1NYL,4YE8,4H3S,1J09


Conserved Protein Domain Family
tRNA-synt_1c

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pfam00749: tRNA-synt_1c 
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tRNA synthetases class I (E and Q), catalytic domain
Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).
Statistics
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Aligned: 20 rows
Threshold Bit Score: 430.583
Threshold Setting Gi: 62296638
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NYL_A   20 VHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWS---------GNVR 90   Escherichia coli
P48525   45 VRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYD---------ETPI 115  Saccharomyces cerev...
P15189    6 VRVRIAPSPTGEPHVGTAYIALFNYLFAKKHGGKFILRIEDTDATRSTPEFEKKVLDALKWCGLEWSegpd-iggpYGPY 84   Sinorhizobium melil...
P22250    5 VRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVEDTDKKRNIEGGEQSQLNYLKWLGIDWDesvd-vggeYGPY 83   Bacillus subtilis s...
P53662    4 LRTRYAPSPTGYLHIGGARTALFNYLLAKHYNGDFIIRIEDTDVKRNIADGEASQIENLKWLNIEANesplkpnekYGPY 83   Mycoplasma pulmonis...
P43818   15 VRTRFAPSPTGYLHVGGARTALYSWLYAKHNNGEFVLRIEDTDLERSTPEATAAIIEGMEWLNLPWEh---------gPY 85   Haemophilus influen...
P04805    3 IKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDe---------gPY 73   Escherichia coli K-12
P07814  198 VTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKP----------DQFT 267  human
P28668  204 VVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKETVEFENVILGDLEQLQIKP----------DVFT 273  fruit fly
Q5L431    5 VRVRYAPSPTGHLHIGGARTALFNYLFARHHGGKMIVRIEDTDIERNVEGGEKSQLENLKWLGIDYDesid-qdggYGPY 83   Geobacillus kaustop...
1NYL_A   91 YSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTltQPGKNsPYRDRSVEENLALF-EKMRAGGFEEGKACLRAKI 169  Escherichia coli
P48525  116 KQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHS--AMELKpPSMASYDRCCAHLGeEEIKSKLAQGIPFTVRFKS 193  Saccharomyces cerev...
P15189   85 RQSDRKDIYKPYVEKIVANGHGFRCFCTPERLEQMREA--QRAAGk--PPKYDGLCLSLSaEEVTSRVDAGEPHVVRMKI 160  Sinorhizobium melil...
P22250   84 RQSERNDIYKVYYEELLEKGLAYKCYCTEEELEKEREE--QIARG--EMPRYSGKHRDLTqEEQEKFIAEGRKPSIRFRV 159  Bacillus subtilis s...
P53662   84 RQSQKLEKYLKIAHELIEKGYAYKAYDNSEELEEQKKH--SEKLG-VASFRYQRDFLKISeEEKQ-KRDASGAYSIRVIC 159  Mycoplasma pulmonis...
P43818   86 YQTKRFDRYNQVIDEMIEQGLAYRCYCTKEHLEELRHT--QEQNK--EKPRYDRHCLHDHn------HSPDEPHVVRFKN 155  Haemophilus influen...
P04805   74 YQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREE--QMAKG--EKPRYDGRCRHSHeH-----HADDEPCVVRFAN 144  Escherichia coli K-12
P07814  268 YTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQ----RIDsKHRKNPIEKNLQMW-EEMKKGSQFGQSCCLRAKI 342  human
P28668  274 HTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQ----RVEsANRSNSVEKNLSLW-EEMVKGSEKGQKYCVRAKI 348  fruit fly
Q5L431   84 RQTERLDIYRKYVNELLEQGHAYKCFCTPEELEREREA--QRAAG-IAAPQYSGKCRHLTpEQVAELEAQGKPYTIRLKV 160  Geobacillus kaustop...
1NYL_A  170 DMASPfiVMRDPVLYRIKFAE---------HHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNI 240  Escherichia coli
P48525  194 PERYP--TFTDLLHGQINLQPqvnfndkryDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAF 271  Saccharomyces cerev...
P15189  161 PTEGSc-KFRDGVYGDVEIPWea------vDMQVLLKADGMPTYHMANVVDDHLMKITHVARGEEWLASVPKHILIYQYL 233  Sinorhizobium melil...
P22250  160 PEGKVi-AFNDIVKGEISFESdg------iGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDHISNTPKQIMIYQAF 232  Bacillus subtilis s...
