5DAD,2NN2,4J8Z,2Q81,4U2N,4U2M,2YY9,2Z8H,6I2M,5EUP,1BUO


Conserved Protein Domain Family
BTB

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pfam00651: BTB 
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BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Statistics
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Aligned: 94 rows
Threshold Bit Score: 59.9708
Threshold Setting Gi: 74654760
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DAD_A   25 MNELRLSQ--QLCDVTLQVKyqdapaAQFMAHKVVLASSSPVFKAMFTNG----------LREQGME--VVSIEGIHPKV 90   human
O08764  832 LDPHFLNNk-EMSDVTFLVEg-----KLFYAHKVLLVTASNRFKTLMTNKs---------EQDGDNSk-TIEISDIKYHI 895  Norway rat
Q8LEV3  201 LGNFLESW--QLSDTVFLVGee---eMDVPAHKVILQASGNFPLRSSDGD-------------------VIQLRGVSYPI 256  thale cress
O16313   54 FDEIFTST--DHSDVTLVLDd----gTEFAAHRLILAVRSSFFRAMLYTG----------FQESHQQ--LVTLQETNSVA 115  Caenorhabditis elegans
Q10225  157 LLSNSALH--FTTDIVFAGQy-----gRVFAHKFYLAARSSYFKSKFSKLg-----------PSE----HEIEVKHFAKE 214  Schizosaccharomyces...
Q19838   23 LQAKRRAGdfSTCDVKIQLKt-----GFDMVHSVVICAHSDVFSETFDNQ-----------RAPYQP---FNMTDFDPDS 83   Caenorhabditis elegans
Q24478   20 LQNFFNKT--DYCDLTLQFRd----nSQLKVHRLVLSACTDYFNVLEQTC-----------EIVDDA--LIMPNEFQADV 80   fruit fly
Q10225  296 LNQPSDQY--SFHDAYLQSYt-----HRYPVHRAIMCRCEYFLDMLAGPFl---------eSNQELP---VLSLPFSSSV 356  Schizosaccharomyces...
O74881  608 LTSYENYKq-SFSDVTIYCGt-----SMFHSHKFILCARSSFLRKLLLQKkkssvsniiyIEEITQShsTIRVEDIPPLA 681  Schizosaccharomyces...
5EUP_A   23 LQNFFNKT--DYCDLTLQFRd----nSQLKVHRLVLSACTDYFNVL-EQT----------CEIVDDA--LIMPNEFQADV 83   fruit fly
5DAD_A   91 MERLIEFAYTASISMG------EKCVLHVMNGA-VMYQIDSVVRACSDFLVQQ 136  human
O08764  896 FQMLMQYLYYGGTESMei---pTADILQLLSAA-NLFQLDALQRHCEILCSQT 944  Norway rat
Q8LEV3  257 LHALLQYIYTGRTQIL------ESELAPLRDLS-SKFEVMSLVRQCEESIDHF 302  thale cress
O16313  116 FRAVLRYMYTSKIDFAgv---eLDILLEYLSLA-HRYDLIQLMTAISEYFKEI 164  Caenorhabditis elegans
Q10225  215 FESILRYLYLDTNAVFt-----KQYNNALLSIG-KKFQLNDFIALYEKDREQL 261  Schizosaccharomyces pombe 972h-
Q19838   84 VRRVFDWMYSGEIDIP------ETTIADVLAVA-SYLRVTMLQRQIEQKILNH 129  Caenorhabditis elegans
Q24478   81 VVPIVNFMYTGTLEFE------LKMYGKLLRTA-KEMNMTVLLKLLEAHRRTM 126  fruit fly
Q10225  357 VEIVLKFLYTDKTDIAp-----ELALDVVYVADmLSLDKDRSLKSLASIVITK 404  Schizosaccharomyces pombe 972h-
O74881  682 VAILLHYLYTDTLLSPwhldsrFSPLKENLSKLaNLLELPHLAEVLPFSVSRQ 734  Schizosaccharomyces pombe 972h-
5EUP_A   84 VVPIVNFMYTGTLEFE------LKMYGKLLRTA-KEMNMTVLLKLLEAHRRTm 129  fruit fly
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