6KW4,5VVR


Conserved Protein Domain Family
SNF2-rel_dom
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pfam00176: SNF2-rel_dom 
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SNF2-related domain
This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Links
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Statistics
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PSSM-Id: 425504
Aligned: 19 rows
Threshold Bit Score: 207.536
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6KW4_Y        473 YQLRGLEWMVSLYNN----------------------------------------------------------------- 487  Saccharomyces...
XP_004935641  310 YQSEAVNWMLHRENFtntpenalhflwrevitldgv-------------------------------------------- 345 
Q03468        510 YQQTGVRWLWELHCQ----------------------------------------------------------------- 524  human
P46100       1563 HQVDGVQFMWDCCCEsvkkt------------------------------------------------------------ 1582 human
P41410        267 HQIEGVKFLYKCVTGrid-------------------------------------------------------------- 284  Schizosacchar...
P38086        299 HQREGVKFMYDCLMGlarptienpdidc---------------------------------------------------- 326  Saccharomyces...
BAS76252       97 HQEAAVEWMLRREQNlqvlehplykglctmdgfpy--------------------------------------------- 131 
EDQ91428      741 HQIRSVKWMRAREAGlhgrfdspqhmpvaarfvqhqerh----------------------------------------- 779 
XP_002947308  217 YQRRAVAWMLRREQVvlereqndedttaaatgfnsgkggaeqrgeaaqvqppqgreamdwdaavavaaargpasadvqeg 296 
P34739        442 HQKHALAWMSWRERKl---------------------------------------------------------------- 457  fruit fly

6KW4_Y        488 -----------------------------------------------HLNGILADEMGLGK--------------TIQSI 506  Saccharomyces...
XP_004935641  346 --------------------------kiyynpftgcvireypfagpqWPGGILADEMGLGK--------------TVEVL 385 
Q03468        525 -----------------------------------------------QAGGILGDEMGLGK--------------TIQII 543  human
P46100       1583 -------------------------------------------kkspGSGCILAHCMGLGK--------------TLQVV 1605 human
P41410        285 ---------------------------------------------rcANGCIMADEMGLGK--------------TLQCI 305  Schizosacchar...
P38086        327 -----------------------------------ttkslvlendsdISGCLLADDMGLGK--------------TLMSI 357  Saccharomyces...
BAS76252      132 ----------------------------yinvtsgeistgsaptvhdFCGGMFCDEPGLGK--------------TVTAL 169 
EDQ91428      780 -----------------------gwqhiffvdaetgnvepspetrqsSRGGLLCDDPAATEtdplpaeksttkpsTLRNL 836 
XP_002947308  297 gdlraaapplhplwrrlrtlpgsaaeavyvnpytgalaavpfpapqpVRGGILADEMGLGK--------------TVELL 362 
P34739        458 -----------------------------------------------PRGGILADDMGLGK--------------TLTMI 476  fruit fly

6KW4_Y        507 SLIT---------------------------------------------------------------------------- 510  Saccharomyces...
XP_004935641  386 ALILthtredikqddltlpegelvnffvppqpsqgskkkktrem------------------------------------ 429 
Q03468        544 AFLA---------------------------------------------------------------------------- 547  human
P46100       1606 SFLH---------------------------------------------------------------------------- 1609 human
P41410        306 ALLW---------------------------------------------------------------------------- 309  Schizosacchar...
P38086        358 TLIW---------------------------------------------------------------------------- 361  Saccharomyces...
BAS76252      170 SLILkthgtlavpppgmnvmwcmhkpdkkygyyelsasnssngniflsgskklrkdviredtcsseslnnggsvvstrss 249 
EDQ91428      837 AFRR---------------------------------------------------------------------------- 840 
XP_002947308  363 ALITanrfgpksqpgmaplvaagqaldpaaaaaaaag------------------------------------------- 399 
P34739        477 SSVL---------------------------------------------------------------------------- 480  fruit fly

