Conserved Protein Domain Family
CNH

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pfam00780: CNH 
CNH domain
Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Statistics
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PSSM-Id: 307087
View PSSM: pfam00780
Aligned: 52 rows
Threshold Bit Score: 161.653
Threshold Setting Gi: 341941195
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
pfam00780 is a member of the superfamily cl02434.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   782 IHPETRDQHLLIG-AEEGIFNLNLn-ELHDAAIEQLYPr--rTVWLYVIK--DILMSL----SGk--tAQLYRHDLLALH 849
gi 341941195 1142 YCGSLWGVNLLLG-TQSHLYLMDR---SGKAEIVKLIKrr-pFRQIQVVEqlNLLITI----SGk--kNRLRVYHLSWLR 1210
gi 123899077  230 LCAALWGVNLLVG-TENGLMLLDR---SGQGKVYNLINrr-rFQQMDVLEglNVLVTIs--gKK----NKLRVYYLSWLR 298
gi 67477462   782 LCAALWGVNLLIG-TDSGLMLLDR---SGQGKVYPLISrr-rFDQMTVLEgqNILATIs--gRK----RRIRVYYLSWLR 850
gi 162416278  493 VCADPWGQALLVS-TDAGVLLVDDdlPSVPVFDRTL-P----VKQMHVLEtlDLLVLR----ADkgkdARLFVFRLSALQ 562
gi 82081855   487 VCADSWGQSLLVS-TDAGILLIDD-----GQTTVQVFDktlqIKQMHVLEalDYLIARtdkgkD----SRLLVFRLSSVQ 556
gi 162416109  502 VCGDSWGQSLLVAtDSAGVMLLED---SPTLPPVQVFDktltVKQMHVLEpqDLLIARadkgkD----ARLYVYRLSTLK 574
gi 29427653   511 THPSTKDQNLLLG-AEEGIFILNr--NDQEATLEMIFPg--rTTWLYCIN--NLLMSL----SGk--tPYLYSHSILGLL 577
gi 74966691   488 VHPLTGAHLLLFG-TEQGIYSFDTn-CMPDGNLSKIHHr--rCSWMFVYA--DRLTAI----QGn--tPYVYRHDLVALT 555
gi 158295691 1232 LCAALWGVNLLIG-TENGLMLLDR---SGQGKVYQLISrr-rFQQMEVLEgqNILVTIs--gKK----NRVRVYYLSWLK 1300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   850 SKQTHrfsmhmkkipe-klvprkfalttKVPDTKGCMQCCv--tRNPYNGYKYLCGSMATGIFLMQWYDplNKF------ 920
gi 341941195 1211 NKILNndpkskkrqk---amrkkeeackAIDKLIGCEHFS----VLQHEETTYIAVAVKSSIHLFAWAP--KSFden--- 1278
gi 123899077  299 NRILHndpeve-----------kkqgwiTVGDLEGCVHYK----VVKYERIKFLVIALKNAVEIYAWAP--KPYhkf--- 358
gi 67477462   851 QKILRtegagsant------tekrngwvNVGDLQGAIHFK----IVRYERIKFLVVGLESSIEIYAWAP--KPYhkf--- 915
gi 162416278  563 KGLEGkqagksr----------sdcrenKLEKTKGCHLYAi---NTHHSRELRIVVAIRNKLLLITRKHnkPSGvtstsl 629
gi 82081855   557 KDIETkqvirsk----------ydcrenKLERTKGCHLYAi---NTHHSSELRIVVAIRNKLLLITKKYnpCNSltgssl 623
gi 162416109  575 QGIEErqlvrtk----------cdsrenKLEKTKGCHLYSi---NTHHGVELRIVAAIRNKLLLITRKQsrLECvssiat 641
gi 29427653   578 ERKDGrtgspiahisphrllarknmvssKIQDTKGCRACCv--aESASSGGPFLCGALETSVVLLQWYQpmNKF------ 649
gi 74966691   556 QKNltlkmsknlnkipekyvpkrlaitvRMPETRGALQCTvkrgQGAQANSLFLCCAVRKTVHLFQWYNpmNQF------ 629
gi 158295691 1301 SKILRtdgltdqq-------verrngwiNVGDLQGAVHFK----IVKYERIKFLVIALKDSIEIYAWAP--KPYhkf--- 1364
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   921 ------------MLLKQ--CEWPsgniqyyganSNVFEMIITpe---leYPIVCVNVrkg-pndTLKLDLINTN-STP-- 979
