2ARY


Conserved Protein Domain Family
Peptidase_C2

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pfam00648: Peptidase_C2 
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Calpain family cysteine protease
Statistics
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PSSM-Id: 334191
View PSSM: pfam00648
Aligned: 171 rows
Threshold Bit Score: 201.992
Threshold Setting Gi: 942193499
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ARY_A         47 FRDEAFPPVPQSLGYKdLG---PnsSkty--giKWKRPTELLS--------NPQ-FivdgATRTDICQGALGDCWLLAAI 112
gi 321478580  382 FVDDSFLPTGRSLH-N-ST---Q--Eg-----vQWLRPSQIVSsaa--shvKWAvFrt--pLPSDISQGILGDCWLLSAL 445
gi 260833574  390 FVDDSFPPAPKSLY-Y-KPsapP--Tmt---vsQWLRPHQITDlsqd-rgtKWVvFrt--pRPSDISQGILGNCWFLSAL 459
gi 762079846  635 FVDDSFPPAPTSVF-L-NEnkpF--Tks---yiQWLRPTEIAAprhgdekvKWAvCrt--pLPDDISQGLLGNCWFLSAL 705
gi 47210305     5 FVDDSFPPSPKSIG-F-PPddgV--Qhr---vkKWLRPGEISScnlreqaaEWSvFcs--pRPSDIQQGLLGNCWFLSAL 75
gi 326679884  526 FVDDSFPPGPRSVG-F-PEndsV--Qqr---ikKWLRPHEINCnnfkdrgvKWSvFrt--pRPSDILQGLLGNCWFLSAL 596
gi 156375370   44 FVDDSFPPVLKSLY-I-NPrhsE--Hpr---vaDWLRPNEIDNfstcrtniPWAvFrn--pRPSDIIQGVLGDCWFLSSL 114
gi 302817499 1631 FTDQEFPPTNQSLFI--NPe-qP--LpklqvvqQWVRPAELVRdig--tnaRPRlFeg-fTKPADVCQGRLGDCWFLSAV 1702
gi 168043467 1717 FTDQEFPPSDQSLFV--DTd-hP--AaklqvvnKWSRPEEVLReqg--qdsRPClFag-tANPSDVCQGHLGDCWFLSAV 1788
gi 566147130 1668 FTDQEFPPNDQSLYM--DPr-nP--PsklqvvsEWMRPVEIVKesh--ldsHPClFsg-aANPSDVCQGHLGDCWFLSAV 1739
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ARY_A        113 ASLTLNDTLLHRVVPHgQsfqNgyAGIFHFQLWQFGEWVDVVVDDLLPI----KdgkLVF---VHSaEgnEFWSALLEKA 185
gi 321478580  446 AVLAERDELVQNVMVTrE---VcnEGAYQIRLCKDGMWRTVLVDDLLPCdqrgH---LLYs-qAKR-K--QLWVPLIEKA 515
gi 260833574  460 AVLAERPELVERVMITrE---IcpEGAYQVRLCKDGEWMTVLVDDLLPCdhrgF---LVYs-qAKR-R--QLWVPLIEKA 529
gi 762079846  706 AVLAERPELVESIILTkD---YcpQGAYQVRLCKDGKWQIVLIDDLLPCdhhkR---LVFs-qAKR-K--QLWVPLIEKA 775
gi 47210305    76 TVLAERPELLERVMVTrW---LcpEGAYQVRLCKDGSWTTVLVDDMLPCddsdH---LLFs-qAQR-K--QLWVPLIEKA 145
gi 326679884  597 AVLAERPELVERVMITrS---IcqEGAYQVRLCKDGMWTTVLVDDMLPCdeygF---LLFs-qAQR-R--QLWVALIEKA 666
gi 156375370  115 AVLAERPELLEKILITrE---VspQGAYQVRLCKDGKWTVILIDDLLPCnqrgQ---PVYs-wAHR-R--QLWVPLIEKA 184
gi 302817499 1703 AVLTAASR-ISEVIITpE---YneEGIYTVRFCIQGEWVPVVVDDWIPCefkgK---PAFatsRKR-H--ELWVSVLEKA 1772
gi 168043467 1789 AVLTEASR-ISDVMITpE---FneEGIYTVRFCIQGEWVPVVVDDWIPCeargK---PAFatsRKG-N--ELWVSILEKA 1858
gi 566147130 1740 AVLTEVSR-ISEVIITpE---YneEGIYTVRFCIQGDWVPVVVDDWIPCespgK---PAFatsQKG-N--ELWVSILEKA 1809