P53662  160 PKNTTy-QWDDLVRGNIAVNSnd------iGDWIIIKSDDYPTYNFAVVIDDIDMEISHILRGEEHITNTPKQMMIYDYL 232  Mycoplasma pulmonis...
P43818  156 PTEGSv-VFDDAVRGRIEISNse------lDDLIIRRTDGSPTYNFCVVVDDWDMGITHVVRGEDHINNTPRQINILKAI 228  Haemophilus influen...
P04805  145 PQEGSv-VFDDQIRGPIEFSNqe------lDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKAL 217  Escherichia coli K-12
P07814  343 DMSSNngCMRDPTLYRCKIQP---------HPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEAL 413  human
P28668  349 DMSSPngCMRDPTIYRCKNEP---------HPRTGTKYKVYPTYDFACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDAL 419  fruit fly
Q5L431  161 PEGKTy-EFYDLVRGKVVFESkd-----vgGDWVIVKANGIPTYNFAVVIDDHLMEISHVFRGEEHLSNTPKQLMVYEYF 234  Geobacillus kaustop...
1NYL_A  241 TIPVHPRQYEFSRLNLEYTVMSKRKLNLLvtDKHVEGWDDPRMPTISGLRRRGYTA-----ASIREFCKRIGVTKQ-DNT 314  Escherichia coli
P48525  272 GWACPKFIHIPLLTTVGDKKLSKRKGDMS--ISDLKRQGVLPEALINFCALFGWSPprdlaSKKHECFSMEELETIfNLN 349  Saccharomyces cerev...
P15189  234 GLEPPVFMHLSLMRNADKSKLSKRKNPTS--ISYYTALGYLPEALMNFLGLFFIQI-----AEGEELLTMEELAEKfDPE 306  Sinorhizobium melil...
P22250  233 GWDIPQFGHMTLIVNESRKKLSKRDESIIqfIEQYKELGYLPEALFNFIGLLGWSP-----VGEEELFTKEQFIEIfDVN 307  Bacillus subtilis s...
P53662  233 NAPKPLFGHLTIITNMEGKKLSKRDLSLKqfIHEYKEEGYNSQAIFNFLTLLGWTD-----EKARELMDHDEIIKSfLYT 307  Mycoplasma pulmonis...
P43818  229 GAPIPTYAHVSMINGDDGQKLSKRHGAVS--VMQYRDDGYLPEALINYLVRLGWG------HGDQEIFSREEMINYfELD 300  Haemophilus influen...
P04805  218 KAPVPVYAHVSMINGDDGKKLSKRHGAVS--VMQYRDDGYLPEALLNYLVRLGWS------HGDQEIFTREEMIKYfTLN 289  Escherichia coli K-12
P07814  414 GIR-KPYIWEYSRLNLNNTVLSKRKLTWFvnEGLVDGWDDPRFPTVRGVLRRGMTV-----EGLKQFIAAQGSSRSv-VN 486  human
P28668  420 KLR-KPYIWSYSRLNMTNTVLSKRKLTWFvdSGLVDGWDDPRFPTVRGIIRRGMTV-----EGLKEFIIAQGSSKSv-VF 492  fruit fly
Q5L431  235 GWEPPQFAHLTLIVNEQRKKLSKRDESIIqfVSQYKELGYLPEAMFNFFALLGWSP-----EGEEEIFTKDELIRMfDVS 309  Geobacillus kaustop...
1NYL_A  315 IEMASLESCIREDLNE 330  Escherichia coli
P48525  350 GLTKGNAKVDDKKLWF 365  Saccharomyces cerevisiae S288C
P15189  307 NLSKAGAIFDIQKLDW 322  Sinorhizobium meliloti 1021
P22250  308 RLSKSPALFDMHKLKW 323  Bacillus subtilis subsp. subtilis str. 168
P53662  308 RLSKSPSKFDITKMQW 323  Mycoplasma pulmonis UAB CTIP
P43818  301 HVSKSASAFNTEKLQW 316  Haemophilus influenzae Rd KW20
P04805  290 AVSKSASAFNTDKLLW 305  Escherichia coli K-12
P07814  487 MEWDKIWAFNKKVIDP 502  human
P28668  493 MNWDKIWAFNKKVIDP 508  fruit fly
Q5L431  310 RLSKSPSMFDTKKLTW 325  Geobacillus kaustophilus HTA426
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