gi 341941195 1279 ---------taiKVFPT--RDLK----------PLTVDLAVGse----kTLKIFFSS-------ANGYHIIDAEsEVM-- 1324
gi 123899077  359 ---------mafKSFTD--LQHK----------PLLVDLTVEeg----qRLKVIYGS-------SVGFHVIDVDsGNP-- 404
gi 67477462   916 ---------msfKSFGS--LSHV----------PLIVDLTVEdn----aRLKVLYGS-------TGGFHAIDLDsAAV-- 961
gi 162416278  630 lsplsespveefQYIRE--ICLS----------DSPMVMTLVdgpaeesDNLICVAY-------RHQFDVVNEStGEA-- 688
gi 82081855   624 sl--sespveefQYIREicLSDPpv------vmTLVDGPTGDs------DNMICVAY-------RHQFDLVNEStGES-- 680
gi 162416109  642 vtgstdspveefQYIREicLCDSpv------vmALVDGPTGEn------DHMICVAY-------RHQFDLINEStGDA-- 700
gi 29427653   650 ------------LLVRQ--VLFPlpt------plPVFTLLTTpg---seLPAVCIGVspgqaakSVLFHTVRFG-ALS-- 703
gi 74966691   630 ------------VLVRSepIREDirf------piRPFALINSrt---sdFPELCIGVgqmsgsnEYQFNMINFC-SSTnn 687
gi 158295691 1365 ---------mafKSFGE--LMHR----------PLLVDLTVEeq----tRLKVIYGS-------AEGFHAVDLDsATV-- 1410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74920668   980 TwFNtTVEEMDgmATVINRRDTLRPIKVHQIEKD---AILVCYDRFVQIVDI---QGFp-----KQSrklISRVEFSFVI 1048
gi 341941195 1325 SeVT-LPNN-----------------NVVILPDClglGVMLSLNAEAASEEA---NEQ------LLK---KILDVWKDIP 1374
gi 123899077  405 YdIY-IPSHG-----------SVTPHAIVVLPKTdgmEMLLCYEDEGVYVNT---YGR------ITK---DVVLQWGEMP 460
gi 67477462   962 YdIY-TPAQSg---------qTTTPHCIVVLPNSngmQLLLCYDNEGVYVNT---YGR------MTK---NVVLQWGEMP 1019
gi 162416278  689 FrLH-HVEANR--VNF---------VAAIDVYEDgeaGLLLCYNYSCIYKKVcpfNGGsflvqpSAS---DFQFCWNQAP 753
gi 82081855   681 YrLH-HIEANKvn-----------fVAAIDVYEDgeaGLLLCYNYVCQYRKVypfNGGspliqpSAY---DFHFSWNQVP 745
gi 162416109  701 YrLH-HVDSNRvn-----------fVAAIDVYEDgeaGLLLCYNNICVYKKVcpfNGAtpmiqpNTS---DFHFSWNQMP 765
gi 29427653   704 CwLD------------DSSTEHKGPVQVIQVKED---MVMVLMDGSLKLVTP---EGA------PAPglrTPEIPMTEAV 759
gi 74966691   688 SeLSgDLNSSY---GSLADDEMLEVGSMHQIDRD---TLCFSFRNKVVLTDL---QGFe-----RPK---PSIFTFNFHI 750
gi 158295691 1411 YdIY-LPKHTq---------gPISPHCIVTLPNSngmQLLLCYDNEGVYVNT---MGR------VSK---NIVLQWGEMP 1468
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 74920668  1049 ESIVC-LTDSVLAFHKYGMQGRSLRNGEI---TQEITDTSRIYELIGS 1092
gi 341941195 1375 SSVAFeCTKRITGWDQKAIEVRSLQSTILeneLKRRSIKKLRFLCARG 1422
gi 123899077  461 TSVAYiHSNQIMGWGEKAIEIRSVETGHLdgvFMHKRAQRLKFLSERN 508
gi 67477462  1020 SSVAYiSTGQIMGWGNKAIEIRSVDTGHLdgvFMHKKAQKLKFLCERN 1067
gi 162416278  754 YAIVC-AFPYLLAFTTDSMEIRLVVNGNL---VHTAVVPQLQLV-ASR 796
gi 82081855   746 YAVVC-AFPYILAFTTDSIEIRLVVNGNL---VHTAVVPELQLVASRS 789
gi 162416109  766 NATVC-AFPYILAFTTDSIEIRLVVNGNL---VYTAVVPELQLTASRS 809
gi 29427653   760 EAVAM-VEDRLEAFWKHGVQVWAPGLKQP---LQELRDPTLTFRLLCS 803
gi 74966691   751 EYLHV-VDGTILAFHANGVQGRDLKSNLN---TQDLCDVSRLYRVIGD 794
gi 158295691 1469 TSVAYiGTGQIMGWGNKAIEIRSVETGHLdgvFMHKKAQRLKFLCERN 1516
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