6SWY,4QT6,4CG4,2IWG,2VOK,6JKJ,5J8V,5J8V,4XW3


Conserved Protein Domain Family
SPRY
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pfam00622: SPRY 
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SPRY domain
SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.
Links
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Statistics
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PSSM-Id: 459877
Aligned: 47 rows
Threshold Bit Score: 71.6052
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6SWY_1  401 IFYYEIKVLsvtsteSAENSNIVIGYklvenelmeattkksvsrssvagsssslggsnnmssnrvpstsfTMEGTQrrDY 480  Saccharomyces cerev...
O95361  428 RYYFEVEIF---------GAGTYVGL--------------------------------------------TCKGIDrkGE 454  human
Q9UPQ4  355 SHAWEVALG--------GLQSWRVGV--------------------------------------------VRVRQDsgAE 382  human
Q9Y577  350 RHYWEVGMN------ITGDALWALGV--------------------------------------------CRDNVSrkDR 379  human
O75677  179 RHYWEVDVG--------TSTEWDLGV--------------------------------------------CRESVHrkGR 206  human
4CG4_F  241 RRYWEVEVG--------DKTAWILGA--------------------------------------------CKTSISrkGN 268  human
Q6UXE8  340 KHYWEVDVG--------QNVGWYVGV--------------------------------------------CRDDVDrgKN 367  human
2IWG_E   57 KHYWEVDVT--------GKEAWDLGV--------------------------------------------CRDSVRrkGH 84   human
2VOK_A   63 KMYWEVDVT--------QKEAWDLGV--------------------------------------------CRDSVQrkGQ 90   house mouse
O00635  346 RRYFEVDVG--------EGTGWDLGV--------------------------------------------CMENVQrgTG 373  human

6SWY_1  481 IYEggvsamslnvdgsinkCQKYGFdlnvFGYCGfDGLITn-STEQSKEYAK-PFGRDDVIGCGINFIDGSIFFTKNG-- 556  Saccharomyces cerev...
O95361  455 ERNsc-------------iSGNNFS----WSLQw-NGKEF--TAWYSDMETPlKAGPFRRLGVYIDFPGGILSFYGVEyd 514  human
Q9UPQ4  383 GHShsc-----------yhDTRSGF----WYVCRtQGVEGdhCVTSDPATSPlVLAIPRRLRVELECEEGELSFYDAEr- 446  human
Q9Y577  380 VPK----------------CPENGF----WVVQLsKGTKY--LSTFSALTPVmLMEPPSHMGIFLDFEAGEVSFYSVSd- 436  human
O75677  207 IHL----------------TTERGF----WTVSLrDGSRL--SASTVPLTFLfVDRKLQRVGIFLDMGMQNVSFFDAEg- 263  human
4CG4_F  269 MTL----------------SPENGY----WVVIMmKENEY--QASSVPPTRLlIKEPPKRVGIFVDYRVGSISFYNVTa- 325  human
Q6UXE8  368 NVTl---------------SPNNGY----WVLRLtTEHLY--FTFNPHFISLpPSTPPTRVGVFLDYEGGTISFFNTNd- 425  human
2IWG_E   85 FLL----------------SSKSGF----WTIWLwNKQKY--EAGTYPQTPLhLQVPPCQVGIFLDYEAGMVSFYNITd- 141  human
2VOK_A   91 FSL----------------SPENGF----WTIWLwQDSY---EAGTSPQTTLhIQVPPCQIGIFVDYEAGVVSFYNITd- 146  house mouse
O00635  374 MKQ----------------EPQSGF----WTLRLcKKKGY--VALTSPPTSLhLHEQPLLVGIFLDYEAGVVSFYNGNt- 430  human

6SWY_1  557 -IHLGNAFTDLNDL-EFVPYVALR---PGNSIKTNFGLN 590  Saccharomyces cerevisiae S288C
O95361  515 tMTLVHKFA-CKFSePVYAAFWLS---KKENAIRIVDLG 549  human
Q9UPQ4  447 -HCHLYTFH-ARFg-EVRPYFYLG---GARGAGPPEPLR 479  human
Q9Y577  437 -GSHLHTYSQATFPgPLQPFFCLG---APKSGQMVISTV 471  human
O75677  264 -GSHVYTFRSVSAEePLHLFFAPPsppNGDKSVLSICPV 301  human
4CG4_F  326 -RSHIYTFASCSFSgPLQPIFSPG---TRDGGKNTAPLT 360  human
Q6UXE8  426 -QSLIYTLLTCQFEgLLRPYIQHA---MYDEEKGT-PIF 459  human
2IWG_E  142 hGSLIYSFSECAFTgPLRPFFSPG---FNDGGKNTAPLT 177  human
2VOK_A  147 hGSLIYTFSECVFAgPLRPFFNVG---FNYSGGNAAPLK 182  house mouse
O00635  431 -GCHIFTFPKASFSdTLRPYFQVY--------------Q 454  human
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