3JBZ,4BFR,5O83,4ANV


Conserved Protein Domain Family
PI3_PI4_kinase

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pfam00454: PI3_PI4_kinase 
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Phosphatidylinositol 3- and 4-kinase
Some members of this family probably do not have lipid kinase activity and are protein kinases.
Statistics
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Aligned: 45 rows
Threshold Bit Score: 135.918
Threshold Setting Gi: 75213215
Created: 22-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3JBZ_A    797 EFVFLLKgHEDLRQderVMQLFGLVNTLLANDPTSLRKnlsIQRYAVIPLSTNSGL-IGWVPHCDTLHALIRDYREk--- 872  human
Q99M64    132 GSSGSYFvKDSQGR---IIAVFKPKNEEPYGNLNPKWTkwlQKLCCPCCFGRDCLV-LNQGYLSEAGASLVDQKLEl--- 204  Norway rat
Q9SXC6    369 dmlpqyerrNDMRQ-------------VLDRDRRQRCL---FKRFSDEDRARNEAI-AYLLDHPEDGHRSQSEQIYgf-- 429  thale cress
Q9SGW8    243 gTGGTYLmQDSSGLn--yVSVFKPMDEEPMAVNNPQ-----QLPVSSDGQGLKRGTrVGEGATREVAAYLLDHPKSglrs 315  thale cress
Q9FNF8    266 GSGGAYFmQDPSGHk--yVSVFKPIDEEPMAVNNPH-----GQPVSVDGEGLKKGTqVGEGAIREVAAYILDYPMTgprt 338  thale cress
Q9ZPY9    264 GTGGAYFmQGPSGNk--FVGVFKPIDEEPMAENNPQ-----GLPLSPNGEGLKKGTkVGEGALREVAAYILDHPKSgnks 336  thale cress
Q9C671    171 GLGGAYYfKNSRGEs---VAIVKPTDEEPYAPNNPKG----FVGKALGQPGLKRSVrVGETGYREVAAYLLDKEHFa--- 240  thale cress
O22199    130 GMGGAYLlQTGKGHn---IAVAKPVDEEPLAFNNPKK----SGNLMLGQPGMKHSIpVGETGIRELAAYLLDYQGFs--- 199  thale cress
Q8CBQ5    117 GSSGSYFvKDSKRN---IIGVFKPKSEEPYGQLNPKWTkyvHKVCCPCCFGRGCLL-PNQGYLSEAGAYLVDVKLNl--- 189  house mouse
BAS71504  164 GIGGALLlEDGRSVd--hVAVIKPL----------------LDDASSPSHGGGGGY-ASKAVLREVAAFLLDHDGFa--- 221  Japanese rice
3JBZ_A    873 ---------KkILLNIEHRIml----------rMAPDYDHLTLMqkv--evFEHAVNNTAGDDLAKLLWLKSPSS----E 927  human
Q99M64    205 ---------N-IVPRTKVVYlasetfnysaidrVKSRGKRLALEkvpkvgqRFNRIGLPPKVGSFQLFVEGYKDA----D 270  Norway rat
Q9SXC6    430 --------sR-VRRAVWVRC----------------------------------RIKNQMKMGVLIEFLESSVTVqslgT 466  thale cress
Q9SGW8    316 vskevmgfaG-VPPTAMVRSs-----------hKVYNYPNG----------FSSCATKDAKVGSLQMFMKNNGSC----E 369  thale cress
Q9FNF8    339 fphdqtgfaG-VPPTTMVKCl-----------hKDFNHPN-----------GYSFSPENTKIGSLQMFVSNVGSC----E 391  thale cress
Q9ZPY9    337 mfgeeigfaG-VPPTAMIECl-----------hPGFNHPKGI----------------KTKIGSLQMFTENDGSC----E 384  thale cress
Q9C671    241 ---------N-VPPTALVKIt-----------hSIFNVNDGVKAs------KPMEKMLVSKIASLQQFIPHDYDA----S 289  thale cress
O22199    200 ---------G-VPPTALVSIs-----------hVPFHVSD-----------AFSFSSMPYKVASLQRFVGHDFDA----G 243  thale cress
Q8CBQ5    190 ---------G-IVPKTKVVWlvsetfnysaidrAKSRGKKYALEkvpkvgrKFHRIGLPPKVGSFQLFVKDYKEA----E 255  house mouse
BAS71504  222 ---------R-VEPTALIKI---------------------------------SRPAMPTTTASIQRFAAHECDA----G 254  Japanese rice
