2IWG,2WL1,3ZO0


Conserved Protein Domain Family
SPRY

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pfam00622: SPRY 
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SPRY domain
SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologs are domains in butyrophilin/marenostrin/pyrin homologs.
Statistics
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PSSM-Id: 366203
View PSSM: pfam00622
Aligned: 52 rows
Threshold Bit Score: 70.0622
Threshold Setting Gi: 74947831
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IWG_B    57 KHYWEVDVTGKE--AWDLGVCRDSVRrkGHFLL-----SSKSGFWTIWLwNKQKY--EAGTYPQTPLhLQVPP--CQVGI 125 human
EGV97829 540 RHYWEVVIS--GstWYAIGLAYKSAP--KHEWI-----GKNSASWALCRcNNN----WVVRHNSKEIpIEPAPhlRRVGI 606 Chinese hamster
O95361   428 RYYFEVEIFg---aGTYVGLTCKGIDrkGEERNsc--iSGNNFSWSLQw-NGKEF--TAWYSDMETPlKAGPF--RRLGV 497 human
Q9TSW0   344 RHRWQVEVQLGEggGCTVGVVGEEVRrkGEQGL-----SAEEGVWAVILsHQQC---WASTSPGTDLpLSEIP--RRVGV 413 pig
Q9WUH5   364 RHTWMVNVDLAHggSCTVGVVREDVRrkGELRL-----RPEEGIWAVRLaWGFV---SALGSFPTRLaLEEQP--RKVQV 433 house mouse
Q9UPQ4   355 SHAWEVALG--GlqSWRVGVVRVRQDsgAEGHShscyhDTRSGFWYVCRtQGVEGdhCVTSDPATSPlVLAIP--RRLRV 430 human
Q9Y577   350 RHYWEVGMNITGdaLWALGVCRDNVSrkDRVPK-----CPENGFWVVQLsKGTKY--LSTFSALTPVmLMEPP--SHMGI 420 human
O75677   179 RHYWEVDVG--TstEWDLGVCRESVHrkGRIHL-----TTERGFWTVSLrDGSRL--SASTVPLTFLfVDRKL--QRVGI 247 human
Q6UXE8   340 KHYWEVDVG--QnvGWYVGVCRDDVDrgKNNVTl----SPNNGYWVLRLtTEHLY--FTFNPHFISLpPSTPP--TRVGV 409 human
O00635   346 RRYFEVDVG--EgtGWDLGVCMENVQrgTGMKQ-----EPQSGFWTLRLcKKKGY--VALTSPPTSLhLHEQP--LLVGI 414 human
2IWG_B   126 FLDYEAGMVSFYNITd-hGSLIYSFSECAFTgPLRPFFSPG---FNDGGKNTAPLT 177 human
EGV97829 607 LLDYDNGSIAFYDALn--SIHLYTFD-VALSqPVCPTFTV----WNKCLTIITGLP 655 Chinese hamster
O95361   498 YIDFPGGILSFYGVEydtMTLVHKFA-CKFSePVYAAFWLS---KKENAIRIVDLG 549 human
Q9TSW0   414 ALDYEAGRVALLNAEt--RAPIFTFA-ASFSgKVFPFFAV----WKKGSCLTLKG- 461 pig
Q9WUH5   434 SLDYEVGWITFVNAVt--QEHIYTFT-ASFTqKIFPLFGL----WGRGSSFSLSCQ 482 house mouse
Q9UPQ4   431 ELECEEGELSFYDAEr--HCHLYTFH-ARFg-EVRPYFYLG---GARGAGPPEPLR 479 human
Q9Y577   421 FLDFEAGEVSFYSVSd--GSHLHTYSQATFPgPLQPFFCLG---APKSGQMVISTV 471 human
O75677   248 FLDMGMQNVSFFDAEg--GSHVYTFRSVSAEePLHLFFAPPsppNGDKSVLSICPV 301 human
Q6UXE8   410 FLDYEGGTISFFNTNd--QSLIYTLLTCQFEgLLRPYIQHA---MYDEEKGT-PIF 459 human
O00635   415 FLDYEAGVVSFYNGNt--GCHIFTFPKASFSdTLRPYFQVY--------------Q 454 human
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