1VEC,2DB3,2PL3,4PX9,2GXQ,3JCR,4D25,1HV8,4LK2,3SQW,2KBE,4W7S,4BGD,4BGD,4KIT,2EYQ,4TMU,4O3M,2V1X,4NL4


Conserved Protein Domain Family
DEAD

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pfam00270: DEAD 
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DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Statistics
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PSSM-Id: 333969
View PSSM: pfam00270
Aligned: 200 rows
Threshold Bit Score: 64.5582
Threshold Setting Gi: 2506763
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1VEC_A        27 SPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERL-D-LKKDNIQAMVIVPTRELALQVSQIC---IQVSK----- 96
gi 1730954    56 YTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIa---QDETNRALYLFPTKALAQDQKSEL---NEIID----- 124
gi 81814834   60 WSHQAEAAELAYAGRHVVIGTGPASGKSLAYQLLVLNALa---TDSRARALYLSPTKALGHDQLRAA---HALAA----- 128
gi 37538026   47 YLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLAIFDNFl---SNPDDRYLLIYPTRALINNQYEKFsmeNELFY----- 118
gi 74579172   48 YSHQVKALNLLYSGKNVVVSTPTASGKSEIFRLFIFDSFl---ENPSSTFLLVYPTRALINNQMEKFdneNKVFA----- 119
gi 74676365  292 YSHQADAINSLHQGENVIITTSTSSGKSLIYQLAAIDLLl---KDPESTFMYIFPTKALAQDQKRAF---KVILSk---i 362
gi 74581775   47 CRIAYES-----PGGVVFLGAPTGAGKTEVFMAPLLASFaS-KRPIAARGFLVEPMHSLIKAMVDRL---KTSIE----- 112
gi 74581301   35 KGI-EETLLNLENGHSVILKAPTGYGKTTLTMILANAVS-S-DIDLGSRVIHVLPYRAIVQDLYLKL---KNYADr---- 104
gi 74579181  234 RPLQLSSSMT--EG-DVILYAPTGYGKTEAALLWANKNAhRtKKGISSRIFYILPYKASINAMHRRL---LEMFKdpglv 307
gi 74514683   15 YEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLn---DYLPPQLIYSLPTRTLVESIGERA---IKYAS----- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1VEC_A        97 HmGGaKVma----tTG---GTNL-RDDIMRLd--------DT--VHVVIATP---------GRILD-LI-------K-KG 140
gi 1730954   125 E-MGiDIks---ftYD---GDTS-PAIRQKV---------RKa-GHIVITNP---------DMLHSaILphh--tkW-VS 174
gi 81814834  129 --AVpRLadvaptaYD---GDSP--DEVRRF---------ARerSRWLFSNP---------EMTHLsVLrnh--arW-AV 180
gi 37538026  119 KiTNkRVka---eiLT---GDVG-LEKRREI---------LKdkPNVLFTTP---------DMLHYqILknh--nnY-LW 170
gi 74579172  120 EiTGmKVka---siLT---GDVD-WSERKKI---------VRnkPNVIFTTP---------DMLHHtILprw--leY-KW 171
gi 74676365  363 PeLKnAVvd----tYD---GDTE-PEERAYI---------RKn-ARVIFTNP---------DMIHTsILpnh--anW-RH 412
gi 74581775  113 T-------------LGvseDHGE-TVQPTFL---------YT--APITVTTPdtyfygfaaSRVYR-ILthe--gvE-TG 163
gi 74581301  105 -----GVi------YTkniGAQDmDYQDSPFfmkkvnvttLDtfILNLFKLP---------TVDFKlIFknygshyEfPR 164
gi 74579181  308 Gl---LHsssgiylYS---SSLEyKRLLSLY---------GKiySPIKITTP---------FQIMKaFFgvgffeiTlVE 363
gi 74514683   84 Fk---KLrv---aiHH---GKKAtSSLFEEDiivttidqtAGayLSVPLSMP---------KRWGN-IF----------- 133
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1VEC_A       141 Va----kVDHV--QMIVLDEADKLLSQ--DFVQIMEDIILTL-------PKNRQ--ILLYSATFP-LSVQKF 194
gi 1730954   175 L------FENL--KYIVIDELHTYRGV---FGSHVANVIRRLkricrfyGSDPV--FICTSATIA--NPKEL 231
gi 81814834  181 L------LRNL--RFVIVDECHYYRGV---FGSNVAMVLRRLlrlcarySAHPT--VIFASATTA--SPGAT 237
gi 37538026  171 L------LKNL--KLLVVDELHVYRGV---FGTNMVYVFKRLlkllkrlNNNLQ--ILCLSATL--KNPKEF 227
gi 74579172  172 L------LKNL--KLLVVDELHTYRGV---FGSNVAYVFRRVffrlrrlNSSPL--ILALSATL--RNPKEF 228
gi 74676365  413 F------LYHL--KLVVVDELHIYKGL---FGSHVALVMRRLlrlchcfYENSG--LQFISCSATlKSPVQH 471
gi 74581775  164 RfsmpvgLQAT--SYTVFDEAHLVQDEvfLSPRLLSLVVAALara--------gglIVVSSATLP-SYYKTV 224
gi 74581301  165 A------LIYS--SIVIFDEFHLLGEDgkSLGAGLAA-LEVLrda--------gvpIVVTSATID-KGLERV 218
gi 74579181  364 L------INSL----LIFDEIHAYESN---ILGIILAMLELL--------KEKRakALVMTATFP-KFLEEL 413
gi 74514683  134 -------VGGIasALTVFDEVHTLDPE---KGLQTAA-AIAMqsaklglP------SIIMSATLPdVFIERV 188
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