3PJR,2IS1,1UAA,5MBV


Conserved Protein Domain Family
UvrD-helicase

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pfam00580: UvrD-helicase 
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UvrD/REP helicase N-terminal domain
The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Some members have large insertions near to the carboxy-terminus relative to other members of the family.
Statistics
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PSSM-Id: 334157
View PSSM: pfam00580
Aligned: 40 rows
Threshold Bit Score: 142.395
Threshold Setting Gi: 8134451
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PJR_A   12 LNKEQQEAVRT-TEGPLLIMAGAGSGKTRVLTHRIAYLMAEKH--VAPWN--------ILAITFTNKAAREMRERVQS-- 78   Geobacillus stearot...
O53348    5 WGVEAGAALAPgLRGPVLVLGGPGTGKSTLLVEAAVAHIGAG---TDPES--------VLLLTGSGRMGMRARSALTTal 73   Mycobacterium tuber...
Q9ZCJ7    1 MSNLQQQASNP--NTSVWVSASAGTGKTKILIDRFLRLLITG---TEPTN--------ILCLTFTNAAAIEMQARINSkl 67   Rickettsia prowazekii
O84645    2 SSFDIFSPTAS-VSGKFFLEASAGTGKTFTIEQVVLRSLLEGS--IEQTKn-------ILVVTFTNAATNELKLRIQAsl 71   Chlamydia trachomat...
P9WMQ3    1 MDRFELLGPLPrEGTTTVLEASAGTGKTFALAGLVTRYLAETA--ATLDE--------MLLITFNRAASRELRERVRGqi 70   Mycobacterium tuber...
P08394    3 DVAETLDPLRLpLQGERLIEASAGTGKTFTIAALYLRLLLGLG--GSAAFprpltveeLLVVTFTEAATAELRGRIRSni 80   Escherichia coli K-12
O25569    7 LNPEQLKAAKA-LQGHNLIIASAGTGKTSTIVGRILYLLDNG---IKPEE--------ILLLTFTNKASNEMIARVAK-- 72   Helicobacter pylori
O51578    1 MNKILEKIQNN---TTILIEASAGTGKTHILENVVINLIKTKL--YSINE--------ILVLTFTKKATEEMHTRILKvi 67   Borrelia burgdorfer...
P23478   11 WTDDQWNAIVS-TGQDILVAAAAGSGKTAVLVERMIRKITAEEnpIDVDR--------LLVVTFTNASAAEMKHRIAE-- 79   Bacillus subtilis s...
P45157    2 AETIPLNPITLpLNQISLIEASAGTGKTYTIGSLYLRLLLKAG--ENNFSrpln-veeILVVTFTEMATEELKKKIREri 78   Haemophilus influen...
3PJR_A   79 -----------------LLGg-------------------------aAEDVWISTFHSMCVRILRRDIDRIG-------- 108  Geobacillus stearot...
O53348   74 l--------------rsRTNgpc---------------------raaIREPVVRTVHSYAYAVLRKAAQRAGd------- 111  Mycobacterium tuber...
Q9ZCJ7   68 kylalc---daekleneLFLmsgnkplpqeia---ntktlyykllnsHEPLNIYTIHAFCQKILKTFPLEAGitpefkil 141  Rickettsia prowazekii
O84645   72 kqalsl---fsqalshpGTPlppyisssetkvk--qlymkirnslatLDEMNIFTIHGFCRFTLEQHFPWIQpiqpssif 146  Chlamydia trachomat...
P9WMQ3   71 veavg-----alqgdapPSGelvehllrgsdaeraqkrsrlrdalanFDAATIATTHEFCGSVLKSLGVAGDn------- 138  Mycobacterium tuber...
P08394   81 helria---clrettdnPLYerlleeiddkaq----aaqwlllaerqMDEAAVFTIHGFCQRMLNLNAFESGmlfeqqli 153  Escherichia coli K-12
O25569   73 -----------------YFKs--------------------------sSKIEAGTFHAVAYRYLKEHYPNLS-------- 101  Helicobacter pylori
O51578   68 enays------nsktneILKeayeq-----------------skklfISTINKFALHALNNFQIETENYSKYkpkekfsk 124  Borrelia burgdorfer...
P23478   80 -----------------ALEkelvqrpgs---------lhirrqlslLNRASISTLHSFCLQVLKKYYYLID-------- 125  Bacillus subtilis s...
P45157   79 tdainkltafaktqdksAFKndefltalcdnlnifeaihrlklaeqnMDLAAIYTIHGFCRRMLMQYAFHSGihfnleli 158  Haemophilus influen...