6KW4_Y        511 -------------------------------------------YLYEVKKDi----------G----------------- 520  Saccharomyces...
XP_004935641  430 ---elklkekiqypslrvmvlaavkemnvkkgasifaifkyisAVYRYDIQr----------Nrrllkrtlekliaeqvv 496 
Q03468        548 -------------------------------------------GLSYSKIRtrgsnyrfeglG----------------- 567  human
P46100       1610 -------------------------------------------TVLLCDKLdf--------------------------- 1619 human
P41410        310 -------------------------------------------TLLKQSPQa----------Gkpt-------------- 322  Schizosacchar...
P38086        362 -------------------------------------------TLIRQTPFaskvscsqs-------------------- 378  Saccharomyces...
BAS76252      250 rkrgrlvnpdlnmiaahpsgkspmsaptgahstpathvlkitkNLKHVRKNl----------Meaysdgsvgnkrkrdat 319 
EDQ91428      841 -------------------------------------------FMKEEARMr----------Giderlfdepvdlslypd 867 
XP_002947308  400 ----------graknrkdwalfpgggaivkwlkcerdeplldsAVYGCRSMw----------Grryngggvggtvqptsp 459 
P34739        481 -------------------------------------------ACKNGQEMsegkdessdsdseddknkk---------- 507  fruit fly

6KW4_Y            --------------------------------------------------------------------------------      Saccharomyces...
XP_004935641  497 eqvkghglagsfklgknykeqkrrertkeqaaktseriqkkqlsdantqtneskdsdvtstdvlkiplrtsiateehdyc 576 
Q03468            --------------------------------------------------------------------------------      human
P46100            --------------------------------------------------------------------------------      human
P41410            --------------------------------------------------------------------------------      Schizosacchar...
P38086            --------------------------------------------------------------------------------      Saccharomyces...
BAS76252      320 selsetwvqcdacrkwrrlldgtaldsstawfcsmnpdsarqkcsipeeswdlkrkitylpgfhkkgtppgneqnasfft 399 
EDQ91428      868 ythtvtrpiavrnirdrhytsfqalyddlqlml----------------------------------------------- 900 
XP_002947308  460 aaavaaarqrlpervdcpcgvraddphdpdveey---------------------------------------------- 493 
P34739            --------------------------------------------------------------------------------      fruit fly

6KW4_Y            --------------------------------------------------------------------------------      Saccharomyces...
XP_004935641  577 atikndrksetdnensmeenniqkaavskspdlhgkplisgdisshsdfdvsksttdvqqemprsshsqehasgsvqrts 656 
Q03468            --------------------------------------------------------------------------------      human
P46100            --------------------------------------------------------------------------------      human
P41410            --------------------------------------------------------------------------------      Schizosacchar...
P38086            --------------------------------------------------------------------------------      Saccharomyces...
BAS76252      400 nilkeh-----------------------------------------aalidsetmkallwlaklspkkhiemeavgltr 438 
EDQ91428          --------------------------------------------------------------------------------     
XP_002947308      --------------------------------------------------------------------------------     
P34739            --------------------------------------------------------------------------------      fruit fly

6KW4_Y        521 ---------------------------------------------------------------------PFLVIVPLSTI 531  Saccharomyces...
XP_004935641  657 svfpfntseyrfecicgelglvdykarvqclkchlwqhaecvnykeenlkikpfycphclvamkpvstgATLIISPSSIC 736 
Q03468        568 ---------------------------------------------------------------------PTVIVCPTTVM 578  human
P46100       1620 --------------------------------------------------------------------sTALVVCPLNTA 1631 human
P41410        323 -------------------------------------------------------------------ieKAIITCPSSLV 335  Schizosacchar...
P38086        379 ------------------------------------------------------------gipltglckKILVVCPVTLI 398  Saccharomyces...
BAS76252      439 pvldaranigkgarpyykifqafglvrkvekgitrwyypsmlddlafdsaalgialekpldlvrlylsrATLIVVPANLI 518 
EDQ91428      901 -------------------angaqynhgtpiqelclvlqqrlhehilslpidrrarrrsgrvdvrpmynATLIIAPTLDL 961 
XP_002947308  494 -------------------eglwilcegcnawmhgacvgvkrspqrsaawvcsrclraralapvsepcgATLIVVPSAIL 554 
P34739        508 ---------------------------------------------------rksvtgwkskgrkdtrrgGTLVVCPASLL 536  fruit fly

