3L54,4JSV


Conserved Protein Domain Family
PI3_PI4_kinase

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pfam00454: PI3_PI4_kinase 
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Phosphatidylinositol 3- and 4-kinase
Some members of this family probably do not have lipid kinase activity and are protein kinases.
Statistics
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PSSM-Id: 306869
View PSSM: pfam00454
Aligned: 41 rows
Threshold Bit Score: 133.219
Threshold Setting Gi: 75213215
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L54_A        685 TIGIIFKhGDDLRQdmlILQILRIMESIWETESLDLC----LLPYGCISTGDKIGM-IEIVKDATTIAKIQQS------- 752
gi 1176483    170 GSSGSYFvYGTRADesvPVGVFKPKDEEPYGPFSPKWtkwaHRTFFPCLFGRSCLI-PNLGYICESAASLLDRrlet--- 245
gi 81867826   132 GSSGSYFvKDSQGR---IIAVFKPKNEEPYGNLNPKWtkwlQKLCCPCCFGRDCLV-LNQGYLSEAGASLVDQkl----- 202
gi 75213215   369 dmlpqyerrNDMRQ-------------VLDRDRRQRCl---FKRFSDEDRARNEAI-AYLLDHPEDGHRSQSEqiy---- 427
gi 544604243  243 gTGGTYLmQDSSGLn--yVSVFKPMDEEPMAVNNPQ-----QLPVSSDGQGLKRGTrVGEGATREVAAYLLDHpksglrs 315
gi 75171843   266 GSGGAYFmQDPSGHk--yVSVFKPIDEEPMAVNNPH-----GQPVSVDGEGLKKGTqVGEGAIREVAAYILDYpmtgprt 338
gi 75216127   264 GTGGAYFmQGPSGNk--FVGVFKPIDEEPMAENNPQ-----GLPLSPNGEGLKKGTkVGEGALREVAAYILDHpksgnks 336
gi 75169053   171 GLGGAYYfKNSRGEs---VAIVKPTDEEPYAPNNPKG----FVGKALGQPGLKRSVrVGETGYREVAAYLLDKeh----- 238
gi 75097366   130 GMGGAYLlQTGKGHn---IAVAKPVDEEPLAFNNPKK----SGNLMLGQPGMKHSIpVGETGIRELAAYLLDYqg----- 197
gi 1011107804 161 GTGGTYLlYNAKKK---ICSVFKPLDEEAFAPFNPR-----GYEGKMYQEGFRAGVlSGEGASREIAAYLLDNcyn---- 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L54_A        753 ---------TVGNTGAFKD--------------------------------------------------EVLNHWLKEKS 773
gi 1176483    246 ------hlvPYTDTASIESfnfydnrkkwvlgynlqkkkqkklgsfqlflkeyinadeffhkyplpgmySDVKHSFHRKS 319
gi 81867826   203 -------elNIVPRTKVVYlasetfnysaidrvksrgkrl---------alekvpkvgqrfnriglppkVGSFQLFVEGY 266
gi 75213215   428 ------gfsRVRRAVWVRCrikn-------------------------------------------qmkMGVLIEFLESS 458
gi 544604243  316 vskevmgfaGVPPTAMVRSshkvynypng------------------------------fsscatkdakVGSLQMFMKNN 365
gi 75171843   339 fphdqtgfaGVPPTTMVKClhkdfnhpng-------------------------------ysfspentkIGSLQMFVSNV 387
gi 75216127   337 mfgeeigfaGVPPTAMIEClhpgfnh------------------------------------pkgiktkIGSLQMFTEND 380
gi 75169053   239 -------faNVPPTALVKIthsifnvndgvk--------------------------askpmekmlvskIASLQQFIPHD 285
gi 75097366   198 -------fsGVPPTALVSIshvpfhvsda-------------------------------fsfssmpykVASLQRFVGHD 239
gi 1011107804 229 ------nfsNVPCTIMVEAcnphfnnksklk---------------------------yvdketnlkwkCGSLQEFIDSR 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L54_A        774 PTE----E------------------------------------KFQAA----------VERF-VYSCAGYCVATFVLGI 802
gi 1176483    320 SGE----DinhkpettrnltdetepskqinsspisteseenskfEWTESs---------LSQF-RLELEKLIILDYIMRN 385
gi 81867826   267 KDA----D------------------------------------YWLRRfeaeplpentNRQL-LLQFERLVVLDYIIRN 305
