1IA0,1MKJ,1T5C,3LRE,2WBE,1SDM


Conserved Protein Domain Family
Kinesin

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pfam00225: Kinesin 
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Kinesin motor domain
Statistics
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PSSM-Id: 333938
View PSSM: pfam00225
Aligned: 77 rows
Threshold Bit Score: 301.015
Threshold Setting Gi: 51316544
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IA0_K          27 RVRPFNSREMSRDSKCIIqms-----------gstTTIVNPKQPKETPKSFSFDYSYWS--HtspedinyAS-----QKQ 88
gi 51316544     11 RVRPKSLRELSKSAEDLLsvdshnktvtitppkhgLKHSRHKNRVNGPRTFAFDECFAPsaP--------ESknlsgQED 82
gi 1100165279  442 RIRPFLQGQNKKQTSIEYtgen----------gelVVANPLKQGKDTYRLFKFNKVFGP--E--------ST-----QEE 496
gi 1176597     251 RIRPQLASETDNQKPVVVide-----------mdnGVVHVSNTTGTRKTSAGADKVIPT--D--------FS-----QDQ 304
gi 74961629    254 RVRPLIKSEADASSSAIEyp--------------aIDTIRINEGSKPGIVVKFEKVFTP--V--------FS-----QKE 304
gi 357529584   451 RVRPVTKEDGEGPEATNAvtf-----------dadDDSIIHLLHKGKPVSFELDKVFSP--Q--------AS-----QQD 504
gi 34098370    415 RLRPAEGQPSSLVSVEPG-----------------QGGTITTCYRGRQHCFRLDWVFPQ--D--------ASq---eEVF 464
gi 75311662    148 RARPLFEDEGPSVIEFPGdc-------------tiCVNTSDDTLSNPKKDFEFDRVYGP--H--------VG-----QAA 199
1SDM_A          12 RLRPLCEKEIIAKERNAIrs-------------vdEFTVEHLWKDDKAKQHMYDRVFDG--N--------AT-----QDD 63
gi 565362161   103 RVRPFSPTDKQRTHQPISv----------------ESEKIVVRSGGSRKEFEFDKVFPQ--E--------SL-----QED 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IA0_K          89 VYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQ---EkdQQGIIPQLCEDLFSRINDttnD-NMSYSVE-VSYM 163
gi 51316544     83 VYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVG-L---Rg-QPGIIPHISESIFEEIDKlkkKsPNTTITVsISLA 157
gi 1100165279  497 VFLDT-RPMIRSILDGYNVCIFAYGQTGSGKTYTMSGPsitsEe-DRGVNYRALNDLFHLTQSrqnS--VMYEVG-VQMV 571
gi 1176597     305 IFNEV-SPIITSCIDGYNVCIFAYGHTGSGKTYTMDG-P---Vt-MPGINQRAIMQLFETAKErtgD--IKYDIK-VAMM 375
gi 74961629    305 VFAN-VEEFIRSSLHGYNVGLIAYGQTGSGKTHTMRGGN---Ge-EEGIIPRAAAFLFAESRKlesL-GWKFDFS-LSFL 377
gi 357529584   505 VFQEV-QALVTSCIDGFNVCIFAYGQTGAGKTYTMEGT----Ae-NPGINQRALQLLFSEVQEkasD--WEYTIT-VSAA 575
gi 34098370    465 RQLE---PAVLSCLQGYSVCIFTYGQTGTGKTYSMEGpP---Ed--PGIAPRALQLLFREMGTg---gHH--HVT-LSMV 530
gi 75311662    200 LFSDV-QPFVQSALDGSNVSILSYGQTNAGKTYTMEGS----Nh-DRGLYARCFEELFDLANSdstS-TSRFSFS-LSVF 271
1SDM_A          64 VFEDT-KYLVQSAVDGYNVCIFAYGQTGSGKTFTIYGA----Ds-NPGLTPRAMSELFRIMKKdsnK--FSFSLK-AYMV 134
gi 565362161   152 VFAE-VEPIIRSALDGHNVCILAYGQTGTGKTYTMEGI----Te-SPGIIPRVLQELFNLSSLd---sSISFTFS-ISML 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IA0_K         164 EIYCERVRDLLNPK-------NKGn---LRVRE-HPLLG-PYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSS 231
gi 51316544    158 EIIEETPYDLLQPNvn----sSHTpgetVFVQK-DSLTG-YHLHGLSEFEVGSAQEIDAFLRLAAKNIRTELSDISG-VR 230
gi 1100165279  572 EIYNEQVRDLLSQD----------------------------VPDASMHSVRSTEDVLELMNIGLMNRTVGATTLNEKSS 623