6KW4_Y        532 TN-WTLEFEKWA------PSLNTIIYKGTPNQRh---------------------------------------------- 558  Saccharomyces...
XP_004935641  737 HQ-WVDEINRHVr----sSSLRVLVYQGVKKHG----------------------------------------------- 764 
Q03468        579 HQ-WVKEFHTWW------PPFRVAILHETGSYThk--------------------------------------------- 606  human
P46100       1632 LN-WMNEFEKWQeglkddEKLEVSELATVKRPQersym------------------------------------------ 1668 human
P41410        336 KN-WANELVKWLg----kDAITPFILDGKSSKQelima------------------------------------------ 368  Schizosacchar...
P38086        399 GN-WKREFGKWLn----lSRIGVLTLSSRNSPDmdk-------------------------------------------- 429  Saccharomyces...
BAS76252      519 DH-WTTQIQRHVs----sDTLNVYVWGDHKKPS----------------------------------------------- 546 
EDQ91428      962 ARhWEHEIDAYTag---pHVLGRTCMLLNTRVL----------------------------------------------- 991 
XP_002947308  555 QQ-WYDEIRRHVh----pGALRVVVYGGQTQPGvsgsgalicsgtftpgrvggtavtcgtaaapgglrgpadrgvdgdgn 629 
P34739        537 RQ-WESEVESKVs----rQKLTVCVHHGNNRET----------------------------------------------- 564  fruit fly

6KW4_Y        559 ----------------sLQHQIRVGNFDVLLTTYEYI----------------------IKDKSLLSK--HD--WAHMII 596  Saccharomyces...
XP_004935641  765 -----------------FLQPHMLAEQDVVITTYDVLrtelnyvdiphsnsedgrrfrnQKRYMAIPSplVAveWWRICL 827 
Q03468        607 ---------------keKLIRDVAHCHGILITSYSYI----------------------RLMQDDISR--YD--WHYVIL 645  human
P46100       1669 -------------lqrwQEDG------GVMIIGYEMYrnlaqg-----------rnvksRKLKEIFNKalVDpgPDFVVC 1718 human
P41410        369 -------------lqqwASVHGRQVTRPVLIASYETL----------------------RSYVEHLNN--AE--IGMLLC 409  Schizosacchar...
P38086        430 --------------mavRNFLKVQRTYQVLIIGYEKL----------------------LSVSEELEK--NKhlIDMLVC 471  Saccharomyces...
BAS76252      547 -------------------AHNLAWDYDIVITTFSRLsae-----------------wgPKKRSVLKQ--IH--WFRVIL 586 
EDQ91428      992 --------------------PETFEDYGVVITTLHTLsrv----------------cslPHHYDLFHQ--RR--WHRIVV 1031
XP_002947308  630 fsvveadvaesmvgrwvVVSAAQLAAADVVLTTYDVLkrdvarqpdp---egqerslrhGKRYEVVPTplTRlrWWRVVL 706 
P34739        565 -------------------KGKYLRDYDIVVTTYQIVa---------------------REHKSLSAV--FGvkWRRIIL 602  fruit fly

6KW4_Y        597 DEGHRM-KNAQSKLSF--TISHyYRTRNRLILTGTPLQN----NLPELW-ALLNFVLPKIFNSak---tfEDWFNTPFAN 665  Saccharomyces...
XP_004935641  828 DEAQMV-ECTTAKAAE--MALR-LSGINRWCVSGTPVQR----GLEDLY-GLVLFLGIDPYWV-------KHWWDQLLYR 891 
Q03468        646 DEGHKI-RNPNAAVTL--ACKQ-FRTPHRIILSGSPMQN----NLRELW-SLFDFIFPGKLGTlp---vfMEQFSVPITM 713  human
P46100       1719 DEGHIL-KNEASAVSK--AMNS-IRSRRRIILTGTPLQN----NLIEYH-CMVNFIKENLLGSik---efRNRFINPIQN 1786 human
P41410        410 DEGHRL-KNSDSLTFT--ALDK-LNVQRRVILSGTPIQN----DLSEYF-SLLNFANPGLLGSrq---efRKNYEIPILK 477  Schizosacchar...
P38086        472 DEGHRL-KNGASKILN--TLKS-LDIRRKLLLTGTPIQN----DLNEFF-TIIDFINPGILGSfa---sfKRRFIIPITR 539  Saccharomyces...
BAS76252      587 DEGHTL-GSSLALTNKlqMAVS-LVASNRWILTGTPTPNtptsQVAHLH-PMLKFLHEEVYGQnyq--swDTGIHRPFEa 661 
EDQ91428     1032 DEGHTLgKGVQSRARE--AIQS-LGTDHMWIVSGTPTPDllasSGIDFIrGLLITLREPPFCEgntrntfRNLLTRPFER 1108
XP_002947308  707 DEAQMV-ESSTAKAAE--MALK-LDTVHRWCVTGTPISR----GLEDVY-GLLAFLGVRPWTE-------RRWWSRCVQR 770 
P34739        603 DEAHVV-RNHKSQSSL--AVCD-LRGKYRWALTGTPIQN----KELDVY-ALLKFLRCSPFDDlh---twKKWIDn---- 666  fruit fly