3JBZ_A    928 VWFDR----------RTNY-TRSLAVMSMVGYILGLGDRHPSNLML--------D--RLSG-------------KILHID 973  human
Q99M64    271 YWLRRfeaeplpentNRQL-LLQFERLVVLDYIIRNTDRGNDNWLIkyd--ypmD--NPNCrdtdwvmvrepviKVAAID 345  Norway rat
Q9SXC6    467 VYSEL----------PDDVgAEEIHKIVVLDIRFGNIDRNLGNLLV--------QaePRNGsa----------aHLVPID 518  thale cress
Q9SGW8    370 DIG------------PGAFpVEEVHKICVFDIRMANADRHAGNILTg-------K--SEEGk-----------tLLIPID 417  thale cress
Q9FNF8    392 DMG------------YRVFpVDQVHKISVLDIRLANADRHAGNILV-----------SRDGkdg--------qmVLTPID 440  thale cress
Q9ZPY9    385 DMG------------PLSFpVEEVHKISVLDIRLANADRHGGNILM-----------TKDEsg---------klVLVPID 432  thale cress
Q9C671    290 EHG------------TSNFpVSAVHRIGILDIRILNTDRHSGNLLV--------K--KLDGdgmf------gqvELVPID 341  thale cress
O22199    244 ELG------------PGSFtATSVHRIGILDVRLLNLDRHAGNMLVkrc--dkkEayNRLGt-----------aELVPID 298  thale cress
Q8CBQ5    256 YWLRRfeaeplpeniRKQF-QSQFEKLVILDYIIRNTDRGNDNWLVkydemkyaK--KIESeesnwidnkqlliKIAAID 332  house mouse
BAS71504  255 ELG------------PSRFsVASVHRIGSLDVRLLNIDRHAGNILVkk----spEseCASGgstl------tplDLVPID 312  Japanese rice
3JBZ_A    974 FgDCF----EVAMTREKF------P-EKIPF-RLTRMLTNAMevTGLDGNYRITCHTVMEVLREHKDSVMAVLEA--FVY 1039 human
Q99M64    346 NgLAFplkhPDSWRAYPFywa-wlPqAKVPFsQEIKDLILPK--ISDPNFVKDLEEDLYELFKKDPGFDRGQFHKqiAVM 422  Norway rat
Q9SXC6    519 HeLSFfn-dAHPYITCGAcwikwlEqIDKDFsSQLVNYVAALdpDRDLEFLRHCGWEPNQRYIENFTVFATFLKK--AVS 595  thale cress
Q9SGW8    418 HgYCL----PENFEDCTFewl-ywPqAKLPFsADTIDYINSLdsEQDIALLQLHGWNVPEAVSRTLRISTMLLKK--GVE 490  thale cress
Q9FNF8    441 HgYCF----PNKFEDCTFewl-ywPqAKEPYsSETLEYIKSLdpEKDIELLRFHGWEIPPSCTRVLRISTMLLKK--GSA 513  thale cress
Q9ZPY9    433 HgYCL----PESFEDCTFewl-ywPqARKPYsAETQEYIRSLdaEEDIDLLKFHGWKMPAETAQTLRISTMLLKK--GVE 505  thale cress
Q9C671    342 HgLCL----PETLEDPYFewi-hwPqASIPFsEDELKYIANLdpLGDCEMLRRELPMVREASLRVLVLCTIFLKE--AAA 414  thale cress
O22199    299 HgLCL----PECLDDPYFewl-nwPqALVPFsDTELDYISNLdpFKDAELLRTELHSLPESAIRVLVVCTVFLKQ--AAA 371  thale cress
Q8CBQ5    333 NgLAFpfkhPDEWRAYPFhwa-wlPqAKVPFsEETRNLILPY--ISDMNFVQDLCEDLYELFKTDKGFDRAAFENqmSVM 409  house mouse
BAS71504  313 HgLCL----PEQLDDPYFewl-hwPqSSLPFsGAELEYVASLdpFRDAAMLRAELPSLTEAAIRILTLCTIFLQR--AAA 385  Japanese rice
3JBZ_A   1040 DPLLNWRL 1047 human
Q99M64    423 RGQILNLT 430  Norway rat
Q9SXC6    596 QGLTALQI 603  thale cress
Q9SGW8    491 RNLTPYQI 498  thale cress
Q9FNF8    514 KGLTPFTI 521  thale cress
Q9ZPY9    506 RGLTAFEI 513  thale cress
Q9C671    415 NGLCLAEI 422  thale cress
O22199    372 AGLCLAEI 379  thale cress
Q8CBQ5    410 RGQILNLT 417  house mouse
BAS71504  386 AGLCLADI 393  Japanese rice
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