4UAR


Conserved Protein Domain Family
Hydrolase

?
pfam00702: Hydrolase 
Click on image for an interactive view with Cn3D
haloacid dehalogenase-like hydrolase
This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.
Statistics
?
PSSM-Id: 334216
View PSSM: pfam00702
Aligned: 228 rows
Threshold Bit Score: 32.549
Threshold Setting Gi: 46396279
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4UAR_A   2 IEAILFDVDGTLAETEELHRRAFNETf----------------------aALGVDWFWDR--EEYRELLTTtgGKERIAR 57  Rhodobacter sphaeroides
O67359   1 MRVILFDLDGTLIDSAKDIALALEKTl-----------------------KELGLEEYYP--DNVTKYIGG--GVRALLE 53  Aquifex aeolicus VF5
P32662   7 IRGVAFDLDGTLVDSAPGLAAAVDMAlyalelpvageervitwigngadvLMERALTWARq-ERATQRKTM--GKPPVDD 83  Escherichia coli K-12
P44755   5 FKLIGFDLDGTLVNSLPDLALSVNSAlae------------------fnlPQAPEELVLTwiGNGAPVLIA--RALDWAK 64  Haemophilus influenza...
P40852   8 CTAVLIDLDGTLVDSAPDIVEAANRMl-----------------------ADFGSPALPF--DTVAGFIGR--GVPNLVR 60  Ralstonia eutropha H16
O33512   2 APALIFDLDGTLIDSAPAIHKVSNDVl-----------------------RARGYAPLGL--DQIRSFVGQ--GAPHLVR 54  Rhodobacter capsulatus
P95650   1 MPGVVFDLDGTLVHSAPDIHAAVNKAl-----------------------AEEGGAPFTL--AEITGFIGN--GVPVLIQ 53  Rhodobacter sphaeroides
O51619   3 IKACIFDMDGTLVNSIMDIAFSMNSAl-----------------------SNLGYSKIEL--SKFNALVGR--GFNKFVI 55  Lyme disease spirochete
O83565   5 TRACIFDLDGTLTNTLGTIAYFVNMQa-----------------------AHYHLPPIPS--EKFALFLGD--GSRALIQ 57  Treponema pallidum
P74697   4 EKIIVFDLDGVLIDSEEANYQAFAYGi-----------------------EQLGLPRPDR--QTVVSLVGL--KASLMLE 56  Synechocystis sp. PCC...
4UAR_A  58 FLr---hQKGDPAPLPIADIHRAKT--ERFVALMAE--GEiaLRPGIADLIAEAKRAGIRLAVATTTSLPNVE-ALCRAc 129 Rhodobacter sphaeroides
O67359  54 KV--------LKDKFREEYVEVFRK--HYLENPVVY--TK--PYPEIPYTLEALKSKGFKLAVVSNKLEELSK-KILDI- 117 Aquifex aeolicus VF5
P32662  84 DI---------PAEEQVRILRKLFD--RYYGEVAE---EGtfLFPHVADTLGALQAKGLPLGLVTNKPTPFVA-PLLEA- 147 Escherichia coli K-12
P44755  65 KQ------TGKVLTETEVKQVTERF--NFYYGENLC--NVsrLYPNVKETLEILKEKGYVLAVVTNKPTRHVQ-PVLAA- 132 Haemophilus influenza...
P40852  61 RVl---eTAGLTPRVEAAEAVAMFH--RHYAETNGR---LgsVFPGVEAGLEALRRQGYRLACVTNKPRALAV-PLLAL- 130 Ralstonia eutropha H16
O33512  55 CL-----LTTAGEDPEGPLFDAIYA--DLVSRYETDv-EGntLYPGVITALQRLREMGC-PMAITTNKPYKPAlAAIAH- 124 Rhodobacter capsulatus
P95650  54 RV-----LAARGEAPDAHRQAELQG--RFMAHYEADpaTLtsVYPGAEAAIRHLRAEGWRIGLCTNKPVGASR-QILSL- 124 Rhodobacter sphaeroides
O51619  56 DTlkllsLEHDNPNLQEKLYKEFVK--EYNKNLSFQ--TK--PYENIKPLLETMNKLNIPIGILSNKNHEELI-NLVKNi 128 Lyme disease spirochete
O83565  58 RV-----LAHYGAAAQTISEDEFLQryCLAYEADFL--QRctVYPGVPEMLVELKRRRIELAILSNKPHSIAQ-KVASAf 129 Treponema pallidum
P74697  57 KL--------GCPRQEVERIFKDFV--QPFYIENLP--QLaaPMPNAVTVLTTLKQRDYRILACTSGDRRTQT-AALQG- 122 Synechocystis sp. PCC...
4UAR_A 130 FGhpareifdviaagDMVAEKKPSPDIYRLALRELdvPPERAVALEDSLNGLRAAKGAG 188 Rhodobacter sphaeroides
O67359 118 LNlsgyfd--livggDTFGEKKPSPTPVLKTLEILgeEPEKALIVGDTDADIEAGKRAG 174 Aquifex aeolicus VF5
P32662 148 LDiakyfs--vviggDDVQNKKPHPDPLLLVAERMgiAPQQMLFVGDSRNDIQAAKAAG 204 Escherichia coli K-12
P44755 133 FGidhlfs-emlggqSLP-AIKPHPAPLYYLCGKFgfEPRQVLFVGDSKNDIIAGHAAG 189 Haemophilus influenzae Rd KW20
P40852 131 TGlsqyle--vlvagDSIAQMKPDPEPLRHACNLLdvDTAQGVLVGDSAVDVAAARAAG 187 Ralstonia eutropha H16
O33512 125 VGltdyfq--lviggDSLPTRKPNPEMVNEARRVLr-RPH-ALYIGDSEIDAQTAQNAG 179 Rhodobacter capsulatus
P95650 125 FGllelfd--aiiggESLPQRKPDPAPLRATAAALn--EEVVLYVGDSEVDAATAEAAG 179 Rhodobacter sphaeroides
O51619 129 FGnilff---eirgySKNFPPKPDPENALDMILELnaQKEEIAYIGDSDVDMLTALNAG 184 Lyme disease spirochete
O83565 130 FGdnvfs---vvlgqREGVPVKPDPAGLFEILRTLnvETAEALFVGDTAVDIRTASAAQ 185 Treponema pallidum
P74697 123 VGlwsaie--tmlaaDDSPFAKPDPRYLQQLLAPYd--YQTLLHVEDAEVGIRMGQACG 177 Synechocystis sp. PCC 6803
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap