Conserved Protein Domain Family
DEP

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pfam00610: DEP 
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Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.
Statistics
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PSSM-Id: 306965
View PSSM: pfam00610
Aligned: 106 rows
Threshold Bit Score: 47.5468
Threshold Setting Gi: 268573510
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FSH_A        34 GLEIRDRMWLKITIANAVIGADVVDWLYTHVegFKERREARKYASSMLKHGFLRHTVNKIt-----------FSEQ--CY 100
gi 82194180  140 GIKDLKLEKDKKVFNHCFTGTCVVDWLIANRs-VRNRQEGLMLASALLNEGHLQPAGDISknaaqg-laettLLDSsdAL 217
1UHW_A        21 GIKELNLEKDKKVFNHCLTGSGVIDWLVSNKl-VRNRQEGLMISASLLSEGYLQPAGDLSknaadg-iaenpFLDSpdAF 98
gi 82252602  147 GIKMSSHVHQGSTYSNCFSGSAVVDWLVFSQl-ALTRVEAMTLASALLEEGYLRTVGLKSaealraaslgeqFMDDstAL 225
gi 677209604  73 GIKELKLEKDKKVFNHCFTGTSVIDWLVSSNs-IRNRKEGLMLASSLLSEGYLHPAGDTSkaaaeg-lsdtpFLDLsdAY 150
gi 47220674   37 GVKSQLQRLVITTIPHAITGEDITAWVAHRFq-IDQ-QEARNFGSLLVALGYIYPLQDHRrl---------vIKADa-SL 104
gi 38174286   36 GVKCQTQRLVITTIPHAITGEDIVAWIAYRFk-VDA-LEARAMGTMMVAFGYIYPLQDHKrl---------iLKPDt-SL 103
gi 63100536   36 GVKGSDQKLNVTTIPHVMKDQDIIAWIAKHMs-MEN-NEAQAFGTMLVAYGYIYPLQDHKkl---------vLKSDg-SL 103
2PBI_A        35 GVRMHNQRVLVTSVPHAMTGGDVLQWITQRLw-ISN-LEAQNLGNFIVKYGYIYPLQDPKnl---------iLKPDs-SL 102
gi 47227993   35 GMKMRNQRLLITVIPHAMTGRDVVDWFIKKHs-VSE-EEALHTGDMLVKYGYIYPLKEPRsl---------vLRPDe-TP 102

                 ...
1FSH_A       101 YVF 103
gi 82194180  218 YYF 220
1UHW_A        99 YYF 101
gi 82252602  226 YSF 228
gi 677209604 151 YYF 153
gi 47220674  105 YRF 107
gi 38174286  104 YRF 106
gi 63100536  104 YRF 106
2PBI_A       103 YRF 105
gi 47227993  103 YRF 105
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