Conserved Protein Domain Family
FERM_M

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pfam00373: FERM_M 
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FERM central domain
This domain is the central structural domain of the FERM domain.
Statistics
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PSSM-Id: 306805
View PSSM: pfam00373
Aligned: 59 rows
Threshold Bit Score: 55.3325
Threshold Setting Gi: 158299868
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DXA_B        107 Q-IEDPLAILILFDEARYNLLKGFY--------T--AP--DAKLITLASL--LLQIVYGNY-E----------------- 153
gi 118582027  273 LlRRDPAAFEYLYIQSRNDVIRERF--------G--MDpkPEMLLGLAAL--HIYITVSATrPs---------------- 324
gi 158705786  272 LlKEDPVAFEYLYLQSCSDVLQERF--------A--VEmkCNSALRLAAL--HIQERIYACaQp---------------- 323
gi 75098088   386 EaVTEPMFVQLSYVQLQHDYIMGNY--------P--VG--KDDAAQMSALqiLVDIGYVDGpE----------------- 436
gi 122102927  106 E-VQCASTAKLFFFDIHNQLARHEL--------L--VT--SEDYFELVAI--LVSVFVPDCq------------------ 152
gi 122108290 2334 R-YDNAAYIDSMFDQVIDDYLRGSListnslgqLtaAT--TEEIIKLAAY--LFLLLPDNPk------------------ 2390
gi 122109776 1898 EdPNGDVIFS--YPQELHKYLKGYY--------P--ID--CEQASQLAGL--VYSADQ---------------------- 1939
gi 341940986 1899 KdVNADTILH--YHQELPKYLRGFH--------K--CS--REDAIHLGGL--ICKIQFGSDsS----------------- 1945
gi 754348972 1925 EwKRGGFLAEIMYYQVLDRYLKGHH--------K--VD--VDQVAKLAAL--QYRVENHDMqAfmsnvcsvcnnpaskrc 1990
gi 742079276   26 LlRRDPVAFEYLYVQSCNDVVQERF--------G--PElkYDIALRLAAL--QMYIATVTTkQt---------------- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DXA_B        154 ---------------------------SKKHKQGFLneeN-----LKSIVPVTKL-----KSKAPH-WTnRI---LHEYK 192
gi 118582027  325 ---------------------------QKISLKNVE---Kew--gLEPFLPPSLLq----VIKEKN-LRkSLsqqLKAHQ 367
gi 158705786  324 ---------------------------QKISLKYIE---Kdw--gIENFISPTLLr----NMKGKD-IKkAIsfhMKRNQ 366
gi 75098088   437 ---------------------------SCTDWTSL----------LERFLPRQIAm----TRAKRE-WElDI---LSRYK 471
gi 122102927  153 ---------------------------EHTTAEA-----------ISRIMPMSHPpyillKTDQSE-VErRV---FEKFR 190
gi 122108290 2391 ----------------------------GLNAKT-----------LPQIVPKSVIe---pKHRHQEeMVtRIsrqLKMFG 2428
gi 122109776 1940 --------------------------------EVSL---QrlpevLPRLVPEDLIp----LQTVAD-WRqQI---LPRIH 1976
gi 341940986 1946 ---------------------------QLASVSKV----------LKELVPQNLTr----LMSSEE-WKkSL---LLECD 1980
gi 754348972 1991 sgcklasycsrecqqkdwnvhqhvcghEKLQAGIQW---R-----WGKYIPRELRt----FMRQDE-WEtRV---FAQNK 2054
gi 742079276   78 ---------------------------QKISLKYIE---Kew--gLETFLPSAVLq----SMKEKN-IKkALshlVKANQ 120
                         170       180       190
                  ....*....|....*....|....*....|....*
4DXA_B        193 NLSTseg-vsKEMHHLQRMFLQNCWEIPTYGAAFF 226
gi 118582027  368 THPScg--tkGSAIQAKLQYLRILNELPTFTGVLF 400
gi 158705786  367 NLLEprqkqlISAAQLRLNYLQILGELKTYGGKVF 401
gi 75098088   472 LMEN------LTKDDAKQQFLRILRTLPYGNSVFF 500
gi 122102927  191 YYRR------LPVGTGMISFIKLAEKSESYGYRMY 219
gi 122108290 2429 GR--------MRPAEAKSHFLELLSTWPTFGVLHY 2455
gi 122109776 1977 HE-Q------LTEDQAKLLFLQALSQQQCFGSTFF 2004
gi 341940986 1981 KNKR------KTVAEAKVEFLKYMYRWPTFGSAFF 2009
gi 754348972 2055 YIKD------MDHEAAMQHFLTEVMAWPHIATNVY 2083
gi 742079276  121 NLVPpg--kkLSALQAKVHYLKFLSDLRLYGGRVF 153
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