5DAD,2NN2,4J8Z,2Q81,4U2N,4U2M,2YY9,2Z8H,5EUP,1BUO


Conserved Protein Domain Family
BTB

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pfam00651: BTB 
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BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Statistics
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PSSM-Id: 334194
View PSSM: pfam00651
Aligned: 93 rows
Threshold Bit Score: 59.9747
Threshold Setting Gi: 74654760
Created: 17-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5DAD_A        25 MNELRLSQ--QLCDVTLQVKyqdapaAQFMAHKVVLASSSPVFKAMFTNG----------LREQGME--VVSIEGIHPKV 90
gi 73921634  832 LDPHFLNNk-EMSDVTFLVEg-----KLFYAHKVLLVTASNRFKTLMTNKs---------EQDGDNSk-TIEISDIKYHI 895
gi 75246041  201 LGNFLESW--QLSDTVFLVGee---eMDVPAHKVILQASGNFPLRSSDGD-------------------VIQLRGVSYPI 256
gi 74956702   54 FDEIFTST--DHSDVTLVLDd----gTEFAAHRLILAVRSSFFRAMLYTG----------FQESHQQ--LVTLQETNSVA 115
gi 1723292   157 LLSNSALH--FTTDIVFAGQy-----gRVFAHKFYLAARSSYFKSKFSKLg-----------PSE----HEIEVKHFAKE 214
gi 74964119   23 LQAKRRAGdfSTCDVKIQLKt-----GFDMVHSVVICAHSDVFSETFDNQ-----------RAPYQP---FNMTDFDPDS 83
gi 93204565   20 LQNFFNKT--DYCDLTLQFRd----nSQLKVHRLVLSACTDYFNVLEQTC-----------EIVDDA--LIMPNEFQADV 80
gi 1723292   296 LNQPSDQY--SFHDAYLQSYt-----HRYPVHRAIMCRCEYFLDMLAGPFl---------eSNQELP---VLSLPFSSSV 356
gi 74654760  608 LTSYENYKq-SFSDVTIYCGt-----SMFHSHKFILCARSSFLRKLLLQKkkssvsniiyIEEITQShsTIRVEDIPPLA 681
5EUP_A        23 LQNFFNKT--DYCDLTLQFRd----nSQLKVHRLVLSACTDYFNVL-EQT----------CEIVDDA--LIMPNEFQADV 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
5DAD_A        91 MERLIEFAYTASISMG------EKCVLHVMNGA-VMYQIDSVVRACSDFLVQQ 136
gi 73921634  896 FQMLMQYLYYGGTESMei---pTADILQLLSAA-NLFQLDALQRHCEILCSQT 944
gi 75246041  257 LHALLQYIYTGRTQIL------ESELAPLRDLS-SKFEVMSLVRQCEESIDHF 302
gi 74956702  116 FRAVLRYMYTSKIDFAgv---eLDILLEYLSLA-HRYDLIQLMTAISEYFKEI 164
gi 1723292   215 FESILRYLYLDTNAVFt-----KQYNNALLSIG-KKFQLNDFIALYEKDREQL 261
gi 74964119   84 VRRVFDWMYSGEIDIP------ETTIADVLAVA-SYLRVTMLQRQIEQKILNH 129
gi 93204565   81 VVPIVNFMYTGTLEFE------LKMYGKLLRTA-KEMNMTVLLKLLEAHRRTM 126
gi 1723292   357 VEIVLKFLYTDKTDIAp-----ELALDVVYVADmLSLDKDRSLKSLASIVITK 404
gi 74654760  682 VAILLHYLYTDTLLSPwhldsrFSPLKENLSKLaNLLELPHLAEVLPFSVSRQ 734
5EUP_A        84 VVPIVNFMYTGTLEFE------LKMYGKLLRTA-KEMNMTVLLKLLEAHRRTm 129
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