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ARY_A        186 YAKVNGSYEALSGGSTSEGFEDFTGGVTEWYel--------------rkAPSdLYQIIL-KALErGSLLGcsidissvl- 249
gi 321478580  516 MAKIHGGYGALVSGRSIEGLASLTGAPCESIslqpstngsnreeaevldEDL-IWARLLsSRTA-GFLMGascgggtmki 593
gi 260833574  530 LAKLHGCYEALISGRSIEGLSTLTGAPCESVqlhraqtn--npdedpvePDL-IWARLLsSKEA-GFLMGascgggnmkv 605
gi 762079846  776 MAKLHGSYESLVAGKCLEGLATLTGAPCDNIelqpgp------qkeeidPNL-IWAKLLsCRES-RFLMGascgggnmkt 847
gi 47210305   146 LAKVHGSYFSLQAGRAIEGLATLTGAPCESLalqlsatn---pkeepidPDL-TWAKMLsSKEA-GFLMGascgggnmkv 220
gi 326679884  667 LAKLHGSYFALQAGRAIEGLATLTGAPCESLmlqvsstn---preepidTDL-IWAKMLsSKEA-GFLMGascgggnmkv 741
gi 156375370  185 MAKLHGSYEALTAGRSIEGLATLTGAPCESIalhesqnn--sgntepidKDL-IWAQLIsSRTA-GFLMGascggdtqpe 260
gi 302817499 1773 YAKLHGSYEALEGGHVQDALVDLTGGAGEeidltsa------qaqldlaSGR-LWSQLLrFKQE-GFLLGagspsgs--- 1841
gi 168043467 1859 YAKLHGSYEALEGGQVHDALVDLTGGAGEeidltne------vaqldlaSGH-LWSQLQrFKQE-GFLLGagspsgs--- 1927
gi 566147130 1810 YAKLHGSYEALEGGLVQDALVDLTGGAGEeidmrsa------qaqidlaSGR-LWSQLLrFKQE-GFLLGagspsgs--- 1878
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ARY_A        250 dmeaitfkKLVKGHAYSVTGAKQVnyrgqvVSLIRMRNPWGEv-EWTGAWSDSSSEWnnvDPYERDQL---RvkmEDGEF 325
gi 321478580  594 deeeyrqkGLRPRHAYSLLDVLDFssk-ggPRLLRMRNPWGHf-SWRGDWADDSKLW---NPELRAICm-pHg-dVEGVF 666
gi 260833574  606 ddaeyeskGLRPRHAYSVLDVQDVn----gSRLLRMRNPWGRf-SWKGDWSDSSPLW---TPEMRDRLl-aHg-aSEGVF 675
gi 762079846  848 edkvyeekGLRPRHAYSILDVKDId----gNRLLRLRNPWGRf-SWNGDWSDDSARWaniSTRAKQDLm-lYg-hTSGVF 920
gi 47210305   221 ddleyeclGLRPRHAYSVLDVRVIn----rHRLLQLRNPWGRf-SWTGPWSDHWPNW---PPHLKRELc-tQr-aEDGLF 290
gi 326679884  742 ddavyeslGLRPRHAYSILDVRDVq----gYRLLRLRNPWGRf-SWNGSWSDEWSDW---PQHLRHELm-aHg-sSEGVF 811
gi 156375370  261 eepgynavGLQTHHAYSVLDVRDVh----gIRLLRLRNPWGQy-SWTGDWSDASSLW---TPELRHELm-vHg-aQEGVF 330
gi 302817499 1842 -dahvsasGIVQGHAYSLLQVREVdg----hKLVQICNPWANevEWNGPWSDSSLEW---TDRMKHKLkysPqaqD-GVF 1912
gi 168043467 1928 -dvhvsssGIVQNHAYSLLQVREVdg----hKLVQIRNPWANevEWNGPWSDFSPEW---TDRMKHKLkysPqaaN-GVF 1998
gi 566147130 1879 -dvqvsssGIVQGHAYSLLQVREVdg----hKLVQIRNPWANevEWNGPWSDSSPEW---TDRMKHKLkhvPqskD-GIF 1949
                         330
                  ....*....|....*...
2ARY_A        326 WMSFRDFMREFTRLEICN 343
gi 321478580  667 WISFQDTLVFFDCIDVCK 684
gi 260833574  676 WMCLADVMKYFDCIDICK 693
gi 762079846  921 WMALDDVLKYFDSVDICK 938
gi 47210305   291 WMDFSDFIRlemfgkase 308
gi 326679884  812 WMEYGDFIKYFDSVDICK 829
gi 156375370  331 WMSLEDFMKYFDSVDVCK 348
gi 302817499 1913 WMSWQDFQLHFRSVYVCR 1930
gi 168043467 1999 WMSWQDFQLHFRSLYVCR 2016
gi 566147130 1950 WMSWQDFQIHFRSIYICR 1967
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