2TS1,4OUD,2JAN,1Y42,6BYQ,2DLC,6NCR,2YY5,1N3L


Conserved Protein Domain Family
tRNA-synt_1b

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pfam00579: tRNA-synt_1b 
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tRNA synthetases class I (W and Y)
Statistics
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Aligned: 46 rows
Threshold Bit Score: 231.773
Threshold Setting Gi: 2501073
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2TS1_A            26 LN-EERVTLYCGFDPTADsLHIG-HLATILTMRRFQQ-----AGHRPIALVGGATGLIGDPSgkkSERTLNAKETVEAWS 98  Geobacillus...
Q5L1T6             1 -----mkTIFSGIQPSGV-ITLGnYIGALRQFVELQ------HEYNCYFCIVDQHAITVWQD----PRELRQNIRRLAAL 64  Geobacillus...
Q49901             3 TA-TGFSRIFSGVQPTSDsLHLGnALGAITQWVALQYdh--pDEYEAFFCVVDLHAITIAQD----PETLWRRTLVTAAQ 75  Mycobacteri...
P73655             3 KP-----RILSGVQPTGN-LHLGnYLGAIRSWVEQQ------QHYDNFFCVVDLHAITVPHN----PQTLAQDTLTIAAL 66  Synechocyst...
JCVI:AT2G25840.2  59 tspsvkkRVVSGVQPTGS-VHLGnYLGAIKNWVALQ------DTYETLFIIVDHHAITLPYD----TRQLGKATTDTAAL 127 thale cress
P56396             3 KK-----RVFSGIQPTGQ-IHLGnYLGAIKHWVEMQ------DEYENLFCVVNSHAITLPID----PAFLKSQSYELVKL 66  Helicobacte...
P75510             3 K------RALTGIQASGK-QHLGnYLGVMQSLIELQ------EQCQLFVFVADLHSITVDFQ----PQALKQNNFDLVRT 65  Mycoplasma ...
O42875             8 TSlLPHSRVVSGIQPTGI-PHIGnYLGSLKQWVQLQEeaartPFSKCFFFVADLHALTVPQD----PLKFRQARLDMLAA 82  Schizosacch...
P04803            29 EAlHSNATVFSMIQPTGC-FHLGnYLGATRVWTDLCElk--qPGQELIFGVADLHAITVPKP---DGEMFRKFRHEAVAS 102 Saccharomyc...
2YY5_A             1 --ghmmkRALTGIQASGK-QHLGnYLGVMQSLIELQE------QCQLFVFVADLHSITVDF----QPQALKQNNFDLV-- 65  Mycoplasma ...
2TS1_A            99 ariKEQLGRFLDFeadgnpAKIKNNYDWIGPLDVITFLRDVGKHFSVNYMMAKES-----VQSRIET------------- 160 Geobacillus...
Q5L1T6            65 -----YLAVGIDPt----qATLFIQSEVPAHAQAAWMLQCIVYIGELERMTQFKE-------KSAGKe------------ 116 Geobacillus...
Q49901            76 -----YLALGIDPg----rAVVFVQSHVPAHTQLAWVLGCFTGFGQASRMTQFKD-------KALRQga----------- 128 Mycobacteri...
P73655            67 -----YLACGIDLq----ySTIFVQSHVAAHSELAWLLNCVTPLNWLERMIQFKE-------KAVKQg------------ 118 Synechocyst...
JCVI:AT2G25840.2 128 -----YLACGIDVs----kASVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQFKE-------KSRKEgv----------- 180 thale cress
P56396            67 -----LLACGIDPk----qSGLFIQSEVDEHPALAWLLNCQVSMGEMQRMTQFKD-------KSLKNp------------ 118 Helicobacte...
P75510            66 -----LLAVGLDPq----kACLFLQSDLLEHSMMGYLMMVQSNLGELQRMTQFKA-------KKAEQtrnp------ngt 123 Mycoplasma ...
O42875            83 -----LLAIGINPq----kSTLFFQSDVAQHSELAWLLACSTSMGQLNRMTQWKSklhlhDHDDLSFldasa-----tss 148 Schizosacch...
P04803           103 -----ILAVGVDPe----kASVIYQSAIPQHSELHWLLSTLASMGLLNRMTQWKS------KSNIKQstngdylvndsdv 167 Saccharomyc...
2YY5_A            66 ---RTLLAVGLDPq----kACLFLQSDLLEHSMMGYLMMVQSNLGELQRMTQFKA-----KKAEQTRn------------ 121 Mycoplasma ...
2TS1_A           161 -G----ISFTEFSYMMLQAYDFLRLYETegcrLQIGGSDQWGNITAGLELIRKTKGEa---------------------R 214 Geobacillus...
Q5L1T6           117 -A----VSAGLLTYPPLMAADILLYNTD----IVPVGEDQKQHIELTRDLAERFNKRyge----------------lftI 171 Geobacillus...
Q49901           129 dS----TTVGLFTYPVLQAADVLAYDTD----LVPVGEDQRQHLELARDLAQRFNSRfpd----------------tfvV 184 Mycobacteri...
P73655           119 eN----VSVGLLDYPVLMAADILLYDAD----KVPVGEDQKQHLELTRDIVIRINDKfgred------------apvlkL 178 Synechocyst...
