3H4P,1J2Q,3UNE,4HRC,3J9I,1VSY,1PMA


Conserved Protein Domain Family
Proteasome

?
pfam00227: Proteasome 
Click on image for an interactive view with Cn3D
Proteasome subunit
The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologs vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homolog (BPH).
Statistics
?
PSSM-Id: 333940
View PSSM: pfam00227
Aligned: 164 rows
Threshold Bit Score: 89.5453
Threshold Setting Gi: 21759166
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3H4P_A        35 VRrgttAIGIACKDGVVLAVDRRIT--SKLVKIRsiEKIFQIDDHVAAATSGLVADARVLIDRARLEAQIYRLTYGEEIS 112 Methanocaldococ...
O09061        33 AFnggtVLAIAGEDFSIVASDTRLSegFSIHTRDs-PKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMT 111 house mouse
Q8SSI0         6 TFyggsILAMASSKGVAIMCDKRLGmsSITVSKDf-TRIHRIGPRLYVGLPAFVPDTQVLLRKIRKNYNLFRLEHQREME 84  Encephalitozoon...
Q23237         5 SYtggtVVAMAGDECVCIASDLRIGeqMTTIATDq-KKVHKVTDKVYVGLAGFQSDARTVLEKIMFRKNLYELRENRNIK 83  Caenorhabditis ...
Q9XYN7         6 YNgg-cVVAMRGKDCVAIATDHRFGiqAQTISTDf-KKVFHIGPRMFLGLTGLQTDILTVRDRLMFRKNLYETRENREMC 83  fruit fly
P25451         7 INgg-iVVAMTGKDCVAIACDLRLGsqSLGVSNKf-EKIFHY-GHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIE 83  Saccharomyces c...
Q9Y7T8         5 EYnggsCVAMAGKNCVAIASDLRLGv-QSISLTNnfPKVFAMGDKTYLGLTGLATDVQTLYELFRYKVNLYKFREERQIQ 83  Schizosaccharom...
Q9XI05         5 EYngsaVVAMVGKNCFAIASDRRLGvqLQTIATDf-QRISKIHDRVFIGLSGLATDVQTLYQRLVFRHKLYQLREERDMK 83  thale cress
XP_015463671   5 synggaVMAMRGKNCVAIASDRRFGiqAQMVTTDf-QKIFPMGDRLYIGLAGLATDVQTVSQRLKFRLNLYELKEGRQIK 83  Mexican tetra
ESU35658       8 eyngsaLIGIKGKDCVALAADKRLGcsYQTLTIGneERIFRLSQSCLLGLAGLQTDVLTTYRQIRMKSNLYHLQEDREIR 87  Giardia intesti...
3H4P_A       113 IEmlaKKICDIKQAYTQHGGVRPFGVSLLiAGID-KN-EARLFETDPSGALIEYK-ATAIG-SgRPVVMELLEKEyRDDI 188 Methanocaldococ...
O09061       112 TG----AIAAMLSTILYSRRFFPYYVYNIiGGLD-EEgKGAVYSFDPVGSYQRDs-FKAGG-SaSAMLQPLLDNQv--GF 182 house mouse
Q8SSI0        85 PE----ELSSMISFLLYSKRETPYITAPIvAGLT-SDgKPYISGMDCIGSIASPGdFVAVGt-aDKNLMGICEALyRPDM 158 Encephalitozoon...
Q23237        84 PQ----VLSEMISNLAYQHRFGSYFTEPLvAGLD-DTnKPYICCMDTIGCVSAPRdFVAVGt-gQEYLLGVCENFwRENM 157 Caenorhabditis ...
Q9XYN7        84 PK---PFSAMMSSFLYEHRFGPYFIEPVVaGLDP-KTmEPFICNMDLIGCPNAPDdFVVAGtC-AEQLYGMCETLwKPDL 158 fruit fly
P25451        84 PE----TFTQLVSSSLYERRFGPYFVGPVvAGINsKSgKPFIAGFDLIGCIDEAKdFIVSGt-aSDQLFGMCESLyEPNL 158 Saccharomyces c...
Q9Y7T8        84 PK----TFANLVSSTLYEKRFGPYFSFPVvAGVS-NDnTPFICGFDSIGCIDFAEdFIVSGt-aTEQLYGMCESVyEPNL 157 Schizosaccharom...
Q9XI05        84 PE----TFASLVSAILYEKRFGPYLCQPViAGLG-DDdKPFICTMDSIGAKELAKdFVVSG-TaSESLYGACEAMyKPDM 157 thale cress
XP_015463671  84 PK----TFMSMVSNLLYERRFGPYYIEPViAGLDpKTfEPFICSLDLIGCPMVTEdFVVSG-TcSEQMYGMCESLwEPDM 158 Mexican tetra
ESU35658      88 PR----ATAKMISSFLYKHRFGPYFISPIiAGFE-ADgKPYLGAMDTIGCLDDCTnFQIAG-TaSDFLLGLCETHvKPDM 161 Giardia intesti...
3H4P_A       189 TLDEGLELAITALTKA--NEDIKPENVDVCII 218 Methanocaldococcus jannaschii
O09061       183 KNMQNVEHVPLTLDRAm--rLVKDVFISAAER 212 house mouse
Q8SSI0       159 DEENLFVTCVQAFLNAidRDALSGWGADCYVI 190 Encephalitozoon cuniculi
Q23237       158 KPDELFEATAQSILSCleRDAASGWGAVVYTI 189 Caenorhabditis elegans
Q9XYN7       159 EPDQLFEVIAQSIVNAfdRDAMSGWGATVYII 190 fruit fly
P25451       159 EPEDLFETISQALLNAadRDALSGWGAVVYII 190 Saccharomyces cerevisiae S288c
Q9Y7T8       158 EPDDLFETISQALLNAqdRDCISGWGCVVYVI 189 Schizosaccharomyces pombe 972h-
Q9XI05       158 EAEELFETISQALLSSvdRDCLSGWGGHVYIV 189 thale cress
XP_015463671 159 EPDDLFETISQAMLNAvdRDAVSGMGVIVHVI 190 Mexican tetra
ESU35658     162 SEDEILPLMEQIIRSAtnRDAYSGWGAHVVVl 193 Giardia intestinalis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap