Conserved Protein Domain Family
RabGAP-TBC

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pfam00566: RabGAP-TBC 
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Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Statistics
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PSSM-Id: 306939
View PSSM: pfam00566
Aligned: 73 rows
Threshold Bit Score: 74.9911
Threshold Setting Gi: 74616670
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A        36 EALRAEVWQLLAgchdnqaxldry-------------------------rilitkdsaqeSVIT-RDIHRTFP----AH- 84
gi 124443681 170 EDFNL--WQTIEndtkrtrqregffhienqe-----------aslfedvkklyiqdqvaiLRLKrVDIEYNYD------- 229
gi 74582960   38 KSLRKSVWVSLCglscrhrmecls-------------------------rstsqssyadqNQVH-LDSERSFFq--yKL- 88
gi 74616670   61 DELRQQAWPILLglppkpfdedssss--------------------syssweslpphqdeDQVQ-LDVDRSFTyypsHT- 118
gi 74636413   36 QRTRSHVWSILSraslekctqeylr-----------------------lvqlgappsnwiSKIK-NDTFRTLS----TD- 86
gi 74962896  450 PTQRADVWCTLLdinetkwrdyl--------------------------nldvlashssdRQLE-VDIPRCHQ----YD- 497
gi 123437242 244 TDLRPLLWPQLLgvlpfakeiesvldqrvdeyklv---kyqwesmssfqlthrpelrsayQTIR-MDVKRTHL-----P- 313
gi 123430681 123 EESRWFVWLYLLgiydpnksydeniasitnnnyiyesirkswnnipkiqmnetssisklaNDVM-KDVKRTDRn--lEQ- 198
gi 847109235 389 pSLRGEVWPFLLgyypweitsedrealrvhrreey--sqiqkkrvsmsptaqkefwknvqFTVD-KDVVRTDRs---NQf 462
gi 195350271  34 eALRPDVWQVCLdvrhksdqmsl---------------------------fneiydlpfqSQLR-EDCQRHVDr--mGN- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A        85 DYfKDtgGDGQESLYKICKAYSVYDE---DIG-------YC--QGQSFLAAVLL--------------L-HX-PEEq--- 133
gi 124443681 230 ------------VLTRILFIYTKLNG---Q---------YI--QGMNELVAILYyc-----------fVnDD-STLlrsq 271
gi 74582960   89 NPfLL--RKHRSQLTKLLSVVFKHYP---ELC-------YY--QGLHDIAQILLl---------------TL-PFSh--- 135
gi 74616670  119 SDsAR--SLQKSLLSSLILSVLRRHP---YLH-------YF--QGYHDISQVLLl---------------VL-PAHl--- 165
gi 74636413   87 EKfRN--KVTESQLIRVLSCFAWDVLdsnQTHelpglspYV--QGMNVLLAPFLy---------------VC-PTEp--- 143
gi 74962896  498 SYmTT--PAIQESLRKVLKGWQIVTEs-qHFV-------YW--QGCDSLATPFL--------------LaNMsKPHv--- 548
gi 123437242 314 EGsNE--QAIKPMMENILKTYAIWNY---DVR-------YT--QGINDVVLPFLl------------vFyNS-KLYtddq 366
gi 123430681 199 FSrDD--HPNLSVLNNVLVSYAMYCK---DTG-------FV--QGMGDIVSLFIilyikswdnektcnLvDG-RKVdket 263
gi 847109235 463 FRgED--NPNVESMRRILLNYAVYSP---GVG-------YS--QGMSDLVAPIL--------------AeVL-DESd--- 510
gi 195350271  83 DEeDK--VSVVSDLESIITFYCKNRN----LQ-------YEpdNGWIELLLPLF--------------AlKL-NRSd--- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HZJ_A       134 ----AFCVLVKIXydYGLRDLYRNNF----ED--LHCKFY---QLERLXQEQLPDLHSHFSD---LNLEAHX-YASQWFL 196
gi 124443681 272 aevdTFFCFTILL--SQFRYNFFSKDeasiCNgfIQNKIR---VVQEIIKKHDFRLYDHMLK---IKIDPKL-FMSKWFM 342
gi 74582960  136 ----ALPLMEHLVf-YRLRDFMLPT---------LDGTVKqlqLILAVIKARDPTLYEYL-----IKADIQCyFALSWLI 196
gi 74616670  166 ----RSPALARLSa-LRIRDFMLPN---------LQAAIAqlrLIPDILRVSDPPLWRHL-------SGTEPfFALSGTI 224
gi 74636413  144 ---iAYKLFHSLCf-QMIPTYLNQSL----SGvhVAAK-----LLDKCLKIIDPKLSKFLTD---NLLTAEI-FGIPSIL 206
gi 74962896  549 ----AFACFKEFTy-RYCHKFYLKDN----SEv-IKEYLG---IFYHLVAYTDPVLYKHLKI---NGFDAEL-FAIPWFL 611
gi 123437242 367 vealGFWCFASFA--EKINSSLIEGS----MDgvTNIDLQ---LVIELLGTHDPKVKEWIIK---SDMQDMN-FVVSSFM 433
gi 123430681 264 aenfIFQILCKMMt-ITQQDRMFTDL--------LKQQEFafeRVFDIIKDFHPNLAEWLQN---NQLQNLI-FLYRHII 330
gi 847109235 511 ----TFWCFVGLM----QNTIFISSP----RDedMEKQLL---YLRELLRLVHPRFYQHLYSlgeDGL-QML-FCHRWIL 573
gi 195350271 132 ----TFNLFESIRd-TYIPKGCRPK----------GNVFH---VFRLLLLYHDPELCTLLDT---KKITPDL-YSLTWFQ 189
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
3HZJ_A       197 TLFTAKFPL-CXVFHIIDlLLCEGl---NiIFH-VALA-LL-KTSKEDLL 239
gi 124443681 343 TVFTKEFKL-YDTIILWD-HILcelddkNeLLNyIALA-II-HWLREDLL 388
gi 74582960  197 TWFAHDVSDiSVVCRLFD-FFIs----sHpLTV-VYTCaQVvLDNRTSII 240
gi 74616670  225 TMYAHDITTlGEITRLFD-VLLa----rEpVFS-VYMFaAIvRSRREELF 268
gi 74636413  207 TLSACNKPL-DQVIKLWD-FMFayg-fhMnILF-IVAQlVI---NRQAIM 249
gi 74962896  612 TCFAHELPL-SKLVLLWDeTMMHGn--aF-PLM-IALA-ML-NRLRDKLL 654
gi 123437242 434 LAFKRSLDE-PNLERAWD-SAMcsdsphTfIIC-FCAAlII-FCY--PAF 477
gi 123430681 331 LLFKREFKL-ESVLRLWD-AIFshe-kpFvFIRyFCAA-ILiNSFPQLIV 376
gi 847109235 574 LCFKREFPD-SEALRMWEaCWAHYqt-dYfHLF-LCVA-II-VLYgddvi 618
gi 195350271 190 SLFASCSSL-SVIIAMWD-LYFQNad-pFmVFF-LALI-IL-INGREQIL 233
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