2G6Z,4YR8,3F81,2J16,2R0B,2RF6


Conserved Protein Domain Family
DSPc

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pfam00782: DSPc 
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Dual specificity phosphatase, catalytic domain
Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region.
Statistics
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PSSM-Id: 334251
View PSSM: pfam00782
Aligned: 28 rows
Threshold Bit Score: 122.754
Threshold Setting Gi: 1168807
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G6Z_A  13 LYLGSAYHASkceflANLHITALLNVSrrtseA--------CMt---HLHYKWIP-VEDs---------HTADISSHFQE 71  human
Q85297  34 VYLGNYNDAKaa-ptSGIGFKYILNLT-----Te------kYTiknsSITIIHMPlVDD----------EYTDLTKYFDY 91  Myxoma virus (strain ...
P07239  34 VYLGNYKNAMda-psSEVKFKYVLNLTmd-----------kYTlpnsNINIIHIP-LVDd---------TTTDISKYFDD 91  Vaccinia virus WR
Q93622  10 LIQKENVGGVvc-ctEEFELKAAMNAMrevd------------wkneGVEFFAVP-MKDf---------TGTAPRAEINE 66  Caenorhabditis elegans
P76093 306 VYLGAFPRHIpa-qnAVLDVTFEFPRGra----------------tkDRLYFCVP-MLD----------LVVPEEGELRQ 357 Escherichia coli K-12
Q00684 198 GYLATKSSHLnqpfkSVLNFFANNNVQlvvrlNs-------HLynkkHFEDIGIQhLDLi---------FEDGTCPDLSI 261 Saccharomyces cerevis...
Q19388  18 LFLAGYGCITps-llKQYNITHGVDCTnlktkP--------IK----GLDRIEVP-VDDn---------TLAKITQYFEP 74  Caenorhabditis elegans
Q93592  21 LFICGVSALSkd-emKKHKITHIINATtev----------pnLrslgDIQRTKLW-LEDt---------PQTYIYPHLEL 79  Caenorhabditis elegans
Q84621  32 VWVGSEATAAdpaflKKNNIKLVVNCT-----A--------DIpkysNIPMLRVP-VHDaa-------fDADKMAKYLGV 90  Paramecium bursaria C...
O13453  69 IYLYAKPTMP-----IIQSFDVVINVAkevlhPfrtdgrhyRD----SKHNLDIQ-VFDhieyvhihwdHDTQFALELDK 138 Schizosaccharomyces p...
2G6Z_A  72 AIDFID-CV---REKGGKVLVHSEAGISRSPTICMAYLMKTKQF-RLKEAFDYI------KQRR-SMVSPNFGFMGQLLQ 139 human
Q85297  92 ATTFLS-NC---EDKHYPVLVHCMAGVNRSGAIIMAYLMSRKSK-DIPAFMYFLyiyhsiREQR-GAFLENPSFRRQIIE 165 Myxoma virus (strain ...
P07239  92 VTAFLS-KC---DQRNEPVLVHCAAGVNRSGAMILAYLMSKNKE-SLPML-YFLyvyhsmRDLR-GAFVENPSFKRQIIE 164 Vaccinia virus WR
Q93622  67 AVEFIE-SV---ASKGKTVYVHCKAGRTRSATVATCYLMKSRNW-MSNVAWEFL------KDKRhQVLLRN-AHWRTVNE 134 Caenorhabditis elegans
P76093 358 AVAMLE-TL---REEQGSVLVHCALGLSRSALVVAAWLLCYGHCkTVNEAISYI------RARR-PQIVLTDEHKAMLRL 426 Escherichia coli K-12
Q00684 262 VKNFVG-AAetiIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGF-TANECIGFL------RFIR-PGMVVG-PQQHWLYL 331 Saccharomyces cerevis...
Q19388  75 VVKYIE-DA---KQQGHNTVIYCAAGVSRSATLTIVYLMVTENL-SLEEAYLQV------NQVR-PIISPNIGFWRQMID 142 Caenorhabditis elegans
Q93592  80 QSDQIQ-AL---IADGGKVLVHCVAGVSRSASICLAFLLKYRCR-NLREAYHLM------KSKR-SMVRPNLGFWRQLIA 147 Caenorhabditis elegans
Q84621  91 SSMAIR-DV---TRYKGNVLVHCRAGQNRSASVTAAYIMTIKGI-TAREAMDIV------RSRKcETFRPS-NFTSSLKA 158 Paramecium bursaria C...
O13453 139 LVSFVAyNA---MQLNKKVLINCQMGISRSACLMIAFIMKTLNL-NVSDAYEYV------KERS-PWIGPNMSLIFQLSE 207 Schizosaccharomyces p...
2G6Z_A 140 YE 141 human
Q85297 166 KY 167 Myxoma virus (strain Lausanne)
P07239 165 KY 166 Vaccinia virus WR
Q93622 135 YR 136 Caenorhabditis elegans
P76093 427 WE 428 Escherichia coli K-12
Q00684 332 HQ 333 Saccharomyces cerevisiae S288c
Q19388 143 FE 144 Caenorhabditis elegans
Q93592 148 YE 149 Caenorhabditis elegans
Q84621 159 YE 160 Paramecium bursaria Chlorella virus 1
O13453 208 YQ 209 Schizosaccharomyces pombe 972h-
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