6KW4_Y        666 Tgtqekl--elteeETLLIIRRLHKVLRP----------------------FLLRRLKKEV--EK--D-LPDKVEKVIKC 716  Saccharomyces...
XP_004935641  892 P-------------YCRKNSQPLYSLIAK----------------------IMWRSAKKDVidQI--Q-IPPQTENIHWL 933 
Q03468        714 Ggysnas--pvqvkTAYKCACVLRDTINP----------------------YLLRRMKSDVkmSL--S-LPDKNEQVLFC 766  human
P46100       1787 Gqcadst--mvdvrVMKKRAHILYEMLAG----------------------CVQRKDYTAL--TK--F-LPPKHEYVLAV 1837 human
P41410        478 Grdadgt--ekdkeNGDAKLAELAKIVNR----------------------FIIRRTNDIL--SK--Y-LPVKYEHVVFC 528  Schizosacchar...
P38086        540 ArdtanryneelleKGEERSKEMIEITKR----------------------FILRRTNAIL--EK--Y-LPPKTDIILFC 592  Saccharomyces...
BAS76252      662 --------------QMEDGRSRLLQLLQR----------------------TMISARKQDL---K--N-IPPCIKKITFL 699 
EDQ91428     1109 h-------------LATDSVWRLAQMLQR----------------------CMVRHSKLET--MR--N-VPRPVCETILL 1148
XP_002947308  771 Pae----------aCDPEGRRLLLHLLRPsravgdcaagsggggggggdggLMWRSAKRDVesEL--G-LPPQSTHLRHL 837 
P34739        667 --------------KSAGGQNRLNLLMKS----------------------LMLRRTKAQLqsDGklNsLPNKELRLIEI 710  fruit fly

6KW4_Y        717 KLSGLQQQLYQ------------QMLKH----------------NALFVGAGTE-------------GAT-KggiKGLNN 754  Saccharomyces...
XP_004935641  934 HFSPVERHFYHrqhevccqdalaKLRKI----------------SDWTLKLSSL-------------DRRtV---TSILY 981 
Q03468        767 RLTDEQHKVYQn-----------FVDSK----------------EVYRILNGE----------------------MQIFS 797  human
P46100       1838 RMTSIQCKLYQ------------YYLDH----------------LTGVGNNSEG-------------GRGkAg--AKLFQ 1874 human
P41410        529 NLSEFQLSLYKh-----------FITSP----------------EINKILRGTG---------------------SQPLK 560  Schizosacchar...
P38086        593 KPYSQQILAFKd-----------ILQGA----------------RLDFGQLTF----------------------SSSLG 623  Saccharomyces...
BAS76252      700 DFSEGHAKSYNe-------------LAV----------------TIRR-------------------------------N 719 
EDQ91428     1149 PLQHHEWRSYNt-----------LLSFL----------------RGNIVLTSLV-------------GNEiSgkqDSILE 1188
XP_002947308  838 RLNAVELHFYNrrhqdcatkaraVLPPR----------------VVAAMESG------------------------RLLG 877 
P34739        711 SLDKEEMNVYQtvmtysrtlfaqFLHQRaeretdfnyrsdankpTYNQIKDPNGayykmhekfarmaGSKkEvksHDILV 790  fruit fly

6KW4_Y        755 KIMQLRKICNHPFVF 769  Saccharomyces cerevisiae S288C
XP_004935641  982 PLLRLRQACCHPQAV 996 
Q03468        798 GLIALRKICNHPDLF 812  human
P46100       1875 DFQMLSRIWTHPWCL 1889 human
P41410        561 AIGLLKKICNHPDLL 575  Schizosaccharomyces pombe 972h-
P38086        624 LITLLKKVCNSPGLV 638  Saccharomyces cerevisiae S288C
BAS76252      720 ILMADWNDPSHVESL 734 
EDQ91428     1189 SPRHLREAMENLRII 1203
XP_002947308  878 YGTEEQQDQQQDQMT 892 
P34739        791 LLLRLRQICCHPGLI 805  fruit fly
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