4QJ3


Conserved Protein Domain Family
G-alpha

?
pfam00503: G-alpha 
Click on image for an interactive view with Cn3D
G-protein alpha subunit
G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.
Statistics
?
Aligned: 133 rows
Threshold Bit Score: 115.785
Threshold Setting Gi: 290988598
Created: 22-Apr-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4QJ3_A        39 RRINDEIERQLRRD---KRDARR----EL-------KLLLLGTGESGKSTFIKQMR------IIH--GSG------YSDE 90  house mouse
XP_002672578  26 QRRGSNVGQIHATS---PPTSTTt--fGA-------NLLFSSRSDDL----FDELE-----------DDDskssqsFQTS 78  Naegleria grube...
XP_002682016  75 SPTTNPQDYNILLDessEPVKKR-----M-------NVIMLGTGGSAKTTVLKQFK------LLG-----------GKRE 125 Naegleria grube...
XP_002680492  48 ATSLADMSEGKRRS---SLVPETpesnKL-------RIVLIGGGGSGKTTLFKQRK------LVL--GGG------FSER 103 Naegleria grube...
XP_002669059  26 EVKSPLVENVIAET-------------DC-------ILALIGTGGCGK---RLEMK--------------------FKEK 62  Naegleria grube...
XP_002682131 239 SSNAQHVAKTKKVQ---KSKYESp--sVY-------TLMLSGTLGSGKTTLFRQFR------LVF--QEG------FNRS 292 Naegleria grube...
XP_002676985  45 NSTNSNSNNSNVSN---NNTINN-------------NIYCVGCSDGGKTSFHNQLKs-----KFH--MKI------HKNE 95  Naegleria grube...
XP_002679780 137 PRFSTGIPSPRLSV---QSSALQvyqsHI-------RFIFLASGESGRKTLSKLIRynlepeVIE--KQA------FDLN 198 Naegleria grube...
XP_002672027   8 KLHSQAIDTALRRR---ITPCKK-------------QILILGACSSGKSTFRHGIY------HLSkeTNSm-----MNAE 60  Naegleria grube...
XP_002674575  73 YQPNHQLDGEILVGlpnITAFSGkdalVVenslekfKILLCGSGSSGKTTFLKSIE------LYK--KGA------FMe- 137 Naegleria grube...
4QJ3_A        91 d-kRG-FTKLVYQNIFTAMQAMIRAMDTlk--------------------------ipYKYEHNKAHAQLVREVDVEKV- 141 house mouse
XP_002672578  79 ---TQ-FLSLLGHNILDQAKKVNDLHTTqvqs------------------------ipiYGNNRKDSVDLSKAPKLVLVg 130 Naegleria grube...
XP_002682016 126 dltQSlWQE---GIVVPCFDLLIAIFNR------------------------------------KNFYYPNAEYHHEe-- 164 Naegleria grube...
XP_002680492 104 e-yEQ-ARLIVHTELLHVMYSLAYELYNgd---------------------------fvSNENVKQIAHDFLKIVSEKCn 154 Naegleria grube...
XP_002669059  63 ---------ENSNNYLNRVKLLSGQEYSl------------------------------------------Fp------- 84  Naegleria grube...
XP_002682131 293 e-iER-MRMYIITNLLQSFSLGVSLYLNevd--------------------------aiKNGTTKVTRENRFMLDETLYe 344 Naegleria grube...
XP_002676985  96 kirAT----LIIKTCLSSIQDIIFIVMS--------------------------------DQERNDFIHKIKKSDPQIYd 139 Naegleria grube...
XP_002679780 199 qsySTlY--FFFSNTIILLEQFYQMLFElkfpnqcin-------------elppilanVEPQIIQEILKDLKEIEDIPMd 263 Naegleria grube...
XP_002672027  61 e-rEL----HIRKYVIRCLDICWQTFKIvd----------------------------fKFSNLNEEIKKARk------- 100 Naegleria grube...
