Conserved Protein Domain Family
Vpu

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pfam00558: Vpu 
Vpu protein
The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.
Statistics
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PSSM-Id: 109608
View PSSM: pfam00558
Aligned: 16 rows
Threshold Bit Score: 57.7362
Threshold Setting Gi: 139441
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P17286  1 MTLL---VGLVLILVGLIAwNICIWGYiikwGYRRYKRHRLE----TEIERLNLILRERAEDSGNESNGEEEErLEQLIH 73  SIVcpz GAB1
Q9QSS5  1 MNLLl--VGIGALIVAFLL-AIVVWTI----AYLEYRKVLKQ----ERINQLYNRLIERAEDSGNESEGEAEE-LAALGE 68  Human immunodeficiency...
Q7SPU3  1 MSDLl-aVTVAAFIVALII-AIVVWTI----VYIEYKKLVRQ----RKINKLFKRIRERAEDS-DESEGDAEE-LAALGE 68  Human immunodeficiency...
O41563  1 MQSLh-iVAIVALVVAIIL-AIVVWSI----VFIEYRKILRQ----RKIDRLIDRIIERAEDSGNESEGDQEE-LSALVE 69  Human immunodeficiency...
O91168  1 MHHKd-lLILIVASILLFT-NIVIWTF----ILKKYLEQKEQdrreRELLKRIKRIREVRDDSDYESNGDGGQeVIHLVH 74  Human immunodeficiency...
Q6Y906  1 MYKDq-iILIIIFCVVFLI-AACIWLF----ILKTYLEQKKQdrreKELLRRLQRIIEIRDDSDYESNGEEEQeVMDLVH 74  Human immunodeficiency...
O91134  1 MHQRd-lLALIACIFLCLL-NAIFWLF----NLRLYLERRRQdrreREILERIRRIREIGDDSDYESNGEEEQeIMDLVH 74  Human immunodeficiency...
Q5MYY3  1 MIL----IALGCLAIALILlNIFIWRN----LWRLCKQNKLE----VEIENLALRLTERAEDSGNESDGGEEEkLQRLLH 68  Simian immunodeficienc...
Q5K6J1  1 MLSMwvaIGLIGIGTLLVI-NIVVWGIvgisVYKRWKRHKEE----QRIIDLIIKITERAEDSGNESDGEDKEtLATLLH 75  Simian immunodeficienc...
Q9ICT3  1 MLIWe-qIGLIALGIELII-VIVVWGI----AYKKWREIKEErnrtQRIYNLAERIRIRQEDSGNESNGEEEAqLDNLLH 74  Simian immunodeficienc...
P17286 74 nynhnNHFANPMFD--L 88  SIVcpz GAB1
Q9QSS5 69 -----VGHLVLGNIhnL 80  Human immunodeficiency virus 1
Q7SPU3 69 -----MGPFIPGDVnnL 80  Human immunodeficiency virus 1
O41563 70 -----RGHLAPWNIddL 81  Human immunodeficiency virus 1
O91168 75 t----HGFVNPMFE--L 85  Human immunodeficiency virus 1
Q6Y906 75 e----HGFVNPMFE--L 85  Human immunodeficiency virus 1
O91134 75 s----HGFDNPMFE--F 85  Human immunodeficiency virus 1
Q5MYY3 69 dhdnmHGFANPLFD--I 83  Simian immunodeficiency virus
Q5K6J1 76 n----NGFDNPMFEdrI 88  Simian immunodeficiency virus
Q9ICT3 75 a----NGFDNPMFDw-P 86  Simian immunodeficiency virus
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