1IFW,2DYD


Conserved Protein Domain Family
PABP

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pfam00658: PABP 
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Poly-adenylate binding protein, unique domain
The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (pfam00076). Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.
Statistics
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PSSM-Id: 334198
View PSSM: pfam00658
Aligned: 154 rows
Threshold Bit Score: 42.8221
Threshold Setting Gi: 156339066
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IFW_A         9 ANDNNQFy-QQKQRQALGEQLYKKVSAK--------------TSneEAAG--------------KITGMILD--LPPQEV 57
gi 124453047 503 mSDFSKLt-TSDQRMILGNLLFNKVQKKv------------qDK--GVAN--------------HIVGMLIE--PSSFTI 551
gi 122071185 683 ieDLVDKt-DEQKKQLLGKPLMEKVGQSlp----------ehQK--PLAG--------------KITNLLLD--FEIYEP 733
gi 124469152 414 lqvMVDRgqKQQVTDLIGMQLFPKVTQVv-------------GP--INAP--------------QVTGILLD--FENYQL 462
gi 124463879 441 lQSLQAQgnEKKITAIVGAILFPLVNQQv-------------EQ--KLAP--------------QVTGILLD--FENYGL 489
gi 124464330 433 LQKLLAEgnQKRVTDTIGVLLFPLVNQQv-------------EQ--KLAP--------------QVTGILLD--FENYGL 481
gi 122096694 737 LEFITNAt-AEEATETLGSEVYNLVLAKyn-----------nNI--ELAA--------------KIAGMIVDavPEHKEL 788
gi 855301531 461 REMIDAMt-NEERRNTFGERIFYLIKTI--------------GD--PRCS--------------KITGMMLE--LPVDDL 507
gi 156339066  21 SYNIEKDk-TEDLKSIIGENIYSQLVEK--------------YP--KDAD--------------KITGMLLE--MELDLL 67
gi 471231913 534 kEEFAKIe-DEQKRTILGQIIFHKIQKLslikeqvgivlkieN-----ANdvqqrielfqkensKITGMLID--KDVFEI 605
                         90       100
                 ....*....|....*....|....
1IFW_A        58 ---FPLLESDELFEQHYKEASAAY 78
gi 124453047 552 sdiFDFFENDQDLNDYIEDGLELi 575
gi 122071185 734 eeiISMLSNADELKENIGTALELi 757
gi 124469152 463 sdqVRMIQDSAYLGENIRQALEIL 486
gi 124463879 490 edqFKMLQDATYLNEQINQAVDLi 513
gi 124464330 482 edqLKMLQNAPYLTEQINQAVDLi 505
gi 122096694 789 ---FEII-SNGQIQSKIEEAKSLL 808
gi 855301531 508 ---MKIISDPGELLKKIDEANDVL 528
gi 156339066  68 ---QKVSQDPDLLGQRATEAVETL 88
gi 471231913 606 kdmLEFVEFNQELIERCDEAIQLi 629
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