1DQ8,3QAE


Conserved Protein Domain Family
HMG-CoA_red

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pfam00368: HMG-CoA_red 
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Hydroxymethylglutaryl-coenzyme A reductase
The HMG-CoA reductases catalyze the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels.
Statistics
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PSSM-Id: 334039
View PSSM: pfam00368
Aligned: 275 rows
Threshold Bit Score: 235.784
Threshold Setting Gi: 339284271
Created: 15-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DQ8_A        70 GVSIRRQLLSK-----KLSEpsSLQYlp--yR-DYNySLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCL 141 human
WP_014799497  11 SKEEKIKWIAQql-gdSSDE--LLEQfssfwhndphqQRVFDEFSENTLTNYYMPFGVVPNVILNGETLAVPMTIEESSV 87  Flexibacter lit...
WP_013687959  26 PEKTMETFK-------SFDH--REAAv----------QEVINEFSENTISNFHLPYSIAPNFLINGKTFAVPMVIEESSV 86  Fluviicola taff...
WP_013869203  27 NSTTAKDTITQ-----YFNS--NQKL-----------QQLHDEFIENTISNYYLPLGVAPNFVINGKTYAIPMAIEESSV 88  Lacinutrix sp. ...
WP_013306347  27 NSIETKNILKR-----YWNR--EKEV-----------QKLHDEFIENTISNYYLPLGIAPNFLIDGQLMAIPMAIEESSV 88  Maribacter sp. ...
WP_013597890  28 GEKKAIETLKQ-----YWNT--DEAL-----------QQLHDEFSENTVSNFYMPFGLAPNFLVNNRLYTIPMAIEESSV 89  Weeksella
WP_024269203 453 NIHRRRRMLANdpvlnLDRE--AVNAg---gH-SDSmLDLADVMVESAVGFMPVPMGIAKGFLIDGRLHHLPLSVEEPSV 526 Spirochaeta sp....
WP_013182187  10 TPVQRRDALKA-----LYLI--DDDElqllaN-QTDlTELSDILVESSIGTFPIPLGIATGFLVDRCLKFIPMATEEPSV 81  Waddlia chondro...
XP_001321843  13 SIQERQEIIKNmf--nLTDE--EIATiqtsdH-SLT-LVKADTMIENCVAMHSTPIGVATNFIVDGKEILVPMANEEPSV 86  Trichomonas vag...
XP_001329920  12 SIEERQAALKSmf--nLTDE--EVALlksteH-GLT-FNAADTMIENLIAMHSTPVGVATNFIVDGKEIMIPMALEEPSV 85  Trichomonas vag...
1DQ8_A       142 VASTNRGCRAIGLGGGASSRVLADgMTRGPVVRLp-------rACDSAEVKAWL--ETSEGFAVIKEAFDST-----SRF 207 human
WP_014799497  88 VAAASKAAKFWQSRGGFHSEIIST-KKIGQVHFLw--------KGDYNKMYCIFd-EAKEQMLKDTADITKNm---rQRG 154 Flexibacter lit...
WP_013687959  87 VAAASNSAKFWYSLGGFHTEIVDT-EKVGQVHFLw--------HDDIEKLTNRFd-ELKQIFLNGSEDITVNm---rNRG 153 Fluviicola taff...
WP_013869203  89 VAAASKAAKFWMERGGFKTTVISTtKIGQVHFMY---------SGEEKMLQAFFn-TVKPKLIADTKSITANm---eKRG 155 Lacinutrix sp. ...
WP_013306347  89 VAGASKAAKFWLDHGGFSTKVLGTeKIGQVHFIF---------KGNPKKLELFF----NHILPILLEEAKPLtknmeKRG 155 Maribacter sp. ...
WP_013597890  90 VAAASKAAKFWLNRGGFKTEVLSTtKLGHVHFMF---------TGNKEKLTSFFekHLREKLIEETNEITHNm---rARG 157 Weeksella
WP_024269203 527 IAAASYAAGIIARNGGF-ETSADEpLMSAYIYLDissrsgdpsPEAIRSALKSV----KDEEQRLKDLLSPVlesmtRRG 601 Spirochaeta sp....
