKILEEKGAGSILFTNVDSEGLLNGINITPTKELVDNLNIPIIASGGVTTIDDLIE---FK---K-IGVSGVVVGS 221 Methanococcus ...
Q58927        148 PIEVIKEFEDK-VGYILFTNVDVEGLLKGINVDIIKELIEKTDIPIIYSGGITTLEDIKA---LK---E-LGIYGVVIGS 219 Methanocaldoco...
Q8TYD6        152 LEDAIERFNEVADGY-LTTAVHVEGKEMGIDEKVVEKSTGATDLPVLYAGGIASIKDVKR---AK---E-AGAYGVVIGT 223 Methanopyrus k...
2X30_A        148 LYETLDRLNKEGCARYVVTDIAKDGTLQGPNLELLKNVCAATDRPVVASGGVSSLDDLRAiagLV---P-AGVEGAIVGK 223 Streptomyces c...
4EVZ_A        227 IFHFGEIT 234 synthetic construct
Q8G4S5        225 SLYARAFT 232 Bifidobacterium longum NCC2705
P16250        224 ALYAKAFT 231 Streptomyces coelicolor A3(2)
O29276        219 ALYTKKLK 226 Archaeoglobus fulgidus DSM 4304
O26931        221 AIYRGLID 228 Methanothermobacter thermautotrophicus str. Delta H
Q8TU55        227 ALYTGRFT 234 Methanosarcina acetivorans C2A
jgi:Mvol_1636 222 ALYKNNFk 229 Methanococcus voltae A3
Q58927        220 ALYKGLID 227 Methanocaldococcus jannaschii DSM 2661
Q8TYD6        224 ALYHGDID 231 Methanopyrus kandleri AV19
2X30_A        224 ALYAKAFT 231 Streptomyces coelicolor
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