5DS3,4F0D,5DSY


Conserved Protein Domain Family
PARP

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pfam00644: PARP 
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Poly(ADP-ribose) polymerase catalytic domain
Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.
Statistics
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PSSM-Id: 334187
View PSSM: pfam00644
Aligned: 30 rows
Threshold Bit Score: 132.449
Threshold Setting Gi: 81913590
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DS3_A   67 SEEAEIIRKYVKNTHATTHnA---YDLEVIDIFKIEREGECQRYKPFk-------qLHN---------RRLLWHGSRTTN 127  human
Q7Z114  460 SAGYQIFIRNFLSNPHHQK-AidnGEIKILNCYRLDKKLESDNFLD----------VGN---------VQYLYHGSKPQN 519  Dictyostelium disco...
Q6A0B1  397 TEEFSRVRKEVLQNNRSEQ------PVDILQIFRVGRVNEATEFLSK---------LGN---------VRLLFHGSPVRN 452  house mouse
Q7TMM8  102 KAEFEKIQQLTGAPHTPVP-T----PDFLFEIEY---------FDPAnsrfyetkgERD---------LIYAFHGSRLEN 158  house mouse
Q6NX05  107 KEEFARLSQLAQREGVSAP-A----PDFLFELQY--CDLLNSKFERTr-------aGRD---------LIYAFHGSRLEN 163  zebrafish
Q6DDF6  129 KDKYEEIQALPGSPSHALP-T----PDFLFELEY--CEKLSAKFQETr-------gDRD---------LIYAFHGSRLEN 185  African clawed frog
Q8BSZ1  776 SQEFQDVVRAFYSTLDAVH-G----RIRIVRVERVSHPLLQQQYQLHrerlmqscqQRPv--------EQVLYHGTSESA 842  house mouse
Q8QGB0  100 SKEGHDIEKEFRKTLL---------NNTILTIERVQNDSLWKSYQIRkklleeknkHTNn--------EKLLFHGTSSDS 162  rainbow trout
Q8BZ20  517 SEEYQKVWNIFNRTLP---------FYFVQKIERIQNMGLWEVYQWQk-------cQMQkqnggkevdERQLFHGTSANF 580  house mouse
4F0D_A  100 KAEFEKIQKLTGAPHTPVP-A----PDFLFEIEYFDPAN--AKFYETk-------gERD---------LIYAFHGSRLEN 156  human
5DS3_A  128 FAGILSQGLRIAPPEAPVTGYM-----FGKGIYFADMVSKSA--NYCHTSQGDPIGL------ILLGEVALGNMYELKHA 194  human
Q7Z114  520 LVGLLSRGILPPDYVKQIGGKRtdfgyLGSGIYFSDDV-VSS--TYTSPIGEKGSRF------IIMSSVSLGKVKEFSKI 590  Dictyostelium disco...
Q6A0B1  453 ILGILSRGLLLPKVAEDRGVQRtdvgnLGSGIYFSDSLSTSI--KYAHAGETDGSRL------LVVCDVALGKCVNLFKK 524  house mouse
Q7TMM8  159 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSLAL--IYSP----HGHGWqhsllgPILSCVAVCE------- 216  house mouse
Q6NX05  164 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSMAI--LYSP----HGNGWresvlgPFISCVALCE------- 221  zebrafish
Q6DDF6  186 FHSILHNGLHCHLNKTSL---------FGEGTYLTSDLGLAL--LYSP----HGQGWtrsmlgPVLSCVAMCE------- 243  African clawed frog
Q8BSZ1  843 VLDICAHGF--NRSFCGRNGTL-----YGQGVYFAKRASLSVldRYSPP---NAEGYk----aVFVAQVLTGD------- 901  house mouse
Q8QGB0  163 ITQINNHGF--NRSYAGTHGAA-----IGNGSYFAVNSSYSA--RGYSKADAQGNKR------MYLARVLVGD------- 220  rainbow trout
Q8BZ20  581 VDAICQQNF--DWRVCGLHGTS-----YGKGSYFARDAAYSH--HYSKS--DTHSHM------MFLARVLVGD------- 636  house mouse
4F0D_A  157 FHSIIHNGLHCHLNKTSL---------FGEGTYLTSDLSLAL--IYSP----HGHGWqhsllgPILSCVAVCEV------ 215  human
5DS3_A  195 SH-ISKLPKGKHSVKGLGKTTPdpsanisldgvdVPLGTGi-SSGVNDTS---LLYNEYIVYDIAQVNLKYLLKLKF 266  human
Q7Z114  591 QPsLQCAPSGHHSCKGLKSTPT------------NPTD---------------FKNNEYVVFNPNQSKLSFLIEYIE 640  Dictyostelium discoideum
Q6A0B1  525 DFsLTEAPPGYDSVHGVSETTS------------VPTD---------------FQDDEFVVYKTNQVKMKYIVKFCT 574  house mouse
Q7TMM8  217 ----VIDHPDVKCQIKKKDSKE------------IDRSRAr-IKHSEGGE---IPPKYFVVTNNQLLRVKYLLVYSQ 273  house mouse
Q6NX05  222 ----IIDHPDVKCQVKKKDSES------------IDRQRLr-ARNSEGGE---VPEKYFVVTNNELLRVKYLLVYSQ 278  zebrafish
Q6DDF6  244 ----MIDHPDVKCQAKKKDSSE------------IDRKRAr-ARNSEGGD---VPQKYFVVTNNQLLRVKYLMVYSQ 300  African clawed frog
Q8BSZ1  902 -----------YGQGSRGLKAP-------------PLRVSgqVLRYDSAVdclQQPRIFVIFHDTQALPTHLITCKN 954  house mouse
Q8QGB0  221 ---------YTQGQAGLIVPPA------------KPSGKD--ADLYDSVTdntSNPTMFVIFSDVQAYPEFLIHSSK 274  rainbow trout
Q8BZ20  637 ------------FVRGSTSFVR------------PPAKEGqsNAFYDSCVnsmSDPTIFVVFEKHQVYPEYLIQYST 689  house mouse
4F0D_A  216 -----IDHPDVKCQTKKKDSKE------------IDRRRAr-IKHSEGGD---IPPKYFVVTNNQLLRVKYLLVYSQ 271  human
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