JCVI:AT2G25840.2 181 eN----ASVGLFTYPDLMTADILLYQSD----FVPVGEDQKQHIELAREIAQRVNHLyggkkwkklggyeifrggslfkI 252 thale cress
P56396           119 kS----VNVGLFNYPILMASDILLYQSD----LVPVGEDQKQHLELTRNIAEKFNRDfgn----------------cfkV 174 Helicobacte...
P75510           124 lN----IPTGLLTYPALMAGDILLYQPD----IVPVGNDQKQHLELTRDLAQRIQKKfkl----------------klrL 179 Mycoplasma ...
O42875           149 tR----FNLGLFSYPVLQAADILLYGAT----HIPVGKDQSQHVELTRSIARSFNSSykek---------------iltV 205 Schizosacch...
P04803           168 gK----VRLGLFSYPVLQAADILLYKST----HVPVGDDQSQHLELTRHLAEKFNKMykkn---------------ffpK 224 Saccharomyc...
2YY5_A           122 pNgtlnIPTGLLTYPALMAGDILLYQPD----IVPVGNDQKQHLELTRDLAQRIQKKfkl----------------klrL 181 Mycoplasma ...
2TS1_A           215 AFGL----TIP----LVTKADGT-KFGKTESGt---IWLDKEKTSPYEFYQFWINTDDR-DVIRYLKYFTFLSKeEIEAL 281 Geobacillus...
Q5L1T6           172 PEAR----IPKvgarIMSLVDPTkKMSKSDPNpkayITLLDDAKTIEKKIKSAVTDSEG-TIRYDKEAKPGISN-LLNIY 245 Geobacillus...
Q49901           185 PDMF----IPKmaakIYDLADPTsKMSKSASSdaglINLLDDPALSVKKIRAAVTDSER-EIRYDPEVKPGVSN-LLNIQ 258 Mycobacteri...
P73655           179 PEPL----IRKegarVMSLADGTkKMSKSDESelsrINLLDPPEMIKKKVKKCKTDPQR-GLWFDDPERPECHN-LLTLY 252 Synechocyst...
JCVI:AT2G25840.2 253 PEPL----IPQagarVMSLTDGLsKMSKSAPSdqsrINLLDSKDLIVDKIKRCKTDSFA-GLEFDNAERPECNN-LLSIY 326 thale cress
P56396           175 PEPL----IAKvgarVMGLDDPKvKMSKSHQGanhaIFLLDEPDIIVKKIKKAATDSMG-VIAFDEKRE-GIFN-LLNIY 247 Helicobacte...
P75510           180 PQFV----QNKdtnrIMDLFDPTkKMSKSSKNqngvIYLDDPKEVVVKKIRQATTDSFN-KIRFAPKTQPGVTN-MLTIL 253 Mycoplasma ...
O42875           206 PDII----LNSss-sIMALCQPEkKMSKSDINsknyILLSDSTGEIRKKISRAQTDNIK-GITYGDSNRPGINN-LINIF 278 Schizosacch...
P04803           225 PVTM----LAQtk-kVLSLSTPEkKMSKSDPNhdsvIFLNDEPKAIQKKIRKALTDSISdRFYYDPVERPGVSN-LINIV 298 Saccharomyc...
2YY5_A           182 PQFVqnkdTNR----IMDLFDPTkKMSKSSKNqngvIYLDDPKEVVVKKIRQATTDSFN-KIRFASKTQPGVTN-MLTIL 255 Mycoplasma ...
2TS1_A           282 EQELREAPe----kRAA-----QKTLAEEVTKLvHGEEALRQAIRISEALFS 324 Geobacillus stearothermophilus
Q5L1T6           246 STLSGQSI--------------EELERQYEGK--GYGVFKADLAQVVIETLr 281 Geobacillus kaustophilus
Q49901           259 SAVTGVDV--------------DTLVQRYVGH--GYGDLKKDTAEAVVEFVS 294 Mycobacterium leprae TN
P73655           253 TLLSNQTK--------------EAVAQECAEM--GWGQFKPLLTETAIAALE 288 Synechocystis sp. PCC 6803 substr. Kazusa
JCVI:AT2G25840.2 327 QIVSGKKK--------------EEVMEECKDM--SWGTFKPLLADALIEHLs 362 thale cress
P56396           248 MLLSNESP--------------ENIEERFKNK--GYGDFKKELAEVMIQALK 283 Helicobacter pylori 26695
P75510           254 KALLKEPVnqsltnQLG-----NDLEAYFSTK--SYLDLKNALTEATVNLLV 298 Mycoplasma pneumoniae M129
O42875           279 AAISDSTP--------------SDIAQANASC--SNAEFKEKVSSAIIRCLQ 314 Schizosaccharomyces pombe 972h-
P04803           299 SGIQRKS---------I-----EDVVEDVSRFN-NYRDFKDYVSEVIIEELK 335 Saccharomyces cerevisiae S288C
2YY5_A           256 KALLKEPVn-----QSLtnqlgNDLEAYFSTK--SYLDLKNALTEATVNLLv 300 Mycoplasma pneumoniae M129
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