Conserved Protein Domain Family
Hexokinase_1

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pfam00349: Hexokinase_1 
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Hexokinase
Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.
Statistics
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PSSM-Id: 306785
View PSSM: pfam00349
Aligned: 424 rows
Threshold Bit Score: 84.4215
Threshold Setting Gi: 74608459
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00349 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O1W_A        26 QIHGLETLFTVSSEKMRSIVKHFiSELDKGLSkkg-----gnIPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVklg 100
gi 565382852  41 iLRKFARECATPVPKLWQIVDDLvAQMHAGLTstq-----stLQMFPSCLPSLPNGDEKGLFYGINLRGTNFIIVQArlg 115
gi 685346856  41 ilRKFARECATPVLKLWAVADALvADMAAFLSattaagscgsLNMLVSFAGALPSGDEKGLHYGVNLRGKELLLLRGalg 120
gi 297798090  41 ILRKFARECATPVSKLWAVADALvADMTASLAaatae-ccgsLNMLVSFAGSLPSGDEKGVHYGVNLRGRELLLLRGtlg 119
gi 566181309  38 iLRKFARESATPVPKLWEVANALvSDMQASLVsqee---tstLNMLVSYAASLPKGDEKGLYYGLNLRGTNFLILCArlg 114
gi 255576035  38 ILRKFARECATPVPKLLEVANALvSDMETSLAgkd----yttLNMLVSHVTSLPNGGEKGLYYGLNLRGNNFLLLCAklg 113
gi 734434949  39 IIRKFASECATPVTKLWQVADDLvSSMKISLVsshe---tttLNMVISNVTSLPLGDEEGFFYGVNLQGKHLLMLCArlg 115
gi 296083526  26 iLRKFARDCATPVSKLWLVADALvSDMNEALTsqe----tttLNMPISYVASLPSGDEEGLYYGLNLRGSNFLILRArlr 101
gi 357129316  44 VVREFEESFETPTERLQRVVNSLaIEMFAGLAsen----askVRMLLTCVDRLPNwNEEGIYYAIDIGGTSFRVLKVqlg 119
gi 159488887  38 LIKRYKDQLVPSAERLAELEVEFqQQMKDGLAkqitv-dgkhMMMLPTYIHRLPDGTETGECYALDLGGTNFRVMHVrlg 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O1W_A       101 -----------gnhDFDTTQNK-YRLPDHLRTGTSEQLWSFIAKCLKEFVDEWy----PdgvsepLPLGFTFSYPASQKK 164
gi 565382852 116 grdapmsriggrsePISDLYRQeIPIPPNIIEASSQELFDWITVELGKFISMHseglqGg----eKNLGFTVSPTIAEVA 191
gi 685346856 121 g----------neePISDVHKQeISIPADVSNGSFKELCDYISLELVKFIGMNpgeetDe----vKNLGFTLTRYVEEIG 186
gi 297798090 120 g----------neePISDVHKQeIPIPEDVLNGSFKELCDFISLELVKFLAMNpgeeaEe----vNNLGFTLTRSVEQIG 185
gi 566181309 115 g----------rnePISDLYRKeISIPPNVLSGTSQELFDYIAVELAKFVSEHppddtLdapereKKLGFTVSYPVDQAA 184
gi 255576035 114 g----------knePISDLYREeISVPTNLLVATSQELFEYVAVELARFVAIHpadenHgaa-raKKLGVTVSYPVDQVA 182
gi 734434949 116 g----------knkPISALQREeISIPDAVLAGASEEIIDYVATEIAKFVSSHpeiddGapa-kkKKLGFTLSYPVDEIL 184
gi 296083526 102 g----------kneSISELHREeVSIPSNVMGGTSQELFDYIALELAKFISEHevttdDtpd-rqKALGFIVSYPVDQAA 170
gi 357129316 120 -----------agyTIIDKKVQlQPIP---TKGTIEDFFNFIASTLKNFIEKEgd--------kgKALGFTFSFPIEQFS 177
gi 159488887 117 a----------grgQVESCQVReVALPREVYEGSGAQLFDFLAATLKDFIAQHsaadaDka--vqPVLGFCFSFAVEQSG 184
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
3O1W_A       165 INSGVLQRWTKGFDIe--gVEg---hDVVPMLQEQIEKLNI-PINVVA-LINDTTGTLVASLY 220
gi 565382852 192 ASKETAITWKDS-LLg--dAAg---nKLLNEINSAMEKHSVdK-RVFA-LVDDTIGVLAGGRY 246
gi 685346856 187 PSSISAIQ-RKGLANddddTVl---kEFVNDMNESLESHGL-KIRMNMaLVDDTIGVLAGGRY 244
gi 297798090 186 SGSISAIH-RKSLANddddKVl---kDLVNDMNESLERHGL-KIRMNTaLVDNTIGELAGGRy 243
gi 566181309 185 ASSGSAIKW-KSFSAn--dTVe---kALINDINRALEKHGL-KFRVFS-LVDDTVGNLAGGRY 239
gi 255576035 183 ATSGSAIKW-KSFSAd--dTVg---kALLNDINRAIEKQGL-NMQVFA-LVDETVGNLAGGRY 237
gi 734434949 185 PFAATTFQRKSAn-----nPVh---kGMVKELNKALTNHGM-KMHVSS-LVDETIGGLAGGRY 237
gi 296083526 171 ASSGAAIKW-RSFSVt--dTVecagkALASNFNRALEKHGV-NLRVLQlQVEDAIGHLAGGRY 229
gi 357129316 178 ITSGSLIRWTKEFSIe--eAVg---kDVAQCLNEALVRNGM-HLQVNA-LMNNTVGTLALGHY 233
gi 159488887 185 LAAGKLLDWTKGFKCs--gVIg---nDPVKLLTAALERAGC-PCRVLA-LLNDTVGVLAAQRY 240
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