2HOQ,2NO4,4UAR,2NYV,3SKX,1QH9,3J09,1QQ5,3NAS,4G9B,4UMV,4FFD,1O03,1TE2,1F5S,3I76,6HRA,3NUQ,1NNL,2QLT,3M1Y,3P96,2C4N,4JDP,1WR8,2G80,4I9F


Conserved Protein Domain Family
Hydrolase

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pfam00702: Hydrolase 
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haloacid dehalogenase-like hydrolase
This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.
Statistics
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Aligned: 254 rows
Threshold Bit Score: 30.2328
Threshold Setting Gi: 46396279
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HOQ_A     2 VKVIFFDLDDTLVDTS---KLAEIARKnaiENmirhgl----------pvdfeTAYSELIELI--KEYGS---------- 56  Pyrococcus horikosh...
P64636    10 VDTVLLDMDGTLLDLAfdnYFWQKLVP---ETwgakn-----------gvtpqEAMEYMRQQY--HDVQH---------- 63  Escherichia coli K-12
P32626     5 YSTYLLDIEGTVCPIS---FVKETLFP---YFtnkv--------------pqlVQQDTRDSPV--SNILS---------- 52  Saccharomyces cerev...
Q21012     8 FNALLLDIEGTITSIS---FVKDELFP---YAfenvgnyleehydnpatqiivEDLRHIADQQaeNDVAVvrireprkec 81  Caenorhabditis elegans
Q48389     2 IRAIVTDIEGTTSDIR---FVHNVLFP---YArerlagf-------vtaqqfvEPVKTILDNL--REEIA---------- 56  Klebsiella oxytoca
Q09893     5 QKIIFFDLDNCLY------PKSYKIHN---MMaar---------------itaFFSDKLGIPT--EEAER---------- 48  Schizosaccharomyces...
P53078    55 LKVFFFDIDNCLYKSS---TRIHDLMQ---QSilrff-----------qthlkLSPEDAHVLN--NSYYK---------- 105 Saccharomyces cerev...
GAA22863  52 RKVFFFDIDNTLYRKS---TKVQLLMQ---QSl--------------------SNFFKYELGFddDEAER---------- 95  Saccharomyces cerev...
3NUQ_A    57 LKVFFFDIDNCLYKSS---TRIHDLMQ---QSilrff-----------qthlkLSPEDAHVLN--NSYYK---------- 107 Saccharomyces cerev...
2G80_A    31 YSTYLLDIEGTVCPIS---FVKETLFP---YFtnkv--------------pqlvQQDTRDSPV--SNILS---------- 78  baker's yeast
2HOQ_A    57 --NFPYHFDYLLRRLd----lPYNPKWISAGVIAYHN--TKFAYLRE------------VPGAR-KVLIRLKEL-GY--E 112 Pyrococcus horikosh...
P64636    64 --TLNWYCLDYWSEQ--------------LGLDICAMt-TEMGPRAVl-----------REDTI-PFLEALKAS-GK--Q 111 Escherichia coli K-12
P32626    53 --QFHIDNKEQLQAH-------ILELVAKDVKDPILK--QLQGYVWAhgye----sgqiKAPVYaDAIDFIKRKkRV--- 114 Saccharomyces cerev...
Q21012    82 ieDVTKNVRHWIKRDk-----KLTPMKALQGLIWEEA--YQRGDVKGh----------vYPDVL-PVLKIVENR-KI--P 140 Caenorhabditis elegans
Q48389    57 --QPAAGAEELIATLfafmdeDRKSTALKALQGIIWRdgYVHGDFTGh----------lYPDVL-PALEKWKSQ-GI--D 120 Klebsiella oxytoca
Q09893    49 --LREVYYRHYGIAI-------RGLVLHHEIDAVDYD--QRVDQSLPlek------vikKDEVLrEMLLELR---KKy-K 107 Schizosaccharomyces...
P53078   106 --EYGLAIRGLVMFH-------------KVNALEYNR--LVDDSLPLqdi------lkpDIPLR-NMLLRLRQSgKId-K 160 Saccharomyces cerev...
