4NYK


Conserved Protein Domain Family
ASC

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pfam00858: ASC 
Amiloride-sensitive sodium channel
Statistics
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PSSM-Id: 334289
View PSSM: pfam00858
Aligned: 411 rows
Threshold Bit Score: 56.0476
Threshold Setting Gi: 321469562
Created: 16-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A        26 FASSSTLHGISH-IFSyErLSLK---RVVWALCFMGSLALLALVCTNRIQYYflYPHVTKLDe---V-A---ATRLTFPA 94
gi 321454684   8 FLRNTSIHGMRY-I-G-QrN-RPifeRIFWMLLVVVGCVISVYGCYLEWIKWsdSSILITRDpsvtT-Hd-pIN---FPV 78
gi 194758188  41 YTERTKVSGMWL-L-R-RnR-TRglsRFIWSSVLLQLLLLSIYLTLLLWLKFysYPILNTISn---D-Ls--ITDVAFPG 110
gi 158289889  40 FASMSKIHGMYY-L-Q-RqV-TTgfvRLLWIAIIVAFFVFGIVLIYLLWQKFvdSPTRMTIAs---E-Mk--IVQVPFPG 109
gi 195334995  30 FCATSSIHGLKY-T-R-DeD-TNkivHLLWLLISLVMFICAVVMAHTFYMDYrsSPTRMNVEs---D-Ht-pVNRLYFPP 100
gi 194756754  30 FCATSSIHGLRY-T-R-DeD-TNrivHFVWLLISLVMFICAVVMARTFYIDFrsNPTRMNVEs---D-St-pVNTLYFPP 100
gi 969487772  30 FCTTSSIHGLRYtRDE-DtNRIV---HFVWLLISLVMFSCAVAMAHTFYVDFrsNPTRMNVE----S-DftpLSNLYFPP 100
gi 195380513  30 FCATSSIHGLKY-T-R-DkD-TNrlvHFVWILISLVMFICAIVMTHTFYVDYrsSPTRMNVEs---D-Ht-pVGKLYFPP 100
gi 313228729  13 dynKTSCGWLKYiFGA-KiNAFR---RILWASFFIFGNYIAVYHVWRNTKHFfeYPH----S----MkEniaDEKDKFPV 80
gi 313224598  11 dmstnscgwLKYiFGK-RiSIPR---RVMWAGVFIFGNYFAFFHIWRIGNRYyeYPH----S----IkDrakIEGHSFPV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A        95 VTFCNLN---------------------------------------------EF------RFSRVTKNDLYHAGELLALL 123
gi 321454684  79 MT----------------------------------------------------------KLEAVINEPKLYSWMNYSSV 100
gi 194758188 111 VTIC--Sp-------------------------------------------kVVnterveRYVKTLKIPK-EYDIGEVAA 144
gi 158289889 110 ITLC--Hp-------------------------------------------qSVvdykaeRFVEKIKLPL-GATKESVLK 143
gi 195334995 101 VTICPDVlfnmqkseaflntlrlpqgaelrgilrklhifygfmldderysaeDIeqmealLFL--------N-------- 164
gi 194756754 101 VTICPDVlfnmqkseaflqtlqlpqgtnqsvilrklhifygfmlddekyseqDTslmesvLSL--------N-------- 164
gi 969487772 101 VTICPEV---------------------------------------------LF------NMQKSKAFLETl-------- 121
gi 195380513 101 ITICPEVlfnmdkskayietlklpegvqvadvlqhlhifsgfmlddarfspaEIelmesvLLD--------N-------- 164
gi 313228729  81 VTICLNS----------------------------------------------------------------MHSRYKTNL 96
gi 313224598  79 ITVCLNS----------------------------------------------------------------MHSRKKLIN 94
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       124 NNRYEIPDTQTADEKQLEILQDKANFRNF----------------KP--KPFNMLEFYDRAGHdiremllsc-------f 178
gi 321454684 101 VMAIRY-----LTKFDGLVSYTEDDNFQHll------------reLNdrNIDIDDLVEVIHQVhprcsdmivdc---qwk 160
gi 194758188 145 GFEFLNAFTDQSFEPPPHESFRVTDTv---------------------lRLNNVSTWEAAMAVspgcsdyvkrcfwghse 203
gi 158289889 144 NLPSLGYFTEHQWTFPRPQDLRMIDNv---------------------lQLNNYTIEQAIDELgmicedfilvcywagkq 202
gi 195334995 165 -----------NLTIP-----------------------------------------EFLEHLrwncdeilyrc---rfn 189
gi 194756754 165 -----------NLTLQ-----------------------------------------QLVEHLrwncdeilyrc---rfn 189