XP_002674575 138 --sAY-KKGIIYFNIIRDLGLMCKQYLSvateflnfisglneenygkslsdlnemfprELPREITDSMDRLIKVASSKNf 214 Naegleria grube...
4QJ3_A       142 ------------------SAFEN-----------PYVD--AIKSLW-N--DP--------------------------GI 161 house mouse
XP_002672578 131 tgssdsi----dnilgdtTFLSD-----------EICE--RLVDFWmD--EP--------------------------II 165 Naegleria grube...
XP_002682016 165 -----------------sDEVEQ-----------------QVFDLF-D--QKkilniihpnnqklieeiaemwnnepiLR 207 Naegleria grube...
XP_002680492 155 h---------------neHALINc---------iEHII--EKSQLW-K--TF--------------------------FT 179 Naegleria grube...
XP_002669059  85 -----------------eSVWNN-----------ELAK--LIFQMY-Q--DE--------------------------GF 105 Naegleria grube...
XP_002682131 345 kfk------------efdSRVTSlqsrytlfdisKLPQkeFVVSMW-E--DT--------------------------DV 383 Naegleria grube...
XP_002676985 140 fllnl-------tnitrkWEFTKse-------siQYGQ--YIRMIW-S--Ky-------------------------kII 175 Naegleria grube...
XP_002679780 264 refsvdq----vnklsnnIPMASnckvvlklitkQVYN--NLILFF-ErqDVk------------------------lLI 312 Naegleria grube...
XP_002672027 101 -----------------sGVFTS-----------SMIE--FMKYLT--------------------------------ML 118 Naegleria grube...
XP_002674575 215 lhssasrssskqynptfdTYFNE-----------QTFE--DIESLWkY--RPfnlfahfhlthssipefltpvltkmdTI 279 Naegleria grube...
4QJ3_A       162 QEC-YD--RRr-EYQl---------sDSTKY---------Y-LN-D---------LDRVADP--SYLP------------ 194 house mouse
XP_002672578 166 QMC-YFfaSIayKFIe----------GYGDYsrnraeksvY-IR-HlnlenlptlIDQLEDVl-SYETegddlqs----- 226 Naegleria grube...
XP_002682016 208 KVC-TEmlLEn-QVEsv-------pvEDVNY---------Y--------------FSRAVAVhrGDKP------------ 243 Naegleria grube...
XP_002680492 180 KEI-FK--QVm-EFNpk-------fsSLFNFsv-----dpY-FS-E---------YDRVMHM--DFKP------------ 218 Naegleria grube...
XP_002669059 106 QNElFQ--NRq-RIPf---------lESINY---------FtDKkN---------SSRLLKN--DFQL------------ 141 Naegleria grube...
XP_002682131 384 RKV-LN--RYalTDSm---------tDGMDY---------Y-LR-Dhgd---tsaVKRMFKKlsEYEP------------ 425 Naegleria grube...
XP_002676985 176 QEL-YY--LYk-DSHhl--------iDNIDV---------L-CN-Emnii--isqLSDHQKN--QFLKntkrrlnqrlns 228 Naegleria grube...
XP_002679780 313 RKY-HDllQTq-QHGti--------fDRIEIlksvs---------------hetlCEILEKPsnSFTK------------ 355 Naegleria grube...
XP_002672027 119 KSEeLE--FIshHFRy---------mENIRY---------F-FSeNf--------IAKLQAI--NADF------------ 155 Naegleria grube...
XP_002674575 280 PNItFGenESt-NYSkfmlslrnsdfDDLIY---------F-LDrR---------LNELYPPy-QYDP------------ 326 Naegleria grube...
4QJ3_A       195 -------------------------------------------------------------------------------T 195 house mouse
XP_002672578 227 ------------------------------------------------------------------------kfssaikD 234 Naegleria grube...
XP_002682016 244 -------------------------------------------------------------------------------S 244 Naegleria grube...
XP_002680492 219 -------------------------------------------------------------------------------L 219 Naegleria grube...
XP_002669059 142 -------------------------------------------------------------------------------N 142 Naegleria grube...