3PJR_A  109 ---------------INRNFSILDPTD----------------------------------QLSVMKTILKe-------k 132  Geobacillus stearot...
O53348  112 ---------------ALPRLLTSAEQDa--------------------------------iIRELLAGDAEdgpa--att 142  Mycobacterium tuber...
Q9ZCJ7  142 ee----tklqdiflkIKNEIYLSDEHNeviqillnrf---------------heitlqdifTEIIEQKIKFkklf--ink 200  Rickettsia prowazekii
O84645  147 se---pqtiqqhildYLRKNLWDTVLSpkqyafls------------------yhhrattqQTRHLIERLLqd-----yt 200  Chlamydia trachomat...
P9WMQ3  139 ----------------AADVELKESLTd---------------------------------LVTEIVDDRYlanf--grq 167  Mycobacterium tuber...
P08394  154 edesllryqacadfwRRHCYPLPREIAqvvfetwkgp---------------qallrdinrYLQGEAPVIKappp--dde 216  Escherichia coli K-12
O25569  102 ---------------LKQPKELRKLLE----------------------------------SIVDTKNAIDdd-----kk 127  Helicobacter pylori
O51578  125 eideivydflrksdsLIQALDIKDYELkvfksdakkteeivlkikkayerdttqelgdwlkTQTAFENILLkkeelikdy 204  Borrelia burgdorfer...
P23478  126 ---------------LDPGFRIADQTEgeligdevld---------------elfedeyakGEKAFFELVDrytt--drh 173  Bacillus subtilis s...
P45157  159 kdq-sdllvrfanefWREHFYPLDFESanfiate---------------------lvspanVLSLLKADLGkdl----qv 212  Haemophilus influen...
3PJR_A  133 NIDPKKFEPRt-----------------------------------------ILGTISAAKNELLPPEQFAKrastyy-- 169  Geobacillus stearot...
O53348  143 TWPAHLRPALttag----------------------------------fateLRNLLARCAERGLDPLELQQlgrrrgr- 187  Mycobacterium tuber...
Q9ZCJ7  201 QIPEQISNKRlaleqlnniydkvaslftaydlaiapktlfftkdggkrkrllSKELTKKYPQLLTELEKITAkihhldel 280  Rickettsia prowazekii
O84645  201 STPNLALSPLsitlqklkawvs------------------ryqhlaplsleeMQAFSLRFKQSDLSIERELPafvqqfet 262  Chlamydia trachomat...
P9WMQ3  168 ETDPELTYAEal---------------------------------------aLALAVVDDPCAQLRPPDPEPgskaav-- 206  Mycobacterium tuber...
P08394  217 TLASRHAQIVaridtvkqqwrdavgeldaliessgidrrkfnrsnqakwidkISAWAEEETNSYQLPESLEKfsqrfled 296  Escherichia coli K-12
O25569  128 PYTSQHLYAL------------------------------------------YSLYTNALKQEDFSAWLSNKnpehtp-- 163  Helicobacter pylori
O51578  205 NKIIEDLDKMtkdeilsfynkhiqtgkleieyskendifkiaetllknkffsTLIEKETKKNSKLSPKELKIkndliclg 284  Borrelia burgdorfer...
P23478  174 DLDLQFLVKQvyeysrshpnpeawlesfvhlydvseksaieelpfyqyvkedIAMVLNGAKEKLLRALELTKapggpapr 253  Bacillus subtilis s...
P45157  213 EIENKQALSVpiqiflpqylggyqkaln-------elkafwlesadeisaiiTNELVKDYPKDQLKSLNRKKyqvkrlgd 285  Haemophilus influen...
3PJR_A  170 -------------ekvvsDVYQEYQQRLLRNHS----------------------------------------------- 189  Geobacillus stearot...
O53348  188 -----------pewiaagQFAQRYEQVMLLRGAvglaap----------------------------------------- 215  Mycobacterium tuber...
Q9ZCJ7  281 rrieelkyhtnlltklayIFLKKYDSYKEENNL----------------------------------------------- 313  Rickettsia prowazekii
O84645  263 -----------npysldmLFFPGMVQKFQEENRnkkklsap--------------------------------------- 292  Chlamydia trachomat...
P9WMQ3  207 ------------rlrfaaEVLEELERRKGRLRA----------------------------------------------- 227  Mycobacterium tuber...
P08394  297 rtka---ggetprhplfeAIDQLLAEPLSIRDLvitralaeire------------------------------------ 337  Escherichia coli K-12
O25569  164 ------------yaalyeNILEEFENTKKKHNY----------------------------------------------- 184  Helicobacter pylori
O51578  285 inikhekyksednrnknrNNLKQYVILKVEYKIlkyiekelk-------------------------------------- 326  Borrelia burgdorfer...
