Conserved Protein Domain Family
RhoGEF

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pfam00621: RhoGEF 
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RhoGEF domain
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.
Statistics
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PSSM-Id: 306973
View PSSM: pfam00621
Aligned: 172 rows
Threshold Bit Score: 77.7086
Threshold Setting Gi: 914904604
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00621 is a member of the superfamily cl02571.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ODX_B         71 VISELLVTEAAHVRMLRVLHDLFFqpmaecLFFP-----------LEELQNIF-PSlDELI----EVHslFLDrlMKr-- 132
gi 122145913  280 ILGSIVQSEGSYVDSLKRVLQDYR------NPLMemep---kalsARKCRAVF-FRvKEIL----HCH--SMF--QIals 341
gi 74871461   179 IVAAIVHSENSYVATLQRLVNDYK------KPLEecsp---pvlnPVKIATLF-HClPDIL----HSH--KLF--RIsla 240
gi 94730437   361 AARELLDTEKSFVEGLEFLVTKYM------RPLRqplec--tlieASLVDKIF-YRiPEIL----AHH--QVL--LTtls 423
gi 122106885  246 VVVELFNTEKSYVESLQTIVLKYL------NQLKspena--glvdTQTVDEIF-FMvPAIL----NIH--ERF--LEelr 308
gi 357528787  456 VAKELYQTESNYVNILATIIQLFQ------VPLEeegqrggpilaPEEIKTIF-GSiPDIF----DVH--MKI--KDdle 520
gi 189046616  570 VVRELLQSERKYVQILEIVRDVYV------APLKaalssnrailsAANIQIIF-CDiLQIL----SLN--RQF--LDnlr 634
gi 156355931   43 IVQEILETEEKYIKCLETIRDVFE------DRLRrlr-----iipTKDVDVIFpPSlSEILtshiRLH--------Etls 103
gi 47214867    57 VMMTLVDTEHSYVESLRTLIQGYM------RPLKqpdss--sivdPLLVDEIF-FQiPEIL----EHH--ENF--LKqva 119
gi 156393938    7 VLQNLLDTEQSYVQNLQYLVTNYL------KPLKrpena--nivePAQVDEMF-YQiPDIL----LCH--EFF--LDqlq 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ODX_B        133 ---------RQESGYlieeiGDV-LLARFdgaeGswfqkiSSRFCSRQSFALEQLKA--------KQrKDPRFcafvqEa 194
gi 122145913  342 --------srvAEWDstekiGDL-FVASfsksm---vldvYSDYVNNFTNAMSIIKKacltkpafLE-FLKRRqvc---- 404
gi 74871461   241 --------ecvRNWDrdekiGDC-FVSAfgkpq---lleiYSGFINNFSAAMELAKMeekrksalAD-FFKVKqis---- 303
gi 94730437   424 q----ridqWHKDAIl----GDVlLAHfskqs----mietYISFVDNFKFAKASIIQarqk-hafEK-YYNRC------- 482
gi 122106885  309 r----rldsWDPMQKi----GDA-FVDVfsrpv---ildtYTSFVNNWNRAKDAIRTtrqkcpafAR-FLEAM------- 368
gi 357528787  521 --------dliANWDesrsiGDI-FLKYAkdlvKt-----YPPFVNFFEMSKEMIIKce--------kqKPRFhaflkIn 578
gi 189046616  635 --------drlQEWGpahcvGEI-VTKFGsqlnT------YTNFFNNYPVILKTIEK--------CReMIPAFrtflkRh 691
gi 156355931  104 --------qriQEWNyrstfGDL-FVRFFsqdeqgdlvqkYSEFSNNFPKAIRTIHK--------WRlSSHKFdnfleTc 166
gi 47214867   120 gcvaqwhdrQ----Tv----GQIlIQSfsket----lanmYSAYIDNFLNAKDAVRTakeakpafHK-FLEQS------- 179
gi 156393938   70 arvndwhdkQ----Ki----GDIiVASFT----KcflmdaYSAFINHFLHARAAVRVatmsrpgfAR-FIEQC------- 129
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
3ODX_B        195 eSRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCREILHHV 253
gi 122145913  405 ----spDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHpDRLSLQLALTELETLAEKL 460
gi 74871461   304 ----ahDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHhDRMSLQLALSQLELLAELL 359
gi 94730437   483 -CRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHTPVEHeDRERLLRAQRHIHCLAVAI 541
gi 122106885  369 -AREHKGKLSLDNLLIKPVQKFPNYELILSRLIKHTDVDHpDQKPLQEALKLVHDILMFL 427
gi 357528787  579 qAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENpDKSTLEKAIGSLKEVMTHI 638
gi 189046616  692 dKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHvDRGDLTTAIDQIKKYKGYI 751
gi 156355931  167 rANWPCNGLDLQAYLLNPIQRLPRYVLLISQLVKFTDVSHpDRVHVEQAFTTLTRSVDEL 226
gi 47214867   180 -MRENKEKQALGDLMIKPVQRIPRYELLVKDLLKHTSEDHpDHSYLLDAQRNIKHLAEKI 238
gi 156393938  130 -CRDHREKLTLQDLMIMPVQRIPRYVLILKDMIKHTPTDHpDHGSLQLAMGEIKTLANRM 188
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