4A6E


Conserved Protein Domain Family
Methyltransf_2

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pfam00891: Methyltransf_2 
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O-methyltransferase
This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.
Statistics
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PSSM-Id: 307169
View PSSM: pfam00891
Aligned: 9 rows
Threshold Bit Score: 267.329
Threshold Setting Gi: 1353193
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4A6E_A       105 MLKYMGRTSYRCWGHLADAVREGRNQ--------YLETFGVPaeeLFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFD 176
gi 2498445   106 IMMYYSNTVYLCWHYLTDAVREGRNQ--------YERAFGISskdLFGARYRSEEEMLKFLAGQNSIWSICGRDVLTAFD 177
gi 2507044   105 MLLYAGRTAYVCWRHLAEAVREGRNQ--------YLKAFGIPseeLFSAIYRSEDERLQFMQGLQDVWRLEGATVLAAFD 176
gi 1353193   124 AAMVLDPTIVSPFSELGAWFQHELPDpc-----iFKHTHGRG---IWELTKDDATFDALVNDGLASDSQLIVDVAIKQSA 195
gi 374110475 104 MLLYLAGTTYGCWAHLAAGVREGRNQ--------YSRAVGISaedPFSAIYRSEPERLLFMRGLQETWSLCGGRVLTAFD 175
gi 85700408  130 LEAMVGHHHVL-YRDLADPVAFLKGEtepelarfWPYVFGAG-------GATDPEVTAKYSRLMTESQGLVAEDALRLVD 201
gi 983616474 129 LALLQDKVFINSWFELKDAVLEGGv--------pFDRVHGVH---AFEYPKLDPKFNDVFNQAMINHTTVVMKRILENYK 197
gi 669031972 121 aLMNQDKVLMESWYYLKDAVLDGGi--------pFNKAYGMS---AFEYHGTDPRFNRVFNEGMKNHSIIITKKLLESYK 189
gi 224118508 128 cLMNQDKVLMESWYYLKDAILDGGi--------pFNKAYGMT---AFEYHGTDPRFNKVFNKGMSDHSTITMKKLLETYK 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4A6E_A       177 --LSVFPLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHfsf-qeeEQIDFQEGDFFkDPLP-EADLYILAR 252
gi 2498445   178 --LSPFTQIYDLGGGGGALAQECVFLYPNCTVTIYDLPKVVQVAKERlvp-peeRRIAFHEGDFFkDSIP-EADLYILSK 253
gi 2507044   177 --LSPFPLICDLGGGSGALAKACVSLYPGCRAIVFDIPGVVQIAKRHfsa-sedERISFHEGDFFkDALP-EADLYILAR 252
gi 1353193   196 evFQGISSLVDVGGGIGAAAQAISKAFPHVKCSVLDLAHVVAKAPTH-------TDVQFIAGDMF-ESIP-PADAVLLKS 266
gi 374110475 176 --LSRFRVICDLGGGSGALAQEAARLYPGSSVCVFDLPDVIAAARTHflspgarPSVRFVAGDFFrSRLP-RADLFILAR 252
gi 85700408  202 --LMGVRRLMDVGGGTGAFLAAVGRAYPLMELMLFDLPVVAEAAPQRlteaglaGRFTVHGGSFRdDPLPlGADAISLVR 279
gi 983616474 198 g-FENLKTLVDVGGGLGVNLKMITSKYPTIKGTNFDLPHVVQHAPSY-------PGVDHVGGDMF-ESVP-QGDAIFMKW 267
gi 669031972 190 g-FEGLGTLVDVGGGVGATVAAITAHYPTIKGINFDLPHVISEAPPF-------PGVTHVGGDMF-QKVP-SGDAILMKW 259
gi 224118508 197 g-FEGLTSLVDVGGGTGAVVNTIVSKYPSIKGINFDLPHVIEDAPSY-------PGVEHVGGDMF-VSVP-KADAVFMKW 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4A6E_A       253 VLHDWADGKCSHLLERIYHTCK---PGGGILVIESL-LDEDRRGPLLTQLY---SLNMLVQt-EGQERTPTHYHMLLSSA 324
gi 2498445   254 ILHDWDDKKCRQLLAEVYKACR---PGGGVLLVESL-LSEDRSGPVETQLY---SLNMLVQt-EGKERTAVEYSELLGAA 325
gi 2507044   253 VLHDWTDAKCSHLLQRVYRACR---TGGGILVIESL-LDTDGRGPLTTLLY---SLNMLVQt-EGRERTPAEYRALLGPA 324
gi 1353193   267 VLHDWDHDDCVKILKNCKKAIPpreAGGKVIIINMV-VGAGPSDMKHKEMQaifDVYIMFI--NGMERDEQEWSKIFSEA 343
gi 374110475 253 VLHDWADGACVELLGRLHRACR---PGGALLLVEAV-LAKGGAGPLRSLLL---SLNMMLQa-EGWERQASDYRNLATRA 324
gi 85700408  280 VLFDHSDETVKLLLHRVREALP---AGGRVIVAEAMsGGARPHRETDTYM----AFYTAAMr-TGRVRSAAEIAELLTGQ 351
gi 983616474 268 ILHDWSDGHCLKLLKNCHKALP---DNGKVIVVEAN-LPVKPDTDTTVVGVsqcDLIMMAQnpGGKERSEQEFRALASEA 343
gi 669031972 260 ILHDWSDEHCATLLKNCYDALP---AHGKVVLVECI-LPVNPEATPKAQGVfhvDMIMLAHnpGGRERYEREFEALAKGA 335
gi 224118508 267 ICHDWSDAHCLKFLKNCYDALP---ENGKVILVECI-LPVAPDTSLATKGVvhiDVIMLAHnpGGKERTEKEFEGLAKGA 342
                        250       260
                 ....*....|....*....|
4A6E_A       325 GFR------------DFQFK 332
gi 2498445   326 GFR------------EVQVR 333
gi 2507044   325 GFR------------DVRCR 332
gi 1353193   344 GYSdyriipvlgvrsIIEVY 363
gi 374110475 325 GFP------------RLQLR 332
gi 85700408  352 GFS------------EIKIF 359
gi 983616474 344 GFKgvnliccvcnfwvmefy 363
gi 669031972 336 GFAamkttyiyanawAIEFt 355
gi 224118508 343 GFQgfevmccafnthVIEFR 362
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