WP_013182187  82 IAAASYAAHLIKAGEGF-TTWADSpVMTTQIFLK-----------EAKHLSLQT---CKEKIGSHVNAIIPRm---vQRG 143 Waddlia chondro...
XP_001321843  87 IAGASLAAKLARGGGGF-KTNSGRnICKGQVIVIp-------pSTEEDPISKVM--EIKDQIISISNSTMPSm---vERT 153 Trichomonas vag...
XP_001329920  86 IAGASLAAKLCRSTGGF-TTASGVnICSGQVVLIv-------pEGETGALSKVS--ELRNEIINIANGTMPSm---vARN 152 Trichomonas vag...
1DQ8_A       208 ARLQKLHT-SIA---GRNLYIRFQSRSGDAMGMNMISKGTEKALSKLH-EY--FP------------E------MQILAV 262 human
WP_014799497 155 GGILDIELlDMChldDNYYQIKATFDTCDSMGANFINSCLEQFAKTLQ-NW--IAsneift-deerdI------TIIMCI 224 Flexibacter lit...
WP_013687959 154 GGIKDIILkDLSdkePGLMQLFVTFETIDSMGANFVNSCLERFAGLFR-SW--HQnqpdf---kkdgL------EIIMSI 221 Fluviicola taff...
WP_013869203 156 GGILDIELrTKTndlDNYYQIHATFETLDAMGANFINSCLEQFAKTFK-AE--AE------------IqldndiDIVMSI 220 Lacinutrix sp. ...
WP_013306347 156 GGITKIELrDKTaelENYYQLHCTFETLDAMGANFINSCLEQFALTFKtKAlvFDq----------fEehekkiEIVMSI 225 Maribacter sp. ...
WP_013597890 158 GGIMSIELvDKTdelEDYFQLKASFETVDSMGANFINSCLEQFAKTME-NE--MAmateftaeekdsL------QVVMCI 228 Weeksella
WP_024269203 602 GGYRSMEAsWLEe--SRTLRVELTLDVRDAMGANILNTAAETISPLLE-EI--TG------------G------EKLMAI 658 Spirochaeta sp....
WP_013182187 144 GGFRGVSTeRKE----DTLLVSIDVDVCDAMGANVMNTVAEGMKDYLS-NL--FE------------G------RVLMSI 198 Waddlia chondro...
XP_001321843 154 GGTQDATArIVNtatNRILVVELHIDVGDAMGANCVNHACEVVEQYIS-EH--LH------------Y------IPLMGI 212 Trichomonas vag...
XP_001329920 153 GGVHDVDYrLIQtrsGLTLSVDIHINVCDAMGANCVNTACEAVLKYLS-EK--LD------------W------EPLMAI 211 Trichomonas vag...
1DQ8_A       263 SGNYCTDKKPAA-----INWIEGRGKs--vVCEAVIPAKVVREVLKTTTEAMIEVNINknlvGSAMAGSiggynahaANI 335 human
WP_014799497 225 LSNYTPECLVKT-----WVECPIEDLg---IVDGLDAQTFALKFFKAIEIAKNDVYRA----TTHNKGI--------FNG 284 Flexibacter lit...
WP_013687959 222 LSNLTPNCVV-------KCWVETDVKnldgIVSGISGKEFAKKFHTAVRIAQVDPYRA----TTHNKGI--------YNG 282 Fluviicola taff...
WP_013869203 221 LSNYVPECLVRA-----EVSCKIEALa---DKGID-PETFANKFAQAVTIAEVEPYRA----VTHNKGI--------MNG 279 Lacinutrix sp. ...
WP_013306347 226 LSNYVPNCLVRA-----SVSCPVDELk--vNSTIE-SQDFAEKFVRAIQIANVEPHRA----VTHNKGI--------MNG 285 Maribacter sp. ...
WP_013597890 229 LSNYTPDCIVRA-----EVSCAVEEL----KDGNVLAEEFVEKFTRAVRIAEIEPYRA----TTHNKGI--------MNG 287 Weeksella
WP_024269203 659 LSNDAVKRRAKA-----RFAIPFTAL----SRGKYSGRELAERIVKLYEIADEDPSRA----VTHNKGI--------MNG 717 Spirochaeta sp....
WP_013182187 199 LTNASSKRKAGAsfkvpVKLFRKGGL---------SGLEACQRIVEANQTAQLFPERA----VTHNKGV--------MNG 257 Waddlia chondro...
