3PJR,2IS1,1UAA,5MBV


Conserved Protein Domain Family
UvrD-helicase

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pfam00580: UvrD-helicase 
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UvrD/REP helicase N-terminal domain
The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Some members have large insertions near to the carboxy-terminus relative to other members of the family.
Statistics
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PSSM-Id: 334157
View PSSM: pfam00580
Aligned: 40 rows
Threshold Bit Score: 142.395
Threshold Setting Gi: 8134451
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A         12 LNKEQQEAVRT-TEGPLLIMAGAGSGKTRVLTHRIAYLMAEKH--VAPWN--------ILAITFTNKAAREMRERVQS-- 78
gi 81669337     5 WGVEAGAALAPgLRGPVLVLGGPGTGKSTLLVEAAVAHIGAG---TDPES--------VLLLTGSGRMGMRARSALTTal 73
gi 81625788     1 MSNLQQQASNP--NTSVWVSASAGTGKTKILIDRFLRLLITG---TEPTN--------ILCLTFTNAAAIEMQARINSkl 67
gi 8134452      2 SSFDIFSPTAS-VSGKFFLEASAGTGKTFTIEQVVLRSLLEGS--IEQTKn-------ILVVTFTNAATNELKLRIQAsl 71
gi 614115543    1 MDRFELLGPLPrEGTTTVLEASAGTGKTFALAGLVTRYLAETA--ATLDE--------MLLITFNRAASRELRERVRGqi 70
gi 119668       3 DVAETLDPLRLpLQGERLIEASAGTGKTFTIAALYLRLLLGLG--GSAAFprpltveeLLVVTFTEAATAELRGRIRSni 80
gi 81555836     7 LNPEQLKAAKA-LQGHNLIIASAGTGKTSTIVGRILYLLDNG---IKPEE--------ILLLTFTNKASNEMIARVAK-- 72
gi 8134451      1 MNKILEKIQNN---TTILIEASAGTGKTHILENVVINLIKTKL--YSINE--------ILVLTFTKKATEEMHTRILKvi 67
gi 239938590   11 WTDDQWNAIVS-TGQDILVAAAAGSGKTAVLVERMIRKITAEEnpIDVDR--------LLVVTFTNASAAEMKHRIAE-- 79
gi 1169572      2 AETIPLNPITLpLNQISLIEASAGTGKTYTIGSLYLRLLLKAG--ENNFSrpln-veeILVVTFTEMATEELKKKIREri 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A         79 -----------------LLGg-------------------------aAEDVWISTFHSMCVRILRRDIDRIG-------- 108
gi 81669337    74 l--------------rsRTNgpc---------------------raaIREPVVRTVHSYAYAVLRKAAQRAGd------- 111
gi 81625788    68 kylalc---daekleneLFLmsgnkplpqeia---ntktlyykllnsHEPLNIYTIHAFCQKILKTFPLEAGitpefkil 141
gi 8134452     72 kqalsl---fsqalshpGTPlppyisssetkvk--qlymkirnslatLDEMNIFTIHGFCRFTLEQHFPWIQpiqpssif 146
gi 614115543   71 veavg-----alqgdapPSGelvehllrgsdaeraqkrsrlrdalanFDAATIATTHEFCGSVLKSLGVAGDn------- 138
gi 119668      81 helria---clrettdnPLYerlleeiddkaq----aaqwlllaerqMDEAAVFTIHGFCQRMLNLNAFESGmlfeqqli 153
gi 81555836    73 -----------------YFKs--------------------------sSKIEAGTFHAVAYRYLKEHYPNLS-------- 101
gi 8134451     68 enays------nsktneILKeayeq-----------------skklfISTINKFALHALNNFQIETENYSKYkpkekfsk 124
gi 239938590   80 -----------------ALEkelvqrpgs---------lhirrqlslLNRASISTLHSFCLQVLKKYYYLID-------- 125
gi 1169572     79 tdainkltafaktqdksAFKndefltalcdnlnifeaihrlklaeqnMDLAAIYTIHGFCRRMLMQYAFHSGihfnleli 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A        109 ---------------INRNFSILDPTD----------------------------------QLSVMKTILKe-------k 132
