2IWG,2WL1


Conserved Protein Domain Family
SPRY

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pfam00622: SPRY 
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SPRY domain
SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologs are domains in butyrophilin/marenostrin/pyrin homologs.
Statistics
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PSSM-Id: 334177
View PSSM: pfam00622
Aligned: 52 rows
Threshold Bit Score: 68.8976
Threshold Setting Gi: 74947831
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IWG_B        57 KHYWEVDVT-GKE--AWDLGVCRDSVRrkGHfl-----lSSKSGFWTIWL------WNKQKY--EAGTYPQTPLhLQV-P 119 human
Q9V3U3       109 RHYWELHVSqRVFgtSIMFGIGTKSARlhANafr--nmlGENEHGWGLS-------HKGVL---WHEGVALLYTkRFR-E 175 fruit fly
Q99619        88 LHAWEISWPlEQRgtHAVVGVATALAPlqTDhya--allGSNSESWGWDI------GRGKLY--HQSKGPGAPQyPAGtQ 157 human
Q9V6L9       123 RHTWEVIWE-GPLgtVAVIGISTKEAAlqCHgyv--allGSDDQSWGWNLvenhllHNGDM---QGSYPLLNNApKYQ-V 195 fruit fly
O95361       428 RYYFEVEIFg----aGTYVGLTCKGIDrkGEern--sciSGNNFSWSLQ-------WNGKEF--TAWYSDMETPlKAG-P 491 human
Q9TSW0       344 RHRWQVEVQ-LGEggGCTVGVVGEEVRrkGEqg-----lSAEEGVWAVIL------SHQQC---WASTSPGTDLpLSE-I 407 pig
Q9WUH5       364 RHTWMVNVD-LAHggSCTVGVVREDVRrkGElr-----lRPEEGIWAVRL------AWGFV---SALGSFPTRLaLEE-Q 427 house mouse
Q9UPQ4       355 SHAWEVALG---GlqSWRVGVVRVRQDsgAEghshscyhDTRSGFWYVCR------TQGVEGdhCVTSDPATSPlVLA-I 424 human
Q6UXE8       340 KHYWEVDVG---QnvGWYVGVCRDDVDrgKNnv----tlSPNNGYWVLRL------TTEHLY--FTFNPHFISLpPST-P 403 human
XP_011891337 486 RHYWEVVIS---GstWYAIGLAYKSAP--KHew-----iGKNSASWALCR------CNNN----WVVRHNSKEIpIEP-A 544 sooty mangabey
2IWG_B       120 P--C------QVGIFLDYEAGMVSFYNITd-hGSLIYSFSECAFt-gPLRPFFSPGFNDGGKNTAPLT 177 human
Q9V3U3       176 NqpT------QIGVLFDGIEGTLTFYKDG---KCLGVAFRGLDQidePLYPIVCSTAAKTEMTLKCTR 234 fruit fly
Q99619       158 G--EqlevpeRLLVVLDMEEGTLGYAIGG---TYLGPAFRGLKGr--TLYPAVSAVWGQCQVRIRYLG 218 human
Q9V6L9       196 G--E------RIRVILDCEDNTLSFEKNY---EFLGVAFRGLPDk--KLYPTVSAVYGNTEVSMVYLG 250 fruit fly
O95361       492 F--R------RLGVYIDFPGGILSFYGVEydtMTLVHKFA-CKFs-ePVYAAFWLSKKENAIRIVDLG 549 human
Q9TSW0       408 P--R------RVGVALDYEAGRVALLNAEt--RAPIFTFA-ASFs-gKVFPFFAV-WKKGSCLTLKG- 461 pig
Q9WUH5       428 P--R------KVQVSLDYEVGWITFVNAVt--QEHIYTFT-ASFt-qKIFPLFGL-WGRGSSFSLSCQ 482 house mouse
Q9UPQ4       425 P--R------RLRVELECEEGELSFYDAEr--HCHLYTFH-ARFg--EVRPYFYLGGARGAGPPEPLR 479 human
Q6UXE8       404 P--T------RVGVFLDYEGGTISFFNTNd--QSLIYTLLTCQFe-gLLRPYIQHAMYDEEKGT-PIF 459 human
XP_011891337 545 PhlR------RVGILLDYDNGSIAFYDALn--SIHLYTFD-VAFa-qPVCPTFTV-WNKCLTIITGLP 601 sooty mangabey
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