3DH3


Conserved Protein Domain Family
PseudoU_synth_2

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pfam00849: PseudoU_synth_2 
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RNA pseudouridylate synthase
Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA.
Statistics
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PSSM-Id: 307134
View PSSM: pfam00849
Aligned: 55 rows
Threshold Bit Score: 66.2909
Threshold Setting Gi: 81643074
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DH3_A        69 LIALNKPVGIVSTTEDg----------------------ERD------NIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHG 120
gi 122489519 154 YLLLNKPKGFIAPRKG-------------------------ErasktvLDLMQSAGVANLHYVGRLGRQSVGLMLFTNDL 208
gi 81643074   63 VLLFHKPEAVDCSLAPskt---------------------------tkTLLDFDFGTDRVFPVGYLDQASEGILLLTNDG 115
gi 74880782  348 TIIVNKPKHYLSISPDnklnnkkllvrnlirnenkyieeEHKcmsyfiYKNINIEKVNNLYVCGRLDANSSGLLIYTQDS 427
gi 501003566  66 YYVLHKPKGYVTSLYDpk----------------------------ekNTIKEFFKDKPLKPAGRLDKDVSGVLILTNDG 117
gi 500931792 130 YILLNKPKNFTTALDE-------------------------GqeyrnvLELVRAATNAKIAPIGRMDKNTTGLLLFTNDT 184
gi 500110345  62 YLMLNKPSGYLSATRDdqh--------------------------ptvMELIDPLLRPHVHIAGRLDRASTGLLILTSDG 115
gi 500000166  62 YYLMNKPSGVVSARKD-------------------------KehqtviDLIRPEDQREGLYPVGRLDRDTEGLVLITNNG 116
gi 495529154   4 HFLIHKPYGYLSQFIY-------------------------ElkrpkkLLGELYDFPGNTMAIGRLDEDSEGLLLLTTDG 58
gi 493165584  65 TVLLNKPRGVICSCHD-----------------------PEGrttvldLLPPELSEATGLHPVGRLDGASRGALLLSNDG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DH3_A       121 DLVNKILRA-GNDHEKEYLVTVD--KPITEEFI--RGMSAgvpilg-------tvtkkcKVKKEAPFVFR---------- 178
gi 122489519 209 EMANKLNNP-NLEMRKIYQVAL--------------------------------------DRSFKHEDLMqlrngiaing 249
gi 81643074  116 EIANKLSLP-EFRPEDEYLLTS--------------------------------------PEEIDAEMIEkltqarkaek 156
gi 74880782  428 IASSYLLNkyKYQVEKEYIITTF--NEINECHLkmLKDNLfvdgkliykchiqyvdsftLIFKLYQGFHKiirk------ 499
gi 501003566 118 DLIDVLTNA-KYGVKKVYIAKI--------------------------------------TGRVKFEDLLslkkgiydkg 158
gi 500931792 185 DMIRKFSLP-NQKSPKIYQVSL--------------------------------------DKNLKFEDLEkiskglvldg 225
gi 500110345 116 VWSRRLTEP-AVKIPKVYRVTTAyaISPETEDRfrEGIWFe-----------------yEQLRTSPASLEplge------ 171
gi 500000166 117 PLGFAMLHP-RYHVAKTYYVEVNdiLGPDAPAFfeSGVVFe------------------DGTVCQSAQLEilssas---- 173
gi 495529154  59 MMSEIV--R-SKKVEKEYYAQVDglITEEAIEKlkNRVEIgfng------------kkyLTKKCNAFILEtipnlgergk 123
gi 493165584 122 ALTLRLTHP-RFGHRKHYRVWV--------------------------------------TGEPAAEALEqwrrgvpldg 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
3DH3_A       179 ---------------------ITLVQGLNRQIR---RMCEH 195
gi 122489519 250 evidv-keinyvedgrnneigIEIHSGKDNIVQ---ALFEA 286
gi 81643074  157 nks-----vvdieqidakhlrILQQGGRSKDIK---KMCEA 189
gi 74880782  500 -----------------icllSNIKIRSLHRIRigkIHLNN 523
gi 501003566 159 dflklehfdileqgfnystvkVEMIKGKKHEVK---RLFEK 196
gi 500931792 226 hrvsv-eeisyiekepksevgL--------------KLRSS 251
gi 500110345 172 -----------------revrLTIYEGRYHQVK---RMFHA 192
gi 500000166 174 ---------------dkscarITISEGKFHQVK---KMFLA 196
gi 495529154 124 ki-------rderhgptswvsITLTEGKFRQVR---KMTSA 154
gi 493165584 163 qpsqpvgvrelargqrgtlleLEMVEGRNRQIR---RTAEL 200
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