1VEC,2DB3,2PL3,4PX9,2GXQ,3JCR,4D25,1HV8,4LK2,3SQW,2KBE,4W7S,4BGD,4BGD,4KIT,2EYQ,4TMU,4O3M,2V1X,4NL4


Conserved Protein Domain Family
DEAD

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pfam00270: DEAD 
Click on image for an interactive view with Cn3D
DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Statistics
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PSSM-Id: 333969
View PSSM: pfam00270
Aligned: 200 rows
Threshold Bit Score: 64.5582
Threshold Setting Gi: 2506763
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VEC_A   27 SPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERL-D-LKKDNIQAMVIVPTRELALQVSQIC---IQVSK----- 96   human
P50830   56 YTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIa---QDETNRALYLFPTKALAQDQKSEL---NEIID----- 124  Bacillus subtilis s...
O06359   60 WSHQAEAAELAYAGRHVVIGTGPASGKSLAYQLLVLNALa---TDSRARALYLSPTKALGHDQLRAA---HALAA----- 128  Mycobacterium tuber...
Q58969   47 YLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLAIFDNFl---SNPDDRYLLIYPTRALINNQYEKFsmeNELFY----- 118  Methanocaldococcus ...
O58731   48 YSHQVKALNLLYSGKNVVVSTPTASGKSEIFRLFIFDSFl---ENPSSTFLLVYPTRALINNQMEKFdneNKVFA----- 119  Pyrococcus horikoshii
Q05549  292 YSHQADAINSLHQGENVIITTSTSSGKSLIYQLAAIDLLl---KDPESTFMYIFPTKALAQDQKRAF---KVILSk---i 362  Saccharomyces cerev...
Q9YCM6   47 CRIAYES-----PGGVVFLGAPTGAGKTEVFMAPLLASFaS-KRPIAARGFLVEPMHSLIKAMVDRL---KTSIE----- 112  Aeropyrum pernix
Q97WW1   35 KGI-EETLLNLENGHSVILKAPTGYGKTTLTMILANAVS-S-DIDLGSRVIHVLPYRAIVQDLYLKL---KNYADr---- 104  Sulfolobus solfatar...
O58935  234 RPLQLSSSMT--EG-DVILYAPTGYGKTEAALLWANKNAhRtKKGISSRIFYILPYKASINAMHRRL---LEMFKdpglv 307  Pyrococcus horikoshii
O30165   15 YEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLn---DYLPPQLIYSLPTRTLVESIGERA---IKYAS----- 83   Archaeoglobus fulgidus
1VEC_A   97 HmGGaKVma----tTG---GTNL-RDDIMRLd--------DT--VHVVIATP---------GRILD-LI-------K-KG 140  human
P50830  125 E-MGiDIks---ftYD---GDTS-PAIRQKV---------RKa-GHIVITNP---------DMLHSaILphh--tkW-VS 174  Bacillus subtilis s...
O06359  129 --AVpRLadvaptaYD---GDSP--DEVRRF---------ARerSRWLFSNP---------EMTHLsVLrnh--arW-AV 180  Mycobacterium tuber...
Q58969  119 KiTNkRVka---eiLT---GDVG-LEKRREI---------LKdkPNVLFTTP---------DMLHYqILknh--nnY-LW 170  Methanocaldococcus ...
O58731  120 EiTGmKVka---siLT---GDVD-WSERKKI---------VRnkPNVIFTTP---------DMLHHtILprw--leY-KW 171  Pyrococcus horikoshii
Q05549  363 PeLKnAVvd----tYD---GDTE-PEERAYI---------RKn-ARVIFTNP---------DMIHTsILpnh--anW-RH 412  Saccharomyces cerev...
Q9YCM6  113 T-------------LGvseDHGE-TVQPTFL---------YT--APITVTTPdtyfygfaaSRVYR-ILthe--gvE-TG 163  Aeropyrum pernix
Q97WW1  105 -----GVi------YTkniGAQDmDYQDSPFfmkkvnvttLDtfILNLFKLP---------TVDFKlIFknygshyEfPR 164  Sulfolobus solfatar...
O58935  308 Gl---LHsssgiylYS---SSLEyKRLLSLY---------GKiySPIKITTP---------FQIMKaFFgvgffeiTlVE 363  Pyrococcus horikoshii
O30165   84 Fk---KLrv---aiHH---GKKAtSSLFEEDiivttidqtAGayLSVPLSMP---------KRWGN-IF----------- 133  Archaeoglobus fulgidus
1VEC_A  141 Va----kVDHV--QMIVLDEADKLLSQ--DFVQIMEDIILTL-------PKNRQ--ILLYSATFP-LSVQKF 194  human
P50830  175 L------FENL--KYIVIDELHTYRGV---FGSHVANVIRRLkricrfyGSDPV--FICTSATIA--NPKEL 231  Bacillus subtilis subsp. su...
O06359  181 L------LRNL--RFVIVDECHYYRGV---FGSNVAMVLRRLlrlcarySAHPT--VIFASATTA--SPGAT 237  Mycobacterium tuberculosis
Q58969  171 L------LKNL--KLLVVDELHVYRGV---FGTNMVYVFKRLlkllkrlNNNLQ--ILCLSATL--KNPKEF 227  Methanocaldococcus jannasch...
O58731  172 L------LKNL--KLLVVDELHTYRGV---FGSNVAYVFRRVffrlrrlNSSPL--ILALSATL--RNPKEF 228  Pyrococcus horikoshii
Q05549  413 F------LYHL--KLVVVDELHIYKGL---FGSHVALVMRRLlrlchcfYENSG--LQFISCSATlKSPVQH 471  Saccharomyces cerevisiae S288c
Q9YCM6  164 RfsmpvgLQAT--SYTVFDEAHLVQDEvfLSPRLLSLVVAALara--------gglIVVSSATLP-SYYKTV 224  Aeropyrum pernix
Q97WW1  165 A------LIYS--SIVIFDEFHLLGEDgkSLGAGLAA-LEVLrda--------gvpIVVTSATID-KGLERV 218  Sulfolobus solfataricus
O58935  364 L------INSL----LIFDEIHAYESN---ILGIILAMLELL--------KEKRakALVMTATFP-KFLEEL 413  Pyrococcus horikoshii
O30165  134 -------VGGIasALTVFDEVHTLDPE---KGLQTAA-AIAMqsaklglP------SIIMSATLPdVFIERV 188  Archaeoglobus fulgidus
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