gi 81669337   112 ---------------ALPRLLTSAEQDa--------------------------------iIRELLAGDAEdgpa--att 142
gi 81625788   142 ee----tklqdiflkIKNEIYLSDEHNeviqillnrf---------------heitlqdifTEIIEQKIKFkklf--ink 200
gi 8134452    147 se---pqtiqqhildYLRKNLWDTVLSpkqyafls------------------yhhrattqQTRHLIERLLqd-----yt 200
gi 614115543  139 ----------------AADVELKESLTd---------------------------------LVTEIVDDRYlanf--grq 167
gi 119668     154 edesllryqacadfwRRHCYPLPREIAqvvfetwkgp---------------qallrdinrYLQGEAPVIKappp--dde 216
gi 81555836   102 ---------------LKQPKELRKLLE----------------------------------SIVDTKNAIDdd-----kk 127
gi 8134451    125 eideivydflrksdsLIQALDIKDYELkvfksdakkteeivlkikkayerdttqelgdwlkTQTAFENILLkkeelikdy 204
gi 239938590  126 ---------------LDPGFRIADQTEgeligdevld---------------elfedeyakGEKAFFELVDrytt--drh 173
gi 1169572    159 kdq-sdllvrfanefWREHFYPLDFESanfiate---------------------lvspanVLSLLKADLGkdl----qv 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A        133 NIDPKKFEPRt-----------------------------------------ILGTISAAKNELLPPEQFAKrastyy-- 169
gi 81669337   143 TWPAHLRPALttag----------------------------------fateLRNLLARCAERGLDPLELQQlgrrrgr- 187
gi 81625788   201 QIPEQISNKRlaleqlnniydkvaslftaydlaiapktlfftkdggkrkrllSKELTKKYPQLLTELEKITAkihhldel 280
gi 8134452    201 STPNLALSPLsitlqklkawvs------------------ryqhlaplsleeMQAFSLRFKQSDLSIERELPafvqqfet 262
gi 614115543  168 ETDPELTYAEal---------------------------------------aLALAVVDDPCAQLRPPDPEPgskaav-- 206
gi 119668     217 TLASRHAQIVaridtvkqqwrdavgeldaliessgidrrkfnrsnqakwidkISAWAEEETNSYQLPESLEKfsqrfled 296
gi 81555836   128 PYTSQHLYAL------------------------------------------YSLYTNALKQEDFSAWLSNKnpehtp-- 163
gi 8134451    205 NKIIEDLDKMtkdeilsfynkhiqtgkleieyskendifkiaetllknkffsTLIEKETKKNSKLSPKELKIkndliclg 284
gi 239938590  174 DLDLQFLVKQvyeysrshpnpeawlesfvhlydvseksaieelpfyqyvkedIAMVLNGAKEKLLRALELTKapggpapr 253
gi 1169572    213 EIENKQALSVpiqiflpqylggyqkaln-------elkafwlesadeisaiiTNELVKDYPKDQLKSLNRKKyqvkrlgd 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A        170 -------------ekvvsDVYQEYQQRLLRNHS----------------------------------------------- 189
gi 81669337   188 -----------pewiaagQFAQRYEQVMLLRGAvglaap----------------------------------------- 215
gi 81625788   281 rrieelkyhtnlltklayIFLKKYDSYKEENNL----------------------------------------------- 313
gi 8134452    263 -----------npysldmLFFPGMVQKFQEENRnkkklsap--------------------------------------- 292
gi 614115543  207 ------------rlrfaaEVLEELERRKGRLRA----------------------------------------------- 227
gi 119668     297 rtka---ggetprhplfeAIDQLLAEPLSIRDLvitralaeire------------------------------------ 337
gi 81555836   164 ------------yaalyeNILEEFENTKKKHNY----------------------------------------------- 184
gi 8134451    285 inikhekyksednrnknrNNLKQYVILKVEYKIlkyiekelk-------------------------------------- 326
gi 239938590  254 a---------dnflddlaQIDELIQHQDDFSELykrvpavsfkrakavkgdefdpalldeatdlrngakklleklktdyf 324
