2G6Z,4YR8,3F81,2J16,2R0B,2RF6


Conserved Protein Domain Family
DSPc

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pfam00782: DSPc 
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Dual specificity phosphatase, catalytic domain
Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region.
Statistics
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PSSM-Id: 334251
View PSSM: pfam00782
Aligned: 28 rows
Threshold Bit Score: 122.754
Threshold Setting Gi: 1168807
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2G6Z_A       13 LYLGSAYHASkceflANLHITALLNVSrrtseA--------CMt---HLHYKWIP-VEDs---------HTADISSHFQE 71
gi 21759106  34 VYLGNYNDAKaa-ptSGIGFKYILNLT-----Te------kYTiknsSITIIHMPlVDD----------EYTDLTKYFDY 91
gi 138374    34 VYLGNYKNAMda-psSEVKFKYVLNLTmd-----------kYTlpnsNINIIHIP-LVDd---------TTTDISKYFDD 91
gi 75018702  10 LIQKENVGGVvc-ctEEFELKAAMNAMrevd------------wkneGVEFFAVP-MKDf---------TGTAPRAEINE 66
gi 2495601  306 VYLGAFPRHIpa-qnAVLDVTFEFPRGra----------------tkDRLYFCVP-MLD----------LVVPEEGELRQ 357
gi 1168807  198 GYLATKSSHLnqpfkSVLNFFANNNVQlvvrlNs-------HLynkkHFEDIGIQhLDLi---------FEDGTCPDLSI 261
gi 74963740  18 LFLAGYGCITps-llKQYNITHGVDCTnlktkP--------IK----GLDRIEVP-VDDn---------TLAKITQYFEP 74
gi 75018690  21 LFICGVSALSkd-emKKHKITHIINATtev----------pnLrslgDIQRTKLW-LEDt---------PQTYIYPHLEL 79
gi 82029412  32 VWVGSEATAAdpaflKKNNIKLVVNCT-----A--------DIpkysNIPMLRVP-VHDaa-------fDADKMAKYLGV 90
gi 26397972  69 IYLYAKPTMP-----IIQSFDVVINVAkevlhPfrtdgrhyRD----SKHNLDIQ-VFDhieyvhihwdHDTQFALELDK 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2G6Z_A       72 AIDFID-CV---REKGGKVLVHSEAGISRSPTICMAYLMKTKQF-RLKEAFDYI------KQRR-SMVSPNFGFMGQLLQ 139
gi 21759106  92 ATTFLS-NC---EDKHYPVLVHCMAGVNRSGAIIMAYLMSRKSK-DIPAFMYFLyiyhsiREQR-GAFLENPSFRRQIIE 165
gi 138374    92 VTAFLS-KC---DQRNEPVLVHCAAGVNRSGAMILAYLMSKNKE-SLPML-YFLyvyhsmRDLR-GAFVENPSFKRQIIE 164
gi 75018702  67 AVEFIE-SV---ASKGKTVYVHCKAGRTRSATVATCYLMKSRNW-MSNVAWEFL------KDKRhQVLLRN-AHWRTVNE 134
gi 2495601  358 AVAMLE-TL---REEQGSVLVHCALGLSRSALVVAAWLLCYGHCkTVNEAISYI------RARR-PQIVLTDEHKAMLRL 426
gi 1168807  262 VKNFVG-AAetiIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGF-TANECIGFL------RFIR-PGMVVG-PQQHWLYL 331
gi 74963740  75 VVKYIE-DA---KQQGHNTVIYCAAGVSRSATLTIVYLMVTENL-SLEEAYLQV------NQVR-PIISPNIGFWRQMID 142
gi 75018690  80 QSDQIQ-AL---IADGGKVLVHCVAGVSRSASICLAFLLKYRCR-NLREAYHLM------KSKR-SMVRPNLGFWRQLIA 147
gi 82029412  91 SSMAIR-DV---TRYKGNVLVHCRAGQNRSASVTAAYIMTIKGI-TAREAMDIV------RSRKcETFRPS-NFTSSLKA 158
gi 26397972 139 LVSFVAyNA---MQLNKKVLINCQMGISRSACLMIAFIMKTLNL-NVSDAYEYV------KERS-PWIGPNMSLIFQLSE 207

                ..
2G6Z_A      140 YE 141
gi 21759106 166 KY 167
gi 138374   165 KY 166
gi 75018702 135 YR 136
gi 2495601  427 WE 428
gi 1168807  332 HQ 333
gi 74963740 143 FE 144
gi 75018690 148 YE 149
gi 82029412 159 YE 160
gi 26397972 208 YQ 209
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