4F7Z


Conserved Protein Domain Family
RasGEF_N

?
pfam00618: RasGEF_N 
Click on image for an interactive view with Cn3D
RasGEF N-terminal motif
A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.
Statistics
?
PSSM-Id: 306971
View PSSM: pfam00618
Aligned: 55 rows
Threshold Bit Score: 46.9104
Threshold Setting Gi: 74680258
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F7Z_A        487 TVMSGTPE--KILEHFLETirlepslneaTD-SVLNDFVMMHCVFMPNTQLCPALVAHYH-------------------- 543
gi 1708003    638 QIRYASVE--RLLERLTDLrf-------lSI-DFLNTFLHSYRVFTNAMVVLDKLINIYRkpmsaipa------rslell 701
gi 162416200  638 QIRYASVE--RLLERLTDLrf-------lSI-DFLNTFLHTYRIFTTAAVVLGKLSDIYKrpftsip--------vrsle 699
gi 74636752  1000 KYNEGNGA--GLLDYAIVKlc------mdND-LYTKTFFSTYKSFTTTASLLENLAKRFIgaksca----------vsie 1060
gi 51701355   980 QHNGQHSI--GLLDFALISli------mdNE-LFAETFFNNYKSFTTTLCVLENLAKRFIgakssaisislinklrnses 1050
gi 74637530  1120 NTNDLSDI--GLLDFAYIKin------mdNA-AYTETFFNTYKSFTTTVNVLEGLARRFIgaksca----------lsie 1180
gi 728959    1123 STRGLSDDniGLLDYAFVKlt------mdND-IFTETFFNTYKSFTTTTTVLENMAKRYVgakscs----------vsis 1185
gi 76800652   640 MIKGATLC--KLIERLTYHiy-------aDP-TFVRTFLTTYRYFCSPQQLLQLLVERFN-------------------- 689
gi 75023437   659 VIKCGTVL--KLIERLTYHsy-------tDS-KYILTFLISYRSFCTPNDLFSLLLERFN-------------------- 708
gi 67516335   406 netGFTFD--ELVDRLVAPpi------skQDsKFASIFLCLYRKFAAPATLLNALINRF--------------------- 456
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F7Z_A        544 --A-QPSQGT-EQE--------------------RMDYALN----------------------NKR--RVIRLVLQWAAM 575
gi 1708003    702 fsS-SHNAKL-LYGdapksprasr-kfssppplaIGT--------------------------SSPsrRRKLSLNIPIIT 752
gi 162416200  700 lfFaTSQNNRgEHLvdgksprlcr-kfssppplaVSRTSSP----------------------VRA--RKLSLTS-PLNS 753
gi 74636752  1061 rlV-K--DDS-RKKatdlsgtt-----nnkflcwDSASSEFgkeh--------------ylhaAKIqiGTAEALFYLINE 1117
gi 51701355  1051 srQ-IPPSTT-SNQfsasgifkps-ydelkfpvwDLKVTSVegcpl------------dylakIQI--GVLESLYHLIRE 1113
gi 74637530  1181 kiI-GNENLD-SLKdetlksklsq-lnakkfplwDLNVNKNetvn--------------lgflAKVqiGAMEAIYYLVKH 1243
gi 728959    1186 kiL-DRSDDS-KMKinedtnlvssslydqnfpvwDMKVTDDenin--------------liymAKIqiGAAEAILHLVKN 1249
gi 76800652   690 --I-PDPSLV-YQDtgtagaggmg-gvggdkehkNSHREDWkryrk------------eyvqpVQF--RVLNVLRHWVDH 750
gi 75023437   709 --I-PTPKKL-QQPkqgggpl------agrydtvQSHGLSAisssscinplceqkfrkefqqpIQL--RVLSVINQWVKL 776
gi 67516335   457 --E-RNEKDI-TDQ----------------------LTRIA----------------------DQL--RLLSVIAQWVSE 486
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
4F7Z_A        576 YGD---L------LQEDDV-------------AMAFLEEF 593
gi 1708003    753 GGKa-lElaslgcSSDSYAn------------IHSPISPF 779
gi 162416200  754 KIGaldL------TTSSSPttttqspaaspppHTGQIPLD 787
gi 74636752  1118 HYS---D------FNDDMHnn----------kLLLDIIKI 1138
gi 51701355  1114 HYA---D------FTDDLAnn----------kTFLDILKI 1134
gi 74637530  1244 HYN---D------FTDDMNch----------tTMLDIVKI 1264
gi 728959    1250 HYS---D------FTDDLCnn----------sTLLDIIKI 1270
gi 76800652   751 HFY---D------FEKDPM-------------LLEKLLNF 768
gi 75023437   777 HWY---D------FQCDPV-------------LLDALELF 794
gi 67516335   487 YPG---D------LAYPK--------------TRKRIVDF 503
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap