1WF6,2EBU


Conserved Protein Domain Family
BRCT

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pfam00533: BRCT 
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BRCA1 C-terminus (BRCT) domain
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Statistics
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PSSM-Id: 334130
View PSSM: pfam00533
Aligned: 84 rows
Threshold Bit Score: 30.741
Threshold Setting Gi: 731729
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WF6_A         37 PEDLLDGCRIYLc-------GFSGRKLDKL---RRLINSGGGVR----------FNQLNEDVTHVIVGDY-----DDELK 91
gi 363548502 1090 FQDQEHEPKFFIv-------SGPRSQRNEY---QQIIRRLKGKCcr-------dSHQWSYQATHFIAPEI------RRTE 1146
gi 41688427  1589 KERAERDISMVV----------SGLTPKEVmivQKFAEKYRLAL----------TDVITEETTHVIIKTDae-fvCERTL 1647
gi 728984    1643 TERVNKRMSMVV----------SGLTPEEFmlvYKFARKHHITL----------TNLITEETTHVVMKTDae-fvCERTL 1701
gi 74960586   857 KNALLDAIREVN--------KTNVMKALKMgsyINAYNKHGNTAlhvavrkahtSDEQMSTTTHCVVKTNengilETESL 928
gi 75018504   973 VPQKFPTTSFHI----------WIDERTDInitNQFMEKFQAIT----------SDEANSNTTHVIVKTDengalETDSL 1032
gi 21431892   931 VPEKFPVSSFHI----------YIEDRTDDnvtNEFTTKFQSIT----------SDEAMITTTHVVVKTTedgilETDDL 990
gi 74964344   725 PILIFNQRGFQLk-------CKDPFLRDRV---RDIIEDNGGRI----------VEQLEPKDFIIMIDAE---------- 774
gi 2494163    682 ISNIFAGLLFYVlsdyvtedTGIRITRAEL---EKTIVEHGGKLiyn-----viLKRHSIGDVRLIs--------CKTTT 745
gi 88911290   815 RHTVYLDSYAVInd----lsTKNEGTRLAIkalE--LRFHGAKV----------VSCLAEGVSHVIIGEDhs--rVADFK 876
                          90       100
                  ....*....|....*....|..
1WF6_A         92 QFWNKSAHRPHVVGAKWLLECF 113
gi 363548502 1147 KFFAAAASGSWILKTDYVADSK 1168
gi 41688427  1648 KYFLGIAGGKWIVSYSWVIKSI 1669
gi 728984    1702 KYFLGIAGGKWVVSYFWVTQSI 1723
gi 74960586   929 EIFFWIFNGTIIVKEQWMSDCL 950
gi 75018504  1033 DLLLWVFNGAIIVKEQWMVDCL 1054
gi 21431892   991 NLLIWIFHGSIIVRDTWMVDCL 1012
gi 74964344   775 --DNPPRYHSRTLDFSWIIASV 794
gi 2494163    746 ECKALIDRGYDILHPNWVLDCI 767
gi 88911290   877 AFRRTFKRKFKILKESWVTDSI 898
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