gi 969487772 122 -----------RLPEGADVARIQRQLHIFygfmldderfadqdieQMesVLTLNNLTLEQFVEhlrwdcheily--rcry 188
gi 195380513 165 -----------NLTMV-----------------------------------------QFVDRLrwdchellhrc---ryh 189
gi 313228729  97 YYPQLELESNGKEDDDQSTLMDFYGNKA-----------------PVsnYSHLDDIDLEQFYKasknnylmil-----ck 154
gi 313224598  95 LHPELGIQPRGNEIKDNCSLWDFYGHNHDg---------------LThdLSLFDHIHLDNFYNetysaflmi------sc 153
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       179 frgeqcsPe-dF-KVVFTRYGKCYTF--------N----AG------QDGKPRLItm-kGGT--GN---GLEIM------ 226
gi 321454684 161 ssvvpcgRl--L-SLRMTDDGFCCSI--------D----VSvydrddENGTTGTVy--dYGV--HS---AFRII------ 212
gi 194758188 204 fqcnqshEylsF-IPTTAYLGPCCSF--------N----YNp----rNASFVPFSan-iFGM--DG---GLTFVgaeg-- 258
gi 158289889 203 fpcfakhAflgW-IGSTSHYGACCSF--------N----YHpn---vRGNKDPFVvn-tYGM--HG---GLSVIgtgypq 260
gi 195334995 190 geimdcsKi--F-QLSKTFFGHCCSF--------N----LRq----kGLNFTAQRa--iGGL--RY---GLSVV------ 237
gi 194756754 190 gqirdclEl--F-QLSKTFFGHCCSF--------N----LRq----tGLNFTAERa--vGGL--KY---GLSVI------ 237
gi 969487772 189 hgkiincSe-lF-QLSKTFFGNCCSF--------NlrqqGLn----fTA----QRa--aGGL--GS---GLSVI------ 237
gi 195380513 190 gdimdctQl--F-QLSKTFFGHCCSF--------N----LRq----hGLDFTAQAa--aGGL--DN---GLSLI------ 237
gi 313228729 155 yrkdkcrTk--W-HEEVTMYGICQRFyppkldghS-----------------------------VSsmrSLQIV------ 196
gi 313224598 154 kykkddcTk--WwKRTLTLYGNCQVL--------D------------------LAampnRASisPDgfrSLQMV------ 199
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       227 --------LDIQQDE-YLPVWgetdetSf------EAGIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSC-QEQRLIY--- 287
gi 321454684 213 --------L----DPnVN--D------Nvls-tisIDGFKILLHNEDEFPDVIERGFIVGSGYENYVAL-NSYSVSYtpv 270
gi 194758188 259 ----sernL-----N---------------------TGLIVLVHHPMDYVTESAASVTITARSESFVEV-SPTVQSSsae 307
gi 158289889 261 asdgksgaL----YS---------------------EGFMLMIHHPHDFAVEASPLTLIRLGKETFVNV-LPTDSRCseq 314
gi 195334995 238 --------L----RYkDDSYD------Plq---sySYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAV-RPQETFCssa 295
gi 194756754 238 --------L----RYkDDSYD------Pvq---sySFGVKLLIQESDAFPSAHSSSKFIAFNSEVFAAI-RPQETFCspa 295
gi 969487772 238 --------LRYQDDN-YDPFQ------Sy------SYGVKLLIQETNAFPSAHAVSKFVSFNTEVFAAL-RP---EEt-- 290
gi 195380513 238 --------L----RYkDENYD------Alq---sySHGFKLLIQETDAFPSAHADCKFLGLNTESFATL-RVVETFCsea 295
gi 313228729 197 --------LAY------NKTD------WtygwnymMDGFSIF-YSPEGEL-------VMDPMTSVTVNSrIVPVLLL--- 245
gi 313224598 200 --------LAY------NQSD------WtygwnsfMDGFSIF-YNPEGET-------VLDPMRSITVNSrIVPIMFL--- 248
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       288 ------LP-----PPWGD----------CKATTG--D---S-EFy--------dTYSITACRIDCETRYLVENCNCRMVH 332
gi 321454684 271 ipsvsfEKr------------------qCYVESE--G---KlKYnls-----glIYTRSSCLFECRTEKILEECQCLPYF 322
gi 194758188 308 vlelseRKr------------------dCLISDDl-Ql-rN--------------YRQAACLLACQTEAIVQKCGCHPYL 353
gi 158289889 315 vlalpqSQr------------------dCIVGSDftPpieR--------------YRQPACTLECLRNEVHRKCGCHPFH 362
gi 195334995 296 vkaltiEEr------------------nCVFQNE--F---PmRYf--------sDYVYPNCELNCRVTNMVKFCGCHTYF 344
gi 194756754 296 vkalsiEDr------------------nCVFRNE--F---KmRYf--------kNYVYPNCELNCRVTNMVKFCNCHTYF 344
