4JND,4RA2,3NMN,2POP


Conserved Protein Domain Family
PP2C

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pfam00481: PP2C 
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Protein phosphatase 2C
Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.
Statistics
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PSSM-Id: 306885
View PSSM: pfam00481
Aligned: 28 rows
Threshold Bit Score: 156.352
Threshold Setting Gi: 151567884
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JND_A        166 IHVSGDQLKGQRHKQEDRFLAYPNGQYmd-----rgEDPISVLAVFDGHGGHECSQYAAGHLWe----TWLEVRKSRDPS 236
gi 49066025   108 YARRFPEGNYWKHKLSTFEKFYNKFIKncnskqellLMKEGDSAILGQNGGRMIFDKMGNIIDkiallTELDRLRLFYGF 187
gi 55584078   181 EDGKSIEKDLYFFGIFDGHGGPFTSEKl-------sKDLVRYVAYQLGQVYDQNKTVFHSDPN-----QLIDSAISKGFL 248
gi 19855052    92 DGHGGTECSEFLSTNLGKIIENQd-----------lNDTEKILKEVHSVGGYMAGLKPPFSLR-----TVLQSRDEDLLW 155
gi 586537      80 AVFDGHGGDDCSKFLSGGRHHRDGNGSsn------gNGEPNAGLIKWIAYSFENHHYTSTTNN-----DSSKFKRSFNTL 148
gi 117794    1032 SDISAGKNNRVLKFVYDNLASCLAHEIna------aDSSSEQICNALRRGFLRLNKKLGNVIH-------YDLRKSSEGD 1098
gi 1345878   1742 FGLFDGRGHGAHVGSRIAHHLAEWSg---------hRLSWEFQKHQNEMTAEPVSVPDALRRA------FLRLQKDYADA 1806
gi 1169151   1373 RDVTFERFRGNDDECLLCLHDSKNQNAdy-----ghNISRIVRDIYDKILIRQLERYGDETDDn----IKTALRFSFLQL 1443
gi 67476867  1568 FDLVVPRLGSVETDTLVALFDGK-ELStg-----gsKIAKFLYEEFSRLFILELEKVKGKPNEn----PADALRRTFLSV 1637
gi 389624677 1306 vDLVVPRFNASETETLLGLFDGQALSSgg------sKIAKYLHENFGQILATELRALKTGLKEt----PEDALRRAFLAL 1375
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JND_A        237 D--SLEDQLRKSLELldERMTVRSv--------kECWKGGSTAVCCAIDMDQk------lMALAWLGDSPGYVMSNIEFR 300
gi 49066025   188 ArfDLDQCCGLGTAAgsTASSIFLypyd---dpnAPIDEGKDDDSWIISHSGll-----kLIVTQVGDSKIILCDQDGIA 259
gi 55584078   249 K--LDNDLVIESFRKlfQDPNNTNia------ntLPAISGSCALLSLYNSTNs------iLKVAVTGDSRALICGLDNEG 314
gi 19855052   156 R-----ARLYYSFLQadMDYLTNYarps--pdsaVPGAVGTVAIITSKNNLSywesdsyiIHLAHVGDTRALLCDSRTGR 228
gi 586537     149 Eg-LVSQIFKDAFILq--DEELYRhf--------anSSCGSTAVVACIINEEs-------LYVANCGDSRCILSSKSNGI 210
gi 117794    1099 -----VDSNYVTTMN--ISEKGYSmd-------sSCLDIGVSIILVYVRDTR--------AFVANVGTSMAIMSTRNDSE 1156
gi 1345878   1807 LinDGSRKLSEAHAEaaADVTRSSapaiaaasnkHDWRAGASAILAYVVDHT--------LYIANAGDALAVMSRNGGTA 1878
gi 1169151   1444 N--KEINGMLNSVDN--GADVANls--------yADLLSGACSTVIYIRGKK--------LFAANLGDCMAILSKNNGDY 1503
gi 67476867  1638 N--KLLMSLSNSADEr-GLDSHPSrnyahtvltkEDLNSGCVATVAYLSELK--------LYVANVGDVQGMLIQANGSF 1706
gi 389624677 1376 N--KELVTIAIQHSEdrPSVPHRSgsqahvilnkEDLNSGGVATVVYLQGQD--------LYVANVGDAQAMIIQSDQTH 1445