gi 1169572    286 winkinqwsnnprdyqinTTLKDYFLQSSIEKNceestdknkdk------------------------------------ 329
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A        190 -----------------------------------------LDFDDLIMTTIQl-------------------------- 202
gi 81669337   216 -----------------------------------qatapaLSAAELVGAALEa-------------------------- 234
gi 81625788   314 -----------------------------------------LDYDDLIYYTEKl-------------------------- 326
gi 8134452    293 ---------------------------------aspldpffQDWIQLAHPFCQkepifhtllksv-----------qqhl 328
gi 614115543  228 -----------------------------------------QGFNDLLIRLATa-------------------------- 240
gi 119668     338 ------------------------------tvarekrrrgeLGFDDMLSRLDSa-------------------------- 361
gi 81555836   185 -----------------------------------------IDYNDLLLLFKK--------------------------- 196
gi 8134451    327 ---------------------------------ktikstntIDQNYIISNLKNy-------------------------- 347
gi 239938590  325 trspeqhlkslaemkpvietlvqlvisygkrfeaakqeksiIDFSDLEHYCLAi-------------------------- 378
gi 1169572    330 ------------------------------kpatpfyspifADLEKRVNALMTpdllskltlyhyrqglqqklldyklnh 379
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PJR_A        203 --------FDRv------------PDVLHYYQYKFQYIHIDEYQDTNRAQYTLVKKLAERFq-------nICAVGDADQS 255
gi 81669337   235 --------FAVd------------PELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTe-------lALIAGDPNQA 287
gi 81625788   327 --------LNNkt---------thEWLFHKFENEINHILIDEAQDTSPTQWNIITTLITKLnvaekpsnsTFIVGDDKQS 389
gi 8134452    329 kthcaqsySHDesiatlesllahnDTVVSQLRKQFQLVLIDEFQDTDKRQWQIFSKLFASPdys----gsLFLIGDPKQS 404
gi 614115543  241 --------LEAa-----------dSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHs-------aLILIGDPKQA 294
gi 119668     362 --------LRSes----------gEVLAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWHHQpe-----taLLLIGDPKQA 418
gi 81555836   197 --------------------------AMLERPSPYKEVLCDEFQDTNPLQESILDAINPPS---------LFCVGDYDQS 241
gi 8134451    348 --------LKSe-----------dKKLLNAIKNRYKIILIDEAQDLSLIQIEIFKILKTAGi-------kLIFIADPKQI 401
gi 239938590  379 --------LTAendkg----erepSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPeet----gnLFMVGDVKQS 442
gi 1169572    380 qeksfddlLRLlceal---qdaqgDELAEMIRFQYPFAMIDEFQDTDSQQYAIFSKIYRDNpek---ntgFIMIGDPKQA 453
                         570       580
                  ....*....|....*....|
3PJR_A        256 IYRWRGADIQNILSFERDYP 275
gi 81669337   288 VFGFRGGEPTGLLADDPPPA 307
gi 81625788   390 IFRFQGANLHNFNLVNDQLK 409
gi 8134452    405 IYEWRNADLPTYLQAKHSFp 424
gi 614115543  295 IYGFRGGDIHTYLKAAGTAD 314
gi 119668     419 IYAFRGADIFTYMKARSEVH 438
gi 81555836   242 IYAFNGADISIISNFTQKYK 261
gi 8134451    402 IYSFRKADISFYNKEIKNKI 421
gi 239938590  443 IYRFRLAEPLLFLSKYKRFT 462
gi 1169572    454 IYRFRGADIFTYLKASDEAQ 473
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