XP_002682131 426 -------------------------------------------------------------------------------S 426 Naegleria grube...
XP_002676985 229 tteivtsnslncnqlennlydqddeedgeeqqqqdaedlyqldnhinnimnskkkskkisifsskfksnfnssqqnnnnT 308 Naegleria grube...
XP_002679780 356 -------------------------------------------------------------------------------E 356 Naegleria grube...
XP_002672027 156 -------------------------------------------------------------------------------T 156 Naegleria grube...
XP_002674575 327 -------------------------------------------------------------------------------N 327 Naegleria grube...
4QJ3_A       196 Q------------------QDVLRVr-----VP--TTGIIEYPFDL--------Q-SVIFRMVDVGGQRSERRKWI--H- 238 house mouse
XP_002672578 235 D------------------SHIVTElivstyVK--TTGIIEIPVKF--------GdNNLIGLYDTGGQRNERKKWK--N- 283 Naegleria grube...
XP_002682016 245 D------------------KDLLISq-----RK--TTGVTHVEFAFn-------NgSTLVNIWDCGGQKNERKKWK--Y- 289 Naegleria grube...
XP_002680492 220 E------------------KDHIVFq-----KK--TTGIVESSFEYmns--fivHlSITFR-FDSGGQRNERKKWP--N- 268 Naegleria grube...
XP_002669059 143 F------------------DDFFFAs-----RK--TTGISPFKY----------VnNHKKAIIDTGGQRTERSKWNrlHn 187 Naegleria grube...
XP_002682131 427 V------------------EDIIGCr-----CK--TTGITCLDYDY--------L-GMPFRVYDVGGARTERKKYN--N- 469 Naegleria grube...
XP_002676985 309 SlnnennnennntshydkySPLIKFl---------TIGKNETKFQF--------DsKNLFTILDLGGRGAEKKKWE--F- 368 Naegleria grube...
XP_002679780 357 E------------------EELILRlffisrQK--LTGCSQFTLQL--------G-PHKLSFCLVAGQRAERKKYP---- 403 Naegleria grube...
XP_002672027 157 I------------------HDLLQTk-----IPhsKSSIYEFSF----------E---TSKLIDPSPQRNEKRKWI--S- 197 Naegleria grube...
XP_002674575 328 W------------------VDLLHRr-----QK--TVGFYHLNYVEdaiseegmReTRNYIFIDTAGQRSERKKWS--I- 379 Naegleria grube...
4QJ3_A       239 CFenv------tsIMFLVALSEYDQVLVES--DNENRMEESKALFRTIITYPWF-Q--NSS-VILFLNKKDLLEEKI--M 304 house mouse
XP_002672578 284 IMndnsq--tlsgVLFLVPLSEYNQICYED--DSINRTIESLNLFSELVNRNTF-G--SLP-FFLIFTKKLVMEEKL--- 352 Naegleria grube...
XP_002682016 290 MFtesqkltgkifVIYFVALSEYNQLCYED--ETTNRTHESLKIFESVANNPEY-E--NYP-LFLIFTKKDIFKQKL--R 361 Naegleria grube...
XP_002680492 269 MFsqp-----vdsVWFVGSLSDFTKMCYEN--NTLNRFEDSLAVFSDWIDSNTT-K--NIRdFRLILTHADELEEMHisP 338 Naegleria grube...
XP_002669059 188 TYsqk------lhIGFVISLSEFDELCYED--DITPRFNEGLSNFEEWYGSPLV-S--EHT-LYLIFSKFEVLEEKI--K 253 Naegleria grube...
XP_002682131 470 IYagl------tgVLYTTSLIDFRKTCYED--DFSNRMIESINLFEEQCNGPLK----YSP-IFLIFTKIDILSETIsdD 536 Naegleria grube...
XP_002676985 369 FLnetn----adfVLFFVSMSEFNQNLIES--DNINRLHESLTIYRDIINRALLrN--TKD-IILIFTKPDIFLHKM--E 437 Naegleria grube...