gi 75213215   459 VTVqslgT------------------------------------VYSEL----------PDDVgAEEIHKIVVLDIRFGN 492
gi 544604243  366 GSC----E------------------------------------DIG------------PGAFpVEEVHKICVFDIRMAN 393
gi 75171843   388 GSC----E------------------------------------DMG------------YRVFpVDQVHKISVLDIRLAN 415
gi 75216127   381 GSC----E------------------------------------DMG------------PLSFpVEEVHKISVLDIRLAN 408
gi 75169053   286 YDA----S------------------------------------EHG------------TSNFpVSAVHRIGILDIRILN 313
gi 75097366   240 FDA----G------------------------------------ELG------------PGSFtATSVHRIGILDVRLLN 267
gi 1011107804 276 ESV----G------------------------------------NYD------------YKQFsIRDIHKIAILDIRVMN 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L54_A        803 GDRHNDNIMI---------TETG-----------------------------------NLFHIDFgHIL----GNYKSFL 834
gi 1176483    386 TDRGLDNWMVkl------iKLSNnkw------------------------------rlKLAAIDNgLSFpwkhPDEWRLY 429
gi 81867826   306 TDRGNDNWLIkydy--pmdNPNCrdtdwvm----------------------vrepviKVAAIDNgLAFplkhPDSWRAY 361
gi 75213215   493 IDRNLGNLLVqa------ePRNGsa--------------------------------aHLVPIDHeLSFfn-dAHPYITC 533
gi 544604243  394 ADRHAGNILTg-------kSEEGk---------------------------------tLLIPIDHgYCL----PENFEDC 429
gi 75171843   416 ADRHAGNILV---------SRDGkdg------------------------------qmVLTPIDHgYCF----PNKFEDC 452
gi 75216127   409 ADRHGGNILM---------TKDEsg-------------------------------klVLVPIDHgYCL----PESFEDC 444
gi 75169053   314 TDRHSGNLLVk--------KLDGdgmf----------------------------gqvELVPIDHgLCL----PETLEDP 353
gi 75097366   268 LDRHAGNMLVkrcdkkeayNRLGt---------------------------------aELVPIDHgLCL----PECLDDP 310
gi 1011107804 304 LDRNDGNILVsp------lKTLKdscnqfvyrnnkftssnnedmlkriitidkkpsryTLIPIDHgLIL----PHIMDVA 373
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3L54_A        835 GI-------NkERV--PF-VLTPDFLFVMgtsgkktSPHFQKFQDVCVKAYLALRHHTNLLIILFSM--MLMTGMPQLTS 902
gi 1176483    430 PYgwl--ylPlQLLakPFsEQMRSHFLPI-------LTSTNWWEESYQEFLALFSRDQDFNVRMWKKqwAVLKGQAFNVV 500
gi 81867826   362 PFywa--wlPqAKV--PFsQEIKDLILPK-------ISDPNFVKDLEEDLYELFKKDPGFDRGQFHKqiAVMRGQILNLT 430
gi 75213215   534 GAcwi-kwlEqIDK--DFsSQLVNYVAALd-----pDRDLEFLRHCGWEPNQRYIENFTVFATFLKK--AVSQGLTALQI 603
gi 544604243  430 TFewl--ywPqAKL--PFsADTIDYINSLd-----sEQDIALLQLHGWNVPEAVSRTLRISTMLLKK--GVERNLTPYQI 498
gi 75171843   453 TFewl--ywPqAKE--PYsSETLEYIKSLd-----pEKDIELLRFHGWEIPPSCTRVLRISTMLLKK--GSAKGLTPFTI 521
gi 75216127   445 TFewl--ywPqARK--PYsAETQEYIRSLd-----aEEDIDLLKFHGWKMPAETAQTLRISTMLLKK--GVERGLTAFEI 513
gi 75169053   354 YFewi--hwPqASI--PFsEDELKYIANLd-----pLGDCEMLRRELPMVREASLRVLVLCTIFLKE--AAANGLCLAEI 422
gi 75097366   311 YFewl--nwPqALV--PFsDTELDYISNLd-----pFKDAELLRTELHSLPESAIRVLVVCTVFLKQ--AAAAGLCLAEI 379
gi 1011107804 374 EIdlvwfewPqIKI--PLdDEELEVVFSFd-----pDKDAEKVRNKL-LIREDCIRTMRVCTRLLQI--GAKMHLTLYEI 443
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