2XBB


Conserved Protein Domain Family
HECT

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pfam00632: HECT 
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HECT-domain (ubiquitin-transferase)
The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Statistics
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PSSM-Id: 306980
View PSSM: pfam00632
Aligned: 88 rows
Threshold Bit Score: 131.563
Threshold Setting Gi: 389601687
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XBB_A         80 FLISKEMFNPYYGLF--------EYsATDNytlqiNPNsgLCnedhLSY----FKFIGRVAGMAVYHGKLLDGFFIRPFY 147
gi 398025220 3812 SEMCRELMSGRLPFFvptanhvhNTgSHREayvpaASA--RS-----AYdleaFAFIGKLMGGALRSEDPLDLFLPPLVW 3884
gi 123426737 2545 TEACMEIMDPSMQLFiqtpnkrrKIaTAQDylipnPSP--LT-----PQsrdfFFYAGVLMTICYTSRLPEPFKFARFVW 2617
gi 123470504 2501 SELAKDICDPNIGLFvstpnfvnHRgSFREcivpnPIS--EW-----GRtshiYESVGCLIAISIRTGMVQPFTFPPFFW 2573
gi 123486058 2634 LDAINESIIPSIGLFiqcpnskfPNsENFDclipvPDP--NN-----MHsedmYKMLGVLFGISTRCGLTKPLPFPDFFW 2706
gi 154420948  133 IELANSIFQPTSHLFiqspngrnHCgSFRDayvpsTT---LG-----KDsydqYKAIGTFLGIIIRNGFPQDIPFAPFIW 204
gi 123476548 2183 TEAAASIFEPTTLLAistpnmrnHTgQYKDvyipfDK---T------MSrlqdYYTIGVLLGIIIRTGLQQDLPFAPIVW 2253
gi 123446414 2273 TECATSIFEKTSCLCfpvpnarhHRgQFKDlfvpyDE---TN-----GEysdiYRGIGIYIGMVVRTGFVQDMPFVPFVW 2344
gi 123466328 2209 NEIAISIFQSQSKLFilspngrnHSgGMRDvyipfSSL--RP-----FTsrslFYAVGVFIGIVIRNGYFQDFPFAPFVW 2281
gi 123484157  658 SEVSLDLRNPNCGFVcptpnsisQVgYYRDkfifvPTN--NE----LRSnkklYKSIGGLLLLIIRTGLVQEFDFAPVVW 731
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XBB_A        148 KMMLHkPITLHDMESVD----SEYYNS-L----RWIL--ENDpt-----------------elDL---RFIideelfGQT 196
gi 398025220 3885 RYLCAyPITEAEVEQVDvicvQCVREFrVlsatHAAAavADAdesg-------------gtetELfedVF-------GEE 3944
gi 123426737 2618 NSLTQrPVTLDDIYEID----SNFKQF-I----LSIEnsSSMspqdf------------hstyML---NFTaens----- 2668
gi 123470504 2574 TCLVTgEITIDDVFSID----NEYKDF-V----TNLEkdSKEktpqqfqel----------------------------- 2615
gi 123486058 2707 KYIAQgILTIEDIYSID----TPYKEL-MisleNNIQniTDEkvfssrfslff--------------------------- 2754
gi 154420948  205 KHLAGeLLQENDIMMVD----EQVKTL-F----DRLRqsKNDldftsrfqqkwtyiswtgeivNL--------------- 260
gi 123476548 2254 KFIANeHVGIDDVTAID----SGLLEH-F----NHIRsvSNDadfaqhyafqwkvddwdgtkvSL--------------- 2309
gi 123446414 2345 KFIAGgELSSNDILMVD----KMLSDQ-F----AQLRqaEADkdfqrcavpw-kieqwngqqaML--------------- 2399
gi 123466328 2282 KYLANePLDKNDILCLD----EHFANM-A----NSLVtiNEHdfnktyanm----------------------------- 2323
gi 123484157  732 RFLVSnKVSIEDIYEID----VNYKNT-I----ESLKdaINSrisede----------fnkqfNL---YFV--------- 780
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XBB_A        197 h---------QHE---------LKNG--GSE------IVV--------TNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 242
gi 398025220 3945 ffvtqlsdhsTKE---------LIEG--GAQ------TRV--------TLARSSEYAEALLQARL-HEFDLQLHKMREGL 3998
gi 123426737 2669 -------lgsIVE---------LIPG--GSL------VPV--------TFDRRLEFLAKIKKFRV-KEFNESLEQLRRGF 2715