gi 1176597     376 EIYNEKIRDLLNTS--------NTn---LAIRQ-TEEGR-SSIPGLEEVSVNSAEEVTETLARGRKNKAVAATEANIESS 442
gi 74961629    378 EVYNNVAYDLLSDRa------------vVQLRL-NDQt--VSMIGLSEHTISNVSDVARLLRVADGGRKTAATKCNESSS 442
gi 357529584   576 EIYNEVLRDLLGKEp-----qEKLe---IRLCP-DGS-GqLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSS 645
gi 34098370    531 EIYNEAVRDLLATGpp---erLVVr-----QGP-AGQ-GgIQVAGLTHWDVPNLETLHQMLSLGRSNRATAATVMNQHSS 600
gi 75311662    272 EIYNEQIRDLLSET--------QSn---LPNINmDLHES---VIELGQEKVDNPLEFLGVLKSAFLNRGNYKSKFNV--- 334
1SDM_A         135 ELYQDTLVDLLLPKq------AKRl--kLDIKK-DSK-GmVSVENVTVVSISTYEELKTIIQRGSEQRHTTGTLMNEQSS 204
gi 565362161   222 EVYLGSIRDLLAPRpssrkytASRc--nLNIQT-DSK-GsVEIDGLTEVEISNFTKAKWWYHKGRRVRSTSWTNVNETSS 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IA0_K         232 RSHAVFNIIFTQKRHDae---tnITTekvSKISLVDLAGSERADSTG---------AKGTRLKEGANINKSLTTLGKVIS 299
gi 51316544    231 KGHSVFSLVVQQRIIDpktrhslkKA---SRLQIIDLASFSKGSQRN----------ESISSFESSSNNKSLSVLNRVIA 297
gi 1100165279  624 RSHSVLSVHVRGVDVKte----svLR---GSLHLVDLAGSERVGRSE---------VTGERLKEAQHINKSLSALGDVIF 687
gi 1176597     443 RSHVIVRVLVSATNLItk----atTV---GRLNLVDLAGSERVSQTN---------ATGQLLKEAQAINKSLSELGNVVL 506
gi 74961629    443 RSHAVYMWKITAHQPStg----isTS---CQLKLVDLAGSERAKESGv--------SGD-QFKEMTNINQSLSILQMCIS 506
gi 357529584   646 RSHALLIVTVRGVDCStg----lrTT---GKLNLVDLAGSERVGKSG---------AEGSRLREAQHINKSLSALGDVIA 709
gi 34098370    601 RSHALVTLTLRAAS-Pprpq------gitgTLHLVDLAGSERVWKAGvaspvqrdpNGARRLREAQAINRSLLALGGVMA 673
gi 75311662    335 -THLIVSIHIYYSNTItg----enIY---SKLSLVDLAGSEGLIMENd---------SGDHVTDLLHVMNSISALGDVLS 397
1SDM_A         205 RSHLIVSVIIESTNLQtq----aIAR---GKLSFVDLAGSERVKKSGs--------AGNQ-LKEAQSINKSLSALGDVIS 268
gi 565362161   298 RSHCLTRISIYRYGDTlg---gkPEA---TKLWMVDLGGSERLLKTG---------ATGQTLDEGRAINLSLSALGDVIA 362
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1IA0_K         300 ALAEMd-SgpnknkkkkktDFIPYRDSVLTWLLRENLG-GNSRTAMVAALSPADINYDETLSTLRYADRAKQI 370
gi 51316544    298 ALTSKknD-----------VLIPYKDSVLTTLLQDALG-GNCRTIMLTCVSPCDF--DDTFSALRYSEAARRI 356
gi 1100165279  688 ALAHK--N-----------PHVPYRNSKLTQVLQNSLG-GQAKTLMFVQINPDEDSYAETVSTLKFAERVSgv 746
gi 1176597     507 ALRQN--Q-----------KHIPFRNCQLTRILEDSLN-GDSKTLVIVHLSPDAKSLNESISSVNFAEKIGQV 565
gi 74961629    507 QQRSQ--K-----------GHVSYRDSKLTQVLMDCLGrGNSKTMVVVNLNPCNEQATESKRSIEFASKMRSt 566
gi 357529584   710 ALRSR--Q-----------GHVPFRNSKLTYLLQDSLS-GDSKTLMVVQVSPVEKNTSETLYSLKFAERVRSV 768
gi 34098370    674 ALRAR--R-----------PHVPFRDSQLTRLLQPALWa-GTTAVLLLQISTRAEDLGETICSLKFAERVGQV 732
gi 75311662    398 SLTSG--K-----------DSIPYDNSILTRVLADSLG-GSSKTLMIVNICPSVQTLSETISCLNYAARARNT 456
1SDM_A         269 ALSSG--N-----------QHIPYRNHKLTMLMSDSLG-GNAKTLMFVNISPAESNLDETHNSLTYASRVRSI 327
gi 565362161   363 ALRRK--K-----------GHVPYRNSKLTQVLKDSLG-DKSKVLMVVHVSPYEEDVGETTCSCTFAKRARaa 421
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