3DH3


Conserved Protein Domain Family
PseudoU_synth_2

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pfam00849: PseudoU_synth_2 
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RNA pseudouridylate synthase
Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Statistics
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PSSM-Id: 376401
View PSSM: pfam00849
Aligned: 55 rows
Threshold Bit Score: 65.5182
Threshold Setting Gi: 81643074
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DH3_A         69 LIALNKPVGIVSTTED----------------------GERD------NIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHG 120 Escherichia co...
OLY96254       77 VVIYHKREGEVCTSKD-------------------------EkdrqtvFDSLPKLAKSRWIMVGRLDINTTGLLLFTTDG 131 Francisella tu...
A0CY18         99 VWIFYKPVGMICSHND-----------------------PFKrpsfydFAKLRLKTDQHIISVGRLDFNSEGLIVVTNDG 155 Paramecium tet...
EAZ95968        4 HFLIHKPYGYLSQFIY-------------------------ElkrpkkLLGELYDFPGNTMAIGRLDEDSEGLLLLTTDG 58  Flavobacteria ...
WP_011680884   62 YYLMNKPSGVVSARKD-------------------------KehqtviDLIRPEDQREGLYPVGRLDRDTEGLVLITNNG 116 Streptococcus ...
jgi:Maqu_2908  62 YLMLNKPSGYLSATRDdqh--------------------------ptvMELIDPLLRPHVHIAGRLDRASTGLLILTSDG 115 Marinobacter h...
Q26G32        154 YLLLNKPKGFIAPRKG-------------------------ErasktvLDLMQSAGVANLHYVGRLGRQSVGLMLFTNDL 208 Flavobacteria ...
OXE97740      130 YILLNKPKNFTTALDE-------------------------GqeyrnvLELVRAATNAKIAPIGRMDKNTTGLLLFTNDT 184 Flavobacterium...
jgi:Tmel_0417  66 YYVLHKPKGYVTSLYDpk----------------------------ekNTIKEFFKDKPLKPAGRLDKDVSGVLILTNDG 117 Thermosipho me...
Q7RHI6        348 TIIVNKPKHYLSISPDnklnnkkllvrnlirnenkyieEEHKcmsyfiYKNINIEKVNNLYVCGRLDANSSGLLIYTQDS 427 Plasmodium yoe...
3DH3_A        121 DLVNKILRA-GNDHEKEYLVTVD--KPITEEFI--RGMSAg-------vPILGTVTKKCKVKKEAPFVFR---------- 178 Escherichia co...
OLY96254      132 DLANRLMHP-SYQIEREYAVRVF-------------------------------------GQQLSDETINklkegiqled 173 Francisella tu...
A0CY18        156 ELARCMELP-ETKLQRIYRVRV--------------------------------------YGTFTEEKLKkirngitiag 196 Paramecium tet...
EAZ95968       59 MMSEIV--R-SKKVEKEYYAQVDglITEEAIEKlkNRVEI------------GFNGKKYLTKKCNAFILEtipnlgergk 123 Flavobacteria ...
WP_011680884  117 PLGFAMLHP-RYHVAKTYYVEVNdiLGPDAPAFfeSGVVF------------------EDGTVCQSAQLEilssas---- 173 Streptococcus ...
jgi:Maqu_2908 116 VWSRRLTEP-AVKIPKVYRVTTAyaISPETEDRfrEGIWF-----------------EYEQLRTSPASLEplge------ 171 Marinobacter h...
Q26G32        209 EMANKLNNP-NLEMRKIYQVAL--------------------------------------DRSFKHEDLMqlrngiaing 249 Flavobacteria ...
OXE97740      185 DMIRKFSLP-NQKSPKIYQVSL--------------------------------------DKNLKFEDLEkiskglvldg 225 Flavobacterium...
jgi:Tmel_0417 118 DLIDVLTNA-KYGVKKVYIAKI--------------------------------------TGRVKFEDLLslkkgiydkg 158 Thermosipho me...
Q7RHI6        428 IASSYLLNkyKYQVEKEYIITTF--NEINECHLkmLKDNLfvdgkliykCHIQYVDSFTLIFKLYQGFHKiirk------ 499 Plasmodium yoe...
3DH3_A        179 ---------------------ITLVQGLNRQIR---RMCEH 195 Escherichia coli K-12
OLY96254      174 giakfnsikfsggeganlwyyVTLSEGRNREVR---RMFEA 211 Francisella tularensis subsp. holarctica
A0CY18        197 vnygpywvnvenrqsrntwliMRLEQGKNREIR---KVMQK 234 Paramecium tetraurelia
EAZ95968      124 ki-------rderhgptswvsITLTEGKFRQVR---KMTSA 154 Flavobacteria bacterium BAL38
WP_011680884  174 ---------------dkscarITISEGKFHQVK---KMFLA 196 Streptococcus thermophilus
jgi:Maqu_2908 172 -----------------revrLTIYEGRYHQVK---RMFHA 192 Marinobacter hydrocarbonoclasticus VT8
Q26G32        250 evidv-keinyvedgrnneigIEIHSGKDNIVQ---ALFEA 286 Flavobacteria bacterium BBFL7
OXE97740      226 hrvsv-eeisyiekepksevgL--------------KLRSS 251 Flavobacterium johnsoniae UW101
jgi:Tmel_0417 159 dflklehfdileqgfnystvkVEMIKGKKHEVK---RLFEK 196 Thermosipho melanesiensis BI429
Q7RHI6        500 -----------------icllSNIKIRSLHRIRigkIHLNN 523 Plasmodium yoelii yoelii
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