XP_001321843 213 LTNLASERIIHA-----EAHWPIKSL----STKDFDGMSVARRIIMAADVAASDLARG----ATHRKGI--------MNG 271 Trichomonas vag...
XP_001329920 212 LSNLPLKRIIHA-----ECKWPIKLL----AQGGFTGMQVAQRIVAAADFAAADPARA----STHRKGI--------MNG 270 Trichomonas vag...
1DQ8_A       336 VTAIYIACGQDAAQNVGSSNCITL-------MEASgptNEd---LYISCTMPsIEIGTVGGGTNLLPQQACL-QMLGVQG 404 human
WP_014799497 285 IDAVVLATGNDFRAIEACGHAYAArsgqyrsLSDCsieNGi---FKFWLEMP-IAVGTVGGLTSLHPLSKRSlEMLGNPS 360 Flexibacter lit...
WP_013687959 283 VDAVVLATGNDFRAVEACGHAYASingsyssLTNCtieNDi---FRFELTLP-IALGVVGGLTNLHPLVKLShELLDFPN 358 Fluviicola taff...
WP_013869203 280 IDAVVLATGNDFRAVEAGVHAYASkngkytsLTHAkieDGi---FSFWIEIP-LALGTVGGLTSLHPLVKVAlNILGNPT 355 Lacinutrix sp. ...
WP_013306347 286 IDAVVLATGNDFRAVEAGVHAYAAknssyksLTHAsiiDGi---FSFWIEIP-LALGTVGGLTNLHPLVKLAlEILQRPS 361 Maribacter sp. ...
WP_013597890 288 CDAVVIATGNDFRAVEACAHTYAAkdgkyssLTHCevkDGi---FRFWIDLP-IAVGTIGGLTSLHPLVKLAlDILGKPN 363 Weeksella
WP_024269203 718 ISSLALATANDTRATEAAAHAWAArsgryrsLSVFrieGDr---LVGELELP-LALGTVGGGISFHPAARFAlDILGKPD 793 Spirochaeta sp....
WP_013182187 258 ISALALATGNDTRAIESAAHFYAQktgqylpLTTYeisDNs---LKGNIELP-LALGTVGGTTSFWPASRFAlKLLSCPD 333 Waddlia chondro...
XP_001321843 272 ITAVVLATGNDTRAVEAAVHSYASsse-npaLTKYyieNDc---LVGEIDVP-LPVGVVGGSMRRDPANPIIkKMLRVES 346 Trichomonas vag...
XP_001329920 271 VTAVVLATGNDTRAVEAAVHSYATqse-npaLTKYr--IDngtnLVGEIWLP-IPVGVVGGSIRRNPDVMLMrKMLKADN 346 Trichomonas vag...
1DQ8_A       405 AckdnpgEnarQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNR 450 human
WP_014799497 361 A------P---KLMQIISALGLAQNFGAIKSLTTTGIQKGHMKMHL 397 Flexibacter litoralis
WP_013687959 359 A------R---ELMGIAAAAGLANNFGAVKSLTTTGIQQGHMKMHL 395 Fluviicola taffensis
WP_013869203 356 A------K---ELMQIVAVAGLAQNFAALRSLTTTGIQEGHMKMHL 392 Lacinutrix sp. 5H-3-7-4
WP_013306347 362 A------K---ELMRIVAVAGLAQNFAAVSSLVTTGIQEGHMKMHL 398 Maribacter sp. HTCC2170
WP_013597890 364 A------K---ELMGFIAVAGLAQNFGALRSLVTTGIQKGHMKMHL 400 Weeksella
WP_024269203 794 A------P---ALSRMAAALGLAQNFAAISALAGEGIQKGHMKLHS 830 Spirochaeta sp. L21-RPul-D2
WP_013182187 334 A------Q---SLNKLAAALGLAQNLAALFALVSDGIQGGHMKLHA 370 Waddlia chondrophila
XP_001321843 347 A------N---DLACVIASVGLASNFAAIRALVTTGINSGHMKLHS 383 Trichomonas vaginalis G3
XP_001329920 347 A------D---TLARTIATVGLANNFAAIRAIVTNGICAGHMKLHS 383 Trichomonas vaginalis G3
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