Conserved Protein Domain Family
Glyco_transf_10

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pfam00852: Glyco_transf_10 
Glycosyltransferase family 10 (fucosyltransferase) C-term
This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).
Statistics
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PSSM-Id: 307136
View PSSM: pfam00852
Aligned: 87 rows
Threshold Bit Score: 191.978
Threshold Setting Gi: 340374108
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2851674   193 KTKLVAWVVSNWNTDSIRVQYYKLLKPH-LQVDVYGRf--HT-------PLPHALMAKQLSQYKFYLAFENSLHPDYITE 262
gi 241846407 184 KTRHVLWLVSNCKTPSNREGFVQELRKF-IQVDVVGQcghLScl----pKMSADCYHNASKVYFFYLALENSICTDYITE 258
gi 196012716 189 KTKLVAWASSKCYP--ERTTFINRLSRL-MQVDKYGKcgnLSc------PRTKGCWKRLGRQYKFYLSFENKVCKDYVTE 259
gi 170594655 154 KVRPVLQLVSNCQTKSKRELYVEQLRTY-INITQHGLcknSIc--------DEKCEVKEAAQHRFYLAFENSVCRDYITE 224
gi 268529864 215 KKKSATWLASNCFTPNRRFDLIKKMVDKgFEIEIWGNcgkQApqcsgvdNQESPCVLELIKPYKFYISMENSNCKDYVTE 294
gi 312066791 196 KSGSIFWLVSNCNTISKRELAVEKLGKY-IMVDKYGAcadNPykr-dacKKASECEKDLGAMNFFYIAIENTICKNYITE 273
gi 340374108 173 KTIEVSALISHCVYD--RLKAVRSLMKY-IDVNLMGTc-nGK-------WLSVTESHSQIKHSKFFLAFENSLCVDYITE 241
gi 341898633 202 KKKSATWLASNCFTQNRRFDLIKKMIDKgFEIDIWGNcgkQApqcsgvdNQESPCVLDLIKPYKFYLSIENSNCKDYVTE 281
gi 308471075 197 KKKSATWLASNCFTPNRRFDLIKKMIDNgFDIEIWGNcgkQApqctgvdNQESPCVLELIKPYKFYISMENSNCKDYVTE 276
gi 671411144 187 KVRPVLQLVSNCQTKSKRELYVEQLRTY-INITQHGLcknSI--------CDEKCEVKEAAQHRFYLAFENSVCRDYITE 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2851674   263 KLWkNALQ-AWAVPVVLGPSRVNYE--Q--FLPPKAFIHVEDFQSPKDLAQYLLALDKDYASYLNYFRWR-----ETl-- 330
gi 241846407 259 KFY-NALT-WGMVPIVMSGA--NYT--S--VAPPRSYIDALSFQNVRHLADHLKQIAKDPLLYNSYHAWR-----QRy-- 323
gi 196012716 260 KFYaNALL-YDMVPIVLGGA--NYQdpQ--VAPPGSYINAFDFKNIEELSQYILKVDKDDSLYNQYFQWR-----ANy-- 327
gi 170594655 225 KLF-KCFL-RLLIPVVL--KRSIYE--G--ILPPGSFIAADDFASPRELAEYLHYLSNNNTAYLSYLKWT-----RHy-- 289
gi 268529864 295 KFW-KALNdRMVVPIVL--SRQYYK--NlnVVPDSAYIAVDDFATFDEFMTHIKKVNSDKDTYLSYHTWR-----KDy-- 362
gi 312066791 274 KYF-DRYH-LPSIPIVM--RRKTYE--N--LVPPHSFIPMDDFESARVMADYLIALMSNKTAYLEYFKWRydgwvRAy-- 343
gi 340374108 242 KTYrNAYT-NEAVPVILSGA--NLS--NplIVPPGSYIDASKFKTAKELADYLKYVGESKERYNKFFEWR-----NKw-- 309
gi 341898633 282 KFW-KALNdRMTIPIVL--ARKYYKdlG---VPDSSYIAIDDFGTFDEFMTHIKKVNSDKATYLSYHEWR-----KDw-- 348
gi 308471075 277 KFW-KALNdRMVIPIVL--ARKYYKdlG---VPDSAYIAVDDFATFDEFMTHIKKVNKDKDTYLSYHAWR-----KDw-- 343
gi 671411144 258 KLF-KCFL-RLLIPVVL--KRSIYE--G--ILPPGSFIAADDFASPRELAEYLHYLSNNNTAYLSYLKWT-----RHyqk 324
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 2851674   331 --RPRSFSWALMFCKacWKLQ-Q----E-PR---YQTvPSIA 361
gi 241846407 324 --KIV---WRPFQCNlcQMLH-E----Q-SP---PRMyEDIN 351
gi 196012716 328 --TIVRMKMSEAFCElcYDIS-F----F-RR---QKIyHDLT 358
gi 170594655 290 ----QKTFDVSNFCElcKYLH-S----DiAR---TRIiPDIK 319
gi 268529864 363 --QIIIGSGFSGWCTlcNKLQ-DkeyiL-KH---PKSyKDVA 397
gi 312066791 344 ----QSIGYRFHFCKlcEALL-E----E-RP---AKTyENVE 372
gi 340374108 310 --NIDTDSWNTRWCHlcEKIH-K----N-SKldsQQYyTDLS 343
gi 341898633 349 --KViigsgfsgWCTlcNKLQdKey-iL-KH---PKSyKDVA 383
gi 308471075 344 --QIiigsgfsgWCTlcDRLQdKek-iL-KN---PKSyKDVA 378
gi 671411144 325 tfDVs------nFCElcKYLHsD----I-AR---TRIiPDIK 352
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