Conserved Protein Domain Family

pfam00533: BRCT 
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BRCA1 C-terminus (BRCT) domain
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
PSSM-Id: 395424
View PSSM: pfam00533
Aligned: 82 rows
Threshold Bit Score: 33.4382
Threshold Setting Gi: 1723501
Created: 11-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q09615  251 NVSRIMEGFSVFVn-----GYTDPPALVI---RDLMISHGGEY----------------------HCYYQHGITSYTIAS 300  Caenorhabditis elegans
Q20129  496 GLGDLFENCMFYIc-----GVDESRMEKW---RRFLNETGATR----------------------VAKFTSATNVVVVSP 545  Caenorhabditis elegans
Q6NZQ4  588 PEESFLLGCVFAIad---yPEQMSDKQLLatwKRIIQAHGGTV----------------------DPTFTSRCTHLLCAS 642  house mouse
3II6_Y  166 RRHTVYLDSYAVInd--lsTKNEGTRLAIkalE--LRFHGAKV----------------------VSCLAEGVSHVIIGE 219  human
P41882 1049 ATTPFLYGVHVAL--------CMKNCPYLaslTAIIQGQGGTM-------------------------LDKFPDKDAFNK 1095 Caenorhabditis elegans
O16568 1044 MRPKLLEQCGFHIl----eTELLKNREGW---EEVIKLFGGSVvqdieaddektpkpywtlssfyKKKKWEQRSCIILKH 1116 Caenorhabditis elegans
O14079  485 HRRTCFNGKRLYItk---aIRDSMVGDSIhglYSILETSGAEIvg-------------------dIKRAQEKDTIILAQP 542  Schizosaccharomyces...
Q20129  724 PPILIFNQRGFQLk-----CKDPFLRDRV---RDIIEDNGGRI----------------------VEQLEPKDFIIMIDA 773  Caenorhabditis elegans
Q94046  514 DPELYLTGIHFHCfdseklFEDKLDRKNL---EFMIKYHGGDIefe----------------askFHERIHQITHVLVDS 574  Caenorhabditis elegans
1WF6_A   86 Y------------------DDELKQFWNKSAHRPHVVGAKWLLECF 113  human
Q09615  301 S--------------------IATAKINRIRENEIFIKADWITESI 326  Caenorhabditis elegans
Q20129  546 Nq-----------------QERITIRKHLHQEDIAIVTVGWVVECV 574  Caenorhabditis elegans
Q6NZQ4  643 Q--------------------VSSMYTQALRERKRCVTAHWLNTVL 668  house mouse
3II6_Y  220 Dhs---------------rVADFKAFRRTFKRKFKILKESWVTDSI 250  human
P41882 1096 GshpylhknlgpifllhdgTGDLDLYRSDPDKMFTLFTEQQFMDLL 1141 Caenorhabditis elegans
O16568 1117 S------------------DSKIEKKWQSMHAMYTLVDFSFLAECI 1144 Caenorhabditis elegans
O14079  543 Dnd---------------qEGRNMSATGLNVYKIELVALSILRDRI 573  Schizosaccharomyces pombe 972h-
Q20129  774 E-------------------------DNPPRYHSRTLDFSWIIASV 794  Caenorhabditis elegans
Q94046  575 C--------------------RNTNVMTSLEHRKRIVSIQWIIDVM 600  Caenorhabditis elegans
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