gi 969487772 291 -----fCAaavkaLAIEEr--------nCVFGNE--F---HlRYf--------pDYVYPNCELNCRVTNMVKFCGCHTYF 344
gi 195380513 296 vkslpiSQr------------------nCVFRHE--F---RlRYf--------sDYVYPNCELNCRAKNMVKLCGCHTYF 344
gi 313228729 246 ------QQ--------HRniklgppytqC--------------HnvtddlkyfkNYTKKNCHYECLIDSIFEECKCGPPY 297
gi 313224598 249 ------QQ--------HRniklgepyteC--------------Trnrsl-qyfkQYSKYNCNYECLIKEVYKRCKCRVPY 299
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       333 MPGDap-------yCt----PEQYkeCadPALDF--L-VEkdneyC------------V-CEMPC------NVTRYGK-E 378
gi 321454684 323 IKVNvs-------vPsc--rLQSYp-CvvKFYVrsvfmASia-nnC------------R-CPATC------KDQWFTT-Q 371
gi 194758188 354 L-PIvg------nkFke-cnLNDTf-Cyse------nyDNfksvrCd-----------Q-CLPNC------YDVTYSTlS 400
gi 158289889 363 LPRPmvgp---ngqGirnctVYDSm-Cfve------nyYMfkrlqC------------N-CLPSC------SDVTYKTaS 413
gi 195334995 345 FAFNrt------snRic--tFRDIp-ClvDNFAN--IiTRkkstqC------------Y-CPLTC------EHIDYNV-Q 393
gi 194756754 345 FDFNrt------tdRic--tFKDIp-ClvDNFAN--IiTRkrstqC------------Y-CPLTC------EHLDYDV-Q 393
gi 969487772 345 FDFNrtrdricsfrD--------Ip-ClvDNFAN--IiTRerstqC------------Y-CPLTC------EHFDYDV-Q 393
gi 195380513 345 FEFNrt------kdRvc--tFRDIp-ClvDNFPD--IiTRrkktqC------------N-CPLTC------EHFDYDV-Q 393
gi 313228729 298 FPR-----------I------EGIpmCn-----------FsqhvnCvakqlkdfdyanCtCLTQCselyyqKTVYYTEiH 349
gi 313224598 300 FPK-----------T------TEYqvCm-----------YhehtrCvahilkefmysdChCPVPCselfykKTVYYTEmH 351
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NYK_A       379 LS---MV-----KIPSKAsakyLak--kYNk----sEQ------YIGENILVLDIFFEAL-NYETIEQKKAYEVAGLLGD 437
gi 321454684 372 IS---SA-----P----LslsgFsa--sRTfqrisrRKnvdanySVKL--IGLRIFFKYN-AGDSFSMDVPFGNKELI-- 432
gi 194758188 401 YRt-dLN-----QHQFSVs--rFy----SPe-----LL------NNDS--FVLRVYLAKQ-VVPVIRKVTVMSWVGLLSD 454
gi 158289889 414 IVs-nFS-----AYNFSIn--pFy----KEt-----NL------TDFE--FIFHIFMSNQ-VVAANRRIVVVSWISLLSN 467
gi 195334995 394 IS----------NFPLELnmpvAdk-fySG------LA-------KND--GVLHVFINSF-SYRRLRRDLLSNMVTLVSN 446
gi 194756754 394 IS----------DFPLKLnmpvAdq-fySG------IN-------KND--GILHVFINSF-GYRRLRHDLLSNMVTLVSN 446
gi 969487772 394 IS----------NFPLYPn---MpvvdpFYs----gIA---------KNDGILHVFINSI-SYRRIRQDLLSNMVTLVSN 446
gi 195380513 394 MS----------NFALMLnmpvVdp-fySG------IE-------KND--AIVHIFLNSQ-VYRRVRVDLLSNMVTLVSN 446
gi 313228729 350 QNfrnKTakilkRFPDIV----------L---------------------ASARISLPDPyEFQH-EEHADYGVSQYLSD 397
gi 313224598 352 QNfrnKTaemlkRFPDIA----------L---------------------ASVRISLPENyEMQH-QEQADYEISQLFSD 399
                        650       660
                 ....*....|....*....|..
4NYK_A       438 IGGQMGLFIGASILTVLELFDY 459
gi 321454684 433 -GGILGLGLGFSMISAIELCYF 453
gi 194758188 455 LGGIFNLCLGLSMISVVEFFYY 476
gi 158289889 468 LGGAFSLCLGISVLSLFEVLFF 489
gi 195334995 447 LGSAFSLFVGMSMLSVVEVIYY 468
gi 194756754 447 LGSAFSLFVGMSMLSVVEIIYY 468
gi 969487772 447 LGSAFSLFVGMSMLSVVEILYY 468
gi 195380513 447 LGSAFSLFVGMSMLSLVEIIYY 468
gi 313228729 398 VGGAMSLVLGVSLVSFLEMIEc 419
gi 313224598 400 VGGAMSLILGISLVSFLELCEL 421
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