Conserved Protein Domain Family

pfam00658: PABP 
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Poly-adenylate binding protein, unique domain
The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (pfam00076). Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.
PSSM-Id: 334198
View PSSM: pfam00658
Aligned: 154 rows
Threshold Bit Score: 42.8221
Threshold Setting Gi: 156339066
Created: 15-Mar-2017
Updated: 23-May-2017
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1IFW_A         9 ANDNNQFy-QQKQRQALGEQLYKKVSAK--------------TSneEAAG--------------KITGMILD--LPPQEV 57  baker's yeast
A0BHJ6       503 mSDFSKLt-TSDQRMILGNLLFNKVQKKv------------qDK--GVAN--------------HIVGMLIE--PSSFTI 551 Paramecium tetr...
Q23D16       683 ieDLVDKt-DEQKKQLLGKPLMEKVGQSlp----------ehQK--PLAG--------------KITNLLLD--FEIYEP 733 Tetrahymena the...
A0DLY6       414 lqvMVDRgqKQQVTDLIGMQLFPKVTQVv-------------GP--INAP--------------QVTGILLD--FENYQL 462 Paramecium tetr...
A0BVN1       441 lQSLQAQgnEKKITAIVGAILFPLVNQQv-------------EQ--KLAP--------------QVTGILLD--FENYGL 489 Paramecium tetr...
A0C144       433 LQKLLAEgnQKRVTDTIGVLLFPLVNQQv-------------EQ--KLAP--------------QVTGILLD--FENYGL 481 Paramecium tetr...
Q1ZXC2       737 LEFITNAt-AEEATETLGSEVYNLVLAKyn-----------nNI--ELAA--------------KIAGMIVDavPEHKEL 788 Dictyostelium d...
XP_012894150 461 REMIDAMt-NEERRNTFGERIFYLIKTI--------------GD--PRCS--------------KITGMMLE--LPVDDL 507 Blastocystis ho...
XP_001620073  21 SYNIEKDk-TEDLKSIIGENIYSQLVEK--------------YP--KDAD--------------KITGMLLE--MELDLL 67  starlet sea ane...
XP_004037088 534 kEEFAKIe-DEQKRTILGQIIFHKIQKLslikeqvgivlkieN-----ANdvqqrielfqkensKITGMLID--KDVFEI 605 Ichthyophthiriu...
1IFW_A        58 ---FPLLESDELFEQHYKEASAAY 78  baker's yeast
A0BHJ6       552 sdiFDFFENDQDLNDYIEDGLELi 575 Paramecium tetraurelia
Q23D16       734 eeiISMLSNADELKENIGTALELi 757 Tetrahymena thermophila SB210
A0DLY6       463 sdqVRMIQDSAYLGENIRQALEIL 486 Paramecium tetraurelia
A0BVN1       490 edqFKMLQDATYLNEQINQAVDLi 513 Paramecium tetraurelia
A0C144       482 edqLKMLQNAPYLTEQINQAVDLi 505 Paramecium tetraurelia
Q1ZXC2       789 ---FEII-SNGQIQSKIEEAKSLL 808 Dictyostelium discoideum
XP_012894150 508 ---MKIISDPGELLKKIDEANDVL 528 Blastocystis hominis
XP_001620073  68 ---QKVSQDPDLLGQRATEAVETL 88  starlet sea anemone
XP_004037088 606 kdmLEFVEFNQELIERCDEAIQLi 629 Ichthyophthirius multifiliis
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