3HZJ


Conserved Protein Domain Family
RabGAP-TBC

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pfam00566: RabGAP-TBC 
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Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Statistics
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PSSM-Id: 334148
View PSSM: pfam00566
Aligned: 73 rows
Threshold Bit Score: 74.9926
Threshold Setting Gi: 74616670
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A         36 EALRAEVWQLLAgchdnqaxldry-----------------rilitkdsaqeSVIT-RDIHRTFP-AH---DYfKDtgG- 92
gi 122020868  309 LVSDARTWLHksaqksmgvsvds----------------sfsllypnmvfpmHAVN-GDGNNLFL------SSlLN--E- 362
gi 1351606    218 SRVRGRVWEKAIgnnlkldyqsffnaranaqkreaaekaeqmnnanqfredvCALE-LDLQSTMPhYS---LFhTE--G- 290
gi 74772864   512 DFARRTLWPIIIgnnlkireely------------------aifvrkttniqEAIR-GDIIRAKQ--Q---YPfIT--D- 564
gi 124479211   86 ISARKQIWPLIVgnklqitkelynilqtqs-----ktfkfdqrkplgrmssfNHIK-QDLGRTFKnESlqkIFhPG--G- 156
gi 121979561  378 QSLRKRVWPYLIgnklrinkklyknl------------enqmnahqvcqktaNLIR-EDMHRTYP-NF---SLfDK--Gs 438
gi 124461622  239 EQHRGKIWSFLIgnqlqinkqlyekll-----------lsipnhplitnelkNLIN-NDLQRTFTii---nDFeNS--D- 300
gi 74855636   459 SLVRSKVWPLLIgndlnitpelfsifgara----erakqksearslgrektvSLIH-LDLPRTFPmLS---IFqDE--G- 527
gi 74852632   293 DKKRNLVWKAIIgtneadqthcynsayss------sfgdesdpnirnipafgGLFSpSDHLITEQ--------------- 351
gi 829165474 1206 kwVRKTIWPLSIgnrleitenlykillkqv----qvsennigiannqimisiEKMK-ADLSNRSG-KRf--FSqFN--A- 1274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A         93 DGQESLYKICKAYSVYDEDIGYC-QGQSFLAAVLL-L-HX-PEEqAFCVLVKIXy-dYGLRDLYRNNFED--LHCKFY-- 163
gi 122020868  363 NAVRRVDSLLQTYMELRPEVVYV-KDMP-CLAMMLsLvIE-DPWeLCVCFTSLLe-yGHLAPFIRSRKEG--ITVHFN-- 434
gi 1351606    291 PLRRDLIGLLRAYSYYRFDTSYI-PGTSFIGALLLl--NM-NLTsAFNCLANLLd-kPFLQAVYTQDTSS--LKSFYQ-- 361
gi 74772864   565 VKAKELSNILHAFSNYRPDFGYI-PDLIDIAVVLIk--HL-QEYdSFQALVNLLh-qYHFLSVFQNDTRQ--IEWRIR-- 635
gi 124479211  157 PLSENLQSILEVFCLYRPDIGYV-QGMTYVGSILLt--YF-DDYqAFVIFSSLIt-hPQLISIFMLDEQN--LQIIFQ-- 227
gi 121979561  439 QINETLQAILEQFNHFRPDIGYV-QGMAYPAAIIF-LyLG-DSYlTFKYFSNLIagsEFISNLYKFKIDK--IKIYVK-- 511
gi 124461622  301 KLKDDLREILTIFHIYRPDMGYI-QGMTYLAFMFLi--RM-PKQkALKCLANILfksQLLRTFYQFKSHY--LEAYFL-- 372
gi 74855636   528 PLHQSLANVLEAYVCYRPDVGYV-QGMSYLAAVFLl--IL-DEFnSFVCLSNFLn-nPCYMTFYTMNLDQ--MAVYMN-- 598
gi 74852632   352 -GVKQVKSILNLIHTNSH-VEYC-PQISDLVHILIs--FM-SEAnTYTTTSLIL---KDAEENRPHRFLNidKKECAKfv 422
gi 829165474 1275 PQLKMLENVLSAFIFYRPDVGYInEAMPNLAAVLIs--QLdEEYaVFKAFINLLh-sYHFLTFFRGEMSE--IKWRVQ-- 1347
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A        164 -QLERLXQEQLPDLHSH-FSDLNLEAHX-YASQWFLTLFT-AKFPLCXVFHIIDlLLC-EGl-NiIFHVALALL-KTSKE 236
gi 122020868  435 -IFDAVLRKAHSALYGL-FQRYEVPLDV-YLLDWWTTVFL-RTLPVAVALHVWD-LFLld--eHyLYRTTLAILvYRF-- 505
gi 1351606    362 -TFLDTLKKNEPELATHlLIKLELVPDD-FVYPLLRKLFIpMVSP-EIASRILDcYVF-EEdsF-FIQLLMAVF-KLLKP 435
gi 74772864   636 -FFEENLQRILPFVYNH-LKAIKLETKL-YLMKWFLKIFL-HQFKFPMLSRLWDnFLL-EGe-IyLFKVGICYL-KYFQI 708
gi 124479211  228 -QFEKLIKLNIPQVHKL-FKQYNINCTN-YLLDWILTLFA-KPLNPDIVGRIWDrMLF-NGt-HiLWKCGIAIL-KILYP 300
gi 121979561  512 -TFEYFLSQKYPNCLKH-LQKLHIQSDI-FLIEWFYTLYC-RAFSFSTIAKIWD-LMLaHGe-ViFYKVGISIF-GCIEK 584
gi 124461622  373 -LFDSFFQEKLPVLANK-FNQINLPKQS-FLVEWFYTVFS-RAFNLITSSKVWDyFLC-EGd-LfLIRLTLAVL-SNLEP 445
gi 74855636   599 -TMDQLMAQNLPKIQKH-LKELGIQPDI-FMIDWVLTVFS-KALPLDVASHVWDtIFL-DGe-VvIFQTALGIL-KMYSK 671
gi 74852632   423 hSFDHLIELHLPKLHRH-MITIGLTNSFvFSDEWFSRLFV-SFLPYNTVLRIFD-ILLnEGykV-LYRIGLALL-KTHKK 497
gi 829165474 1348 -FFNEYLQKRMHLVLQH-FKALDLSSEL-FVMHWFLNLFS-NVFDQETVLRIWDnFLL-EGe-VfAYKAGIAFI-EYFHl 1420

                  ...
3HZJ_A        237 DLL 239
gi 122020868  506 GLY 508
gi 1351606    436 KLL 438
gi 74772864   709 ELK 711
gi 124479211  301 KFK 303
gi 121979561  585 DLi 587
gi 124461622  446 ELL 448
gi 74855636   672 DLE 674
gi 74852632   498 QLK 500
gi 829165474 1421 efk 1423
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