XP_002679780 404 RYmeqg----feyVIFCMNLSEYNRNLYEN--DTITRFRDTIYMAHEYCCQDCK-KygNMS-VIPVFTHLDQLMRQI--- 472 Naegleria grube...
XP_002672027 198 HFdnt-----mtrVIYLISLADY--NLTDSisG-ANCLWLALQNFSEFVNYSEY-I--PAD-VSIVFTKLDLFKEKL--E 263 Naegleria grube...
XP_002674575 380 CYpnt------ftLFYFVSLADINLTLYES--NVENRLLDSLHLFEHVCQEPDL-I--QTP-IVLFFTKTDILKRKIknG 447 Naegleria grube...
4QJ3_A       305 YS-HLVD--Yf------------------PEYD---------------GPQRD------AQAA-REFIL----KMFVDL- 336 house mouse
XP_002672578 353 ---KLYDltYv------------------PFKT---------------ELPQD------LKVE-LKLNEenkkDLLVNIl 389 Naegleria grube...
XP_002682016 362 YT-SLSV--Cfedcp----------edlkANEDttkikrdiinnwtgfLEDRQcvsdeiYEKS-FDFVK----RKFMERi 423 Naegleria grube...
XP_002680492 339 ETiSFLKsnLi------------------PH-----------------GNAKE------IIDG----IT----AKYQLL- 368 Naegleria grube...
XP_002669059 254 KGiSFSR--Fv------------------SEFK---------------GDETS------IESI-VEFIV----KKYLEL- 286 Naegleria grube...
XP_002682131 537 KS-LFDLf---------------------PDFN-----------------QYP------VPDQ-NNFFT----NTSSQLn 566 Naegleria grube...
XP_002676985 438 NNiEFKL----------------------PNIEglnipkmetirpellKLKDN------IKLE-INNLI----NLFENIh 484 Naegleria grube...
XP_002679780 473 ---------Yy-------------------------------------GNVPN------SANV---WIPm--cEEIAKLh 495 Naegleria grube...
XP_002672027 264 KY-PFSD--Yf------------------TEYT---------------G-PND------SETI-LTFLL----SQNTDL- 294 Naegleria grube...
XP_002674575 448 LK-PIEL--FekieklysqryeaativdmPPSSatndteknselslniSSGNQ------ANQVdAEF------NQFIEYi 512 Naegleria grube...
4QJ3_A       337 --Np------DSDK----IIYSH--FTC-ATDTENIRFvF-AAV-KDt---I 368 house mouse
XP_002672578 390 kmKnsqidnlTPREiqliDRFSS--DTR-YSPSQLLKIiGgDKT-------I 431 Naegleria gruberi strain NEG-M
XP_002682016 424 ---------sNADRrkqtEKNIK--VVN-AMDADDVRSnLvEELlEQt---M 460 Naegleria gruberi strain NEG-M
XP_002680492 369 ----------DKNN----RLTQV--SVInCTDTEQIRDyL-TTT-LNs---I 399 Naegleria gruberi strain NEG-M
XP_002669059 287 ----------DVKR----RVVKY--YVIsAFKTEQVYQmL-NEI-FEi---- 316 Naegleria gruberi strain NEG-M
XP_002682131 567 p--------nNNP-----QRYLL------DKEVQISQKvL-KTL-SFieskF 597 Naegleria gruberi strain NEG-M
XP_002676985 485 lnSf------NNI-----TFKYH--IVN-IINIKECQEfI-EILlRQt---I 518 Naegleria gruberi strain NEG-M
XP_002679780 496 nsRr-----sNVMD----FIFSS--LIP-VKEVLNKLKyF-AFI-VGy---P 530 Naegleria gruberi strain NEG-M
XP_002672027 295 ------------------TQFNIgnMLS-MNNIDNINYlA-QE--NEn---V 321 Naegleria gruberi strain NEG-M
XP_002674575 513 saKfkekllpTQTI----TIYT---LDC--TEPTQFKTtF-KEI-MQm---L 550 Naegleria gruberi strain NEG-M
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap