2IWG,2WL1


Conserved Protein Domain Family
SPRY

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pfam00622: SPRY 
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SPRY domain
SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologs are domains in butyrophilin/marenostrin/pyrin homologs.
Statistics
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PSSM-Id: 334177
View PSSM: pfam00622
Aligned: 52 rows
Threshold Bit Score: 68.8976
Threshold Setting Gi: 74947831
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IWG_B        57 KHYWEVDVT-GKE--AWDLGVCRDSVRrkGHfl-----lSSKSGFWTIWL------WNKQKY--EAGTYPQTPLhLQV-P 119
gi 74867078  109 RHYWELHVSqRVFgtSIMFGIGTKSARlhANafr--nmlGENEHGWGLS-------HKGVL---WHEGVALLYTkRFR-E 175
gi 74732788   88 LHAWEISWPlEQRgtHAVVGVATALAPlqTDhya--allGSNSESWGWDI------GRGKLY--HQSKGPGAPQyPAGtQ 157
gi 74947490  123 RHTWEVIWE-GPLgtVAVIGISTKEAAlqCHgyv--allGSDDQSWGWNLvenhllHNGDM---QGSYPLLNNApKYQ-V 195
gi 145559535 428 RYYFEVEIFg----aGTYVGLTCKGIDrkGEern--sciSGNNFSWSLQ-------WNGKEF--TAWYSDMETPlKAG-P 491
gi 38605101  344 RHRWQVEVQ-LGEggGCTVGVVGEEVRrkGEqg-----lSAEEGVWAVIL------SHQQC---WASTSPGTDLpLSE-I 407
gi 18203572  364 RHTWMVNVD-LAHggSCTVGVVREDVRrkGElr-----lRPEEGIWAVRL------AWGFV---SALGSFPTRLaLEE-Q 427
gi 56404980  355 SHAWEVALG---GlqSWRVGVVRVRQDsgAEghshscyhDTRSGFWYVCR------TQGVEGdhCVTSDPATSPlVLA-I 424
gi 296434411 340 KHYWEVDVG---QnvGWYVGVCRDDVDrgKNnv----tlSPNNGYWVLRL------TTEHLY--FTFNPHFISLpPST-P 403
gi 795472895 486 RHYWEVVIS---GstWYAIGLAYKSAP--KHew-----iGKNSASWALCR------CNNN----WVVRHNSKEIpIEP-A 544
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2IWG_B       120 P--C------QVGIFLDYEAGMVSFYNITd-hGSLIYSFSECAFt-gPLRPFFSPGFNDGGKNTAPLT 177
gi 74867078  176 NqpT------QIGVLFDGIEGTLTFYKDG---KCLGVAFRGLDQidePLYPIVCSTAAKTEMTLKCTR 234
gi 74732788  158 G--EqlevpeRLLVVLDMEEGTLGYAIGG---TYLGPAFRGLKGr--TLYPAVSAVWGQCQVRIRYLG 218
gi 74947490  196 G--E------RIRVILDCEDNTLSFEKNY---EFLGVAFRGLPDk--KLYPTVSAVYGNTEVSMVYLG 250
gi 145559535 492 F--R------RLGVYIDFPGGILSFYGVEydtMTLVHKFA-CKFs-ePVYAAFWLSKKENAIRIVDLG 549
gi 38605101  408 P--R------RVGVALDYEAGRVALLNAEt--RAPIFTFA-ASFs-gKVFPFFAV-WKKGSCLTLKG- 461
gi 18203572  428 P--R------KVQVSLDYEVGWITFVNAVt--QEHIYTFT-ASFt-qKIFPLFGL-WGRGSSFSLSCQ 482
gi 56404980  425 P--R------RLRVELECEEGELSFYDAEr--HCHLYTFH-ARFg--EVRPYFYLGGARGAGPPEPLR 479
gi 296434411 404 P--T------RVGVFLDYEGGTISFFNTNd--QSLIYTLLTCQFe-gLLRPYIQHAMYDEEKGT-PIF 459
gi 795472895 545 PhlR------RVGILLDYDNGSIAFYDALn--SIHLYTFD-VAFa-qPVCPTFTV-WNKCLTIITGLP 601
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