gi 123470504 2616 ----------------ygnnhnkiKNirGEE------VSVfsfsskslNQGSAGRFISSANSLRIQKLLTPLLL-IRNGF 2672
gi 123486058 2755 -------------vvkdslgqerpLSeyGRT------RPV--------TLQNVREYISLSKDFRI-KELKSNLDIIRQGY 2806
gi 154420948  261 ------------------------PSqhHTD-------YV--------TGESVEQFIDEFVQARI-NEISQYLDLIRSGF 300
gi 123476548 2310 ------------------------PGhdKGD-------IL--------NKEDVEQYIKECVDYRL-NSILPLLREMKAAF 2349
gi 123446414 2400 ------------------------PGhsADS-------TV--------GPGEVENFIIECINFRI-NSIKPTLQLIRQGF 2439
gi 123466328 2324 -------------------kwavtdwddSTNwlkskdQIV--------GYNDIKNYLNMCVGARI-NSVKANLENMKRGF 2375
gi 123484157  781 ------------VkdslgqdhsLNQN--GTS------CKV--------SISNANEYIALSNEFRI-KELQKYLNWVRIGF 831
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XBB_A        243 FELIPQDLIKIFDENELELLMCGLG----D--VDVNDWREHTKY---KNGysANHQVIQWFWKAVlMMDSEKRIRLLQFV 313
gi 398025220 3999 LSVVPEVAVLLLTPEELELRVCGQAd------YTPEELRKGASYeglT----SEDRRVQLLWKALeEATPLQRRLFLRFV 4068
gi 123426737 2716 NFFFPAPAASILAPWELELIICGDNe------CPIEDMKRNCSF---P----ANDPSSTMLWDALeGFTPEERMLFIKFG 2782
gi 123470504 2673 WKALDLAPPPFVTPQLLEFLACGDRt------ISVSKLRALTEFqgaPR------KMIDIFWTVIsRLSEQEKRKFLQFA 2740
gi 123486058 2807 WENLGLKPPPFVTGDIIRSCCSPPNeltaEaiLSVTEFDHGLPK-----------ELKDLFIEILnEMNKSQLSLLLKFA 2875
gi 154420948  301 AINIGFETHPMMNATLIALLVQGSNv------ITTAQLRQITTFdgfNK---SNEYVISNYWAAVdRMSNEQRSLLLKFV 371
gi 123476548 2350 RRNTGFKHNALLTGALLSRMAQGSGd------ISVQHLKQITHVsdfEDG--IKNEYVKRFFRAVdRLNKEQKKLLLKFI 2421
gi 123446414 2440 IDNTKIDSHPLLTGARLSHMAQGSNv------ITTQQLRSITQVndyKG---LEDKNIRWFFNAVdRFNPDQRKLLLKFI 2510
gi 123466328 2376 YDNLGFSNPSIFNSNLISYLAQGSRt------VTTQAFKSITSMlapTN------QQERYFWEAVdRMTNEQRSLLLKFA 2443
gi 123484157  832 LKNIKEGIPNSLDPDTLEFSCCGDPecsyEnlVKIVRFEEISE------------DQQSIFFKVIqKFTPEQRACLIKFA 899
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2XBB_A        314 TGTSRVPMNGFA-ELygsngpqSFTVEQWG-----TPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENT-QGFDGV 385
gi 398025220 4069 SGRDRMPVK--------------LRILPLTtq-adADTVLPRAATCFFAIEVPDYSTLEVMKRKLYYSIENCaD-MDTD 4131
gi 123426737 2783 TGRMGLPPPGSKwMT-------PLQIQFKMseaqdAQKPLPTAMTCNSTMIIPRYSSVEMMAKKIRTAIT-----FGAD 2849
gi 123470504 2741 TGTTQIPSN-----Aky----pFLIVDYNRvp--aPDTNLPSASTCFYRLHIQEYSSAEVFHRKLLQAIEYT-GTFENS 2807
gi 123486058 2876 TARENLPFN-----Pps---kpLLNICYMNds--aWRDGLPKARTCFGEFDMPIYTSKEIAKKKILLAIEIS-GTFENN 2943
gi 154420948  372 TTLTRFPNKELNpTF-------HIQIKSSGg----TEDRLPHAQTCFCRLHLPNYTTPDIAYNKISLAIEIC-TTMENM 438
gi 123476548 2422 TTLTRLPNSTLNpDF-------KLKIDLKDcp--kPDEMLPTASTCFNKLHLPKYSTDEICYQKLLIAIQYC-QTMEIK 2490
gi 123446414 2511 TTLTRLPNSSINsSF-------VLKIDKLEre--nPDQSLPTASTCFNRLHLPPYSSEEITYQKLLIAIQYC-QTMENR 2579
gi 123466328 2444 TTMTRIPNPAINlGF-------KLFVNFEAq---lSDSSLPKASTCFNRLYLPLYSSSEVMYNKLVTAIEFC-DTMENS 2511
gi 123484157  900 TGRSRLPPSGSSnQF-------KFTVDSNGa----QIDKLPTSSTCFHTLHMPRYTSFDNAYKMISIAVENT-ESFENT 966
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