P23478  254 a---------dnflddlaQIDELIQHQDDFSELykrvpavsfkrakavkgdefdpalldeatdlrngakklleklktdyf 324  Bacillus subtilis s...
P45157  286 winkinqwsnnprdyqinTTLKDYFLQSSIEKNceestdknkdk------------------------------------ 329  Haemophilus influen...
3PJR_A  190 -----------------------------------------LDFDDLIMTTIQl-------------------------- 202  Geobacillus stearot...
O53348  216 -----------------------------------qatapaLSAAELVGAALEa-------------------------- 234  Mycobacterium tuber...
Q9ZCJ7  314 -----------------------------------------LDYDDLIYYTEKl-------------------------- 326  Rickettsia prowazekii
O84645  293 ---------------------------------aspldpffQDWIQLAHPFCQkepifhtllksv-----------qqhl 328  Chlamydia trachomat...
P9WMQ3  228 -----------------------------------------QGFNDLLIRLATa-------------------------- 240  Mycobacterium tuber...
P08394  338 ------------------------------tvarekrrrgeLGFDDMLSRLDSa-------------------------- 361  Escherichia coli K-12
O25569  185 -----------------------------------------IDYNDLLLLFKK--------------------------- 196  Helicobacter pylori
O51578  327 ---------------------------------ktikstntIDQNYIISNLKNy-------------------------- 347  Borrelia burgdorfer...
P23478  325 trspeqhlkslaemkpvietlvqlvisygkrfeaakqeksiIDFSDLEHYCLAi-------------------------- 378  Bacillus subtilis s...
P45157  330 ------------------------------kpatpfyspifADLEKRVNALMTpdllskltlyhyrqglqqklldyklnh 379  Haemophilus influen...
3PJR_A  203 --------FDRv------------PDVLHYYQYKFQYIHIDEYQDTNRAQYTLVKKLAERFq-------nICAVGDADQS 255  Geobacillus stearot...
O53348  235 --------FAVd------------PELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTe-------lALIAGDPNQA 287  Mycobacterium tuber...
Q9ZCJ7  327 --------LNNkt---------thEWLFHKFENEINHILIDEAQDTSPTQWNIITTLITKLnvaekpsnsTFIVGDDKQS 389  Rickettsia prowazekii
O84645  329 kthcaqsySHDesiatlesllahnDTVVSQLRKQFQLVLIDEFQDTDKRQWQIFSKLFASPdys----gsLFLIGDPKQS 404  Chlamydia trachomat...
P9WMQ3  241 --------LEAa-----------dSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHs-------aLILIGDPKQA 294  Mycobacterium tuber...
P08394  362 --------LRSes----------gEVLAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWHHQpe-----taLLLIGDPKQA 418  Escherichia coli K-12
O25569  197 --------------------------AMLERPSPYKEVLCDEFQDTNPLQESILDAINPPS---------LFCVGDYDQS 241  Helicobacter pylori
O51578  348 --------LKSe-----------dKKLLNAIKNRYKIILIDEAQDLSLIQIEIFKILKTAGi-------kLIFIADPKQI 401  Borrelia burgdorfer...
P23478  379 --------LTAendkg----erepSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPeet----gnLFMVGDVKQS 442  Bacillus subtilis s...
P45157  380 qeksfddlLRLlceal---qdaqgDELAEMIRFQYPFAMIDEFQDTDSQQYAIFSKIYRDNpek---ntgFIMIGDPKQA 453  Haemophilus influen...
3PJR_A  256 IYRWRGADIQNILSFERDYP 275  Geobacillus stearothermophilus
O53348  288 VFGFRGGEPTGLLADDPPPA 307  Mycobacterium tuberculosis
Q9ZCJ7  390 IFRFQGANLHNFNLVNDQLK 409  Rickettsia prowazekii
O84645  405 IYEWRNADLPTYLQAKHSFp 424  Chlamydia trachomatis D/UW-3/CX
P9WMQ3  295 IYGFRGGDIHTYLKAAGTAD 314  Mycobacterium tuberculosis H37Rv
P08394  419 IYAFRGADIFTYMKARSEVH 438  Escherichia coli K-12
O25569  242 IYAFNGADISIISNFTQKYK 261  Helicobacter pylori
O51578  402 IYSFRKADISFYNKEIKNKI 421  Borrelia burgdorferi B31
P23478  443 IYRFRLAEPLLFLSKYKRFT 462  Bacillus subtilis subsp. subtilis str. 168
P45157  454 IYRFRGADIFTYLKASDEAQ 473  Haemophilus influenzae Rd KW20
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