GAA22863  96 --LIESYYQEYGLSVk-----GLIKNKQIDDVLQYNT--FIDDSLPLqdy------lkpDWKLR-ELLINLKKK-KLg-K 157 Saccharomyces cerev...
3NUQ_A   108 --EYGLAIRGLVMFHkv--naLEYNRL-------------VDDSLPLqdi------lkpDIPLR-NMLLRLRQS-GKidK 162 Saccharomyces cerev...
2G80_A    79 --QFHIDNKEQLQAH-------ILELVAKDVKDPILK--QLQGYVWAhgyesgqikapvYADAI-DFIK----R-KK--R 139 baker's yeast
2HOQ_A   113 ---LGIITDGNP--------VKQW-EKI-----------LR-LElddffe----hviisDFEG-----VKKP------HP 153 Pyrococcus horikosh...
P64636   112 ---RILLTNAHP--------HNLA-VKL-----------EH-TGldahld----lllstHTFG-----YPKE------DQ 152 Escherichia coli K-12
P32626   115 ---FIYSSGSVKaqkllfgyVQDPnAPA-----------HDsLDlnsyid----gyfdiNTSG------KKT------ET 164 Saccharomyces cerev...
Q21012   141 ---IYIYSSGSV--------HAQKlLFA-----------NSiEGdmtkily-gyfdtniGLKG---------------ES 182 Caenorhabditis elegans
Q48389   121 ---LYVYSSGSV-------------AAQ-----------KLlFGysdeg------dithLFNG-----YFDTlvgakrEA 162 Klebsiella oxytoca
Q09893   108 ---CWIFTNAYI--------VHAN-RVL-----------KY-LGiedcfd---gitycdYNAKd---lIAKP------MP 151 Schizosaccharomyces...
P53078   161 ---LWLFTNAYK--------NHAI-RCL-----------RL-LGiadlfd---gltycdYSRTdt--lVCKP------HV 205 Saccharomyces cerev...
GAA22863 158 fdkLWLFTNSYK--------NHAI-RCV-----------KI-LGiadlfd---gitychYDRPieeefICKP------DP 207 Saccharomyces cerev...
3NUQ_A   163 ---LWLFTNAYK--------NHAI-RCL-----------RL-LGiadlfdgltycdysrTDTL-----VCKP------HV 207 Saccharomyces cerev...
2G80_A   140 ---VFIYSSGSV--------KAQK-LLFgyvqdpnapahDS-LDlnsyid----gyfdiNTSG------KKT------ET 190 baker's yeast
2HOQ_A   154 KIFKKALKAFn-vK--PEEALMVGDRLYsDIYGAKRVG 188 Pyrococcus horikoshii OT3
P64636   153 RLWHAVAEATg-lK--AERTLFIDDSEA-ILDAAAQFG 186 Escherichia coli K-12
P32626   165 QSYANILRDIg-aK--ASEVLFLSDNPL-ELDAAAGVG 198 Saccharomyces cerevisiae S288C
Q21012   183 NSYTKISERIk-iP--PSEILFLTDVEA-EAAAAKKAG 216 Caenorhabditis elegans
Q48389   163 QSYRNIAEQLg-qP--PAAILFLSDIHQ-ELDAAEEAG 196 Klebsiella oxytoca
Q09893   152 EMYERVMREAg--VtdKDKCIFVDDSYG-NILGAREFG 186 Schizosaccharomyces pombe 972h-
P53078   206 KAFEKAMKESg--LarYENAYFIDDSGK-NIETGIKLG 240 Saccharomyces cerevisiae S288C
GAA22863 208 KFFETAKLQSg--LssFANAWFIDDNES-NVRSALSMG 242 Saccharomyces cerevisiae Kyokai no. 7
3NUQ_A   208 KAFEKAMKESglaR--YENAYFIDDSGK-NIETGIKLG 242 Saccharomyces cerevisiae S288C
2G80_A   191 QSYANILRDIg-aK--ASEVLFLSDNPL-ELDAAAGVG 224 baker's yeast
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