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JND_A        301 -----QLTRGHSPSDEREARRVEEAGGQLFVig-gELRVNGV-LNLTRALGDVPGRP----------------------- 350
gi 49066025   260 h----ALTTTHHINSSRERHRLSIDPSRLDPdafgETRFLNN-FANTRSFGDVAGKPygissepd--------------- 319
gi 55584078   315 nwtvkSLSTDQTGDNLDEVRRIRKEHPGEPNvi-rNGRILGS-LQPSRAFGDYRYKIkevdgkplsdlpevaklyfrrep 392
gi 19855052   229 a---hRLTFQHHPADVEEARRLRRYNMGFSRd--sFGQKRFAwVANTRSFGDGYKLKk---------------------- 281
gi 586537     211 k----TMSFDHKPQHIGELIRINDNGGTVS-----LGRVGGV-LALSRAFSDFQFKRgvtyphrrtkltni---tqnlty 277
gi 117794    1157 p---tTLSVMHDVYNRDEIRRIVDSCGFIS------GEIKST---TTRAIGRLSQFP----------------------- 1201
gi 1345878   1879 h----LISNKHEPFDRAEIERIRSAEGWVSl----RGYVNDM-LDVSRSFGYFHLFP----------------------- 1926
gi 1169151   1504 q----TLTKQHLPTKREEYERIRISGGYVN-----NGKLDGV-VDVSRAVGFFDLLP----------------------- 1550
gi 67476867  1707 k----MLTKKHDPADPVERSRIRNAGGWVSR----NGRLNDV-LNVSRAFGYTELLP----------------------- 1754
gi 389624677 1446 k----MLTRKHDPAEPTERSRIREAGGWVSR----NGKLNDQ-LGVSRAFGYVDLMP----------------------- 1493
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JND_A        351 -------MISNEPETC--QVPIESS-DYLVLLACDGISDVFNERDLYQLVEAFANDypv--edYAELSRFICTKAIEAGS 418
gi 49066025   320 ifsflvgNTLHLPRSErsKLPFNGD-ECFLALVTDGITNKLADQEVVDLITSTVNSwglkkatPQFVAEETIKFIQAIAT 398
gi 55584078   393 rdfktppYVTAEPVIT--SAKIGEN-TKFMVMGSDGLFELLTNEEIASLVIRWMDKn-------MNLAPVKAEPGKLPKV 462
gi 19855052   282 ------lGVVAEPQLT--SIHSLRDdWSFLTLLSDGITDVVSDDEVVDIIKLSES--------PQDAANNIIRYAQNVGA 345
gi 586537     278 gtppqeaQVTVEPDVL--MHKIDYSkDEFLVLACDGIWDIYNNKQLIHFIKYHLVSgt----kLDTIITKLLDHGIAQAN 351
gi 117794    1202 -------GVQAVPYVN--VQYLSEL-NEFIILANQEFWSVLSKRTVIDVVRANRHS-------PLLASTKLRDYAIAYGA 1264
gi 1345878   1927 -------IVNAAPAVT--TVQLTDS-DEFVIIANRTLWQYVSYQTAVDIARTQRND-------PMIAAQKLRDFAISYGA 1989
gi 1169151   1551 -------HIHASPDIS--VVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTD-------PLRAAAELKDHAMAYGC 1613
gi 67476867  1755 -------AVQAAPDIT--EHTIDDK-DETVLIASKELWEHLRPELIVDVARECRSD-------LMKASQKLRDLAIAYGS 1817
gi 389624677 1494 -------AVQAAPHVS--HVAIREQ-DEMILLATSELWEHLAPELIVDIARQERGD-------LMRATQKLRDLAIAYGS 1556

                  ....
4JND_A        419 ADNV 422
gi 49066025   399 KHSD 402
gi 55584078   463 IDVS 466
gi 19855052   346 VDDI 349
gi 586537     352 SNTG 355
gi 117794    1265 EKNV 1268
gi 1345878   1990 EESI 1993
gi 1169151   1614 TENI 1617
gi 67476867  1818 TNKL 1821
gi 389624677 1557 TNKI 1560
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