1WF6,2EBU


Conserved Protein Domain Family
BRCT

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pfam00533: BRCT 
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BRCA1 C-terminus (BRCT) domain
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Statistics
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Aligned: 84 rows
Threshold Bit Score: 31.1237
Threshold Setting Gi: 731729
Created: 22-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WF6_A   37 PEDLLDGCRIYLc-----GFSGRKLDKL---RRLINSGGGVRfnql-------------------------nedVTHVI- 82   human
P38850  262 NKTLFKNHHFAIs-----PDLNFFTPLYwflKGFIEDLDGKV--------------------------------TPLSF- 303  Saccharomyces cerev...
Q10337  217 FRNVLHGKRIYFs-----NDLNLPTNFRhslQKFSVGIGAKIaesi-------------------------ndcDIFIGl 266  Schizosaccharomyces...
O16568 1045 RPKLLEQCGFHI-------LETELLKNRegwEEVIKLFGGSVvqdi-------------------------eadDEKTPk 1092 Caenorhabditis elegans
Q92547 1261 HEELKKQYIFQLs-----SLNPQERIDY---CHLIEKLGGLViekqc-----------------------fdptCTHIV- 1308 human
Q6NZQ4  589 EESFLLGCVFAIad---yPEQMSDKQLLatwKRIIQAHGGTVdptf-------------------------tsrCTHLL- 639  house mouse
P87074  536 NQLIFDDCVFAFsg--pvHEDAYDRSAL---ETVVQDHGGLVldtglrplfndpfkskqkklrhlkpqkrskswNQAFV- 609  Schizosaccharomyces...
Q94046  515 PELYLTGIHFHCfdseklFEDKLDRKNL---EFMIKYHGGDIefeaskf-------------------herihqITHVL- 571  Caenorhabditis elegans
O44844  155 RPPLFYGFNFTIlpt-tnRRMQATREFW---NRIIEGFGGTCsmspip--------------------geagkiPYHLV- 209  Caenorhabditis elegans
P14737  995 TGNVFDKCIFVL------TSLFENREEL---RQTIESQGGTViesgfstlfnfthpl--akslvnkgntdnireLALKL- 1062 Saccharomyces cerev...
1WF6_A   83 ---VGDY------------------DDELKQFWNKSAHRPHVVGAKWLLECF 113  human
P38850  304 ---SDDLksvyqafpdidcyighsaNSPILEKTKSIKPEIHVGNVSWLFYMF 352  Saccharomyces cerevisiae S288C
Q10337  267 -------------------------KRDTIEFNLASNKNTTIGTISWLLNLF 293  Schizosaccharomyces pombe 972h-
O16568 1093 pywTLSSfykkkkweqrsciilkhsDSKIEKKWQSMHAMYTLVDFSFLAECI 1144 Caenorhabditis elegans
Q92547 1309 ---VGHP-------------------LRNEKYLASVAAGKWVLHRSYLEACR 1338 human
Q6NZQ4  640 ---CASQ--------------------VSSMYTQALRERKRCVTAHWLNTVL 668  house mouse
P87074  610 ---VSDT------------------FSRKVKYLEALAFNIPCVHPQFIKQCL 640  Schizosaccharomyces pombe 972h-
Q94046  572 ---VDSC--------------------RNTNVMTSLEHRKRIVSIQWIIDVM 600  Caenorhabditis elegans
O44844  210 ---KRNLkvpsasid--ssvvlyfnDSVLHEKWTFANNCISFLGMGWLVECI 256  Caenorhabditis elegans
P14737 1063 ---AWKPhslfadcr--faclitkrHLRSLKYLETLALGWPTLHWKFISACI 1109 Saccharomyces cerevisiae S288C
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