5DS3,4F0D,5DSY


Conserved Protein Domain Family
PARP

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pfam00644: PARP 
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Poly(ADP-ribose) polymerase catalytic domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
Statistics
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PSSM-Id: 334187
View PSSM: pfam00644
Aligned: 30 rows
Threshold Bit Score: 132.449
Threshold Setting Gi: 81913590
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5DS3_A         67 SEEAEIIRKYVKNTHATTHnA---YDLEVIDIFKIEREGECQRYKPFk-------qLHN---------RRLLWHGSRTTN 127
gi 74811779   460 SAGYQIFIRNFLSNPHHQK-AidnGEIKILNCYRLDKKLESDNFLD----------VGN---------VQYLYHGSKPQN 519
gi 81891183   397 TEEFSRVRKEVLQNNRSEQ------PVDILQIFRVGRVNEATEFLSK---------LGN---------VRLLFHGSPVRN 452
gi 116248566  102 KAEFEKIQQLTGAPHTPVP-T----PDFLFEIEY---------FDPAnsrfyetkgERD---------LIYAFHGSRLEN 158
gi 82185814   107 KEEFARLSQLAQREGVSAP-A----PDFLFELQY--CDLLNSKFERTr-------aGRD---------LIYAFHGSRLEN 163
gi 82182428   129 KDKYEEIQALPGSPSHALP-T----PDFLFELEY--CEKLSAKFQETr-------gDRD---------LIYAFHGSRLEN 185
gi 81913590   776 SQEFQDVVRAFYSTLDAVH-G----RIRIVRVERVSHPLLQQQYQLHrerlmqscqQRPv--------EQVLYHGTSESA 842
gi 82104748   100 SKEGHDIEKEFRKTLL---------NNTILTIERVQNDSLWKSYQIRkklleeknkHTNn--------EKLLFHGTSSDS 162
gi 341942208  517 SEEYQKVWNIFNRTLP---------FYFVQKIERIQNMGLWEVYQWQk-------cQMQkqnggkevdERQLFHGTSANF 580
4F0D_A        100 KAEFEKIQKLTGAPHTPVP-A----PDFLFEIEYFDPAN--AKFYETk-------gERD---------LIYAFHGSRLEN 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5DS3_A        128 FAGILSQGLRIAPPEAPVTGYM-----FGKGIYFADMVSKSA--NYCHTSQGDPIGL------ILLGEVALGNMYELKHA 194
gi 74811779   520 LVGLLSRGILPPDYVKQIGGKRtdfgyLGSGIYFSDDV-VSS--TYTSPIGEKGSRF------IIMSSVSLGKVKEFSKI 590
gi 81891183   453 ILGILSRGLLLPKVAEDRGVQRtdvgnLGSGIYFSDSLSTSI--KYAHAGETDGSRL------LVVCDVALGKCVNLFKK 524
gi 116248566  159 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSLAL--IYSP----HGHGWqhsllgPILSCVAVCE------- 216
gi 82185814   164 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSMAI--LYSP----HGNGWresvlgPFISCVALCE------- 221
gi 82182428   186 FHSILHNGLHCHLNKTSL---------FGEGTYLTSDLGLAL--LYSP----HGQGWtrsmlgPVLSCVAMCE------- 243
gi 81913590   843 VLDICAHGF--NRSFCGRNGTL-----YGQGVYFAKRASLSVldRYSPP---NAEGYk----aVFVAQVLTGD------- 901
gi 82104748   163 ITQINNHGF--NRSYAGTHGAA-----IGNGSYFAVNSSYSA--RGYSKADAQGNKR------MYLARVLVGD------- 220
gi 341942208  581 VDAICQQNF--DWRVCGLHGTS-----YGKGSYFARDAAYSH--HYSKS--DTHSHM------MFLARVLVGD------- 636
4F0D_A        157 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSLAL--IYSP----HGHGWqhsllgPILSCVAVCEV------ 215
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
5DS3_A        195 SH-ISKLPKGKHSVKGLGKTTPdpsanisldgvdVPLGTGi-SSGVNDTS---LLYNEYIVYDIAQVNLKYLLKLKF 266
gi 74811779   591 QPsLQCAPSGHHSCKGLKSTPT------------NPTD---------------FKNNEYVVFNPNQSKLSFLIEYIE 640
gi 81891183   525 DFsLTEAPPGYDSVHGVSETTS------------VPTD---------------FQDDEFVVYKTNQVKMKYIVKFCT 574
gi 116248566  217 ----VIDHPDVKCQIKKKDSKE------------IDRSRAr-IKHSEGGE---IPPKYFVVTNNQLLRVKYLLVYSQ 273
gi 82185814   222 ----IIDHPDVKCQVKKKDSES------------IDRQRLr-ARNSEGGE---VPEKYFVVTNNELLRVKYLLVYSQ 278
gi 82182428   244 ----MIDHPDVKCQAKKKDSSE------------IDRKRAr-ARNSEGGD---VPQKYFVVTNNQLLRVKYLMVYSQ 300
gi 81913590   902 -----------YGQGSRGLKAP-------------PLRVSgqVLRYDSAVdclQQPRIFVIFHDTQALPTHLITCKN 954
gi 82104748   221 ---------YTQGQAGLIVPPA------------KPSGKD--ADLYDSVTdntSNPTMFVIFSDVQAYPEFLIHSSK 274
gi 341942208  637 ------------FVRGSTSFVR------------PPAKEGqsNAFYDSCVnsmSDPTIFVVFEKHQVYPEYLIQYST 689
4F0D_A        216 -----IDHPDVKCQTKKKDSKE------------IDRRRAr-IKHSEGGD---IPPKYFVVTNNQLLRVKYLLVYSQ 271
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