1WBD,5YK4,2O8B,1NNE


Conserved Protein Domain Family
MutS_V

?
pfam00488: MutS_V 
Click on image for an interactive view with Cn3D
MutS domain V
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain V of Thermus aquaticus MutS, which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.
Statistics
?
Aligned: 34 rows
Threshold Bit Score: 256.355
Threshold Setting Gi: 308153466
Created: 14-Mar-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1WBD_A  610 LIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSL 689  Escherichia coli
P40965  630 QIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARV-CNDSMELTSSNFGFEMKEMAYFLDDINTETL 708  Saccharomyces cerev...
O74502 1020 IVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECGPKSL 1099 Schizosaccharomyces...
P43248  663 FIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSL 742  fruit fly
P25847  684 LIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSL 763  Saccharomyces cerev...
O24617  662 QIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSL 741  thale cress
P43246  665 HIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSL 744  human
O84797  614 ILLTGPNMAGKSTYIRQIALLVIMAQMGSFIPARSAHIGIVDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSL 693  Chlamydia trachomat...
Q9SMV7  849 LLLTGPNMGGKSTLLRATCLAVIFAQLGCYVPCESCEISLVDTIFTRLGASDRIMTGESTFLVECTETASVLQNATQDSL 928  thale cress
2O8B_A  665 HIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSL 744  human
1WBD_A  690 VLMDEIGRGTSTYDGLSLAWACAENLA--NKIKALTLFATHYFELTQLPEKmeG-------VA--NVHLDAL-------- 750  Escherichia coli
P40965  709 LILDELGRGSSIADGFCVSLAVTEHLL--R-TEATVFLSTHFQDIPKIMSKkpA-------VS--HLHMDAV-------- 768  Saccharomyces cerev...
O74502 1100 VILDELGRGTSTYDGHAIAYAVLHHLV--SNIGCLGFFSTHYQSLCVDFMHhrQ-------VRlmQMAAAVD-------- 1162 Schizosaccharomyces...
P43248  743 VIIDELGRGTSTYEGCGIAWSIAEHLA--KETKCFTLFATHFHEITKLAETlsT-------VK--NCHMAAV-------- 803  fruit fly
P25847  764 IIVDELGRGTSTYDGFGLAWAIAEHIA--SKIGCFALFATHFHELTELSEKlpN-------VK--NMHVVAHieknl-ke 831  Saccharomyces cerev...
O24617  742 IIIDELGRGTSTYDGFGLAWAICEHLV--QVKRAPTLFATHFHELTALAQAnsEvsgntvgVA--NFHVSAHi------- 810  thale cress
P43246  745 IIIDELGRGTSTYDGFGLAWAISEYIA--TKIGAFCMFATHFHELTALANQipT-------VN--NLHVTAL-------- 805  human
O84797  694 VILDEIGRGTSTYDGLAIAQAVVEFLLftDGKKAKTLFATHYKELTELEMHcqH-------VE--NFHAMVK-------- 756  Chlamydia trachomat...
Q9SMV7  929 VILDELGRGTSTFDGYAIAYSVFRHLV--EKVQCRMLFATHYHPLTKEFAShpR-------VT--SKHMACAfksrsdyq 997  thale cress
2O8B_A  745 IIIDELGRGTSTYDGFGLAWAISEYIA--TKIGAFCMFATHFHELTALANQipT-------VN--NLHVTAL-------- 805  human
1WBD_A  751 --EHG-DTIAFMHSV-QDGAASKSYGLAVAALAGVPKEVIKRARQKLRELE 797  Escherichia coli
P40965  769 --LLNdNSVKMNYQLtQKSVAIENSGIRVVKKIFNPD-IIAEAYNIHSLLK 816  Saccharomyces cerevisiae S288C
O74502 1163 --EKI-RRVTFLYKL-EDGICPKSYGMNVASMAGLPEKVIDAAEEKASELE 1209 Schizosaccharomyces pombe 972h-
P43248  804 --ADA-DDFTLLYQV-RSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFE 850  fruit fly
P25847  832 qkHDD-EDITLLYKV-EPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELD 880  Saccharomyces cerevisiae S288C
O24617  811 -dTES-RKLTMLYKV-EPGACDQSFGIHVAEFANFPESVVALAREKAAELE 858  thale cress
P43246  806 --TTE-ETLTMLYQV-KKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852  human
O84797  757 --ENS-GQPIFMYEI-VKGHSKKSFGIHVAKLAGFPLSVVSRAQQILHQFE 803  Chlamydia trachomatis D/UW-3/CX
Q9SMV7  998 prGCD-QDLVFLYRL-TEGACPESYGLQVALMAGIPNQVVETASGAAQAMK 1046 thale cress
2O8B_A  806 --TTE-ETLTMLYQV-KKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852  human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap