4NC6


Conserved Protein Domain Family
RabGAP-TBC

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pfam00566: RabGAP-TBC 
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Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Statistics
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PSSM-Id: 366170
View PSSM: pfam00566
Aligned: 72 rows
Threshold Bit Score: 74.5987
Threshold Setting Gi: 74616670
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NC6_A                          34 EALRGEVWQLLAgchnndhlveky-----------------rilitkespqdSAIT-RDINRTFP-AH---DYFKDtgG- 90   human...
Q29RJ2                          48 YALRGQVYQRLIrdipcrtvtpdasvyrd------ivgkivgkhssaslplpEFVDnTQVPSYCL----------N--S- 108  cattle...
Q4DAN6                         309 LVSDARTWLHksaqksmgvsvds----------------sfsllypnmvfpmHAVN-GDGNNLFL------SSLLN--E- 362  Trypanosoma cruzi...
Q09844                         218 SRVRGRVWEKAIgnnlkldyqsffnaranaqkreaaekaeqmnnanqfredvCALE-LDLQSTMPhYS---LFHTE--G- 290  Schizosaccharomyces pombe 972h-...
Q5CZH0                         512 DFARRTLWPIIIgnnlkireely------------------aifvrkttniqEAIR-GDIIRAKQ--Q---YPFIT--D- 564  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00402039A 1206 kwVRKTIWPLSIgnrleitenlykillkqv----qvsennigiannqimisiEKMK-ADLSNRSG-KRf--FSQFN--A- 1274 Tetrahymena thermophila SB210...
A0DT74                          86 ISARKQIWPLIVgnklqitkelynilqtqs-----ktfkfdqrkplgrmssfNHIK-QDLGRTFKnESlqkIFHPG--G- 156  Paramecium tetraurelia...
Q23QD2                         378 QSLRKRVWPYLIgnklrinkklyknl------------enqmnahqvcqktaNLIR-EDMHRTYP-NF---SLFDK--Gs 438  Tetrahymena thermophila SB210...
A0EBU5                         239 EQHRGKIWSFLIgnqlqinkqlyekll-----------lsipnhplitnelkNLIN-NDLQRTFTii---nDFENS--D- 300  Paramecium tetraurelia...
Q54UM5                         459 SLVRSKVWPLLIgndlnitpelfsifgara----erakqksearslgrektvSLIH-LDLPRTFPmLS---IFQDE--G- 527  Dictyostelium discoideum AX4...
4NC6_A                          91 DGQDSLYKICKAYSVYDEEIGYC-QGQSFLAAVLLl--HM-PEEQAFSVLVKIMf-dYGLRELFKQNFEDLHCKFYQLER 165  human...
Q29RJ2                         109 KGEGAVRKILLCISNQFPDVSFC-PALPAVVALLLh-ySA-DEAECFEKACRILacnDSSRKLVDQSFLAFESSCMTFGD 185  cattle...
Q4DAN6                         363 NAVRRVDSLLQTYMELRPEVVYV-KDMP-CLAMMLslvIE-DPWELCVCFTSLLe-yGHLAPFIRSRKEGITVHFNIFDA 438  Trypanosoma cruzi...
Q09844                         291 PLRRDLIGLLRAYSYYRFDTSYI-PGTSFIGALLLl--NM-NLTSAFNCLANLLd-kPFLQAVYTQDTSSLKSFYQTFLD 365  Schizosaccharomyces pombe 972h-...
Q5CZH0                         565 VKAKELSNILHAFSNYRPDFGYI-PDLIDIAVVLIk--HL-QEYDSFQALVNLLh-qYHFLSVFQNDTRQIEWRIRFFEE 639  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00402039A 1275 PQLKMLENVLSAFIFYRPDVGYInEAMPNLAAVLIs--QLdEEYAVFKAFINLLh-sYHFLTFFRGEMSEIKWRVQFFNE 1351 Tetrahymena thermophila SB210...
A0DT74                         157 PLSENLQSILEVFCLYRPDIGYV-QGMTYVGSILLt--YF-DDYQAFVIFSSLIt-hPQLISIFMLDEQNLQIIFQQFEK 231  Paramecium tetraurelia...
Q23QD2                         439 QINETLQAILEQFNHFRPDIGYV-QGMAYPAAIIFl-yLG-DSYLTFKYFSNLIagsEFISNLYKFKIDKIKIYVKTFEY 515  Tetrahymena thermophila SB210...
A0EBU5                         301 KLKDDLREILTIFHIYRPDMGYI-QGMTYLAFMFLi--RM-PKQKALKCLANILfksQLLRTFYQFKSHYLEAYFLLFDS 376  Paramecium tetraurelia...
Q54UM5                         528 PLHQSLANVLEAYVCYRPDVGYV-QGMSYLAAVFLl--IL-DEFNSFVCLSNFLn-nPCYMTFYTMNLDQMAVYMNTMDQ 602  Dictyostelium discoideum AX4...
4NC6_A                         166 LMQEYIPDLYNH-FLD----ISLEAHMYASQWFLTLFT-AKFPLYMVFHIID-LLL-CEgISvIFNVALGLL-KTS---K 233  human...
Q29RJ2                         186 LVNKYCQAAHKLmVAVsedvLQV-----YADWQRWLF--GELPLSYFARVFD-VFLvEGyKV-LYRVALAIL-KFFhkvR 255  cattle...
Q4DAN6                         439 VLRKAHSALYGL-FQR----YEVPLDVYLLDWWTTVFL-RTLPVAVALHVWD-LFLl--dEHyLYRTTLAILvYRF---- 505  Trypanosoma cruzi...
Q09844                         366 TLKKNEPELATHlLIK----LELVPDDFVYPLLRKLFIpMVSP-EIASRILDcYVF-EEdSF-FIQLLMAVF-KLL---K 434  Schizosaccharomyces pombe 972h-...
Q5CZH0                         640 NLQRILPFVYNH-LKA----IKLETKLYLMKWFLKIFL-HQFKFPMLSRLWDnFLL-EG-EIyLFKVGICYL-KYF---Q 707  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00402039A 1352 YLQKRMHLVLQH-FKA----LDLSSELFVMHWFLNLFS-NVFDQETVLRIWDnFLL-EGe-VfAYKAGIAFI-EYF---H 1419 Tetrahymena thermophila SB210...
A0DT74                         232 LIKLNIPQVHKL-FKQ----YNINCTNYLLDWILTLFA-KPLNPDIVGRIWDrMLF-NGt-HiLWKCGIAIL-KIL---Y 299  Paramecium tetraurelia...
Q23QD2                         516 FLSQKYPNCLKH-LQK----LHIQSDIFLIEWFYTLYC-RAFSFSTIAKIWD-LMLaHGe-ViFYKVGISIF-GCI---E 583  Tetrahymena thermophila SB210...
A0EBU5                         377 FFQEKLPVLANK-FNQ----INLPKQSFLVEWFYTVFS-RAFNLITSSKVWDyFLC-EGd-LfLIRLTLAVL-SNL---E 444  Paramecium tetraurelia...
Q54UM5                         603 LMAQNLPKIQKH-LKE----LGIQPDIFMIDWVLTVFS-KALPLDVASHVWDtIFL-DGe-VvIFQTALGIL-KMY---S 670  Dictyostelium discoideum AX4...
4NC6_A                         234 D-DLL 237  human
Q29RJ2                         256 AgQPL 260  cattle
Q4DAN6                         506 --GLY 508  Trypanosoma cruzi
Q09844                         435 P-KLL 438  Schizosaccharomyces pombe 972h-
Q5CZH0                         708 I-ELK 711  Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00402039A 1420 lefkm 1424 Tetrahymena thermophila SB210
A0DT74                         300 P-KFK 303  Paramecium tetraurelia
Q23QD2                         584 K-DLi 587  Tetrahymena thermophila SB210
A0EBU5                         445 P-ELL 448  Paramecium tetraurelia
Q54UM5                         671 K-DLE 674  Dictyostelium discoideum AX4
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